Effects of Chronic Exercise on Endothelial Progenitor Cells and Microparticles in Professional Runners
Abstract Background: The effects of chronic exposure to exercise training on vascular biomarkers have been poorly explored. Objective: Our study aimed to compare the amounts of endothelial progenitor cells (EPCs), and endothelial (EMP) and platelet (PMP) microparticles between professional runners...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Célia Regina de Oliveira Bittencourt [verfasserIn] Maria Cristina de Oliveira Izar [verfasserIn] Carolina Nunes França [verfasserIn] Valdir Lauro Schwerz [verfasserIn] Rui Manuel dos Santos Póvoa [verfasserIn] Francisco Antonio Helfenstein Fonseca [verfasserIn] |
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| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch ; Portugiesisch |
| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Arquivos Brasileiros de Cardiologia - Sociedade Brasileira de Cardiologia (SBC), 2004 |
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| Links: |
|---|
| DOI / URN: |
10.5935/abc.20170022 |
|---|
| Katalog-ID: |
DOAJ037326066 |
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| 520 | |a Abstract Background: The effects of chronic exposure to exercise training on vascular biomarkers have been poorly explored. Objective: Our study aimed to compare the amounts of endothelial progenitor cells (EPCs), and endothelial (EMP) and platelet (PMP) microparticles between professional runners and healthy controls. Methods: Twenty-five half-marathon runners and 24 age- and gender-matched healthy controls were included in the study. EPCs (CD34+/KDR+, CD133+/KDR+, and CD34+/CD133+), EMP (CD51+) and PMP (CD42+/CD31+) were quantified by flow-cytometry. All blood samples were obtained after 12 h of fasting and the athletes were encouraged to perform their routine exercises on the day before. Results: As compared with controls, the CD34+/KDR+ EPCs (p=0.038) and CD133+/KDR+ EPCs (p=0.018) were increased, whereas CD34+/CD133+ EPCs were not different (p=0.51) in athletes. In addition, there was no difference in MPs levels between the groups. Conclusion: Chronic exposure to exercise in professional runners was associated with higher percentage of EPCs. Taking into account the similar number of MPs in athletes and controls, the study suggests a favorable effect of exercise on these vascular biomarkers. | ||
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10.5935/abc.20170022 doi (DE-627)DOAJ037326066 (DE-599)DOAJbf38e0fe9baf470aabe3f582cce75faa DE-627 ger DE-627 rakwb eng por RC666-701 Célia Regina de Oliveira Bittencourt verfasserin aut Effects of Chronic Exercise on Endothelial Progenitor Cells and Microparticles in Professional Runners Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: The effects of chronic exposure to exercise training on vascular biomarkers have been poorly explored. Objective: Our study aimed to compare the amounts of endothelial progenitor cells (EPCs), and endothelial (EMP) and platelet (PMP) microparticles between professional runners and healthy controls. Methods: Twenty-five half-marathon runners and 24 age- and gender-matched healthy controls were included in the study. EPCs (CD34+/KDR+, CD133+/KDR+, and CD34+/CD133+), EMP (CD51+) and PMP (CD42+/CD31+) were quantified by flow-cytometry. All blood samples were obtained after 12 h of fasting and the athletes were encouraged to perform their routine exercises on the day before. Results: As compared with controls, the CD34+/KDR+ EPCs (p=0.038) and CD133+/KDR+ EPCs (p=0.018) were increased, whereas CD34+/CD133+ EPCs were not different (p=0.51) in athletes. In addition, there was no difference in MPs levels between the groups. Conclusion: Chronic exposure to exercise in professional runners was associated with higher percentage of EPCs. Taking into account the similar number of MPs in athletes and controls, the study suggests a favorable effect of exercise on these vascular biomarkers. Células Progenitoras Endoteliais Exercício Biomarcadores Atletas Esportes Corrida Diseases of the circulatory (Cardiovascular) system Maria Cristina de Oliveira Izar verfasserin aut Carolina Nunes França verfasserin aut Valdir Lauro Schwerz verfasserin aut Rui Manuel dos Santos Póvoa verfasserin aut Francisco Antonio Helfenstein Fonseca verfasserin aut In Arquivos Brasileiros de Cardiologia Sociedade Brasileira de Cardiologia (SBC), 2004 (DE-627)320623572 (DE-600)2023015-1 16784170 nnns https://doi.org/10.5935/abc.20170022 kostenfrei https://doaj.org/article/bf38e0fe9baf470aabe3f582cce75faa kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2017000300212&lng=en&tlng=en kostenfrei https://doaj.org/toc/1678-4170 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR |
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10.5935/abc.20170022 doi (DE-627)DOAJ037326066 (DE-599)DOAJbf38e0fe9baf470aabe3f582cce75faa DE-627 ger DE-627 rakwb eng por RC666-701 Célia Regina de Oliveira Bittencourt verfasserin aut Effects of Chronic Exercise on Endothelial Progenitor Cells and Microparticles in Professional Runners Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: The effects of chronic exposure to exercise training on vascular biomarkers have been poorly explored. Objective: Our study aimed to compare the amounts of endothelial progenitor cells (EPCs), and endothelial (EMP) and platelet (PMP) microparticles between professional runners and healthy controls. Methods: Twenty-five half-marathon runners and 24 age- and gender-matched healthy controls were included in the study. EPCs (CD34+/KDR+, CD133+/KDR+, and CD34+/CD133+), EMP (CD51+) and PMP (CD42+/CD31+) were quantified by flow-cytometry. All blood samples were obtained after 12 h of fasting and the athletes were encouraged to perform their routine exercises on the day before. Results: As compared with controls, the CD34+/KDR+ EPCs (p=0.038) and CD133+/KDR+ EPCs (p=0.018) were increased, whereas CD34+/CD133+ EPCs were not different (p=0.51) in athletes. In addition, there was no difference in MPs levels between the groups. Conclusion: Chronic exposure to exercise in professional runners was associated with higher percentage of EPCs. Taking into account the similar number of MPs in athletes and controls, the study suggests a favorable effect of exercise on these vascular biomarkers. Células Progenitoras Endoteliais Exercício Biomarcadores Atletas Esportes Corrida Diseases of the circulatory (Cardiovascular) system Maria Cristina de Oliveira Izar verfasserin aut Carolina Nunes França verfasserin aut Valdir Lauro Schwerz verfasserin aut Rui Manuel dos Santos Póvoa verfasserin aut Francisco Antonio Helfenstein Fonseca verfasserin aut In Arquivos Brasileiros de Cardiologia Sociedade Brasileira de Cardiologia (SBC), 2004 (DE-627)320623572 (DE-600)2023015-1 16784170 nnns https://doi.org/10.5935/abc.20170022 kostenfrei https://doaj.org/article/bf38e0fe9baf470aabe3f582cce75faa kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2017000300212&lng=en&tlng=en kostenfrei https://doaj.org/toc/1678-4170 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR |
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10.5935/abc.20170022 doi (DE-627)DOAJ037326066 (DE-599)DOAJbf38e0fe9baf470aabe3f582cce75faa DE-627 ger DE-627 rakwb eng por RC666-701 Célia Regina de Oliveira Bittencourt verfasserin aut Effects of Chronic Exercise on Endothelial Progenitor Cells and Microparticles in Professional Runners Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background: The effects of chronic exposure to exercise training on vascular biomarkers have been poorly explored. Objective: Our study aimed to compare the amounts of endothelial progenitor cells (EPCs), and endothelial (EMP) and platelet (PMP) microparticles between professional runners and healthy controls. Methods: Twenty-five half-marathon runners and 24 age- and gender-matched healthy controls were included in the study. EPCs (CD34+/KDR+, CD133+/KDR+, and CD34+/CD133+), EMP (CD51+) and PMP (CD42+/CD31+) were quantified by flow-cytometry. All blood samples were obtained after 12 h of fasting and the athletes were encouraged to perform their routine exercises on the day before. Results: As compared with controls, the CD34+/KDR+ EPCs (p=0.038) and CD133+/KDR+ EPCs (p=0.018) were increased, whereas CD34+/CD133+ EPCs were not different (p=0.51) in athletes. In addition, there was no difference in MPs levels between the groups. Conclusion: Chronic exposure to exercise in professional runners was associated with higher percentage of EPCs. Taking into account the similar number of MPs in athletes and controls, the study suggests a favorable effect of exercise on these vascular biomarkers. Células Progenitoras Endoteliais Exercício Biomarcadores Atletas Esportes Corrida Diseases of the circulatory (Cardiovascular) system Maria Cristina de Oliveira Izar verfasserin aut Carolina Nunes França verfasserin aut Valdir Lauro Schwerz verfasserin aut Rui Manuel dos Santos Póvoa verfasserin aut Francisco Antonio Helfenstein Fonseca verfasserin aut In Arquivos Brasileiros de Cardiologia Sociedade Brasileira de Cardiologia (SBC), 2004 (DE-627)320623572 (DE-600)2023015-1 16784170 nnns https://doi.org/10.5935/abc.20170022 kostenfrei https://doaj.org/article/bf38e0fe9baf470aabe3f582cce75faa kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2017000300212&lng=en&tlng=en kostenfrei https://doaj.org/toc/1678-4170 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA AR |
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RC666-701 Effects of Chronic Exercise on Endothelial Progenitor Cells and Microparticles in Professional Runners Células Progenitoras Endoteliais Exercício Biomarcadores Atletas Esportes Corrida |
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Effects of Chronic Exercise on Endothelial Progenitor Cells and Microparticles in Professional Runners |
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Effects of Chronic Exercise on Endothelial Progenitor Cells and Microparticles in Professional Runners |
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Célia Regina de Oliveira Bittencourt |
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Arquivos Brasileiros de Cardiologia |
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Célia Regina de Oliveira Bittencourt Maria Cristina de Oliveira Izar Carolina Nunes França Valdir Lauro Schwerz Rui Manuel dos Santos Póvoa Francisco Antonio Helfenstein Fonseca |
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Célia Regina de Oliveira Bittencourt |
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10.5935/abc.20170022 |
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effects of chronic exercise on endothelial progenitor cells and microparticles in professional runners |
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RC666-701 |
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Effects of Chronic Exercise on Endothelial Progenitor Cells and Microparticles in Professional Runners |
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Abstract Background: The effects of chronic exposure to exercise training on vascular biomarkers have been poorly explored. Objective: Our study aimed to compare the amounts of endothelial progenitor cells (EPCs), and endothelial (EMP) and platelet (PMP) microparticles between professional runners and healthy controls. Methods: Twenty-five half-marathon runners and 24 age- and gender-matched healthy controls were included in the study. EPCs (CD34+/KDR+, CD133+/KDR+, and CD34+/CD133+), EMP (CD51+) and PMP (CD42+/CD31+) were quantified by flow-cytometry. All blood samples were obtained after 12 h of fasting and the athletes were encouraged to perform their routine exercises on the day before. Results: As compared with controls, the CD34+/KDR+ EPCs (p=0.038) and CD133+/KDR+ EPCs (p=0.018) were increased, whereas CD34+/CD133+ EPCs were not different (p=0.51) in athletes. In addition, there was no difference in MPs levels between the groups. Conclusion: Chronic exposure to exercise in professional runners was associated with higher percentage of EPCs. Taking into account the similar number of MPs in athletes and controls, the study suggests a favorable effect of exercise on these vascular biomarkers. |
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Abstract Background: The effects of chronic exposure to exercise training on vascular biomarkers have been poorly explored. Objective: Our study aimed to compare the amounts of endothelial progenitor cells (EPCs), and endothelial (EMP) and platelet (PMP) microparticles between professional runners and healthy controls. Methods: Twenty-five half-marathon runners and 24 age- and gender-matched healthy controls were included in the study. EPCs (CD34+/KDR+, CD133+/KDR+, and CD34+/CD133+), EMP (CD51+) and PMP (CD42+/CD31+) were quantified by flow-cytometry. All blood samples were obtained after 12 h of fasting and the athletes were encouraged to perform their routine exercises on the day before. Results: As compared with controls, the CD34+/KDR+ EPCs (p=0.038) and CD133+/KDR+ EPCs (p=0.018) were increased, whereas CD34+/CD133+ EPCs were not different (p=0.51) in athletes. In addition, there was no difference in MPs levels between the groups. Conclusion: Chronic exposure to exercise in professional runners was associated with higher percentage of EPCs. Taking into account the similar number of MPs in athletes and controls, the study suggests a favorable effect of exercise on these vascular biomarkers. |
| abstract_unstemmed |
Abstract Background: The effects of chronic exposure to exercise training on vascular biomarkers have been poorly explored. Objective: Our study aimed to compare the amounts of endothelial progenitor cells (EPCs), and endothelial (EMP) and platelet (PMP) microparticles between professional runners and healthy controls. Methods: Twenty-five half-marathon runners and 24 age- and gender-matched healthy controls were included in the study. EPCs (CD34+/KDR+, CD133+/KDR+, and CD34+/CD133+), EMP (CD51+) and PMP (CD42+/CD31+) were quantified by flow-cytometry. All blood samples were obtained after 12 h of fasting and the athletes were encouraged to perform their routine exercises on the day before. Results: As compared with controls, the CD34+/KDR+ EPCs (p=0.038) and CD133+/KDR+ EPCs (p=0.018) were increased, whereas CD34+/CD133+ EPCs were not different (p=0.51) in athletes. In addition, there was no difference in MPs levels between the groups. Conclusion: Chronic exposure to exercise in professional runners was associated with higher percentage of EPCs. Taking into account the similar number of MPs in athletes and controls, the study suggests a favorable effect of exercise on these vascular biomarkers. |
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Effects of Chronic Exercise on Endothelial Progenitor Cells and Microparticles in Professional Runners |
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