Restless legs syndrome is associated with increased risk of migraine

Migraine and restless legs syndrome (RLS) are common disorders that are associated with a high level of individual suffering and major comorbidities. The aetiologies of the disorders are largely unknown, although both migraine and RLS have been linked to disturbances in the dopaminergic system and s...
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Autor*in:	Maria Didriksen [verfasserIn] Thomas F Hansen [verfasserIn] Lise W Thørner [verfasserIn] Kristoffer S Burgdorf [verfasserIn] Christian Erikstrup [verfasserIn] Ole B Pedersen [verfasserIn] Helene M Paarup [verfasserIn] Kaspar R Nielsen [verfasserIn] Henrik Hjalgrim [verfasserIn] Erik Sørensen [verfasserIn] Henrik Ullum [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Übergeordnetes Werk:	In: Cephalalgia Reports - SAGE Publishing, 2020, 1(2018)
Übergeordnetes Werk:	volume:1 ; year:2018

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1177/2515816318780743

Katalog-ID:	DOAJ036946729

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allfields	10.1177/2515816318780743 doi (DE-627)DOAJ036946729 (DE-599)DOAJe5a79fdc46fd4bc3adbad27fbd3f4416 DE-627 ger DE-627 rakwb eng RM1-950 RC321-571 Maria Didriksen verfasserin aut Restless legs syndrome is associated with increased risk of migraine 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Migraine and restless legs syndrome (RLS) are common disorders that are associated with a high level of individual suffering and major comorbidities. The aetiologies of the disorders are largely unknown, although both migraine and RLS have been linked to disturbances in the dopaminergic system and sleep issues, suggesting a relationship between the disorders. This study examines the association between RLS and migraine in a large population of otherwise healthy adults who are not taking medication. Cross-sectional study that included 20,938 participants enrolled in the Danish Blood Donor Study from 1 May 2015 to 1 February 2017. The study included complete information on migraines, the Cambridge-Hopkins RLS questionnaire, the Major Depression Inventory Scale, sex, age, body mass index (BMI), educational level, smoking status and alcohol consumption. Associations between RLS and migraine, with and without aura, were examined using multivariable logistic regression analysis. Among the participants, 4827 were self-reported migraine sufferers and 1091 were classified as suffering from RLS. Individuals with RLS had an increased risk of migraine compared to non-RLS sufferers, with an odds ratio (OR) = 1.52 (95% confidence interval: 1.33–1.73). For the investigated subtypes of migraine, this association was found to be OR = 1.55 (1.31–1.83) for migraines with aura and OR = 1.29 (1.09–1.52) for migraines without aura. We found a significantly increased occurrence of migraine in individuals with RLS. This risk was independent of sex, age, BMI, educational level, smoking status, alcohol consumption and depressive disorder. Our findings suggest that RLS and migraine may have a common aetiology. Therapeutics. Pharmacology Neurosciences. Biological psychiatry. Neuropsychiatry Thomas F Hansen verfasserin aut Lise W Thørner verfasserin aut Kristoffer S Burgdorf verfasserin aut Christian Erikstrup verfasserin aut Ole B Pedersen verfasserin aut Helene M Paarup verfasserin aut Kaspar R Nielsen verfasserin aut Henrik Hjalgrim verfasserin aut Erik Sørensen verfasserin aut Henrik Ullum verfasserin aut In Cephalalgia Reports SAGE Publishing, 2020 1(2018) (DE-627)1066736340 25158163 nnns volume:1 year:2018 https://doi.org/10.1177/2515816318780743 kostenfrei https://doaj.org/article/e5a79fdc46fd4bc3adbad27fbd3f4416 kostenfrei https://doi.org/10.1177/2515816318780743 kostenfrei https://doaj.org/toc/2515-8163 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2055 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2707 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2018
spelling	10.1177/2515816318780743 doi (DE-627)DOAJ036946729 (DE-599)DOAJe5a79fdc46fd4bc3adbad27fbd3f4416 DE-627 ger DE-627 rakwb eng RM1-950 RC321-571 Maria Didriksen verfasserin aut Restless legs syndrome is associated with increased risk of migraine 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Migraine and restless legs syndrome (RLS) are common disorders that are associated with a high level of individual suffering and major comorbidities. The aetiologies of the disorders are largely unknown, although both migraine and RLS have been linked to disturbances in the dopaminergic system and sleep issues, suggesting a relationship between the disorders. This study examines the association between RLS and migraine in a large population of otherwise healthy adults who are not taking medication. Cross-sectional study that included 20,938 participants enrolled in the Danish Blood Donor Study from 1 May 2015 to 1 February 2017. The study included complete information on migraines, the Cambridge-Hopkins RLS questionnaire, the Major Depression Inventory Scale, sex, age, body mass index (BMI), educational level, smoking status and alcohol consumption. Associations between RLS and migraine, with and without aura, were examined using multivariable logistic regression analysis. Among the participants, 4827 were self-reported migraine sufferers and 1091 were classified as suffering from RLS. Individuals with RLS had an increased risk of migraine compared to non-RLS sufferers, with an odds ratio (OR) = 1.52 (95% confidence interval: 1.33–1.73). For the investigated subtypes of migraine, this association was found to be OR = 1.55 (1.31–1.83) for migraines with aura and OR = 1.29 (1.09–1.52) for migraines without aura. We found a significantly increased occurrence of migraine in individuals with RLS. This risk was independent of sex, age, BMI, educational level, smoking status, alcohol consumption and depressive disorder. Our findings suggest that RLS and migraine may have a common aetiology. Therapeutics. Pharmacology Neurosciences. Biological psychiatry. Neuropsychiatry Thomas F Hansen verfasserin aut Lise W Thørner verfasserin aut Kristoffer S Burgdorf verfasserin aut Christian Erikstrup verfasserin aut Ole B Pedersen verfasserin aut Helene M Paarup verfasserin aut Kaspar R Nielsen verfasserin aut Henrik Hjalgrim verfasserin aut Erik Sørensen verfasserin aut Henrik Ullum verfasserin aut In Cephalalgia Reports SAGE Publishing, 2020 1(2018) (DE-627)1066736340 25158163 nnns volume:1 year:2018 https://doi.org/10.1177/2515816318780743 kostenfrei https://doaj.org/article/e5a79fdc46fd4bc3adbad27fbd3f4416 kostenfrei https://doi.org/10.1177/2515816318780743 kostenfrei https://doaj.org/toc/2515-8163 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2055 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2707 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2018
allfields_unstemmed	10.1177/2515816318780743 doi (DE-627)DOAJ036946729 (DE-599)DOAJe5a79fdc46fd4bc3adbad27fbd3f4416 DE-627 ger DE-627 rakwb eng RM1-950 RC321-571 Maria Didriksen verfasserin aut Restless legs syndrome is associated with increased risk of migraine 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Migraine and restless legs syndrome (RLS) are common disorders that are associated with a high level of individual suffering and major comorbidities. The aetiologies of the disorders are largely unknown, although both migraine and RLS have been linked to disturbances in the dopaminergic system and sleep issues, suggesting a relationship between the disorders. This study examines the association between RLS and migraine in a large population of otherwise healthy adults who are not taking medication. Cross-sectional study that included 20,938 participants enrolled in the Danish Blood Donor Study from 1 May 2015 to 1 February 2017. The study included complete information on migraines, the Cambridge-Hopkins RLS questionnaire, the Major Depression Inventory Scale, sex, age, body mass index (BMI), educational level, smoking status and alcohol consumption. Associations between RLS and migraine, with and without aura, were examined using multivariable logistic regression analysis. Among the participants, 4827 were self-reported migraine sufferers and 1091 were classified as suffering from RLS. Individuals with RLS had an increased risk of migraine compared to non-RLS sufferers, with an odds ratio (OR) = 1.52 (95% confidence interval: 1.33–1.73). For the investigated subtypes of migraine, this association was found to be OR = 1.55 (1.31–1.83) for migraines with aura and OR = 1.29 (1.09–1.52) for migraines without aura. We found a significantly increased occurrence of migraine in individuals with RLS. This risk was independent of sex, age, BMI, educational level, smoking status, alcohol consumption and depressive disorder. Our findings suggest that RLS and migraine may have a common aetiology. Therapeutics. Pharmacology Neurosciences. Biological psychiatry. Neuropsychiatry Thomas F Hansen verfasserin aut Lise W Thørner verfasserin aut Kristoffer S Burgdorf verfasserin aut Christian Erikstrup verfasserin aut Ole B Pedersen verfasserin aut Helene M Paarup verfasserin aut Kaspar R Nielsen verfasserin aut Henrik Hjalgrim verfasserin aut Erik Sørensen verfasserin aut Henrik Ullum verfasserin aut In Cephalalgia Reports SAGE Publishing, 2020 1(2018) (DE-627)1066736340 25158163 nnns volume:1 year:2018 https://doi.org/10.1177/2515816318780743 kostenfrei https://doaj.org/article/e5a79fdc46fd4bc3adbad27fbd3f4416 kostenfrei https://doi.org/10.1177/2515816318780743 kostenfrei https://doaj.org/toc/2515-8163 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2055 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2707 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2018
allfieldsGer	10.1177/2515816318780743 doi (DE-627)DOAJ036946729 (DE-599)DOAJe5a79fdc46fd4bc3adbad27fbd3f4416 DE-627 ger DE-627 rakwb eng RM1-950 RC321-571 Maria Didriksen verfasserin aut Restless legs syndrome is associated with increased risk of migraine 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Migraine and restless legs syndrome (RLS) are common disorders that are associated with a high level of individual suffering and major comorbidities. The aetiologies of the disorders are largely unknown, although both migraine and RLS have been linked to disturbances in the dopaminergic system and sleep issues, suggesting a relationship between the disorders. This study examines the association between RLS and migraine in a large population of otherwise healthy adults who are not taking medication. Cross-sectional study that included 20,938 participants enrolled in the Danish Blood Donor Study from 1 May 2015 to 1 February 2017. The study included complete information on migraines, the Cambridge-Hopkins RLS questionnaire, the Major Depression Inventory Scale, sex, age, body mass index (BMI), educational level, smoking status and alcohol consumption. Associations between RLS and migraine, with and without aura, were examined using multivariable logistic regression analysis. Among the participants, 4827 were self-reported migraine sufferers and 1091 were classified as suffering from RLS. Individuals with RLS had an increased risk of migraine compared to non-RLS sufferers, with an odds ratio (OR) = 1.52 (95% confidence interval: 1.33–1.73). For the investigated subtypes of migraine, this association was found to be OR = 1.55 (1.31–1.83) for migraines with aura and OR = 1.29 (1.09–1.52) for migraines without aura. We found a significantly increased occurrence of migraine in individuals with RLS. This risk was independent of sex, age, BMI, educational level, smoking status, alcohol consumption and depressive disorder. Our findings suggest that RLS and migraine may have a common aetiology. Therapeutics. Pharmacology Neurosciences. Biological psychiatry. Neuropsychiatry Thomas F Hansen verfasserin aut Lise W Thørner verfasserin aut Kristoffer S Burgdorf verfasserin aut Christian Erikstrup verfasserin aut Ole B Pedersen verfasserin aut Helene M Paarup verfasserin aut Kaspar R Nielsen verfasserin aut Henrik Hjalgrim verfasserin aut Erik Sørensen verfasserin aut Henrik Ullum verfasserin aut In Cephalalgia Reports SAGE Publishing, 2020 1(2018) (DE-627)1066736340 25158163 nnns volume:1 year:2018 https://doi.org/10.1177/2515816318780743 kostenfrei https://doaj.org/article/e5a79fdc46fd4bc3adbad27fbd3f4416 kostenfrei https://doi.org/10.1177/2515816318780743 kostenfrei https://doaj.org/toc/2515-8163 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2055 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2707 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2018
allfieldsSound	10.1177/2515816318780743 doi (DE-627)DOAJ036946729 (DE-599)DOAJe5a79fdc46fd4bc3adbad27fbd3f4416 DE-627 ger DE-627 rakwb eng RM1-950 RC321-571 Maria Didriksen verfasserin aut Restless legs syndrome is associated with increased risk of migraine 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Migraine and restless legs syndrome (RLS) are common disorders that are associated with a high level of individual suffering and major comorbidities. The aetiologies of the disorders are largely unknown, although both migraine and RLS have been linked to disturbances in the dopaminergic system and sleep issues, suggesting a relationship between the disorders. This study examines the association between RLS and migraine in a large population of otherwise healthy adults who are not taking medication. Cross-sectional study that included 20,938 participants enrolled in the Danish Blood Donor Study from 1 May 2015 to 1 February 2017. The study included complete information on migraines, the Cambridge-Hopkins RLS questionnaire, the Major Depression Inventory Scale, sex, age, body mass index (BMI), educational level, smoking status and alcohol consumption. Associations between RLS and migraine, with and without aura, were examined using multivariable logistic regression analysis. Among the participants, 4827 were self-reported migraine sufferers and 1091 were classified as suffering from RLS. Individuals with RLS had an increased risk of migraine compared to non-RLS sufferers, with an odds ratio (OR) = 1.52 (95% confidence interval: 1.33–1.73). For the investigated subtypes of migraine, this association was found to be OR = 1.55 (1.31–1.83) for migraines with aura and OR = 1.29 (1.09–1.52) for migraines without aura. We found a significantly increased occurrence of migraine in individuals with RLS. This risk was independent of sex, age, BMI, educational level, smoking status, alcohol consumption and depressive disorder. Our findings suggest that RLS and migraine may have a common aetiology. Therapeutics. Pharmacology Neurosciences. Biological psychiatry. Neuropsychiatry Thomas F Hansen verfasserin aut Lise W Thørner verfasserin aut Kristoffer S Burgdorf verfasserin aut Christian Erikstrup verfasserin aut Ole B Pedersen verfasserin aut Helene M Paarup verfasserin aut Kaspar R Nielsen verfasserin aut Henrik Hjalgrim verfasserin aut Erik Sørensen verfasserin aut Henrik Ullum verfasserin aut In Cephalalgia Reports SAGE Publishing, 2020 1(2018) (DE-627)1066736340 25158163 nnns volume:1 year:2018 https://doi.org/10.1177/2515816318780743 kostenfrei https://doaj.org/article/e5a79fdc46fd4bc3adbad27fbd3f4416 kostenfrei https://doi.org/10.1177/2515816318780743 kostenfrei https://doaj.org/toc/2515-8163 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2055 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2707 GBV_ILN_2890 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2018
language	English
source	In Cephalalgia Reports 1(2018) volume:1 year:2018
sourceStr	In Cephalalgia Reports 1(2018) volume:1 year:2018
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Therapeutics. Pharmacology Neurosciences. Biological psychiatry. Neuropsychiatry
isfreeaccess_bool	true
container_title	Cephalalgia Reports
authorswithroles_txt_mv	Maria Didriksen @@aut@@ Thomas F Hansen @@aut@@ Lise W Thørner @@aut@@ Kristoffer S Burgdorf @@aut@@ Christian Erikstrup @@aut@@ Ole B Pedersen @@aut@@ Helene M Paarup @@aut@@ Kaspar R Nielsen @@aut@@ Henrik Hjalgrim @@aut@@ Erik Sørensen @@aut@@ Henrik Ullum @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
hierarchy_top_id	1066736340
id	DOAJ036946729
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author	Maria Didriksen
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topic_title	RM1-950 RC321-571 Restless legs syndrome is associated with increased risk of migraine
topic	misc RM1-950 misc RC321-571 misc Therapeutics. Pharmacology misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Restless legs syndrome is associated with increased risk of migraine
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title_full	Restless legs syndrome is associated with increased risk of migraine
author_sort	Maria Didriksen
journal	Cephalalgia Reports
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author_browse	Maria Didriksen Thomas F Hansen Lise W Thørner Kristoffer S Burgdorf Christian Erikstrup Ole B Pedersen Helene M Paarup Kaspar R Nielsen Henrik Hjalgrim Erik Sørensen Henrik Ullum
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title_sort	restless legs syndrome is associated with increased risk of migraine
callnumber	RM1-950
title_auth	Restless legs syndrome is associated with increased risk of migraine
abstract	Migraine and restless legs syndrome (RLS) are common disorders that are associated with a high level of individual suffering and major comorbidities. The aetiologies of the disorders are largely unknown, although both migraine and RLS have been linked to disturbances in the dopaminergic system and sleep issues, suggesting a relationship between the disorders. This study examines the association between RLS and migraine in a large population of otherwise healthy adults who are not taking medication. Cross-sectional study that included 20,938 participants enrolled in the Danish Blood Donor Study from 1 May 2015 to 1 February 2017. The study included complete information on migraines, the Cambridge-Hopkins RLS questionnaire, the Major Depression Inventory Scale, sex, age, body mass index (BMI), educational level, smoking status and alcohol consumption. Associations between RLS and migraine, with and without aura, were examined using multivariable logistic regression analysis. Among the participants, 4827 were self-reported migraine sufferers and 1091 were classified as suffering from RLS. Individuals with RLS had an increased risk of migraine compared to non-RLS sufferers, with an odds ratio (OR) = 1.52 (95% confidence interval: 1.33–1.73). For the investigated subtypes of migraine, this association was found to be OR = 1.55 (1.31–1.83) for migraines with aura and OR = 1.29 (1.09–1.52) for migraines without aura. We found a significantly increased occurrence of migraine in individuals with RLS. This risk was independent of sex, age, BMI, educational level, smoking status, alcohol consumption and depressive disorder. Our findings suggest that RLS and migraine may have a common aetiology.
abstractGer	Migraine and restless legs syndrome (RLS) are common disorders that are associated with a high level of individual suffering and major comorbidities. The aetiologies of the disorders are largely unknown, although both migraine and RLS have been linked to disturbances in the dopaminergic system and sleep issues, suggesting a relationship between the disorders. This study examines the association between RLS and migraine in a large population of otherwise healthy adults who are not taking medication. Cross-sectional study that included 20,938 participants enrolled in the Danish Blood Donor Study from 1 May 2015 to 1 February 2017. The study included complete information on migraines, the Cambridge-Hopkins RLS questionnaire, the Major Depression Inventory Scale, sex, age, body mass index (BMI), educational level, smoking status and alcohol consumption. Associations between RLS and migraine, with and without aura, were examined using multivariable logistic regression analysis. Among the participants, 4827 were self-reported migraine sufferers and 1091 were classified as suffering from RLS. Individuals with RLS had an increased risk of migraine compared to non-RLS sufferers, with an odds ratio (OR) = 1.52 (95% confidence interval: 1.33–1.73). For the investigated subtypes of migraine, this association was found to be OR = 1.55 (1.31–1.83) for migraines with aura and OR = 1.29 (1.09–1.52) for migraines without aura. We found a significantly increased occurrence of migraine in individuals with RLS. This risk was independent of sex, age, BMI, educational level, smoking status, alcohol consumption and depressive disorder. Our findings suggest that RLS and migraine may have a common aetiology.
abstract_unstemmed	Migraine and restless legs syndrome (RLS) are common disorders that are associated with a high level of individual suffering and major comorbidities. The aetiologies of the disorders are largely unknown, although both migraine and RLS have been linked to disturbances in the dopaminergic system and sleep issues, suggesting a relationship between the disorders. This study examines the association between RLS and migraine in a large population of otherwise healthy adults who are not taking medication. Cross-sectional study that included 20,938 participants enrolled in the Danish Blood Donor Study from 1 May 2015 to 1 February 2017. The study included complete information on migraines, the Cambridge-Hopkins RLS questionnaire, the Major Depression Inventory Scale, sex, age, body mass index (BMI), educational level, smoking status and alcohol consumption. Associations between RLS and migraine, with and without aura, were examined using multivariable logistic regression analysis. Among the participants, 4827 were self-reported migraine sufferers and 1091 were classified as suffering from RLS. Individuals with RLS had an increased risk of migraine compared to non-RLS sufferers, with an odds ratio (OR) = 1.52 (95% confidence interval: 1.33–1.73). For the investigated subtypes of migraine, this association was found to be OR = 1.55 (1.31–1.83) for migraines with aura and OR = 1.29 (1.09–1.52) for migraines without aura. We found a significantly increased occurrence of migraine in individuals with RLS. This risk was independent of sex, age, BMI, educational level, smoking status, alcohol consumption and depressive disorder. Our findings suggest that RLS and migraine may have a common aetiology.
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title_short	Restless legs syndrome is associated with increased risk of migraine
url	https://doi.org/10.1177/2515816318780743 https://doaj.org/article/e5a79fdc46fd4bc3adbad27fbd3f4416 https://doaj.org/toc/2515-8163
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