A family history of breast cancer will not predict female early onset breast cancer in a population-based setting

<p<Abstract</p< <p<Background</p< <p<An increased risk of breast cancer for relatives of breast cancer patients has been demonstrated in many studies, and having a relative diagnosed with breast cancer at an early age is an indication for breast cancer screening. This i...
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Autor*in:	Klijn Jan GM [verfasserIn] Cornelisse Cees J [verfasserIn] van Asperen Christi J [verfasserIn] Blom Jannet [verfasserIn] Krol-Warmerdam Elly MM [verfasserIn] Seynaeve Caroline [verfasserIn] Jacobi Catharina E [verfasserIn] de Bock Geertruida H [verfasserIn] Devilee Peter [verfasserIn] Tollenaar Rob AEM [verfasserIn] Brekelmans Cecile TM [verfasserIn] van Houwelingen Johannes C [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2008

Übergeordnetes Werk:	In: BMC Cancer - BMC, 2003, 8(2008), 1, p 203
Übergeordnetes Werk:	volume:8 ; year:2008 ; number:1, p 203

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/1471-2407-8-203

Katalog-ID:	DOAJ03720212X

Internformat


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520			\|a <p<Abstract</p< <p<Background</p< <p<An increased risk of breast cancer for relatives of breast cancer patients has been demonstrated in many studies, and having a relative diagnosed with breast cancer at an early age is an indication for breast cancer screening. This indication has been derived from estimates based on data from cancer-prone families or from BRCA1/2 mutation families, and might be biased because BRCA1/2 mutations explain only a small proportion of the familial clustering of breast cancer. The aim of the current study was to determine the predictive value of a family history of cancer with regard to early onset of female breast cancer in a population based setting.</p< <p<Methods</p< <p<An unselected sample of 1,987 women with and without breast cancer was studied with regard to the age of diagnosis of breast cancer.</p< <p<Results</p< <p<The risk of early-onset breast cancer was increased when there were: (1) at least 2 cases of female breast cancer in first-degree relatives (yes/no; HR at age 30: 3.09; 95% CI: 128-7.44), (2) at least 2 cases of female breast cancer in first or second-degree relatives under the age of 50 (yes/no; HR at age 30: 3.36; 95% CI: 1.12–10.08), (3) at least 1 case of female breast cancer under the age of 40 in a first- or second-degree relative (yes/no; HR at age 30: 2.06; 95% CI: 0.83–5.12) and (4) any case of bilateral breast cancer (yes/no; HR at age 30: 3.47; 95%: 1.33–9.05). The positive predictive value of having 2 or more of these characteristics was 13% for breast cancer before the age of 70, 11% for breast cancer before the age of 50, and 1% for breast cancer before the age of 30.</p< <p<Conclusion</p< <p<Applying family history related criteria in an unselected population could result in the screening of many women who will not develop breast cancer at an early age.</p<
653		0	\|a Neoplasms. Tumors. Oncology. Including cancer and carcinogens
700	0		\|a Cornelisse Cees J \|e verfasserin \|4 aut
700	0		\|a van Asperen Christi J \|e verfasserin \|4 aut
700	0		\|a Blom Jannet \|e verfasserin \|4 aut
700	0		\|a Krol-Warmerdam Elly MM \|e verfasserin \|4 aut
700	0		\|a Seynaeve Caroline \|e verfasserin \|4 aut
700	0		\|a Jacobi Catharina E \|e verfasserin \|4 aut
700	0		\|a de Bock Geertruida H \|e verfasserin \|4 aut
700	0		\|a Devilee Peter \|e verfasserin \|4 aut
700	0		\|a Tollenaar Rob AEM \|e verfasserin \|4 aut
700	0		\|a Brekelmans Cecile TM \|e verfasserin \|4 aut
700	0		\|a van Houwelingen Johannes C \|e verfasserin \|4 aut
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912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_602
912			\|a GBV_ILN_702
912			\|a GBV_ILN_2001
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2006
912			\|a GBV_ILN_2008
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2010
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
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912			\|a GBV_ILN_2190
912			\|a GBV_ILN_4012
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912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
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912			\|a GBV_ILN_4307
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912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4700
951			\|a AR
952			\|d 8 \|j 2008 \|e 1, p 203

Indexfelder

author_variant	k j g kjg c c j ccj v a c j vacj b j bj k w e m kwem s c sc j c e jce d b g h dbgh d p dp t r a tra b c t bct v h j c vhjc
matchkey_str	article:14712407:2008----::fmlhsoyfratacrilopeiteaealostratac
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publishDate	2008
allfields	10.1186/1471-2407-8-203 doi (DE-627)DOAJ03720212X (DE-599)DOAJb56947af2a6241128583e6e312c78713 DE-627 ger DE-627 rakwb eng RC254-282 Klijn Jan GM verfasserin aut A family history of breast cancer will not predict female early onset breast cancer in a population-based setting 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<An increased risk of breast cancer for relatives of breast cancer patients has been demonstrated in many studies, and having a relative diagnosed with breast cancer at an early age is an indication for breast cancer screening. This indication has been derived from estimates based on data from cancer-prone families or from BRCA1/2 mutation families, and might be biased because BRCA1/2 mutations explain only a small proportion of the familial clustering of breast cancer. The aim of the current study was to determine the predictive value of a family history of cancer with regard to early onset of female breast cancer in a population based setting.</p< <p<Methods</p< <p<An unselected sample of 1,987 women with and without breast cancer was studied with regard to the age of diagnosis of breast cancer.</p< <p<Results</p< <p<The risk of early-onset breast cancer was increased when there were: (1) at least 2 cases of female breast cancer in first-degree relatives (yes/no; HR at age 30: 3.09; 95% CI: 128-7.44), (2) at least 2 cases of female breast cancer in first or second-degree relatives under the age of 50 (yes/no; HR at age 30: 3.36; 95% CI: 1.12–10.08), (3) at least 1 case of female breast cancer under the age of 40 in a first- or second-degree relative (yes/no; HR at age 30: 2.06; 95% CI: 0.83–5.12) and (4) any case of bilateral breast cancer (yes/no; HR at age 30: 3.47; 95%: 1.33–9.05). The positive predictive value of having 2 or more of these characteristics was 13% for breast cancer before the age of 70, 11% for breast cancer before the age of 50, and 1% for breast cancer before the age of 30.</p< <p<Conclusion</p< <p<Applying family history related criteria in an unselected population could result in the screening of many women who will not develop breast cancer at an early age.</p< Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cornelisse Cees J verfasserin aut van Asperen Christi J verfasserin aut Blom Jannet verfasserin aut Krol-Warmerdam Elly MM verfasserin aut Seynaeve Caroline verfasserin aut Jacobi Catharina E verfasserin aut de Bock Geertruida H verfasserin aut Devilee Peter verfasserin aut Tollenaar Rob AEM verfasserin aut Brekelmans Cecile TM verfasserin aut van Houwelingen Johannes C verfasserin aut In BMC Cancer BMC, 2003 8(2008), 1, p 203 (DE-627)326643710 (DE-600)2041352-X 14712407 nnns volume:8 year:2008 number:1, p 203 https://doi.org/10.1186/1471-2407-8-203 kostenfrei https://doaj.org/article/b56947af2a6241128583e6e312c78713 kostenfrei http://www.biomedcentral.com/1471-2407/8/203 kostenfrei https://doaj.org/toc/1471-2407 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2008 1, p 203
spelling	10.1186/1471-2407-8-203 doi (DE-627)DOAJ03720212X (DE-599)DOAJb56947af2a6241128583e6e312c78713 DE-627 ger DE-627 rakwb eng RC254-282 Klijn Jan GM verfasserin aut A family history of breast cancer will not predict female early onset breast cancer in a population-based setting 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<An increased risk of breast cancer for relatives of breast cancer patients has been demonstrated in many studies, and having a relative diagnosed with breast cancer at an early age is an indication for breast cancer screening. This indication has been derived from estimates based on data from cancer-prone families or from BRCA1/2 mutation families, and might be biased because BRCA1/2 mutations explain only a small proportion of the familial clustering of breast cancer. The aim of the current study was to determine the predictive value of a family history of cancer with regard to early onset of female breast cancer in a population based setting.</p< <p<Methods</p< <p<An unselected sample of 1,987 women with and without breast cancer was studied with regard to the age of diagnosis of breast cancer.</p< <p<Results</p< <p<The risk of early-onset breast cancer was increased when there were: (1) at least 2 cases of female breast cancer in first-degree relatives (yes/no; HR at age 30: 3.09; 95% CI: 128-7.44), (2) at least 2 cases of female breast cancer in first or second-degree relatives under the age of 50 (yes/no; HR at age 30: 3.36; 95% CI: 1.12–10.08), (3) at least 1 case of female breast cancer under the age of 40 in a first- or second-degree relative (yes/no; HR at age 30: 2.06; 95% CI: 0.83–5.12) and (4) any case of bilateral breast cancer (yes/no; HR at age 30: 3.47; 95%: 1.33–9.05). The positive predictive value of having 2 or more of these characteristics was 13% for breast cancer before the age of 70, 11% for breast cancer before the age of 50, and 1% for breast cancer before the age of 30.</p< <p<Conclusion</p< <p<Applying family history related criteria in an unselected population could result in the screening of many women who will not develop breast cancer at an early age.</p< Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cornelisse Cees J verfasserin aut van Asperen Christi J verfasserin aut Blom Jannet verfasserin aut Krol-Warmerdam Elly MM verfasserin aut Seynaeve Caroline verfasserin aut Jacobi Catharina E verfasserin aut de Bock Geertruida H verfasserin aut Devilee Peter verfasserin aut Tollenaar Rob AEM verfasserin aut Brekelmans Cecile TM verfasserin aut van Houwelingen Johannes C verfasserin aut In BMC Cancer BMC, 2003 8(2008), 1, p 203 (DE-627)326643710 (DE-600)2041352-X 14712407 nnns volume:8 year:2008 number:1, p 203 https://doi.org/10.1186/1471-2407-8-203 kostenfrei https://doaj.org/article/b56947af2a6241128583e6e312c78713 kostenfrei http://www.biomedcentral.com/1471-2407/8/203 kostenfrei https://doaj.org/toc/1471-2407 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2008 1, p 203
allfields_unstemmed	10.1186/1471-2407-8-203 doi (DE-627)DOAJ03720212X (DE-599)DOAJb56947af2a6241128583e6e312c78713 DE-627 ger DE-627 rakwb eng RC254-282 Klijn Jan GM verfasserin aut A family history of breast cancer will not predict female early onset breast cancer in a population-based setting 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<An increased risk of breast cancer for relatives of breast cancer patients has been demonstrated in many studies, and having a relative diagnosed with breast cancer at an early age is an indication for breast cancer screening. This indication has been derived from estimates based on data from cancer-prone families or from BRCA1/2 mutation families, and might be biased because BRCA1/2 mutations explain only a small proportion of the familial clustering of breast cancer. The aim of the current study was to determine the predictive value of a family history of cancer with regard to early onset of female breast cancer in a population based setting.</p< <p<Methods</p< <p<An unselected sample of 1,987 women with and without breast cancer was studied with regard to the age of diagnosis of breast cancer.</p< <p<Results</p< <p<The risk of early-onset breast cancer was increased when there were: (1) at least 2 cases of female breast cancer in first-degree relatives (yes/no; HR at age 30: 3.09; 95% CI: 128-7.44), (2) at least 2 cases of female breast cancer in first or second-degree relatives under the age of 50 (yes/no; HR at age 30: 3.36; 95% CI: 1.12–10.08), (3) at least 1 case of female breast cancer under the age of 40 in a first- or second-degree relative (yes/no; HR at age 30: 2.06; 95% CI: 0.83–5.12) and (4) any case of bilateral breast cancer (yes/no; HR at age 30: 3.47; 95%: 1.33–9.05). The positive predictive value of having 2 or more of these characteristics was 13% for breast cancer before the age of 70, 11% for breast cancer before the age of 50, and 1% for breast cancer before the age of 30.</p< <p<Conclusion</p< <p<Applying family history related criteria in an unselected population could result in the screening of many women who will not develop breast cancer at an early age.</p< Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cornelisse Cees J verfasserin aut van Asperen Christi J verfasserin aut Blom Jannet verfasserin aut Krol-Warmerdam Elly MM verfasserin aut Seynaeve Caroline verfasserin aut Jacobi Catharina E verfasserin aut de Bock Geertruida H verfasserin aut Devilee Peter verfasserin aut Tollenaar Rob AEM verfasserin aut Brekelmans Cecile TM verfasserin aut van Houwelingen Johannes C verfasserin aut In BMC Cancer BMC, 2003 8(2008), 1, p 203 (DE-627)326643710 (DE-600)2041352-X 14712407 nnns volume:8 year:2008 number:1, p 203 https://doi.org/10.1186/1471-2407-8-203 kostenfrei https://doaj.org/article/b56947af2a6241128583e6e312c78713 kostenfrei http://www.biomedcentral.com/1471-2407/8/203 kostenfrei https://doaj.org/toc/1471-2407 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2008 1, p 203
allfieldsGer	10.1186/1471-2407-8-203 doi (DE-627)DOAJ03720212X (DE-599)DOAJb56947af2a6241128583e6e312c78713 DE-627 ger DE-627 rakwb eng RC254-282 Klijn Jan GM verfasserin aut A family history of breast cancer will not predict female early onset breast cancer in a population-based setting 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<An increased risk of breast cancer for relatives of breast cancer patients has been demonstrated in many studies, and having a relative diagnosed with breast cancer at an early age is an indication for breast cancer screening. This indication has been derived from estimates based on data from cancer-prone families or from BRCA1/2 mutation families, and might be biased because BRCA1/2 mutations explain only a small proportion of the familial clustering of breast cancer. The aim of the current study was to determine the predictive value of a family history of cancer with regard to early onset of female breast cancer in a population based setting.</p< <p<Methods</p< <p<An unselected sample of 1,987 women with and without breast cancer was studied with regard to the age of diagnosis of breast cancer.</p< <p<Results</p< <p<The risk of early-onset breast cancer was increased when there were: (1) at least 2 cases of female breast cancer in first-degree relatives (yes/no; HR at age 30: 3.09; 95% CI: 128-7.44), (2) at least 2 cases of female breast cancer in first or second-degree relatives under the age of 50 (yes/no; HR at age 30: 3.36; 95% CI: 1.12–10.08), (3) at least 1 case of female breast cancer under the age of 40 in a first- or second-degree relative (yes/no; HR at age 30: 2.06; 95% CI: 0.83–5.12) and (4) any case of bilateral breast cancer (yes/no; HR at age 30: 3.47; 95%: 1.33–9.05). The positive predictive value of having 2 or more of these characteristics was 13% for breast cancer before the age of 70, 11% for breast cancer before the age of 50, and 1% for breast cancer before the age of 30.</p< <p<Conclusion</p< <p<Applying family history related criteria in an unselected population could result in the screening of many women who will not develop breast cancer at an early age.</p< Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cornelisse Cees J verfasserin aut van Asperen Christi J verfasserin aut Blom Jannet verfasserin aut Krol-Warmerdam Elly MM verfasserin aut Seynaeve Caroline verfasserin aut Jacobi Catharina E verfasserin aut de Bock Geertruida H verfasserin aut Devilee Peter verfasserin aut Tollenaar Rob AEM verfasserin aut Brekelmans Cecile TM verfasserin aut van Houwelingen Johannes C verfasserin aut In BMC Cancer BMC, 2003 8(2008), 1, p 203 (DE-627)326643710 (DE-600)2041352-X 14712407 nnns volume:8 year:2008 number:1, p 203 https://doi.org/10.1186/1471-2407-8-203 kostenfrei https://doaj.org/article/b56947af2a6241128583e6e312c78713 kostenfrei http://www.biomedcentral.com/1471-2407/8/203 kostenfrei https://doaj.org/toc/1471-2407 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2008 1, p 203
allfieldsSound	10.1186/1471-2407-8-203 doi (DE-627)DOAJ03720212X (DE-599)DOAJb56947af2a6241128583e6e312c78713 DE-627 ger DE-627 rakwb eng RC254-282 Klijn Jan GM verfasserin aut A family history of breast cancer will not predict female early onset breast cancer in a population-based setting 2008 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<An increased risk of breast cancer for relatives of breast cancer patients has been demonstrated in many studies, and having a relative diagnosed with breast cancer at an early age is an indication for breast cancer screening. This indication has been derived from estimates based on data from cancer-prone families or from BRCA1/2 mutation families, and might be biased because BRCA1/2 mutations explain only a small proportion of the familial clustering of breast cancer. The aim of the current study was to determine the predictive value of a family history of cancer with regard to early onset of female breast cancer in a population based setting.</p< <p<Methods</p< <p<An unselected sample of 1,987 women with and without breast cancer was studied with regard to the age of diagnosis of breast cancer.</p< <p<Results</p< <p<The risk of early-onset breast cancer was increased when there were: (1) at least 2 cases of female breast cancer in first-degree relatives (yes/no; HR at age 30: 3.09; 95% CI: 128-7.44), (2) at least 2 cases of female breast cancer in first or second-degree relatives under the age of 50 (yes/no; HR at age 30: 3.36; 95% CI: 1.12–10.08), (3) at least 1 case of female breast cancer under the age of 40 in a first- or second-degree relative (yes/no; HR at age 30: 2.06; 95% CI: 0.83–5.12) and (4) any case of bilateral breast cancer (yes/no; HR at age 30: 3.47; 95%: 1.33–9.05). The positive predictive value of having 2 or more of these characteristics was 13% for breast cancer before the age of 70, 11% for breast cancer before the age of 50, and 1% for breast cancer before the age of 30.</p< <p<Conclusion</p< <p<Applying family history related criteria in an unselected population could result in the screening of many women who will not develop breast cancer at an early age.</p< Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cornelisse Cees J verfasserin aut van Asperen Christi J verfasserin aut Blom Jannet verfasserin aut Krol-Warmerdam Elly MM verfasserin aut Seynaeve Caroline verfasserin aut Jacobi Catharina E verfasserin aut de Bock Geertruida H verfasserin aut Devilee Peter verfasserin aut Tollenaar Rob AEM verfasserin aut Brekelmans Cecile TM verfasserin aut van Houwelingen Johannes C verfasserin aut In BMC Cancer BMC, 2003 8(2008), 1, p 203 (DE-627)326643710 (DE-600)2041352-X 14712407 nnns volume:8 year:2008 number:1, p 203 https://doi.org/10.1186/1471-2407-8-203 kostenfrei https://doaj.org/article/b56947af2a6241128583e6e312c78713 kostenfrei http://www.biomedcentral.com/1471-2407/8/203 kostenfrei https://doaj.org/toc/1471-2407 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2008 1, p 203
language	English
source	In BMC Cancer 8(2008), 1, p 203 volume:8 year:2008 number:1, p 203
sourceStr	In BMC Cancer 8(2008), 1, p 203 volume:8 year:2008 number:1, p 203
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	BMC Cancer
authorswithroles_txt_mv	Klijn Jan GM @@aut@@ Cornelisse Cees J @@aut@@ van Asperen Christi J @@aut@@ Blom Jannet @@aut@@ Krol-Warmerdam Elly MM @@aut@@ Seynaeve Caroline @@aut@@ Jacobi Catharina E @@aut@@ de Bock Geertruida H @@aut@@ Devilee Peter @@aut@@ Tollenaar Rob AEM @@aut@@ Brekelmans Cecile TM @@aut@@ van Houwelingen Johannes C @@aut@@
publishDateDaySort_date	2008-01-01T00:00:00Z
hierarchy_top_id	326643710
id	DOAJ03720212X
language_de	englisch
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This indication has been derived from estimates based on data from cancer-prone families or from BRCA1/2 mutation families, and might be biased because BRCA1/2 mutations explain only a small proportion of the familial clustering of breast cancer. The aim of the current study was to determine the predictive value of a family history of cancer with regard to early onset of female breast cancer in a population based setting.</p< <p<Methods</p< <p<An unselected sample of 1,987 women with and without breast cancer was studied with regard to the age of diagnosis of breast cancer.</p< <p<Results</p< <p<The risk of early-onset breast cancer was increased when there were: (1) at least 2 cases of female breast cancer in first-degree relatives (yes/no; HR at age 30: 3.09; 95% CI: 128-7.44), (2) at least 2 cases of female breast cancer in first or second-degree relatives under the age of 50 (yes/no; HR at age 30: 3.36; 95% CI: 1.12–10.08), (3) at least 1 case of female breast cancer under the age of 40 in a first- or second-degree relative (yes/no; HR at age 30: 2.06; 95% CI: 0.83–5.12) and (4) any case of bilateral breast cancer (yes/no; HR at age 30: 3.47; 95%: 1.33–9.05). The positive predictive value of having 2 or more of these characteristics was 13% for breast cancer before the age of 70, 11% for breast cancer before the age of 50, and 1% for breast cancer before the age of 30.</p< <p<Conclusion</p< <p<Applying family history related criteria in an unselected population could result in the screening of many women who will not develop breast cancer at an early age.</p<</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Neoplasms. Tumors. Oncology. 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topic_title	RC254-282 A family history of breast cancer will not predict female early onset breast cancer in a population-based setting
topic	misc RC254-282 misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	A family history of breast cancer will not predict female early onset breast cancer in a population-based setting
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title_full	A family history of breast cancer will not predict female early onset breast cancer in a population-based setting
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author_browse	Klijn Jan GM Cornelisse Cees J van Asperen Christi J Blom Jannet Krol-Warmerdam Elly MM Seynaeve Caroline Jacobi Catharina E de Bock Geertruida H Devilee Peter Tollenaar Rob AEM Brekelmans Cecile TM van Houwelingen Johannes C
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title_sort	family history of breast cancer will not predict female early onset breast cancer in a population-based setting
callnumber	RC254-282
title_auth	A family history of breast cancer will not predict female early onset breast cancer in a population-based setting
abstract	<p<Abstract</p< <p<Background</p< <p<An increased risk of breast cancer for relatives of breast cancer patients has been demonstrated in many studies, and having a relative diagnosed with breast cancer at an early age is an indication for breast cancer screening. This indication has been derived from estimates based on data from cancer-prone families or from BRCA1/2 mutation families, and might be biased because BRCA1/2 mutations explain only a small proportion of the familial clustering of breast cancer. The aim of the current study was to determine the predictive value of a family history of cancer with regard to early onset of female breast cancer in a population based setting.</p< <p<Methods</p< <p<An unselected sample of 1,987 women with and without breast cancer was studied with regard to the age of diagnosis of breast cancer.</p< <p<Results</p< <p<The risk of early-onset breast cancer was increased when there were: (1) at least 2 cases of female breast cancer in first-degree relatives (yes/no; HR at age 30: 3.09; 95% CI: 128-7.44), (2) at least 2 cases of female breast cancer in first or second-degree relatives under the age of 50 (yes/no; HR at age 30: 3.36; 95% CI: 1.12–10.08), (3) at least 1 case of female breast cancer under the age of 40 in a first- or second-degree relative (yes/no; HR at age 30: 2.06; 95% CI: 0.83–5.12) and (4) any case of bilateral breast cancer (yes/no; HR at age 30: 3.47; 95%: 1.33–9.05). The positive predictive value of having 2 or more of these characteristics was 13% for breast cancer before the age of 70, 11% for breast cancer before the age of 50, and 1% for breast cancer before the age of 30.</p< <p<Conclusion</p< <p<Applying family history related criteria in an unselected population could result in the screening of many women who will not develop breast cancer at an early age.</p<
abstractGer	<p<Abstract</p< <p<Background</p< <p<An increased risk of breast cancer for relatives of breast cancer patients has been demonstrated in many studies, and having a relative diagnosed with breast cancer at an early age is an indication for breast cancer screening. This indication has been derived from estimates based on data from cancer-prone families or from BRCA1/2 mutation families, and might be biased because BRCA1/2 mutations explain only a small proportion of the familial clustering of breast cancer. The aim of the current study was to determine the predictive value of a family history of cancer with regard to early onset of female breast cancer in a population based setting.</p< <p<Methods</p< <p<An unselected sample of 1,987 women with and without breast cancer was studied with regard to the age of diagnosis of breast cancer.</p< <p<Results</p< <p<The risk of early-onset breast cancer was increased when there were: (1) at least 2 cases of female breast cancer in first-degree relatives (yes/no; HR at age 30: 3.09; 95% CI: 128-7.44), (2) at least 2 cases of female breast cancer in first or second-degree relatives under the age of 50 (yes/no; HR at age 30: 3.36; 95% CI: 1.12–10.08), (3) at least 1 case of female breast cancer under the age of 40 in a first- or second-degree relative (yes/no; HR at age 30: 2.06; 95% CI: 0.83–5.12) and (4) any case of bilateral breast cancer (yes/no; HR at age 30: 3.47; 95%: 1.33–9.05). The positive predictive value of having 2 or more of these characteristics was 13% for breast cancer before the age of 70, 11% for breast cancer before the age of 50, and 1% for breast cancer before the age of 30.</p< <p<Conclusion</p< <p<Applying family history related criteria in an unselected population could result in the screening of many women who will not develop breast cancer at an early age.</p<
abstract_unstemmed	<p<Abstract</p< <p<Background</p< <p<An increased risk of breast cancer for relatives of breast cancer patients has been demonstrated in many studies, and having a relative diagnosed with breast cancer at an early age is an indication for breast cancer screening. This indication has been derived from estimates based on data from cancer-prone families or from BRCA1/2 mutation families, and might be biased because BRCA1/2 mutations explain only a small proportion of the familial clustering of breast cancer. The aim of the current study was to determine the predictive value of a family history of cancer with regard to early onset of female breast cancer in a population based setting.</p< <p<Methods</p< <p<An unselected sample of 1,987 women with and without breast cancer was studied with regard to the age of diagnosis of breast cancer.</p< <p<Results</p< <p<The risk of early-onset breast cancer was increased when there were: (1) at least 2 cases of female breast cancer in first-degree relatives (yes/no; HR at age 30: 3.09; 95% CI: 128-7.44), (2) at least 2 cases of female breast cancer in first or second-degree relatives under the age of 50 (yes/no; HR at age 30: 3.36; 95% CI: 1.12–10.08), (3) at least 1 case of female breast cancer under the age of 40 in a first- or second-degree relative (yes/no; HR at age 30: 2.06; 95% CI: 0.83–5.12) and (4) any case of bilateral breast cancer (yes/no; HR at age 30: 3.47; 95%: 1.33–9.05). The positive predictive value of having 2 or more of these characteristics was 13% for breast cancer before the age of 70, 11% for breast cancer before the age of 50, and 1% for breast cancer before the age of 30.</p< <p<Conclusion</p< <p<Applying family history related criteria in an unselected population could result in the screening of many women who will not develop breast cancer at an early age.</p<
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title_short	A family history of breast cancer will not predict female early onset breast cancer in a population-based setting
url	https://doi.org/10.1186/1471-2407-8-203 https://doaj.org/article/b56947af2a6241128583e6e312c78713 http://www.biomedcentral.com/1471-2407/8/203 https://doaj.org/toc/1471-2407
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The aim of the current study was to determine the predictive value of a family history of cancer with regard to early onset of female breast cancer in a population based setting.</p< <p<Methods</p< <p<An unselected sample of 1,987 women with and without breast cancer was studied with regard to the age of diagnosis of breast cancer.</p< <p<Results</p< <p<The risk of early-onset breast cancer was increased when there were: (1) at least 2 cases of female breast cancer in first-degree relatives (yes/no; HR at age 30: 3.09; 95% CI: 128-7.44), (2) at least 2 cases of female breast cancer in first or second-degree relatives under the age of 50 (yes/no; HR at age 30: 3.36; 95% CI: 1.12–10.08), (3) at least 1 case of female breast cancer under the age of 40 in a first- or second-degree relative (yes/no; HR at age 30: 2.06; 95% CI: 0.83–5.12) and (4) any case of bilateral breast cancer (yes/no; HR at age 30: 3.47; 95%: 1.33–9.05). The positive predictive value of having 2 or more of these characteristics was 13% for breast cancer before the age of 70, 11% for breast cancer before the age of 50, and 1% for breast cancer before the age of 30.</p< <p<Conclusion</p< <p<Applying family history related criteria in an unselected population could result in the screening of many women who will not develop breast cancer at an early age.</p<</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Neoplasms. Tumors. Oncology. 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A family history of breast cancer will not predict female early onset breast cancer in a population-based setting

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