Morphology of the bone marrow, spleen and liver during hematopoietic cell mobilization with cyclophosphamide in mice.

Cyclophosphamide (CY), the agent with cytoreductive activity, is widely exploited in cancer chemotherapy, and can be used alone or in combination with various cytokines and growth factors to stimulate the egress of hematopoietic stem/progenitor cells (HSPC) from the BM compartment. The aim of the pr...
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Autor*in:	Barbara Wiszniewska [verfasserIn] Ryszard Grzegrzółka [verfasserIn] Mariola Marchlewicz [verfasserIn] Paweł Szumilas [verfasserIn] Anna Karbicka [verfasserIn] Kamila Barcew [verfasserIn] Bogusław Machaliński [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2009

Übergeordnetes Werk:	In: Folia Histochemica et Cytobiologica - Via Medica, 2008, 46(2009), 4, Seite 501-509
Übergeordnetes Werk:	volume:46 ; year:2009 ; number:4 ; pages:501-509

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.5603/4404

Katalog-ID:	DOAJ03735664X

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520			\|a Cyclophosphamide (CY), the agent with cytoreductive activity, is widely exploited in cancer chemotherapy, and can be used alone or in combination with various cytokines and growth factors to stimulate the egress of hematopoietic stem/progenitor cells (HSPC) from the BM compartment. The aim of the present study was to exam the morphology and ultrastructure of the bone marrow, spleen and liver of mice injected intraperitoneally with a single dose of cyclophosphamide (200 mg/kg bw) and the localization of cells expressing markers of early hematopoietic cells in studied organs and the peripheral blood. We observed that the CY-induced morphological changes in the BM and spleen were reconstructed on day 4. of experiment, and the spleen was repopulated by HSPC on the 6th day. In this time, the highest number of c-Kit-R-positive cells was determined by flow cytometry in the peripheral blood. The results confirmed, that the egress of HSPC from the bone marrow into the peripheral blood was delayed compared to mice treated with G-CSF or GCS-F plus CY.
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allfields	10.5603/4404 doi (DE-627)DOAJ03735664X (DE-599)DOAJe571e0d81e23442aae869ea9f72732b4 DE-627 ger DE-627 rakwb eng QH573-671 Barbara Wiszniewska verfasserin aut Morphology of the bone marrow, spleen and liver during hematopoietic cell mobilization with cyclophosphamide in mice. 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cyclophosphamide (CY), the agent with cytoreductive activity, is widely exploited in cancer chemotherapy, and can be used alone or in combination with various cytokines and growth factors to stimulate the egress of hematopoietic stem/progenitor cells (HSPC) from the BM compartment. The aim of the present study was to exam the morphology and ultrastructure of the bone marrow, spleen and liver of mice injected intraperitoneally with a single dose of cyclophosphamide (200 mg/kg bw) and the localization of cells expressing markers of early hematopoietic cells in studied organs and the peripheral blood. We observed that the CY-induced morphological changes in the BM and spleen were reconstructed on day 4. of experiment, and the spleen was repopulated by HSPC on the 6th day. In this time, the highest number of c-Kit-R-positive cells was determined by flow cytometry in the peripheral blood. The results confirmed, that the egress of HSPC from the bone marrow into the peripheral blood was delayed compared to mice treated with G-CSF or GCS-F plus CY. Cytology Ryszard Grzegrzółka verfasserin aut Mariola Marchlewicz verfasserin aut Paweł Szumilas verfasserin aut Anna Karbicka verfasserin aut Kamila Barcew verfasserin aut Bogusław Machaliński verfasserin aut In Folia Histochemica et Cytobiologica Via Medica, 2008 46(2009), 4, Seite 501-509 (DE-627)558387705 (DE-600)2409007-4 18975631 nnns volume:46 year:2009 number:4 pages:501-509 https://doi.org/10.5603/4404 kostenfrei https://doaj.org/article/e571e0d81e23442aae869ea9f72732b4 kostenfrei http://czasopisma.viamedica.pl/fhc/article/view/4404 kostenfrei https://doaj.org/toc/0239-8508 Journal toc kostenfrei https://doaj.org/toc/1897-5631 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 46 2009 4 501-509
spelling	10.5603/4404 doi (DE-627)DOAJ03735664X (DE-599)DOAJe571e0d81e23442aae869ea9f72732b4 DE-627 ger DE-627 rakwb eng QH573-671 Barbara Wiszniewska verfasserin aut Morphology of the bone marrow, spleen and liver during hematopoietic cell mobilization with cyclophosphamide in mice. 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cyclophosphamide (CY), the agent with cytoreductive activity, is widely exploited in cancer chemotherapy, and can be used alone or in combination with various cytokines and growth factors to stimulate the egress of hematopoietic stem/progenitor cells (HSPC) from the BM compartment. The aim of the present study was to exam the morphology and ultrastructure of the bone marrow, spleen and liver of mice injected intraperitoneally with a single dose of cyclophosphamide (200 mg/kg bw) and the localization of cells expressing markers of early hematopoietic cells in studied organs and the peripheral blood. We observed that the CY-induced morphological changes in the BM and spleen were reconstructed on day 4. of experiment, and the spleen was repopulated by HSPC on the 6th day. In this time, the highest number of c-Kit-R-positive cells was determined by flow cytometry in the peripheral blood. The results confirmed, that the egress of HSPC from the bone marrow into the peripheral blood was delayed compared to mice treated with G-CSF or GCS-F plus CY. Cytology Ryszard Grzegrzółka verfasserin aut Mariola Marchlewicz verfasserin aut Paweł Szumilas verfasserin aut Anna Karbicka verfasserin aut Kamila Barcew verfasserin aut Bogusław Machaliński verfasserin aut In Folia Histochemica et Cytobiologica Via Medica, 2008 46(2009), 4, Seite 501-509 (DE-627)558387705 (DE-600)2409007-4 18975631 nnns volume:46 year:2009 number:4 pages:501-509 https://doi.org/10.5603/4404 kostenfrei https://doaj.org/article/e571e0d81e23442aae869ea9f72732b4 kostenfrei http://czasopisma.viamedica.pl/fhc/article/view/4404 kostenfrei https://doaj.org/toc/0239-8508 Journal toc kostenfrei https://doaj.org/toc/1897-5631 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 46 2009 4 501-509
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allfieldsGer	10.5603/4404 doi (DE-627)DOAJ03735664X (DE-599)DOAJe571e0d81e23442aae869ea9f72732b4 DE-627 ger DE-627 rakwb eng QH573-671 Barbara Wiszniewska verfasserin aut Morphology of the bone marrow, spleen and liver during hematopoietic cell mobilization with cyclophosphamide in mice. 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cyclophosphamide (CY), the agent with cytoreductive activity, is widely exploited in cancer chemotherapy, and can be used alone or in combination with various cytokines and growth factors to stimulate the egress of hematopoietic stem/progenitor cells (HSPC) from the BM compartment. The aim of the present study was to exam the morphology and ultrastructure of the bone marrow, spleen and liver of mice injected intraperitoneally with a single dose of cyclophosphamide (200 mg/kg bw) and the localization of cells expressing markers of early hematopoietic cells in studied organs and the peripheral blood. We observed that the CY-induced morphological changes in the BM and spleen were reconstructed on day 4. of experiment, and the spleen was repopulated by HSPC on the 6th day. In this time, the highest number of c-Kit-R-positive cells was determined by flow cytometry in the peripheral blood. The results confirmed, that the egress of HSPC from the bone marrow into the peripheral blood was delayed compared to mice treated with G-CSF or GCS-F plus CY. Cytology Ryszard Grzegrzółka verfasserin aut Mariola Marchlewicz verfasserin aut Paweł Szumilas verfasserin aut Anna Karbicka verfasserin aut Kamila Barcew verfasserin aut Bogusław Machaliński verfasserin aut In Folia Histochemica et Cytobiologica Via Medica, 2008 46(2009), 4, Seite 501-509 (DE-627)558387705 (DE-600)2409007-4 18975631 nnns volume:46 year:2009 number:4 pages:501-509 https://doi.org/10.5603/4404 kostenfrei https://doaj.org/article/e571e0d81e23442aae869ea9f72732b4 kostenfrei http://czasopisma.viamedica.pl/fhc/article/view/4404 kostenfrei https://doaj.org/toc/0239-8508 Journal toc kostenfrei https://doaj.org/toc/1897-5631 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 46 2009 4 501-509
allfieldsSound	10.5603/4404 doi (DE-627)DOAJ03735664X (DE-599)DOAJe571e0d81e23442aae869ea9f72732b4 DE-627 ger DE-627 rakwb eng QH573-671 Barbara Wiszniewska verfasserin aut Morphology of the bone marrow, spleen and liver during hematopoietic cell mobilization with cyclophosphamide in mice. 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Cyclophosphamide (CY), the agent with cytoreductive activity, is widely exploited in cancer chemotherapy, and can be used alone or in combination with various cytokines and growth factors to stimulate the egress of hematopoietic stem/progenitor cells (HSPC) from the BM compartment. The aim of the present study was to exam the morphology and ultrastructure of the bone marrow, spleen and liver of mice injected intraperitoneally with a single dose of cyclophosphamide (200 mg/kg bw) and the localization of cells expressing markers of early hematopoietic cells in studied organs and the peripheral blood. We observed that the CY-induced morphological changes in the BM and spleen were reconstructed on day 4. of experiment, and the spleen was repopulated by HSPC on the 6th day. In this time, the highest number of c-Kit-R-positive cells was determined by flow cytometry in the peripheral blood. The results confirmed, that the egress of HSPC from the bone marrow into the peripheral blood was delayed compared to mice treated with G-CSF or GCS-F plus CY. Cytology Ryszard Grzegrzółka verfasserin aut Mariola Marchlewicz verfasserin aut Paweł Szumilas verfasserin aut Anna Karbicka verfasserin aut Kamila Barcew verfasserin aut Bogusław Machaliński verfasserin aut In Folia Histochemica et Cytobiologica Via Medica, 2008 46(2009), 4, Seite 501-509 (DE-627)558387705 (DE-600)2409007-4 18975631 nnns volume:46 year:2009 number:4 pages:501-509 https://doi.org/10.5603/4404 kostenfrei https://doaj.org/article/e571e0d81e23442aae869ea9f72732b4 kostenfrei http://czasopisma.viamedica.pl/fhc/article/view/4404 kostenfrei https://doaj.org/toc/0239-8508 Journal toc kostenfrei https://doaj.org/toc/1897-5631 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 46 2009 4 501-509
language	English
source	In Folia Histochemica et Cytobiologica 46(2009), 4, Seite 501-509 volume:46 year:2009 number:4 pages:501-509
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authorswithroles_txt_mv	Barbara Wiszniewska @@aut@@ Ryszard Grzegrzółka @@aut@@ Mariola Marchlewicz @@aut@@ Paweł Szumilas @@aut@@ Anna Karbicka @@aut@@ Kamila Barcew @@aut@@ Bogusław Machaliński @@aut@@
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callnumber-first	Q - Science
author	Barbara Wiszniewska
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topic_title	QH573-671 Morphology of the bone marrow, spleen and liver during hematopoietic cell mobilization with cyclophosphamide in mice
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title	Morphology of the bone marrow, spleen and liver during hematopoietic cell mobilization with cyclophosphamide in mice.
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title_full	Morphology of the bone marrow, spleen and liver during hematopoietic cell mobilization with cyclophosphamide in mice
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title_sort	morphology of the bone marrow, spleen and liver during hematopoietic cell mobilization with cyclophosphamide in mice
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title_auth	Morphology of the bone marrow, spleen and liver during hematopoietic cell mobilization with cyclophosphamide in mice.
abstract	Cyclophosphamide (CY), the agent with cytoreductive activity, is widely exploited in cancer chemotherapy, and can be used alone or in combination with various cytokines and growth factors to stimulate the egress of hematopoietic stem/progenitor cells (HSPC) from the BM compartment. The aim of the present study was to exam the morphology and ultrastructure of the bone marrow, spleen and liver of mice injected intraperitoneally with a single dose of cyclophosphamide (200 mg/kg bw) and the localization of cells expressing markers of early hematopoietic cells in studied organs and the peripheral blood. We observed that the CY-induced morphological changes in the BM and spleen were reconstructed on day 4. of experiment, and the spleen was repopulated by HSPC on the 6th day. In this time, the highest number of c-Kit-R-positive cells was determined by flow cytometry in the peripheral blood. The results confirmed, that the egress of HSPC from the bone marrow into the peripheral blood was delayed compared to mice treated with G-CSF or GCS-F plus CY.
abstractGer	Cyclophosphamide (CY), the agent with cytoreductive activity, is widely exploited in cancer chemotherapy, and can be used alone or in combination with various cytokines and growth factors to stimulate the egress of hematopoietic stem/progenitor cells (HSPC) from the BM compartment. The aim of the present study was to exam the morphology and ultrastructure of the bone marrow, spleen and liver of mice injected intraperitoneally with a single dose of cyclophosphamide (200 mg/kg bw) and the localization of cells expressing markers of early hematopoietic cells in studied organs and the peripheral blood. We observed that the CY-induced morphological changes in the BM and spleen were reconstructed on day 4. of experiment, and the spleen was repopulated by HSPC on the 6th day. In this time, the highest number of c-Kit-R-positive cells was determined by flow cytometry in the peripheral blood. The results confirmed, that the egress of HSPC from the bone marrow into the peripheral blood was delayed compared to mice treated with G-CSF or GCS-F plus CY.
abstract_unstemmed	Cyclophosphamide (CY), the agent with cytoreductive activity, is widely exploited in cancer chemotherapy, and can be used alone or in combination with various cytokines and growth factors to stimulate the egress of hematopoietic stem/progenitor cells (HSPC) from the BM compartment. The aim of the present study was to exam the morphology and ultrastructure of the bone marrow, spleen and liver of mice injected intraperitoneally with a single dose of cyclophosphamide (200 mg/kg bw) and the localization of cells expressing markers of early hematopoietic cells in studied organs and the peripheral blood. We observed that the CY-induced morphological changes in the BM and spleen were reconstructed on day 4. of experiment, and the spleen was repopulated by HSPC on the 6th day. In this time, the highest number of c-Kit-R-positive cells was determined by flow cytometry in the peripheral blood. The results confirmed, that the egress of HSPC from the bone marrow into the peripheral blood was delayed compared to mice treated with G-CSF or GCS-F plus CY.
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title_short	Morphology of the bone marrow, spleen and liver during hematopoietic cell mobilization with cyclophosphamide in mice.
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Morphology of the bone marrow, spleen and liver during hematopoietic cell mobilization with cyclophosphamide in mice.

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