Protein Kinase C: An Attractive Target for Cancer Therapy
Apoptosis plays an important role during all stages of carcinogenesis and the development of chemoresistance in tumor cells may be due to their selective defects in the intracellular signaling proteins, central to apoptotic pathways. Consequently, many studies have focused on rendering the chemother...
Ausführliche Beschreibung
Autor*in: |
Cinzia Domenicotti [verfasserIn] Umberto M. Marinari [verfasserIn] Maria A. Pronzato [verfasserIn] Roberta Ricciarelli [verfasserIn] Chiara De Ciucis [verfasserIn] Barbara Marengo [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
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2011 |
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Übergeordnetes Werk: |
In: Cancers - MDPI AG, 2010, 3(2011), 1, Seite 531-567 |
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Übergeordnetes Werk: |
volume:3 ; year:2011 ; number:1 ; pages:531-567 |
Links: |
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DOI / URN: |
10.3390/cancers3010531 |
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Katalog-ID: |
DOAJ037038966 |
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10.3390/cancers3010531 doi (DE-627)DOAJ037038966 (DE-599)DOAJd439204bbcc142808e31f3f331f212c9 DE-627 ger DE-627 rakwb eng RC254-282 Cinzia Domenicotti verfasserin aut Protein Kinase C: An Attractive Target for Cancer Therapy 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Apoptosis plays an important role during all stages of carcinogenesis and the development of chemoresistance in tumor cells may be due to their selective defects in the intracellular signaling proteins, central to apoptotic pathways. Consequently, many studies have focused on rendering the chemotherapy more effective in order to prevent chemoresistance and pre-clinical and clinical data has suggested that protein kinase C (PKC) may represent an attractive target for cancer therapy. Therefore, a complete understanding of how PKC regulates apoptosis and chemoresistance may lead to obtaining a PKC-based therapy that is able to reduce drug dosages and to prevent the development of chemoresistance. apoptosis PKC cancer chemoresistance Neoplasms. Tumors. Oncology. Including cancer and carcinogens Umberto M. Marinari verfasserin aut Maria A. Pronzato verfasserin aut Roberta Ricciarelli verfasserin aut Chiara De Ciucis verfasserin aut Barbara Marengo verfasserin aut In Cancers MDPI AG, 2010 3(2011), 1, Seite 531-567 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:3 year:2011 number:1 pages:531-567 https://doi.org/10.3390/cancers3010531 kostenfrei https://doaj.org/article/d439204bbcc142808e31f3f331f212c9 kostenfrei http://www.mdpi.com/2072-6694/3/1/531/ kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2011 1 531-567 |
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10.3390/cancers3010531 doi (DE-627)DOAJ037038966 (DE-599)DOAJd439204bbcc142808e31f3f331f212c9 DE-627 ger DE-627 rakwb eng RC254-282 Cinzia Domenicotti verfasserin aut Protein Kinase C: An Attractive Target for Cancer Therapy 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Apoptosis plays an important role during all stages of carcinogenesis and the development of chemoresistance in tumor cells may be due to their selective defects in the intracellular signaling proteins, central to apoptotic pathways. Consequently, many studies have focused on rendering the chemotherapy more effective in order to prevent chemoresistance and pre-clinical and clinical data has suggested that protein kinase C (PKC) may represent an attractive target for cancer therapy. Therefore, a complete understanding of how PKC regulates apoptosis and chemoresistance may lead to obtaining a PKC-based therapy that is able to reduce drug dosages and to prevent the development of chemoresistance. apoptosis PKC cancer chemoresistance Neoplasms. Tumors. Oncology. Including cancer and carcinogens Umberto M. Marinari verfasserin aut Maria A. Pronzato verfasserin aut Roberta Ricciarelli verfasserin aut Chiara De Ciucis verfasserin aut Barbara Marengo verfasserin aut In Cancers MDPI AG, 2010 3(2011), 1, Seite 531-567 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:3 year:2011 number:1 pages:531-567 https://doi.org/10.3390/cancers3010531 kostenfrei https://doaj.org/article/d439204bbcc142808e31f3f331f212c9 kostenfrei http://www.mdpi.com/2072-6694/3/1/531/ kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2011 1 531-567 |
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10.3390/cancers3010531 doi (DE-627)DOAJ037038966 (DE-599)DOAJd439204bbcc142808e31f3f331f212c9 DE-627 ger DE-627 rakwb eng RC254-282 Cinzia Domenicotti verfasserin aut Protein Kinase C: An Attractive Target for Cancer Therapy 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Apoptosis plays an important role during all stages of carcinogenesis and the development of chemoresistance in tumor cells may be due to their selective defects in the intracellular signaling proteins, central to apoptotic pathways. Consequently, many studies have focused on rendering the chemotherapy more effective in order to prevent chemoresistance and pre-clinical and clinical data has suggested that protein kinase C (PKC) may represent an attractive target for cancer therapy. Therefore, a complete understanding of how PKC regulates apoptosis and chemoresistance may lead to obtaining a PKC-based therapy that is able to reduce drug dosages and to prevent the development of chemoresistance. apoptosis PKC cancer chemoresistance Neoplasms. Tumors. Oncology. Including cancer and carcinogens Umberto M. Marinari verfasserin aut Maria A. Pronzato verfasserin aut Roberta Ricciarelli verfasserin aut Chiara De Ciucis verfasserin aut Barbara Marengo verfasserin aut In Cancers MDPI AG, 2010 3(2011), 1, Seite 531-567 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:3 year:2011 number:1 pages:531-567 https://doi.org/10.3390/cancers3010531 kostenfrei https://doaj.org/article/d439204bbcc142808e31f3f331f212c9 kostenfrei http://www.mdpi.com/2072-6694/3/1/531/ kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2011 1 531-567 |
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10.3390/cancers3010531 doi (DE-627)DOAJ037038966 (DE-599)DOAJd439204bbcc142808e31f3f331f212c9 DE-627 ger DE-627 rakwb eng RC254-282 Cinzia Domenicotti verfasserin aut Protein Kinase C: An Attractive Target for Cancer Therapy 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Apoptosis plays an important role during all stages of carcinogenesis and the development of chemoresistance in tumor cells may be due to their selective defects in the intracellular signaling proteins, central to apoptotic pathways. Consequently, many studies have focused on rendering the chemotherapy more effective in order to prevent chemoresistance and pre-clinical and clinical data has suggested that protein kinase C (PKC) may represent an attractive target for cancer therapy. Therefore, a complete understanding of how PKC regulates apoptosis and chemoresistance may lead to obtaining a PKC-based therapy that is able to reduce drug dosages and to prevent the development of chemoresistance. apoptosis PKC cancer chemoresistance Neoplasms. Tumors. Oncology. Including cancer and carcinogens Umberto M. Marinari verfasserin aut Maria A. Pronzato verfasserin aut Roberta Ricciarelli verfasserin aut Chiara De Ciucis verfasserin aut Barbara Marengo verfasserin aut In Cancers MDPI AG, 2010 3(2011), 1, Seite 531-567 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:3 year:2011 number:1 pages:531-567 https://doi.org/10.3390/cancers3010531 kostenfrei https://doaj.org/article/d439204bbcc142808e31f3f331f212c9 kostenfrei http://www.mdpi.com/2072-6694/3/1/531/ kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2011 1 531-567 |
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10.3390/cancers3010531 doi (DE-627)DOAJ037038966 (DE-599)DOAJd439204bbcc142808e31f3f331f212c9 DE-627 ger DE-627 rakwb eng RC254-282 Cinzia Domenicotti verfasserin aut Protein Kinase C: An Attractive Target for Cancer Therapy 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Apoptosis plays an important role during all stages of carcinogenesis and the development of chemoresistance in tumor cells may be due to their selective defects in the intracellular signaling proteins, central to apoptotic pathways. Consequently, many studies have focused on rendering the chemotherapy more effective in order to prevent chemoresistance and pre-clinical and clinical data has suggested that protein kinase C (PKC) may represent an attractive target for cancer therapy. Therefore, a complete understanding of how PKC regulates apoptosis and chemoresistance may lead to obtaining a PKC-based therapy that is able to reduce drug dosages and to prevent the development of chemoresistance. apoptosis PKC cancer chemoresistance Neoplasms. Tumors. Oncology. Including cancer and carcinogens Umberto M. Marinari verfasserin aut Maria A. Pronzato verfasserin aut Roberta Ricciarelli verfasserin aut Chiara De Ciucis verfasserin aut Barbara Marengo verfasserin aut In Cancers MDPI AG, 2010 3(2011), 1, Seite 531-567 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:3 year:2011 number:1 pages:531-567 https://doi.org/10.3390/cancers3010531 kostenfrei https://doaj.org/article/d439204bbcc142808e31f3f331f212c9 kostenfrei http://www.mdpi.com/2072-6694/3/1/531/ kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2011 1 531-567 |
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RC254-282 Protein Kinase C: An Attractive Target for Cancer Therapy apoptosis PKC cancer chemoresistance |
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Apoptosis plays an important role during all stages of carcinogenesis and the development of chemoresistance in tumor cells may be due to their selective defects in the intracellular signaling proteins, central to apoptotic pathways. Consequently, many studies have focused on rendering the chemotherapy more effective in order to prevent chemoresistance and pre-clinical and clinical data has suggested that protein kinase C (PKC) may represent an attractive target for cancer therapy. Therefore, a complete understanding of how PKC regulates apoptosis and chemoresistance may lead to obtaining a PKC-based therapy that is able to reduce drug dosages and to prevent the development of chemoresistance. |
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Apoptosis plays an important role during all stages of carcinogenesis and the development of chemoresistance in tumor cells may be due to their selective defects in the intracellular signaling proteins, central to apoptotic pathways. Consequently, many studies have focused on rendering the chemotherapy more effective in order to prevent chemoresistance and pre-clinical and clinical data has suggested that protein kinase C (PKC) may represent an attractive target for cancer therapy. Therefore, a complete understanding of how PKC regulates apoptosis and chemoresistance may lead to obtaining a PKC-based therapy that is able to reduce drug dosages and to prevent the development of chemoresistance. |
abstract_unstemmed |
Apoptosis plays an important role during all stages of carcinogenesis and the development of chemoresistance in tumor cells may be due to their selective defects in the intracellular signaling proteins, central to apoptotic pathways. Consequently, many studies have focused on rendering the chemotherapy more effective in order to prevent chemoresistance and pre-clinical and clinical data has suggested that protein kinase C (PKC) may represent an attractive target for cancer therapy. Therefore, a complete understanding of how PKC regulates apoptosis and chemoresistance may lead to obtaining a PKC-based therapy that is able to reduce drug dosages and to prevent the development of chemoresistance. |
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score |
7.3985195 |