A hypothesis-generating search for new genetic breast cancer syndromes - a national study in 803 Swedish families

<p<Abstract</p< <p<Among Swedish families with an inherited predisposition for breast cancer, less than one third segregate mutations in genes known to be associated with an increased risk of breast cancer in combination with other types of tumours. In a search for new putative fam...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	von Wachenfeldt Anna [verfasserIn] Lindblom Annika [verfasserIn] Grönberg Henrik [verfasserIn] Einbeigi Zakaria [verfasserIn] Rosenquist Richard [verfasserIn] Gardman Camilla [verfasserIn] Iselius Lennart [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2007

Schlagwörter:	breast cancer endometrial cancer family history syndromes genetics

Übergeordnetes Werk:	In: Hereditary Cancer in Clinical Practice - BMC, 2010, 5(2007), 1, Seite 17-24
Übergeordnetes Werk:	volume:5 ; year:2007 ; number:1 ; pages:17-24

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/1897-4287-5-1-17

Katalog-ID:	DOAJ037004093

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allfieldsSound	10.1186/1897-4287-5-1-17 doi (DE-627)DOAJ037004093 (DE-599)DOAJ8fb15009cdfd4bbe88fee1eba3bbdfb5 DE-627 ger DE-627 rakwb eng RC254-282 QH426-470 von Wachenfeldt Anna verfasserin aut A hypothesis-generating search for new genetic breast cancer syndromes - a national study in 803 Swedish families 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Among Swedish families with an inherited predisposition for breast cancer, less than one third segregate mutations in genes known to be associated with an increased risk of breast cancer in combination with other types of tumours. In a search for new putative familial breast cancer syndromes we studied Swedish families undergoing genetic counselling during 1992-2000.</p< <p<Four thousand families from counselling clinics in Sweden were eligible for study. Families with breast cancer only were excluded, as were families with mutations in genes already known to be associated with malignant diseases. We identified 803 families with two or more cases of breast cancer and at least one other type of cancer. The observed proportion of different types of non-breast cancer was compared with the percentage distribution of non-breast cancer tumours in Sweden in 1958 and 1999.</p< <p<We found tumours in the colon, ovary, endometrium, pancreas and liver, as well as leukaemia in a significantly larger proportion of the study population than in the general population in both years. These tumours were also seen among families where several members had one additional tumour, suggesting that malignancies at these sites, in combination with breast tumours, could constitute genetic syndromes. Endometrial carcinoma has not previously been described in the context of breast cancer syndromes and the excess of malignancies at this site could not be explained by secondary tumours. Thus, we suggest that endometrial carcinoma and breast cancer constitute a new breast cancer syndrome. Further investigation is warranted to categorize phenotypes of both breast and endometrial tumours in this subgroup.</p< breast cancer endometrial cancer family history syndromes genetics Neoplasms. Tumors. Oncology. Including cancer and carcinogens Genetics Lindblom Annika verfasserin aut Grönberg Henrik verfasserin aut Einbeigi Zakaria verfasserin aut Rosenquist Richard verfasserin aut Gardman Camilla verfasserin aut Iselius Lennart verfasserin aut In Hereditary Cancer in Clinical Practice BMC, 2010 5(2007), 1, Seite 17-24 (DE-627)511229925 (DE-600)2233352-6 18974287 nnns volume:5 year:2007 number:1 pages:17-24 https://doi.org/10.1186/1897-4287-5-1-17 kostenfrei https://doaj.org/article/8fb15009cdfd4bbe88fee1eba3bbdfb5 kostenfrei http://www.hccpjournal.com/content/5/1/17 kostenfrei https://doaj.org/toc/1897-4287 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2007 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2007 1 17-24
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container_title	Hereditary Cancer in Clinical Practice
authorswithroles_txt_mv	von Wachenfeldt Anna @@aut@@ Lindblom Annika @@aut@@ Grönberg Henrik @@aut@@ Einbeigi Zakaria @@aut@@ Rosenquist Richard @@aut@@ Gardman Camilla @@aut@@ Iselius Lennart @@aut@@
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spellingShingle	von Wachenfeldt Anna misc RC254-282 misc QH426-470 misc breast cancer misc endometrial cancer misc family history misc syndromes misc genetics misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens misc Genetics A hypothesis-generating search for new genetic breast cancer syndromes - a national study in 803 Swedish families
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topic_title	RC254-282 QH426-470 A hypothesis-generating search for new genetic breast cancer syndromes - a national study in 803 Swedish families breast cancer endometrial cancer family history syndromes genetics
topic	misc RC254-282 misc QH426-470 misc breast cancer misc endometrial cancer misc family history misc syndromes misc genetics misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens misc Genetics
topic_unstemmed	misc RC254-282 misc QH426-470 misc breast cancer misc endometrial cancer misc family history misc syndromes misc genetics misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens misc Genetics
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title_full	A hypothesis-generating search for new genetic breast cancer syndromes - a national study in 803 Swedish families
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title_sort	hypothesis-generating search for new genetic breast cancer syndromes - a national study in 803 swedish families
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title_auth	A hypothesis-generating search for new genetic breast cancer syndromes - a national study in 803 Swedish families
abstract	<p<Abstract</p< <p<Among Swedish families with an inherited predisposition for breast cancer, less than one third segregate mutations in genes known to be associated with an increased risk of breast cancer in combination with other types of tumours. In a search for new putative familial breast cancer syndromes we studied Swedish families undergoing genetic counselling during 1992-2000.</p< <p<Four thousand families from counselling clinics in Sweden were eligible for study. Families with breast cancer only were excluded, as were families with mutations in genes already known to be associated with malignant diseases. We identified 803 families with two or more cases of breast cancer and at least one other type of cancer. The observed proportion of different types of non-breast cancer was compared with the percentage distribution of non-breast cancer tumours in Sweden in 1958 and 1999.</p< <p<We found tumours in the colon, ovary, endometrium, pancreas and liver, as well as leukaemia in a significantly larger proportion of the study population than in the general population in both years. These tumours were also seen among families where several members had one additional tumour, suggesting that malignancies at these sites, in combination with breast tumours, could constitute genetic syndromes. Endometrial carcinoma has not previously been described in the context of breast cancer syndromes and the excess of malignancies at this site could not be explained by secondary tumours. Thus, we suggest that endometrial carcinoma and breast cancer constitute a new breast cancer syndrome. Further investigation is warranted to categorize phenotypes of both breast and endometrial tumours in this subgroup.</p<
abstractGer	<p<Abstract</p< <p<Among Swedish families with an inherited predisposition for breast cancer, less than one third segregate mutations in genes known to be associated with an increased risk of breast cancer in combination with other types of tumours. In a search for new putative familial breast cancer syndromes we studied Swedish families undergoing genetic counselling during 1992-2000.</p< <p<Four thousand families from counselling clinics in Sweden were eligible for study. Families with breast cancer only were excluded, as were families with mutations in genes already known to be associated with malignant diseases. We identified 803 families with two or more cases of breast cancer and at least one other type of cancer. The observed proportion of different types of non-breast cancer was compared with the percentage distribution of non-breast cancer tumours in Sweden in 1958 and 1999.</p< <p<We found tumours in the colon, ovary, endometrium, pancreas and liver, as well as leukaemia in a significantly larger proportion of the study population than in the general population in both years. These tumours were also seen among families where several members had one additional tumour, suggesting that malignancies at these sites, in combination with breast tumours, could constitute genetic syndromes. Endometrial carcinoma has not previously been described in the context of breast cancer syndromes and the excess of malignancies at this site could not be explained by secondary tumours. Thus, we suggest that endometrial carcinoma and breast cancer constitute a new breast cancer syndrome. Further investigation is warranted to categorize phenotypes of both breast and endometrial tumours in this subgroup.</p<
abstract_unstemmed	<p<Abstract</p< <p<Among Swedish families with an inherited predisposition for breast cancer, less than one third segregate mutations in genes known to be associated with an increased risk of breast cancer in combination with other types of tumours. In a search for new putative familial breast cancer syndromes we studied Swedish families undergoing genetic counselling during 1992-2000.</p< <p<Four thousand families from counselling clinics in Sweden were eligible for study. Families with breast cancer only were excluded, as were families with mutations in genes already known to be associated with malignant diseases. We identified 803 families with two or more cases of breast cancer and at least one other type of cancer. The observed proportion of different types of non-breast cancer was compared with the percentage distribution of non-breast cancer tumours in Sweden in 1958 and 1999.</p< <p<We found tumours in the colon, ovary, endometrium, pancreas and liver, as well as leukaemia in a significantly larger proportion of the study population than in the general population in both years. These tumours were also seen among families where several members had one additional tumour, suggesting that malignancies at these sites, in combination with breast tumours, could constitute genetic syndromes. Endometrial carcinoma has not previously been described in the context of breast cancer syndromes and the excess of malignancies at this site could not be explained by secondary tumours. Thus, we suggest that endometrial carcinoma and breast cancer constitute a new breast cancer syndrome. Further investigation is warranted to categorize phenotypes of both breast and endometrial tumours in this subgroup.</p<
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title_short	A hypothesis-generating search for new genetic breast cancer syndromes - a national study in 803 Swedish families
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A hypothesis-generating search for new genetic breast cancer syndromes - a national study in 803 Swedish families

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