Structure Dependent-Immunomodulation by Sugar Beet Arabinans via a SYK Tyrosine Kinase-Dependent Signaling Pathway

There is much interest in the immunomodulatory properties of dietary fibers but their activity may be influenced by contamination with microbial-associated molecular patterns (MAMPs) such as lipopolysaccharide (LPS) and lipoteichoic acids, which are difficult to remove completely from biological sam...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Marjolein Meijerink [verfasserIn] Christiane Rösch [verfasserIn] Nico Taverne [verfasserIn] Koen Venema [verfasserIn] Harry Gruppen [verfasserIn] Henk A. Schols [verfasserIn] Jerry M. Wells [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	immunomodulation dietary fiber arabinans pectin structure-function relationship C-type lectin receptors

Übergeordnetes Werk:	In: Frontiers in Immunology - Frontiers Media S.A., 2011, 9(2018)
Übergeordnetes Werk:	volume:9 ; year:2018

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fimmu.2018.01972

Katalog-ID:	DOAJ037322443

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allfieldsGer	10.3389/fimmu.2018.01972 doi (DE-627)DOAJ037322443 (DE-599)DOAJ57f472d5c7d3456abfa525aaa6770765 DE-627 ger DE-627 rakwb eng RC581-607 Marjolein Meijerink verfasserin aut Structure Dependent-Immunomodulation by Sugar Beet Arabinans via a SYK Tyrosine Kinase-Dependent Signaling Pathway 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier There is much interest in the immunomodulatory properties of dietary fibers but their activity may be influenced by contamination with microbial-associated molecular patterns (MAMPs) such as lipopolysaccharide (LPS) and lipoteichoic acids, which are difficult to remove completely from biological samples. Bone marrow-derived dendritic cells (BMDCs) from TLR2x4 double-KO mice were shown to be a reliable approach to analyse the immunomodulatory properties of a diverse range of dietary fibers, by avoiding immune cell activation due to contaminating MAMPs. Several of the 44 tested dietary fiber preparations induced cytokine responses in BMDCs from TLR2x4 double-KO mice. The particulate fractions of linear arabinan (LA) and branched arabinan (BA) from sugar beet pectin were shown to be strongly immune stimulatory with LA being more immune stimulatory than BA. Enzymatic debranching of BA increased its immune stimulatory activity, possibly due to increased particle formation by the alignment of debranched linear arabinan. Mechanistic studies showed that the immunostimulatory activity of LA and BA was independent of the Dectin-1 recognition but Syk kinase-dependent. immunomodulation dietary fiber arabinans pectin structure-function relationship C-type lectin receptors Immunologic diseases. Allergy Marjolein Meijerink verfasserin aut Christiane Rösch verfasserin aut Christiane Rösch verfasserin aut Nico Taverne verfasserin aut Nico Taverne verfasserin aut Koen Venema verfasserin aut Koen Venema verfasserin aut Koen Venema verfasserin aut Harry Gruppen verfasserin aut Henk A. Schols verfasserin aut Henk A. Schols verfasserin aut Jerry M. Wells verfasserin aut Jerry M. Wells verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 9(2018) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:9 year:2018 https://doi.org/10.3389/fimmu.2018.01972 kostenfrei https://doaj.org/article/57f472d5c7d3456abfa525aaa6770765 kostenfrei https://www.frontiersin.org/article/10.3389/fimmu.2018.01972/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018
allfieldsSound	10.3389/fimmu.2018.01972 doi (DE-627)DOAJ037322443 (DE-599)DOAJ57f472d5c7d3456abfa525aaa6770765 DE-627 ger DE-627 rakwb eng RC581-607 Marjolein Meijerink verfasserin aut Structure Dependent-Immunomodulation by Sugar Beet Arabinans via a SYK Tyrosine Kinase-Dependent Signaling Pathway 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier There is much interest in the immunomodulatory properties of dietary fibers but their activity may be influenced by contamination with microbial-associated molecular patterns (MAMPs) such as lipopolysaccharide (LPS) and lipoteichoic acids, which are difficult to remove completely from biological samples. Bone marrow-derived dendritic cells (BMDCs) from TLR2x4 double-KO mice were shown to be a reliable approach to analyse the immunomodulatory properties of a diverse range of dietary fibers, by avoiding immune cell activation due to contaminating MAMPs. Several of the 44 tested dietary fiber preparations induced cytokine responses in BMDCs from TLR2x4 double-KO mice. The particulate fractions of linear arabinan (LA) and branched arabinan (BA) from sugar beet pectin were shown to be strongly immune stimulatory with LA being more immune stimulatory than BA. Enzymatic debranching of BA increased its immune stimulatory activity, possibly due to increased particle formation by the alignment of debranched linear arabinan. Mechanistic studies showed that the immunostimulatory activity of LA and BA was independent of the Dectin-1 recognition but Syk kinase-dependent. immunomodulation dietary fiber arabinans pectin structure-function relationship C-type lectin receptors Immunologic diseases. Allergy Marjolein Meijerink verfasserin aut Christiane Rösch verfasserin aut Christiane Rösch verfasserin aut Nico Taverne verfasserin aut Nico Taverne verfasserin aut Koen Venema verfasserin aut Koen Venema verfasserin aut Koen Venema verfasserin aut Harry Gruppen verfasserin aut Henk A. Schols verfasserin aut Henk A. Schols verfasserin aut Jerry M. Wells verfasserin aut Jerry M. Wells verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 9(2018) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:9 year:2018 https://doi.org/10.3389/fimmu.2018.01972 kostenfrei https://doaj.org/article/57f472d5c7d3456abfa525aaa6770765 kostenfrei https://www.frontiersin.org/article/10.3389/fimmu.2018.01972/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2018
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topic_facet	immunomodulation dietary fiber arabinans pectin structure-function relationship C-type lectin receptors Immunologic diseases. Allergy
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authorswithroles_txt_mv	Marjolein Meijerink @@aut@@ Christiane Rösch @@aut@@ Nico Taverne @@aut@@ Koen Venema @@aut@@ Harry Gruppen @@aut@@ Henk A. Schols @@aut@@ Jerry M. Wells @@aut@@
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callnumber-first	R - Medicine
author	Marjolein Meijerink
spellingShingle	Marjolein Meijerink misc RC581-607 misc immunomodulation misc dietary fiber misc arabinans misc pectin misc structure-function relationship misc C-type lectin receptors misc Immunologic diseases. Allergy Structure Dependent-Immunomodulation by Sugar Beet Arabinans via a SYK Tyrosine Kinase-Dependent Signaling Pathway
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topic_title	RC581-607 Structure Dependent-Immunomodulation by Sugar Beet Arabinans via a SYK Tyrosine Kinase-Dependent Signaling Pathway immunomodulation dietary fiber arabinans pectin structure-function relationship C-type lectin receptors
topic	misc RC581-607 misc immunomodulation misc dietary fiber misc arabinans misc pectin misc structure-function relationship misc C-type lectin receptors misc Immunologic diseases. Allergy
topic_unstemmed	misc RC581-607 misc immunomodulation misc dietary fiber misc arabinans misc pectin misc structure-function relationship misc C-type lectin receptors misc Immunologic diseases. Allergy
topic_browse	misc RC581-607 misc immunomodulation misc dietary fiber misc arabinans misc pectin misc structure-function relationship misc C-type lectin receptors misc Immunologic diseases. Allergy
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title	Structure Dependent-Immunomodulation by Sugar Beet Arabinans via a SYK Tyrosine Kinase-Dependent Signaling Pathway
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title_full	Structure Dependent-Immunomodulation by Sugar Beet Arabinans via a SYK Tyrosine Kinase-Dependent Signaling Pathway
author_sort	Marjolein Meijerink
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author_browse	Marjolein Meijerink Christiane Rösch Nico Taverne Koen Venema Harry Gruppen Henk A. Schols Jerry M. Wells
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title_sort	structure dependent-immunomodulation by sugar beet arabinans via a syk tyrosine kinase-dependent signaling pathway
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title_auth	Structure Dependent-Immunomodulation by Sugar Beet Arabinans via a SYK Tyrosine Kinase-Dependent Signaling Pathway
abstract	There is much interest in the immunomodulatory properties of dietary fibers but their activity may be influenced by contamination with microbial-associated molecular patterns (MAMPs) such as lipopolysaccharide (LPS) and lipoteichoic acids, which are difficult to remove completely from biological samples. Bone marrow-derived dendritic cells (BMDCs) from TLR2x4 double-KO mice were shown to be a reliable approach to analyse the immunomodulatory properties of a diverse range of dietary fibers, by avoiding immune cell activation due to contaminating MAMPs. Several of the 44 tested dietary fiber preparations induced cytokine responses in BMDCs from TLR2x4 double-KO mice. The particulate fractions of linear arabinan (LA) and branched arabinan (BA) from sugar beet pectin were shown to be strongly immune stimulatory with LA being more immune stimulatory than BA. Enzymatic debranching of BA increased its immune stimulatory activity, possibly due to increased particle formation by the alignment of debranched linear arabinan. Mechanistic studies showed that the immunostimulatory activity of LA and BA was independent of the Dectin-1 recognition but Syk kinase-dependent.
abstractGer	There is much interest in the immunomodulatory properties of dietary fibers but their activity may be influenced by contamination with microbial-associated molecular patterns (MAMPs) such as lipopolysaccharide (LPS) and lipoteichoic acids, which are difficult to remove completely from biological samples. Bone marrow-derived dendritic cells (BMDCs) from TLR2x4 double-KO mice were shown to be a reliable approach to analyse the immunomodulatory properties of a diverse range of dietary fibers, by avoiding immune cell activation due to contaminating MAMPs. Several of the 44 tested dietary fiber preparations induced cytokine responses in BMDCs from TLR2x4 double-KO mice. The particulate fractions of linear arabinan (LA) and branched arabinan (BA) from sugar beet pectin were shown to be strongly immune stimulatory with LA being more immune stimulatory than BA. Enzymatic debranching of BA increased its immune stimulatory activity, possibly due to increased particle formation by the alignment of debranched linear arabinan. Mechanistic studies showed that the immunostimulatory activity of LA and BA was independent of the Dectin-1 recognition but Syk kinase-dependent.
abstract_unstemmed	There is much interest in the immunomodulatory properties of dietary fibers but their activity may be influenced by contamination with microbial-associated molecular patterns (MAMPs) such as lipopolysaccharide (LPS) and lipoteichoic acids, which are difficult to remove completely from biological samples. Bone marrow-derived dendritic cells (BMDCs) from TLR2x4 double-KO mice were shown to be a reliable approach to analyse the immunomodulatory properties of a diverse range of dietary fibers, by avoiding immune cell activation due to contaminating MAMPs. Several of the 44 tested dietary fiber preparations induced cytokine responses in BMDCs from TLR2x4 double-KO mice. The particulate fractions of linear arabinan (LA) and branched arabinan (BA) from sugar beet pectin were shown to be strongly immune stimulatory with LA being more immune stimulatory than BA. Enzymatic debranching of BA increased its immune stimulatory activity, possibly due to increased particle formation by the alignment of debranched linear arabinan. Mechanistic studies showed that the immunostimulatory activity of LA and BA was independent of the Dectin-1 recognition but Syk kinase-dependent.
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title_short	Structure Dependent-Immunomodulation by Sugar Beet Arabinans via a SYK Tyrosine Kinase-Dependent Signaling Pathway
url	https://doi.org/10.3389/fimmu.2018.01972 https://doaj.org/article/57f472d5c7d3456abfa525aaa6770765 https://www.frontiersin.org/article/10.3389/fimmu.2018.01972/full https://doaj.org/toc/1664-3224
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author2	Marjolein Meijerink Christiane Rösch Nico Taverne Koen Venema Harry Gruppen Henk A. Schols Jerry M. Wells
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up_date	2024-07-04T00:46:39.622Z
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Bone marrow-derived dendritic cells (BMDCs) from TLR2x4 double-KO mice were shown to be a reliable approach to analyse the immunomodulatory properties of a diverse range of dietary fibers, by avoiding immune cell activation due to contaminating MAMPs. Several of the 44 tested dietary fiber preparations induced cytokine responses in BMDCs from TLR2x4 double-KO mice. The particulate fractions of linear arabinan (LA) and branched arabinan (BA) from sugar beet pectin were shown to be strongly immune stimulatory with LA being more immune stimulatory than BA. Enzymatic debranching of BA increased its immune stimulatory activity, possibly due to increased particle formation by the alignment of debranched linear arabinan. 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Structure Dependent-Immunomodulation by Sugar Beet Arabinans via a SYK Tyrosine Kinase-Dependent Signaling Pathway

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