Expression of Aurora Kinase A and B in chondrosarcoma and its relationship with the prognosis

<p<Abstract</p< <p<Purpose</p< <p<To investigate the expression of Aurora Kinase A and B in patients with chondrosarcoma and consider it as a prognostic marker and molecular target of therapy.</p< <p<Methods</p< <p<To evaluate the relationship of the Aurora Kinase A and B and the clinical pathological parameters and prognosis of chondrosarcoma. 72 case chondrosarcoma and 42 case chondroma were performed immunohistochemistry on the tissue microarray paraffin sections. The survival time of patients was followed-up.</p< <p<Results</p< <p<The expression of Aurora Kinase A and B in chondrosarcoma was significantly higher than that in chondroma (<it<p<0.01</it<). There were differences about the expression of Aurora Kinase A and B in chondrosarcoma between the recurrence group and the non-recurrence group, metastatic group and non-metastatic group (<it<p<0.05</it<), but not age and gender (<it<p<0.05</it<). The expression of Aurora Kinase A and B were significantly lower in group low grade conventional chondrosarcoma than that in groups medium and high grade conventional chondrosarcoma (<it<p<0.01</it<). The expression of Aurora Kinase A and B in chondrosarcoma showed a positive correlation (<it<p<0.01</it<). According to the Kaplan Meier analysis and multivariate Cox regression analysis, the survival rate was significantly different between the patients with positive Aurora Kinase A and the patients with negative expression (<it<p<0.05</it<) and Aurora Kinase A expression was an independent risk marker of survival(<it<HR=11.263</it<, <it<95%CI: 2.317–54.748, P=0.003</it<).</p< <p<Conclusion</p< <p<Both the Aurora Kinase A and B might involve in the oncogenic, invasive and metastatic process of chondrosarcoma; however, the mechanism is still unclear. The Aurora Kinase A and B could be used as a new prognostic marker and molecular therapeutic target for chondrosarcoma.</p< <p<Virtual Slide</p< <p<The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/9101494267377096.</p< Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Liang Xiaohui [verfasserIn] Wang Danying [verfasserIn] Wang Yan [verfasserIn] Zhou Zhiqiang [verfasserIn] Zhang Juan [verfasserIn] Li Jinsong [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Schlagwörter:	Aurora kinase A Aurora kinase B Chondrosarcoma

Übergeordnetes Werk:	In: Diagnostic Pathology - BMC, 2005, 7(2012), 1, p 84
Übergeordnetes Werk:	volume:7 ; year:2012 ; number:1, p 84

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/1746-1596-7-84

Katalog-ID:	DOAJ037243632

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allfields	10.1186/1746-1596-7-84 doi (DE-627)DOAJ037243632 (DE-599)DOAJffc0f91a78d44a0993e43a659b0b783f DE-627 ger DE-627 rakwb eng RB1-214 Liang Xiaohui verfasserin aut Expression of Aurora Kinase A and B in chondrosarcoma and its relationship with the prognosis 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Purpose</p< <p<To investigate the expression of Aurora Kinase A and B in patients with chondrosarcoma and consider it as a prognostic marker and molecular target of therapy.</p< <p<Methods</p< <p<To evaluate the relationship of the Aurora Kinase A and B and the clinical pathological parameters and prognosis of chondrosarcoma. 72 case chondrosarcoma and 42 case chondroma were performed immunohistochemistry on the tissue microarray paraffin sections. The survival time of patients was followed-up.</p< <p<Results</p< <p<The expression of Aurora Kinase A and B in chondrosarcoma was significantly higher than that in chondroma (<it<p<0.01</it<). There were differences about the expression of Aurora Kinase A and B in chondrosarcoma between the recurrence group and the non-recurrence group, metastatic group and non-metastatic group (<it<p<0.05</it<), but not age and gender (<it<p<0.05</it<). The expression of Aurora Kinase A and B were significantly lower in group low grade conventional chondrosarcoma than that in groups medium and high grade conventional chondrosarcoma (<it<p<0.01</it<). The expression of Aurora Kinase A and B in chondrosarcoma showed a positive correlation (<it<p<0.01</it<). According to the Kaplan Meier analysis and multivariate Cox regression analysis, the survival rate was significantly different between the patients with positive Aurora Kinase A and the patients with negative expression (<it<p<0.05</it<) and Aurora Kinase A expression was an independent risk marker of survival(<it<HR=11.263</it<, <it<95%CI: 2.317–54.748, P=0.003</it<).</p< <p<Conclusion</p< <p<Both the Aurora Kinase A and B might involve in the oncogenic, invasive and metastatic process of chondrosarcoma; however, the mechanism is still unclear. The Aurora Kinase A and B could be used as a new prognostic marker and molecular therapeutic target for chondrosarcoma.</p< <p<Virtual Slide</p< <p<The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/9101494267377096.</p< Aurora kinase A Aurora kinase B Chondrosarcoma Pathology Wang Danying verfasserin aut Wang Yan verfasserin aut Zhou Zhiqiang verfasserin aut Zhang Juan verfasserin aut Li Jinsong verfasserin aut In Diagnostic Pathology BMC, 2005 7(2012), 1, p 84 (DE-627)503328960 (DE-600)2210518-9 17461596 nnns volume:7 year:2012 number:1, p 84 https://doi.org/10.1186/1746-1596-7-84 kostenfrei https://doaj.org/article/ffc0f91a78d44a0993e43a659b0b783f kostenfrei http://www.diagnosticpathology.org/content/7/1/84 kostenfrei https://doaj.org/toc/1746-1596 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2012 1, p 84
spelling	10.1186/1746-1596-7-84 doi (DE-627)DOAJ037243632 (DE-599)DOAJffc0f91a78d44a0993e43a659b0b783f DE-627 ger DE-627 rakwb eng RB1-214 Liang Xiaohui verfasserin aut Expression of Aurora Kinase A and B in chondrosarcoma and its relationship with the prognosis 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Purpose</p< <p<To investigate the expression of Aurora Kinase A and B in patients with chondrosarcoma and consider it as a prognostic marker and molecular target of therapy.</p< <p<Methods</p< <p<To evaluate the relationship of the Aurora Kinase A and B and the clinical pathological parameters and prognosis of chondrosarcoma. 72 case chondrosarcoma and 42 case chondroma were performed immunohistochemistry on the tissue microarray paraffin sections. The survival time of patients was followed-up.</p< <p<Results</p< <p<The expression of Aurora Kinase A and B in chondrosarcoma was significantly higher than that in chondroma (<it<p<0.01</it<). There were differences about the expression of Aurora Kinase A and B in chondrosarcoma between the recurrence group and the non-recurrence group, metastatic group and non-metastatic group (<it<p<0.05</it<), but not age and gender (<it<p<0.05</it<). The expression of Aurora Kinase A and B were significantly lower in group low grade conventional chondrosarcoma than that in groups medium and high grade conventional chondrosarcoma (<it<p<0.01</it<). The expression of Aurora Kinase A and B in chondrosarcoma showed a positive correlation (<it<p<0.01</it<). According to the Kaplan Meier analysis and multivariate Cox regression analysis, the survival rate was significantly different between the patients with positive Aurora Kinase A and the patients with negative expression (<it<p<0.05</it<) and Aurora Kinase A expression was an independent risk marker of survival(<it<HR=11.263</it<, <it<95%CI: 2.317–54.748, P=0.003</it<).</p< <p<Conclusion</p< <p<Both the Aurora Kinase A and B might involve in the oncogenic, invasive and metastatic process of chondrosarcoma; however, the mechanism is still unclear. The Aurora Kinase A and B could be used as a new prognostic marker and molecular therapeutic target for chondrosarcoma.</p< <p<Virtual Slide</p< <p<The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/9101494267377096.</p< Aurora kinase A Aurora kinase B Chondrosarcoma Pathology Wang Danying verfasserin aut Wang Yan verfasserin aut Zhou Zhiqiang verfasserin aut Zhang Juan verfasserin aut Li Jinsong verfasserin aut In Diagnostic Pathology BMC, 2005 7(2012), 1, p 84 (DE-627)503328960 (DE-600)2210518-9 17461596 nnns volume:7 year:2012 number:1, p 84 https://doi.org/10.1186/1746-1596-7-84 kostenfrei https://doaj.org/article/ffc0f91a78d44a0993e43a659b0b783f kostenfrei http://www.diagnosticpathology.org/content/7/1/84 kostenfrei https://doaj.org/toc/1746-1596 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2012 1, p 84
allfields_unstemmed	10.1186/1746-1596-7-84 doi (DE-627)DOAJ037243632 (DE-599)DOAJffc0f91a78d44a0993e43a659b0b783f DE-627 ger DE-627 rakwb eng RB1-214 Liang Xiaohui verfasserin aut Expression of Aurora Kinase A and B in chondrosarcoma and its relationship with the prognosis 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Purpose</p< <p<To investigate the expression of Aurora Kinase A and B in patients with chondrosarcoma and consider it as a prognostic marker and molecular target of therapy.</p< <p<Methods</p< <p<To evaluate the relationship of the Aurora Kinase A and B and the clinical pathological parameters and prognosis of chondrosarcoma. 72 case chondrosarcoma and 42 case chondroma were performed immunohistochemistry on the tissue microarray paraffin sections. The survival time of patients was followed-up.</p< <p<Results</p< <p<The expression of Aurora Kinase A and B in chondrosarcoma was significantly higher than that in chondroma (<it<p<0.01</it<). There were differences about the expression of Aurora Kinase A and B in chondrosarcoma between the recurrence group and the non-recurrence group, metastatic group and non-metastatic group (<it<p<0.05</it<), but not age and gender (<it<p<0.05</it<). The expression of Aurora Kinase A and B were significantly lower in group low grade conventional chondrosarcoma than that in groups medium and high grade conventional chondrosarcoma (<it<p<0.01</it<). The expression of Aurora Kinase A and B in chondrosarcoma showed a positive correlation (<it<p<0.01</it<). According to the Kaplan Meier analysis and multivariate Cox regression analysis, the survival rate was significantly different between the patients with positive Aurora Kinase A and the patients with negative expression (<it<p<0.05</it<) and Aurora Kinase A expression was an independent risk marker of survival(<it<HR=11.263</it<, <it<95%CI: 2.317–54.748, P=0.003</it<).</p< <p<Conclusion</p< <p<Both the Aurora Kinase A and B might involve in the oncogenic, invasive and metastatic process of chondrosarcoma; however, the mechanism is still unclear. The Aurora Kinase A and B could be used as a new prognostic marker and molecular therapeutic target for chondrosarcoma.</p< <p<Virtual Slide</p< <p<The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/9101494267377096.</p< Aurora kinase A Aurora kinase B Chondrosarcoma Pathology Wang Danying verfasserin aut Wang Yan verfasserin aut Zhou Zhiqiang verfasserin aut Zhang Juan verfasserin aut Li Jinsong verfasserin aut In Diagnostic Pathology BMC, 2005 7(2012), 1, p 84 (DE-627)503328960 (DE-600)2210518-9 17461596 nnns volume:7 year:2012 number:1, p 84 https://doi.org/10.1186/1746-1596-7-84 kostenfrei https://doaj.org/article/ffc0f91a78d44a0993e43a659b0b783f kostenfrei http://www.diagnosticpathology.org/content/7/1/84 kostenfrei https://doaj.org/toc/1746-1596 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2012 1, p 84
allfieldsGer	10.1186/1746-1596-7-84 doi (DE-627)DOAJ037243632 (DE-599)DOAJffc0f91a78d44a0993e43a659b0b783f DE-627 ger DE-627 rakwb eng RB1-214 Liang Xiaohui verfasserin aut Expression of Aurora Kinase A and B in chondrosarcoma and its relationship with the prognosis 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Purpose</p< <p<To investigate the expression of Aurora Kinase A and B in patients with chondrosarcoma and consider it as a prognostic marker and molecular target of therapy.</p< <p<Methods</p< <p<To evaluate the relationship of the Aurora Kinase A and B and the clinical pathological parameters and prognosis of chondrosarcoma. 72 case chondrosarcoma and 42 case chondroma were performed immunohistochemistry on the tissue microarray paraffin sections. The survival time of patients was followed-up.</p< <p<Results</p< <p<The expression of Aurora Kinase A and B in chondrosarcoma was significantly higher than that in chondroma (<it<p<0.01</it<). There were differences about the expression of Aurora Kinase A and B in chondrosarcoma between the recurrence group and the non-recurrence group, metastatic group and non-metastatic group (<it<p<0.05</it<), but not age and gender (<it<p<0.05</it<). The expression of Aurora Kinase A and B were significantly lower in group low grade conventional chondrosarcoma than that in groups medium and high grade conventional chondrosarcoma (<it<p<0.01</it<). The expression of Aurora Kinase A and B in chondrosarcoma showed a positive correlation (<it<p<0.01</it<). According to the Kaplan Meier analysis and multivariate Cox regression analysis, the survival rate was significantly different between the patients with positive Aurora Kinase A and the patients with negative expression (<it<p<0.05</it<) and Aurora Kinase A expression was an independent risk marker of survival(<it<HR=11.263</it<, <it<95%CI: 2.317–54.748, P=0.003</it<).</p< <p<Conclusion</p< <p<Both the Aurora Kinase A and B might involve in the oncogenic, invasive and metastatic process of chondrosarcoma; however, the mechanism is still unclear. The Aurora Kinase A and B could be used as a new prognostic marker and molecular therapeutic target for chondrosarcoma.</p< <p<Virtual Slide</p< <p<The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/9101494267377096.</p< Aurora kinase A Aurora kinase B Chondrosarcoma Pathology Wang Danying verfasserin aut Wang Yan verfasserin aut Zhou Zhiqiang verfasserin aut Zhang Juan verfasserin aut Li Jinsong verfasserin aut In Diagnostic Pathology BMC, 2005 7(2012), 1, p 84 (DE-627)503328960 (DE-600)2210518-9 17461596 nnns volume:7 year:2012 number:1, p 84 https://doi.org/10.1186/1746-1596-7-84 kostenfrei https://doaj.org/article/ffc0f91a78d44a0993e43a659b0b783f kostenfrei http://www.diagnosticpathology.org/content/7/1/84 kostenfrei https://doaj.org/toc/1746-1596 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2012 1, p 84
allfieldsSound	10.1186/1746-1596-7-84 doi (DE-627)DOAJ037243632 (DE-599)DOAJffc0f91a78d44a0993e43a659b0b783f DE-627 ger DE-627 rakwb eng RB1-214 Liang Xiaohui verfasserin aut Expression of Aurora Kinase A and B in chondrosarcoma and its relationship with the prognosis 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Purpose</p< <p<To investigate the expression of Aurora Kinase A and B in patients with chondrosarcoma and consider it as a prognostic marker and molecular target of therapy.</p< <p<Methods</p< <p<To evaluate the relationship of the Aurora Kinase A and B and the clinical pathological parameters and prognosis of chondrosarcoma. 72 case chondrosarcoma and 42 case chondroma were performed immunohistochemistry on the tissue microarray paraffin sections. The survival time of patients was followed-up.</p< <p<Results</p< <p<The expression of Aurora Kinase A and B in chondrosarcoma was significantly higher than that in chondroma (<it<p<0.01</it<). There were differences about the expression of Aurora Kinase A and B in chondrosarcoma between the recurrence group and the non-recurrence group, metastatic group and non-metastatic group (<it<p<0.05</it<), but not age and gender (<it<p<0.05</it<). The expression of Aurora Kinase A and B were significantly lower in group low grade conventional chondrosarcoma than that in groups medium and high grade conventional chondrosarcoma (<it<p<0.01</it<). The expression of Aurora Kinase A and B in chondrosarcoma showed a positive correlation (<it<p<0.01</it<). According to the Kaplan Meier analysis and multivariate Cox regression analysis, the survival rate was significantly different between the patients with positive Aurora Kinase A and the patients with negative expression (<it<p<0.05</it<) and Aurora Kinase A expression was an independent risk marker of survival(<it<HR=11.263</it<, <it<95%CI: 2.317–54.748, P=0.003</it<).</p< <p<Conclusion</p< <p<Both the Aurora Kinase A and B might involve in the oncogenic, invasive and metastatic process of chondrosarcoma; however, the mechanism is still unclear. The Aurora Kinase A and B could be used as a new prognostic marker and molecular therapeutic target for chondrosarcoma.</p< <p<Virtual Slide</p< <p<The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/9101494267377096.</p< Aurora kinase A Aurora kinase B Chondrosarcoma Pathology Wang Danying verfasserin aut Wang Yan verfasserin aut Zhou Zhiqiang verfasserin aut Zhang Juan verfasserin aut Li Jinsong verfasserin aut In Diagnostic Pathology BMC, 2005 7(2012), 1, p 84 (DE-627)503328960 (DE-600)2210518-9 17461596 nnns volume:7 year:2012 number:1, p 84 https://doi.org/10.1186/1746-1596-7-84 kostenfrei https://doaj.org/article/ffc0f91a78d44a0993e43a659b0b783f kostenfrei http://www.diagnosticpathology.org/content/7/1/84 kostenfrei https://doaj.org/toc/1746-1596 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_168 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2012 1, p 84
language	English
source	In Diagnostic Pathology 7(2012), 1, p 84 volume:7 year:2012 number:1, p 84
sourceStr	In Diagnostic Pathology 7(2012), 1, p 84 volume:7 year:2012 number:1, p 84
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Aurora kinase A Aurora kinase B Chondrosarcoma Pathology
isfreeaccess_bool	true
container_title	Diagnostic Pathology
authorswithroles_txt_mv	Liang Xiaohui @@aut@@ Wang Danying @@aut@@ Wang Yan @@aut@@ Zhou Zhiqiang @@aut@@ Zhang Juan @@aut@@ Li Jinsong @@aut@@
publishDateDaySort_date	2012-01-01T00:00:00Z
hierarchy_top_id	503328960
id	DOAJ037243632
language_de	englisch
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The survival time of patients was followed-up.</p< <p<Results</p< <p<The expression of Aurora Kinase A and B in chondrosarcoma was significantly higher than that in chondroma (<it<p<0.01</it<). There were differences about the expression of Aurora Kinase A and B in chondrosarcoma between the recurrence group and the non-recurrence group, metastatic group and non-metastatic group (<it<p<0.05</it<), but not age and gender (<it<p<0.05</it<). The expression of Aurora Kinase A and B were significantly lower in group low grade conventional chondrosarcoma than that in groups medium and high grade conventional chondrosarcoma (<it<p<0.01</it<). The expression of Aurora Kinase A and B in chondrosarcoma showed a positive correlation (<it<p<0.01</it<). According to the Kaplan Meier analysis and multivariate Cox regression analysis, the survival rate was significantly different between the patients with positive Aurora Kinase A and the patients with negative expression (<it<p<0.05</it<) and Aurora Kinase A expression was an independent risk marker of survival(<it<HR=11.263</it<, <it<95%CI: 2.317–54.748, P=0.003</it<).</p< <p<Conclusion</p< <p<Both the Aurora Kinase A and B might involve in the oncogenic, invasive and metastatic process of chondrosarcoma; however, the mechanism is still unclear. 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callnumber-first	R - Medicine
author	Liang Xiaohui
spellingShingle	Liang Xiaohui misc RB1-214 misc Aurora kinase A misc Aurora kinase B misc Chondrosarcoma misc Pathology Expression of Aurora Kinase A and B in chondrosarcoma and its relationship with the prognosis
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topic_title	RB1-214 Expression of Aurora Kinase A and B in chondrosarcoma and its relationship with the prognosis Aurora kinase A Aurora kinase B Chondrosarcoma
topic	misc RB1-214 misc Aurora kinase A misc Aurora kinase B misc Chondrosarcoma misc Pathology
topic_unstemmed	misc RB1-214 misc Aurora kinase A misc Aurora kinase B misc Chondrosarcoma misc Pathology
topic_browse	misc RB1-214 misc Aurora kinase A misc Aurora kinase B misc Chondrosarcoma misc Pathology
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title	Expression of Aurora Kinase A and B in chondrosarcoma and its relationship with the prognosis
ctrlnum	(DE-627)DOAJ037243632 (DE-599)DOAJffc0f91a78d44a0993e43a659b0b783f
title_full	Expression of Aurora Kinase A and B in chondrosarcoma and its relationship with the prognosis
author_sort	Liang Xiaohui
journal	Diagnostic Pathology
journalStr	Diagnostic Pathology
callnumber-first-code	R
lang_code	eng
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author_browse	Liang Xiaohui Wang Danying Wang Yan Zhou Zhiqiang Zhang Juan Li Jinsong
container_volume	7
class	RB1-214
format_se	Elektronische Aufsätze
author-letter	Liang Xiaohui
doi_str_mv	10.1186/1746-1596-7-84
author2-role	verfasserin
title_sort	expression of aurora kinase a and b in chondrosarcoma and its relationship with the prognosis
callnumber	RB1-214
title_auth	Expression of Aurora Kinase A and B in chondrosarcoma and its relationship with the prognosis
abstract	<p<Abstract</p< <p<Purpose</p< <p<To investigate the expression of Aurora Kinase A and B in patients with chondrosarcoma and consider it as a prognostic marker and molecular target of therapy.</p< <p<Methods</p< <p<To evaluate the relationship of the Aurora Kinase A and B and the clinical pathological parameters and prognosis of chondrosarcoma. 72 case chondrosarcoma and 42 case chondroma were performed immunohistochemistry on the tissue microarray paraffin sections. The survival time of patients was followed-up.</p< <p<Results</p< <p<The expression of Aurora Kinase A and B in chondrosarcoma was significantly higher than that in chondroma (<it<p<0.01</it<). There were differences about the expression of Aurora Kinase A and B in chondrosarcoma between the recurrence group and the non-recurrence group, metastatic group and non-metastatic group (<it<p<0.05</it<), but not age and gender (<it<p<0.05</it<). The expression of Aurora Kinase A and B were significantly lower in group low grade conventional chondrosarcoma than that in groups medium and high grade conventional chondrosarcoma (<it<p<0.01</it<). The expression of Aurora Kinase A and B in chondrosarcoma showed a positive correlation (<it<p<0.01</it<). According to the Kaplan Meier analysis and multivariate Cox regression analysis, the survival rate was significantly different between the patients with positive Aurora Kinase A and the patients with negative expression (<it<p<0.05</it<) and Aurora Kinase A expression was an independent risk marker of survival(<it<HR=11.263</it<, <it<95%CI: 2.317–54.748, P=0.003</it<).</p< <p<Conclusion</p< <p<Both the Aurora Kinase A and B might involve in the oncogenic, invasive and metastatic process of chondrosarcoma; however, the mechanism is still unclear. The Aurora Kinase A and B could be used as a new prognostic marker and molecular therapeutic target for chondrosarcoma.</p< <p<Virtual Slide</p< <p<The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/9101494267377096.</p<
abstractGer	<p<Abstract</p< <p<Purpose</p< <p<To investigate the expression of Aurora Kinase A and B in patients with chondrosarcoma and consider it as a prognostic marker and molecular target of therapy.</p< <p<Methods</p< <p<To evaluate the relationship of the Aurora Kinase A and B and the clinical pathological parameters and prognosis of chondrosarcoma. 72 case chondrosarcoma and 42 case chondroma were performed immunohistochemistry on the tissue microarray paraffin sections. The survival time of patients was followed-up.</p< <p<Results</p< <p<The expression of Aurora Kinase A and B in chondrosarcoma was significantly higher than that in chondroma (<it<p<0.01</it<). There were differences about the expression of Aurora Kinase A and B in chondrosarcoma between the recurrence group and the non-recurrence group, metastatic group and non-metastatic group (<it<p<0.05</it<), but not age and gender (<it<p<0.05</it<). The expression of Aurora Kinase A and B were significantly lower in group low grade conventional chondrosarcoma than that in groups medium and high grade conventional chondrosarcoma (<it<p<0.01</it<). The expression of Aurora Kinase A and B in chondrosarcoma showed a positive correlation (<it<p<0.01</it<). According to the Kaplan Meier analysis and multivariate Cox regression analysis, the survival rate was significantly different between the patients with positive Aurora Kinase A and the patients with negative expression (<it<p<0.05</it<) and Aurora Kinase A expression was an independent risk marker of survival(<it<HR=11.263</it<, <it<95%CI: 2.317–54.748, P=0.003</it<).</p< <p<Conclusion</p< <p<Both the Aurora Kinase A and B might involve in the oncogenic, invasive and metastatic process of chondrosarcoma; however, the mechanism is still unclear. The Aurora Kinase A and B could be used as a new prognostic marker and molecular therapeutic target for chondrosarcoma.</p< <p<Virtual Slide</p< <p<The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/9101494267377096.</p<
abstract_unstemmed	<p<Abstract</p< <p<Purpose</p< <p<To investigate the expression of Aurora Kinase A and B in patients with chondrosarcoma and consider it as a prognostic marker and molecular target of therapy.</p< <p<Methods</p< <p<To evaluate the relationship of the Aurora Kinase A and B and the clinical pathological parameters and prognosis of chondrosarcoma. 72 case chondrosarcoma and 42 case chondroma were performed immunohistochemistry on the tissue microarray paraffin sections. The survival time of patients was followed-up.</p< <p<Results</p< <p<The expression of Aurora Kinase A and B in chondrosarcoma was significantly higher than that in chondroma (<it<p<0.01</it<). There were differences about the expression of Aurora Kinase A and B in chondrosarcoma between the recurrence group and the non-recurrence group, metastatic group and non-metastatic group (<it<p<0.05</it<), but not age and gender (<it<p<0.05</it<). The expression of Aurora Kinase A and B were significantly lower in group low grade conventional chondrosarcoma than that in groups medium and high grade conventional chondrosarcoma (<it<p<0.01</it<). The expression of Aurora Kinase A and B in chondrosarcoma showed a positive correlation (<it<p<0.01</it<). According to the Kaplan Meier analysis and multivariate Cox regression analysis, the survival rate was significantly different between the patients with positive Aurora Kinase A and the patients with negative expression (<it<p<0.05</it<) and Aurora Kinase A expression was an independent risk marker of survival(<it<HR=11.263</it<, <it<95%CI: 2.317–54.748, P=0.003</it<).</p< <p<Conclusion</p< <p<Both the Aurora Kinase A and B might involve in the oncogenic, invasive and metastatic process of chondrosarcoma; however, the mechanism is still unclear. The Aurora Kinase A and B could be used as a new prognostic marker and molecular therapeutic target for chondrosarcoma.</p< <p<Virtual Slide</p< <p<The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/9101494267377096.</p<
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title_short	Expression of Aurora Kinase A and B in chondrosarcoma and its relationship with the prognosis
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