Stimuli-Regulated Smart Polymeric Systems for Gene Therapy

The physiological condition of the human body is a composite of different environments, each with its own parameters that may differ under normal, as well as diseased conditions. These environmental conditions include factors, such as pH, temperature and enzymes that are specific to a type of cell,...
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Autor*in:	Ansuja Pulickal Mathew [verfasserIn] Ki-Hyun Cho [verfasserIn] Saji Uthaman [verfasserIn] Chong-Su Cho [verfasserIn] In-Kyu Park [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	stimuli-responsive system internal stimuli transfection gene carrier enzyme temperature polyplexes

Übergeordnetes Werk:	In: Polymers - MDPI AG, 2011, 9(2017), 4, p 152
Übergeordnetes Werk:	volume:9 ; year:2017 ; number:4, p 152

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/polym9040152

Katalog-ID:	DOAJ036917036

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allfields	10.3390/polym9040152 doi (DE-627)DOAJ036917036 (DE-599)DOAJ4d43a9e3eece4ce18a258ed9388bb258 DE-627 ger DE-627 rakwb eng QD241-441 Ansuja Pulickal Mathew verfasserin aut Stimuli-Regulated Smart Polymeric Systems for Gene Therapy 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The physiological condition of the human body is a composite of different environments, each with its own parameters that may differ under normal, as well as diseased conditions. These environmental conditions include factors, such as pH, temperature and enzymes that are specific to a type of cell, tissue or organ or a pathological state, such as inflammation, cancer or infection. These conditions can act as specific triggers or stimuli for the efficient release of therapeutics at their destination by overcoming many physiological and biological barriers. The efficacy of conventional treatment modalities can be enhanced, side effects decreased and patient compliance improved by using stimuli-responsive material that respond to these triggers at the target site. These stimuli or triggers can be physical, chemical or biological and can be internal or external in nature. Many smart/intelligent stimuli-responsive therapeutic gene carriers have been developed that can respond to either internal stimuli, which may be normally present, overexpressed or present in decreased levels, owing to a disease, or to stimuli that are applied externally, such as magnetic fields. This review focuses on the effects of various internal stimuli, such as temperature, pH, redox potential, enzymes, osmotic activity and other biomolecules that are present in the body, on modulating gene expression by using stimuli-regulated smart polymeric carriers. stimuli-responsive system internal stimuli transfection gene carrier enzyme temperature polyplexes Organic chemistry Ki-Hyun Cho verfasserin aut Saji Uthaman verfasserin aut Chong-Su Cho verfasserin aut In-Kyu Park verfasserin aut In Polymers MDPI AG, 2011 9(2017), 4, p 152 (DE-627)61409612X (DE-600)2527146-5 20734360 nnns volume:9 year:2017 number:4, p 152 https://doi.org/10.3390/polym9040152 kostenfrei https://doaj.org/article/4d43a9e3eece4ce18a258ed9388bb258 kostenfrei http://www.mdpi.com/2073-4360/9/4/152 kostenfrei https://doaj.org/toc/2073-4360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2017 4, p 152
spelling	10.3390/polym9040152 doi (DE-627)DOAJ036917036 (DE-599)DOAJ4d43a9e3eece4ce18a258ed9388bb258 DE-627 ger DE-627 rakwb eng QD241-441 Ansuja Pulickal Mathew verfasserin aut Stimuli-Regulated Smart Polymeric Systems for Gene Therapy 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The physiological condition of the human body is a composite of different environments, each with its own parameters that may differ under normal, as well as diseased conditions. These environmental conditions include factors, such as pH, temperature and enzymes that are specific to a type of cell, tissue or organ or a pathological state, such as inflammation, cancer or infection. These conditions can act as specific triggers or stimuli for the efficient release of therapeutics at their destination by overcoming many physiological and biological barriers. The efficacy of conventional treatment modalities can be enhanced, side effects decreased and patient compliance improved by using stimuli-responsive material that respond to these triggers at the target site. These stimuli or triggers can be physical, chemical or biological and can be internal or external in nature. Many smart/intelligent stimuli-responsive therapeutic gene carriers have been developed that can respond to either internal stimuli, which may be normally present, overexpressed or present in decreased levels, owing to a disease, or to stimuli that are applied externally, such as magnetic fields. This review focuses on the effects of various internal stimuli, such as temperature, pH, redox potential, enzymes, osmotic activity and other biomolecules that are present in the body, on modulating gene expression by using stimuli-regulated smart polymeric carriers. stimuli-responsive system internal stimuli transfection gene carrier enzyme temperature polyplexes Organic chemistry Ki-Hyun Cho verfasserin aut Saji Uthaman verfasserin aut Chong-Su Cho verfasserin aut In-Kyu Park verfasserin aut In Polymers MDPI AG, 2011 9(2017), 4, p 152 (DE-627)61409612X (DE-600)2527146-5 20734360 nnns volume:9 year:2017 number:4, p 152 https://doi.org/10.3390/polym9040152 kostenfrei https://doaj.org/article/4d43a9e3eece4ce18a258ed9388bb258 kostenfrei http://www.mdpi.com/2073-4360/9/4/152 kostenfrei https://doaj.org/toc/2073-4360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2017 4, p 152
allfields_unstemmed	10.3390/polym9040152 doi (DE-627)DOAJ036917036 (DE-599)DOAJ4d43a9e3eece4ce18a258ed9388bb258 DE-627 ger DE-627 rakwb eng QD241-441 Ansuja Pulickal Mathew verfasserin aut Stimuli-Regulated Smart Polymeric Systems for Gene Therapy 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The physiological condition of the human body is a composite of different environments, each with its own parameters that may differ under normal, as well as diseased conditions. These environmental conditions include factors, such as pH, temperature and enzymes that are specific to a type of cell, tissue or organ or a pathological state, such as inflammation, cancer or infection. These conditions can act as specific triggers or stimuli for the efficient release of therapeutics at their destination by overcoming many physiological and biological barriers. The efficacy of conventional treatment modalities can be enhanced, side effects decreased and patient compliance improved by using stimuli-responsive material that respond to these triggers at the target site. These stimuli or triggers can be physical, chemical or biological and can be internal or external in nature. Many smart/intelligent stimuli-responsive therapeutic gene carriers have been developed that can respond to either internal stimuli, which may be normally present, overexpressed or present in decreased levels, owing to a disease, or to stimuli that are applied externally, such as magnetic fields. This review focuses on the effects of various internal stimuli, such as temperature, pH, redox potential, enzymes, osmotic activity and other biomolecules that are present in the body, on modulating gene expression by using stimuli-regulated smart polymeric carriers. stimuli-responsive system internal stimuli transfection gene carrier enzyme temperature polyplexes Organic chemistry Ki-Hyun Cho verfasserin aut Saji Uthaman verfasserin aut Chong-Su Cho verfasserin aut In-Kyu Park verfasserin aut In Polymers MDPI AG, 2011 9(2017), 4, p 152 (DE-627)61409612X (DE-600)2527146-5 20734360 nnns volume:9 year:2017 number:4, p 152 https://doi.org/10.3390/polym9040152 kostenfrei https://doaj.org/article/4d43a9e3eece4ce18a258ed9388bb258 kostenfrei http://www.mdpi.com/2073-4360/9/4/152 kostenfrei https://doaj.org/toc/2073-4360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2017 4, p 152
allfieldsGer	10.3390/polym9040152 doi (DE-627)DOAJ036917036 (DE-599)DOAJ4d43a9e3eece4ce18a258ed9388bb258 DE-627 ger DE-627 rakwb eng QD241-441 Ansuja Pulickal Mathew verfasserin aut Stimuli-Regulated Smart Polymeric Systems for Gene Therapy 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The physiological condition of the human body is a composite of different environments, each with its own parameters that may differ under normal, as well as diseased conditions. These environmental conditions include factors, such as pH, temperature and enzymes that are specific to a type of cell, tissue or organ or a pathological state, such as inflammation, cancer or infection. These conditions can act as specific triggers or stimuli for the efficient release of therapeutics at their destination by overcoming many physiological and biological barriers. The efficacy of conventional treatment modalities can be enhanced, side effects decreased and patient compliance improved by using stimuli-responsive material that respond to these triggers at the target site. These stimuli or triggers can be physical, chemical or biological and can be internal or external in nature. Many smart/intelligent stimuli-responsive therapeutic gene carriers have been developed that can respond to either internal stimuli, which may be normally present, overexpressed or present in decreased levels, owing to a disease, or to stimuli that are applied externally, such as magnetic fields. This review focuses on the effects of various internal stimuli, such as temperature, pH, redox potential, enzymes, osmotic activity and other biomolecules that are present in the body, on modulating gene expression by using stimuli-regulated smart polymeric carriers. stimuli-responsive system internal stimuli transfection gene carrier enzyme temperature polyplexes Organic chemistry Ki-Hyun Cho verfasserin aut Saji Uthaman verfasserin aut Chong-Su Cho verfasserin aut In-Kyu Park verfasserin aut In Polymers MDPI AG, 2011 9(2017), 4, p 152 (DE-627)61409612X (DE-600)2527146-5 20734360 nnns volume:9 year:2017 number:4, p 152 https://doi.org/10.3390/polym9040152 kostenfrei https://doaj.org/article/4d43a9e3eece4ce18a258ed9388bb258 kostenfrei http://www.mdpi.com/2073-4360/9/4/152 kostenfrei https://doaj.org/toc/2073-4360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2017 4, p 152
allfieldsSound	10.3390/polym9040152 doi (DE-627)DOAJ036917036 (DE-599)DOAJ4d43a9e3eece4ce18a258ed9388bb258 DE-627 ger DE-627 rakwb eng QD241-441 Ansuja Pulickal Mathew verfasserin aut Stimuli-Regulated Smart Polymeric Systems for Gene Therapy 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The physiological condition of the human body is a composite of different environments, each with its own parameters that may differ under normal, as well as diseased conditions. These environmental conditions include factors, such as pH, temperature and enzymes that are specific to a type of cell, tissue or organ or a pathological state, such as inflammation, cancer or infection. These conditions can act as specific triggers or stimuli for the efficient release of therapeutics at their destination by overcoming many physiological and biological barriers. The efficacy of conventional treatment modalities can be enhanced, side effects decreased and patient compliance improved by using stimuli-responsive material that respond to these triggers at the target site. These stimuli or triggers can be physical, chemical or biological and can be internal or external in nature. Many smart/intelligent stimuli-responsive therapeutic gene carriers have been developed that can respond to either internal stimuli, which may be normally present, overexpressed or present in decreased levels, owing to a disease, or to stimuli that are applied externally, such as magnetic fields. This review focuses on the effects of various internal stimuli, such as temperature, pH, redox potential, enzymes, osmotic activity and other biomolecules that are present in the body, on modulating gene expression by using stimuli-regulated smart polymeric carriers. stimuli-responsive system internal stimuli transfection gene carrier enzyme temperature polyplexes Organic chemistry Ki-Hyun Cho verfasserin aut Saji Uthaman verfasserin aut Chong-Su Cho verfasserin aut In-Kyu Park verfasserin aut In Polymers MDPI AG, 2011 9(2017), 4, p 152 (DE-627)61409612X (DE-600)2527146-5 20734360 nnns volume:9 year:2017 number:4, p 152 https://doi.org/10.3390/polym9040152 kostenfrei https://doaj.org/article/4d43a9e3eece4ce18a258ed9388bb258 kostenfrei http://www.mdpi.com/2073-4360/9/4/152 kostenfrei https://doaj.org/toc/2073-4360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2017 4, p 152
language	English
source	In Polymers 9(2017), 4, p 152 volume:9 year:2017 number:4, p 152
sourceStr	In Polymers 9(2017), 4, p 152 volume:9 year:2017 number:4, p 152
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institution	findex.gbv.de
topic_facet	stimuli-responsive system internal stimuli transfection gene carrier enzyme temperature polyplexes Organic chemistry
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container_title	Polymers
authorswithroles_txt_mv	Ansuja Pulickal Mathew @@aut@@ Ki-Hyun Cho @@aut@@ Saji Uthaman @@aut@@ Chong-Su Cho @@aut@@ In-Kyu Park @@aut@@
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callnumber-first	Q - Science
author	Ansuja Pulickal Mathew
spellingShingle	Ansuja Pulickal Mathew misc QD241-441 misc stimuli-responsive system misc internal stimuli misc transfection misc gene carrier misc enzyme misc temperature misc polyplexes misc Organic chemistry Stimuli-Regulated Smart Polymeric Systems for Gene Therapy
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topic_title	QD241-441 Stimuli-Regulated Smart Polymeric Systems for Gene Therapy stimuli-responsive system internal stimuli transfection gene carrier enzyme temperature polyplexes
topic	misc QD241-441 misc stimuli-responsive system misc internal stimuli misc transfection misc gene carrier misc enzyme misc temperature misc polyplexes misc Organic chemistry
topic_unstemmed	misc QD241-441 misc stimuli-responsive system misc internal stimuli misc transfection misc gene carrier misc enzyme misc temperature misc polyplexes misc Organic chemistry
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title	Stimuli-Regulated Smart Polymeric Systems for Gene Therapy
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title_full	Stimuli-Regulated Smart Polymeric Systems for Gene Therapy
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title_sort	stimuli-regulated smart polymeric systems for gene therapy
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title_auth	Stimuli-Regulated Smart Polymeric Systems for Gene Therapy
abstract	The physiological condition of the human body is a composite of different environments, each with its own parameters that may differ under normal, as well as diseased conditions. These environmental conditions include factors, such as pH, temperature and enzymes that are specific to a type of cell, tissue or organ or a pathological state, such as inflammation, cancer or infection. These conditions can act as specific triggers or stimuli for the efficient release of therapeutics at their destination by overcoming many physiological and biological barriers. The efficacy of conventional treatment modalities can be enhanced, side effects decreased and patient compliance improved by using stimuli-responsive material that respond to these triggers at the target site. These stimuli or triggers can be physical, chemical or biological and can be internal or external in nature. Many smart/intelligent stimuli-responsive therapeutic gene carriers have been developed that can respond to either internal stimuli, which may be normally present, overexpressed or present in decreased levels, owing to a disease, or to stimuli that are applied externally, such as magnetic fields. This review focuses on the effects of various internal stimuli, such as temperature, pH, redox potential, enzymes, osmotic activity and other biomolecules that are present in the body, on modulating gene expression by using stimuli-regulated smart polymeric carriers.
abstractGer	The physiological condition of the human body is a composite of different environments, each with its own parameters that may differ under normal, as well as diseased conditions. These environmental conditions include factors, such as pH, temperature and enzymes that are specific to a type of cell, tissue or organ or a pathological state, such as inflammation, cancer or infection. These conditions can act as specific triggers or stimuli for the efficient release of therapeutics at their destination by overcoming many physiological and biological barriers. The efficacy of conventional treatment modalities can be enhanced, side effects decreased and patient compliance improved by using stimuli-responsive material that respond to these triggers at the target site. These stimuli or triggers can be physical, chemical or biological and can be internal or external in nature. Many smart/intelligent stimuli-responsive therapeutic gene carriers have been developed that can respond to either internal stimuli, which may be normally present, overexpressed or present in decreased levels, owing to a disease, or to stimuli that are applied externally, such as magnetic fields. This review focuses on the effects of various internal stimuli, such as temperature, pH, redox potential, enzymes, osmotic activity and other biomolecules that are present in the body, on modulating gene expression by using stimuli-regulated smart polymeric carriers.
abstract_unstemmed	The physiological condition of the human body is a composite of different environments, each with its own parameters that may differ under normal, as well as diseased conditions. These environmental conditions include factors, such as pH, temperature and enzymes that are specific to a type of cell, tissue or organ or a pathological state, such as inflammation, cancer or infection. These conditions can act as specific triggers or stimuli for the efficient release of therapeutics at their destination by overcoming many physiological and biological barriers. The efficacy of conventional treatment modalities can be enhanced, side effects decreased and patient compliance improved by using stimuli-responsive material that respond to these triggers at the target site. These stimuli or triggers can be physical, chemical or biological and can be internal or external in nature. Many smart/intelligent stimuli-responsive therapeutic gene carriers have been developed that can respond to either internal stimuli, which may be normally present, overexpressed or present in decreased levels, owing to a disease, or to stimuli that are applied externally, such as magnetic fields. This review focuses on the effects of various internal stimuli, such as temperature, pH, redox potential, enzymes, osmotic activity and other biomolecules that are present in the body, on modulating gene expression by using stimuli-regulated smart polymeric carriers.
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container_issue	4, p 152
title_short	Stimuli-Regulated Smart Polymeric Systems for Gene Therapy
url	https://doi.org/10.3390/polym9040152 https://doaj.org/article/4d43a9e3eece4ce18a258ed9388bb258 http://www.mdpi.com/2073-4360/9/4/152 https://doaj.org/toc/2073-4360
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up_date	2024-07-03T23:07:40.234Z
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