Continuously available ratio of SpO2/FiO2 serves as a noninvasive prognostic marker for intensive care patients with COVID-19

Abstract Rationale Oxygen saturation to fraction of inspired oxygen ratio (SpO2/FiO2) has been described as potential predictor of poor outcome for COVID-19, without considering its time-varying behavior though. Methods Prognostic value of SpO2/FiO2 was evaluated by jointly modeling the longitudinal...
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Autor*in:	Xiaofan Lu [verfasserIn] Liyun Jiang [verfasserIn] Taige Chen [verfasserIn] Yang Wang [verfasserIn] Bing Zhang [verfasserIn] Yizhou Hong [verfasserIn] Jun Wang [verfasserIn] Fangrong Yan [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	COVID-19 SpO2/FiO2 Joint model Prognostic marker

Übergeordnetes Werk:	In: Respiratory Research - BMC, 2003, 21(2020), 1, Seite 4
Übergeordnetes Werk:	volume:21 ; year:2020 ; number:1 ; pages:4

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12931-020-01455-4

Katalog-ID:	DOAJ037196014

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520			\|a Abstract Rationale Oxygen saturation to fraction of inspired oxygen ratio (SpO2/FiO2) has been described as potential predictor of poor outcome for COVID-19, without considering its time-varying behavior though. Methods Prognostic value of SpO2/FiO2 was evaluated by jointly modeling the longitudinal responses of SpO2/FiO2 and time-to-event data retrieved from 280 severe and critically ill (intensive care) patients with COVID-19. Results A sharply decrease of SpO2/FiO2 from the first to second measurement for non-survivors was observed, and a strong association between square root SpO2/FiO2 and mortality risk was demonstrated, with a unit decrease in the marker corresponding to 1.82-fold increase in mortality risk (95% CI: 1.56–2.13). Conclusions The current study suggested that SpO2/FiO2 could serve as a non-invasive prognostic marker to facilitate early adjustment for treatment, thus improving overall survival.
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author_variant	x l xl l j lj t c tc y w yw b z bz y h yh j w jw f y fy
matchkey_str	article:1465993X:2020----::otnosyvialrtofp2i2evssnnnaiergotcakroit
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allfields	10.1186/s12931-020-01455-4 doi (DE-627)DOAJ037196014 (DE-599)DOAJa0f64be88a3244b6aacda6e2def9f7fc DE-627 ger DE-627 rakwb eng RC705-779 Xiaofan Lu verfasserin aut Continuously available ratio of SpO2/FiO2 serves as a noninvasive prognostic marker for intensive care patients with COVID-19 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Rationale Oxygen saturation to fraction of inspired oxygen ratio (SpO2/FiO2) has been described as potential predictor of poor outcome for COVID-19, without considering its time-varying behavior though. Methods Prognostic value of SpO2/FiO2 was evaluated by jointly modeling the longitudinal responses of SpO2/FiO2 and time-to-event data retrieved from 280 severe and critically ill (intensive care) patients with COVID-19. Results A sharply decrease of SpO2/FiO2 from the first to second measurement for non-survivors was observed, and a strong association between square root SpO2/FiO2 and mortality risk was demonstrated, with a unit decrease in the marker corresponding to 1.82-fold increase in mortality risk (95% CI: 1.56–2.13). Conclusions The current study suggested that SpO2/FiO2 could serve as a non-invasive prognostic marker to facilitate early adjustment for treatment, thus improving overall survival. COVID-19 SpO2/FiO2 Joint model Prognostic marker Diseases of the respiratory system Liyun Jiang verfasserin aut Taige Chen verfasserin aut Yang Wang verfasserin aut Bing Zhang verfasserin aut Yizhou Hong verfasserin aut Jun Wang verfasserin aut Fangrong Yan verfasserin aut In Respiratory Research BMC, 2003 21(2020), 1, Seite 4 (DE-627)326646485 (DE-600)2041675-1 1465993X nnns volume:21 year:2020 number:1 pages:4 https://doi.org/10.1186/s12931-020-01455-4 kostenfrei https://doaj.org/article/a0f64be88a3244b6aacda6e2def9f7fc kostenfrei http://link.springer.com/article/10.1186/s12931-020-01455-4 kostenfrei https://doaj.org/toc/1465-993X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2020 1 4
spelling	10.1186/s12931-020-01455-4 doi (DE-627)DOAJ037196014 (DE-599)DOAJa0f64be88a3244b6aacda6e2def9f7fc DE-627 ger DE-627 rakwb eng RC705-779 Xiaofan Lu verfasserin aut Continuously available ratio of SpO2/FiO2 serves as a noninvasive prognostic marker for intensive care patients with COVID-19 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Rationale Oxygen saturation to fraction of inspired oxygen ratio (SpO2/FiO2) has been described as potential predictor of poor outcome for COVID-19, without considering its time-varying behavior though. Methods Prognostic value of SpO2/FiO2 was evaluated by jointly modeling the longitudinal responses of SpO2/FiO2 and time-to-event data retrieved from 280 severe and critically ill (intensive care) patients with COVID-19. Results A sharply decrease of SpO2/FiO2 from the first to second measurement for non-survivors was observed, and a strong association between square root SpO2/FiO2 and mortality risk was demonstrated, with a unit decrease in the marker corresponding to 1.82-fold increase in mortality risk (95% CI: 1.56–2.13). Conclusions The current study suggested that SpO2/FiO2 could serve as a non-invasive prognostic marker to facilitate early adjustment for treatment, thus improving overall survival. COVID-19 SpO2/FiO2 Joint model Prognostic marker Diseases of the respiratory system Liyun Jiang verfasserin aut Taige Chen verfasserin aut Yang Wang verfasserin aut Bing Zhang verfasserin aut Yizhou Hong verfasserin aut Jun Wang verfasserin aut Fangrong Yan verfasserin aut In Respiratory Research BMC, 2003 21(2020), 1, Seite 4 (DE-627)326646485 (DE-600)2041675-1 1465993X nnns volume:21 year:2020 number:1 pages:4 https://doi.org/10.1186/s12931-020-01455-4 kostenfrei https://doaj.org/article/a0f64be88a3244b6aacda6e2def9f7fc kostenfrei http://link.springer.com/article/10.1186/s12931-020-01455-4 kostenfrei https://doaj.org/toc/1465-993X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2020 1 4
allfields_unstemmed	10.1186/s12931-020-01455-4 doi (DE-627)DOAJ037196014 (DE-599)DOAJa0f64be88a3244b6aacda6e2def9f7fc DE-627 ger DE-627 rakwb eng RC705-779 Xiaofan Lu verfasserin aut Continuously available ratio of SpO2/FiO2 serves as a noninvasive prognostic marker for intensive care patients with COVID-19 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Rationale Oxygen saturation to fraction of inspired oxygen ratio (SpO2/FiO2) has been described as potential predictor of poor outcome for COVID-19, without considering its time-varying behavior though. Methods Prognostic value of SpO2/FiO2 was evaluated by jointly modeling the longitudinal responses of SpO2/FiO2 and time-to-event data retrieved from 280 severe and critically ill (intensive care) patients with COVID-19. Results A sharply decrease of SpO2/FiO2 from the first to second measurement for non-survivors was observed, and a strong association between square root SpO2/FiO2 and mortality risk was demonstrated, with a unit decrease in the marker corresponding to 1.82-fold increase in mortality risk (95% CI: 1.56–2.13). Conclusions The current study suggested that SpO2/FiO2 could serve as a non-invasive prognostic marker to facilitate early adjustment for treatment, thus improving overall survival. COVID-19 SpO2/FiO2 Joint model Prognostic marker Diseases of the respiratory system Liyun Jiang verfasserin aut Taige Chen verfasserin aut Yang Wang verfasserin aut Bing Zhang verfasserin aut Yizhou Hong verfasserin aut Jun Wang verfasserin aut Fangrong Yan verfasserin aut In Respiratory Research BMC, 2003 21(2020), 1, Seite 4 (DE-627)326646485 (DE-600)2041675-1 1465993X nnns volume:21 year:2020 number:1 pages:4 https://doi.org/10.1186/s12931-020-01455-4 kostenfrei https://doaj.org/article/a0f64be88a3244b6aacda6e2def9f7fc kostenfrei http://link.springer.com/article/10.1186/s12931-020-01455-4 kostenfrei https://doaj.org/toc/1465-993X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2020 1 4
allfieldsGer	10.1186/s12931-020-01455-4 doi (DE-627)DOAJ037196014 (DE-599)DOAJa0f64be88a3244b6aacda6e2def9f7fc DE-627 ger DE-627 rakwb eng RC705-779 Xiaofan Lu verfasserin aut Continuously available ratio of SpO2/FiO2 serves as a noninvasive prognostic marker for intensive care patients with COVID-19 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Rationale Oxygen saturation to fraction of inspired oxygen ratio (SpO2/FiO2) has been described as potential predictor of poor outcome for COVID-19, without considering its time-varying behavior though. Methods Prognostic value of SpO2/FiO2 was evaluated by jointly modeling the longitudinal responses of SpO2/FiO2 and time-to-event data retrieved from 280 severe and critically ill (intensive care) patients with COVID-19. Results A sharply decrease of SpO2/FiO2 from the first to second measurement for non-survivors was observed, and a strong association between square root SpO2/FiO2 and mortality risk was demonstrated, with a unit decrease in the marker corresponding to 1.82-fold increase in mortality risk (95% CI: 1.56–2.13). Conclusions The current study suggested that SpO2/FiO2 could serve as a non-invasive prognostic marker to facilitate early adjustment for treatment, thus improving overall survival. COVID-19 SpO2/FiO2 Joint model Prognostic marker Diseases of the respiratory system Liyun Jiang verfasserin aut Taige Chen verfasserin aut Yang Wang verfasserin aut Bing Zhang verfasserin aut Yizhou Hong verfasserin aut Jun Wang verfasserin aut Fangrong Yan verfasserin aut In Respiratory Research BMC, 2003 21(2020), 1, Seite 4 (DE-627)326646485 (DE-600)2041675-1 1465993X nnns volume:21 year:2020 number:1 pages:4 https://doi.org/10.1186/s12931-020-01455-4 kostenfrei https://doaj.org/article/a0f64be88a3244b6aacda6e2def9f7fc kostenfrei http://link.springer.com/article/10.1186/s12931-020-01455-4 kostenfrei https://doaj.org/toc/1465-993X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2020 1 4
allfieldsSound	10.1186/s12931-020-01455-4 doi (DE-627)DOAJ037196014 (DE-599)DOAJa0f64be88a3244b6aacda6e2def9f7fc DE-627 ger DE-627 rakwb eng RC705-779 Xiaofan Lu verfasserin aut Continuously available ratio of SpO2/FiO2 serves as a noninvasive prognostic marker for intensive care patients with COVID-19 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Rationale Oxygen saturation to fraction of inspired oxygen ratio (SpO2/FiO2) has been described as potential predictor of poor outcome for COVID-19, without considering its time-varying behavior though. Methods Prognostic value of SpO2/FiO2 was evaluated by jointly modeling the longitudinal responses of SpO2/FiO2 and time-to-event data retrieved from 280 severe and critically ill (intensive care) patients with COVID-19. Results A sharply decrease of SpO2/FiO2 from the first to second measurement for non-survivors was observed, and a strong association between square root SpO2/FiO2 and mortality risk was demonstrated, with a unit decrease in the marker corresponding to 1.82-fold increase in mortality risk (95% CI: 1.56–2.13). Conclusions The current study suggested that SpO2/FiO2 could serve as a non-invasive prognostic marker to facilitate early adjustment for treatment, thus improving overall survival. COVID-19 SpO2/FiO2 Joint model Prognostic marker Diseases of the respiratory system Liyun Jiang verfasserin aut Taige Chen verfasserin aut Yang Wang verfasserin aut Bing Zhang verfasserin aut Yizhou Hong verfasserin aut Jun Wang verfasserin aut Fangrong Yan verfasserin aut In Respiratory Research BMC, 2003 21(2020), 1, Seite 4 (DE-627)326646485 (DE-600)2041675-1 1465993X nnns volume:21 year:2020 number:1 pages:4 https://doi.org/10.1186/s12931-020-01455-4 kostenfrei https://doaj.org/article/a0f64be88a3244b6aacda6e2def9f7fc kostenfrei http://link.springer.com/article/10.1186/s12931-020-01455-4 kostenfrei https://doaj.org/toc/1465-993X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2020 1 4
language	English
source	In Respiratory Research 21(2020), 1, Seite 4 volume:21 year:2020 number:1 pages:4
sourceStr	In Respiratory Research 21(2020), 1, Seite 4 volume:21 year:2020 number:1 pages:4
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	COVID-19 SpO2/FiO2 Joint model Prognostic marker Diseases of the respiratory system
isfreeaccess_bool	true
container_title	Respiratory Research
authorswithroles_txt_mv	Xiaofan Lu @@aut@@ Liyun Jiang @@aut@@ Taige Chen @@aut@@ Yang Wang @@aut@@ Bing Zhang @@aut@@ Yizhou Hong @@aut@@ Jun Wang @@aut@@ Fangrong Yan @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	326646485
id	DOAJ037196014
language_de	englisch
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callnumber-first	R - Medicine
author	Xiaofan Lu
spellingShingle	Xiaofan Lu misc RC705-779 misc COVID-19 misc SpO2/FiO2 misc Joint model misc Prognostic marker misc Diseases of the respiratory system Continuously available ratio of SpO2/FiO2 serves as a noninvasive prognostic marker for intensive care patients with COVID-19
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topic_title	RC705-779 Continuously available ratio of SpO2/FiO2 serves as a noninvasive prognostic marker for intensive care patients with COVID-19 COVID-19 SpO2/FiO2 Joint model Prognostic marker
topic	misc RC705-779 misc COVID-19 misc SpO2/FiO2 misc Joint model misc Prognostic marker misc Diseases of the respiratory system
topic_unstemmed	misc RC705-779 misc COVID-19 misc SpO2/FiO2 misc Joint model misc Prognostic marker misc Diseases of the respiratory system
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title	Continuously available ratio of SpO2/FiO2 serves as a noninvasive prognostic marker for intensive care patients with COVID-19
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title_full	Continuously available ratio of SpO2/FiO2 serves as a noninvasive prognostic marker for intensive care patients with COVID-19
author_sort	Xiaofan Lu
journal	Respiratory Research
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author_browse	Xiaofan Lu Liyun Jiang Taige Chen Yang Wang Bing Zhang Yizhou Hong Jun Wang Fangrong Yan
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title_sort	continuously available ratio of spo2/fio2 serves as a noninvasive prognostic marker for intensive care patients with covid-19
callnumber	RC705-779
title_auth	Continuously available ratio of SpO2/FiO2 serves as a noninvasive prognostic marker for intensive care patients with COVID-19
abstract	Abstract Rationale Oxygen saturation to fraction of inspired oxygen ratio (SpO2/FiO2) has been described as potential predictor of poor outcome for COVID-19, without considering its time-varying behavior though. Methods Prognostic value of SpO2/FiO2 was evaluated by jointly modeling the longitudinal responses of SpO2/FiO2 and time-to-event data retrieved from 280 severe and critically ill (intensive care) patients with COVID-19. Results A sharply decrease of SpO2/FiO2 from the first to second measurement for non-survivors was observed, and a strong association between square root SpO2/FiO2 and mortality risk was demonstrated, with a unit decrease in the marker corresponding to 1.82-fold increase in mortality risk (95% CI: 1.56–2.13). Conclusions The current study suggested that SpO2/FiO2 could serve as a non-invasive prognostic marker to facilitate early adjustment for treatment, thus improving overall survival.
abstractGer	Abstract Rationale Oxygen saturation to fraction of inspired oxygen ratio (SpO2/FiO2) has been described as potential predictor of poor outcome for COVID-19, without considering its time-varying behavior though. Methods Prognostic value of SpO2/FiO2 was evaluated by jointly modeling the longitudinal responses of SpO2/FiO2 and time-to-event data retrieved from 280 severe and critically ill (intensive care) patients with COVID-19. Results A sharply decrease of SpO2/FiO2 from the first to second measurement for non-survivors was observed, and a strong association between square root SpO2/FiO2 and mortality risk was demonstrated, with a unit decrease in the marker corresponding to 1.82-fold increase in mortality risk (95% CI: 1.56–2.13). Conclusions The current study suggested that SpO2/FiO2 could serve as a non-invasive prognostic marker to facilitate early adjustment for treatment, thus improving overall survival.
abstract_unstemmed	Abstract Rationale Oxygen saturation to fraction of inspired oxygen ratio (SpO2/FiO2) has been described as potential predictor of poor outcome for COVID-19, without considering its time-varying behavior though. Methods Prognostic value of SpO2/FiO2 was evaluated by jointly modeling the longitudinal responses of SpO2/FiO2 and time-to-event data retrieved from 280 severe and critically ill (intensive care) patients with COVID-19. Results A sharply decrease of SpO2/FiO2 from the first to second measurement for non-survivors was observed, and a strong association between square root SpO2/FiO2 and mortality risk was demonstrated, with a unit decrease in the marker corresponding to 1.82-fold increase in mortality risk (95% CI: 1.56–2.13). Conclusions The current study suggested that SpO2/FiO2 could serve as a non-invasive prognostic marker to facilitate early adjustment for treatment, thus improving overall survival.
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title_short	Continuously available ratio of SpO2/FiO2 serves as a noninvasive prognostic marker for intensive care patients with COVID-19
url	https://doi.org/10.1186/s12931-020-01455-4 https://doaj.org/article/a0f64be88a3244b6aacda6e2def9f7fc http://link.springer.com/article/10.1186/s12931-020-01455-4 https://doaj.org/toc/1465-993X
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Continuously available ratio of SpO2/FiO2 serves as a noninvasive prognostic marker for intensive care patients with COVID-19

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