CD4+ T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features
Summary: T cell recognition of peptides presented by human leukocyte antigens (HLAs) is mediated by the highly variable T cell receptor (TCR). Despite this built-in TCR variability, individuals can mount immune responses against viral epitopes by using identical or highly related TCRs expressed on C...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Alexander Greenshields-Watson [verfasserIn] Meriem Attaf [verfasserIn] Bruce J. MacLachlan [verfasserIn] Thomas Whalley [verfasserIn] Cristina Rius [verfasserIn] Aaron Wall [verfasserIn] Angharad Lloyd [verfasserIn] Hywel Hughes [verfasserIn] Kathryn E. Strange [verfasserIn] Georgina H. Mason [verfasserIn] Andrea J. Schauenburg [verfasserIn] Sarah L. Hulin-Curtis [verfasserIn] James Geary [verfasserIn] Yuan Chen [verfasserIn] Sarah N. Lauder [verfasserIn] Kathryn Smart [verfasserIn] Dhanasekaran Vijaykrishna [verfasserIn] Miguel L. Grau [verfasserIn] Mikhail Shugay [verfasserIn] Robert Andrews [verfasserIn] Garry Dolton [verfasserIn] Pierre J. Rizkallah [verfasserIn] Awen M. Gallimore [verfasserIn] Andrew K. Sewell [verfasserIn] Andrew J. Godkin [verfasserIn] David K. Cole [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2020 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Cell Reports - Elsevier, 2015, 32(2020), 2, Seite 107885- |
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| Übergeordnetes Werk: |
volume:32 ; year:2020 ; number:2 ; pages:107885- |
| Links: |
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| DOI / URN: |
10.1016/j.celrep.2020.107885 |
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| Katalog-ID: |
DOAJ03741366X |
|---|
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| 245 | 1 | 0 | |a CD4+ T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features |
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| 520 | |a Summary: T cell recognition of peptides presented by human leukocyte antigens (HLAs) is mediated by the highly variable T cell receptor (TCR). Despite this built-in TCR variability, individuals can mount immune responses against viral epitopes by using identical or highly related TCRs expressed on CD8+ T cells. Characterization of these TCRs has extended our understanding of the molecular mechanisms that govern the recognition of peptide-HLA. However, few examples exist for CD4+ T cells. Here, we investigate CD4+ T cell responses to the internal proteins of the influenza A virus that correlate with protective immunity. We identify five internal epitopes that are commonly recognized by CD4+ T cells in five HLA-DR1+ subjects and show conservation across viral strains and zoonotic reservoirs. TCR repertoire analysis demonstrates several shared gene usage biases underpinned by complementary biochemical features evident in a structural comparison. These epitopes are attractive targets for vaccination and other T cell therapies. | ||
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| 653 | 0 | |a Biology (General) | |
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| 700 | 0 | |a Bruce J. MacLachlan |e verfasserin |4 aut | |
| 700 | 0 | |a Thomas Whalley |e verfasserin |4 aut | |
| 700 | 0 | |a Cristina Rius |e verfasserin |4 aut | |
| 700 | 0 | |a Aaron Wall |e verfasserin |4 aut | |
| 700 | 0 | |a Angharad Lloyd |e verfasserin |4 aut | |
| 700 | 0 | |a Hywel Hughes |e verfasserin |4 aut | |
| 700 | 0 | |a Kathryn E. Strange |e verfasserin |4 aut | |
| 700 | 0 | |a Georgina H. Mason |e verfasserin |4 aut | |
| 700 | 0 | |a Andrea J. Schauenburg |e verfasserin |4 aut | |
| 700 | 0 | |a Sarah L. Hulin-Curtis |e verfasserin |4 aut | |
| 700 | 0 | |a James Geary |e verfasserin |4 aut | |
| 700 | 0 | |a Yuan Chen |e verfasserin |4 aut | |
| 700 | 0 | |a Sarah N. Lauder |e verfasserin |4 aut | |
| 700 | 0 | |a Kathryn Smart |e verfasserin |4 aut | |
| 700 | 0 | |a Dhanasekaran Vijaykrishna |e verfasserin |4 aut | |
| 700 | 0 | |a Miguel L. Grau |e verfasserin |4 aut | |
| 700 | 0 | |a Mikhail Shugay |e verfasserin |4 aut | |
| 700 | 0 | |a Robert Andrews |e verfasserin |4 aut | |
| 700 | 0 | |a Garry Dolton |e verfasserin |4 aut | |
| 700 | 0 | |a Pierre J. Rizkallah |e verfasserin |4 aut | |
| 700 | 0 | |a Awen M. Gallimore |e verfasserin |4 aut | |
| 700 | 0 | |a Andrew K. Sewell |e verfasserin |4 aut | |
| 700 | 0 | |a Andrew J. Godkin |e verfasserin |4 aut | |
| 700 | 0 | |a David K. Cole |e verfasserin |4 aut | |
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10.1016/j.celrep.2020.107885 doi (DE-627)DOAJ03741366X (DE-599)DOAJac1881b0cc804226bb104e9cab830657 DE-627 ger DE-627 rakwb eng QH301-705.5 Alexander Greenshields-Watson verfasserin aut CD4+ T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: T cell recognition of peptides presented by human leukocyte antigens (HLAs) is mediated by the highly variable T cell receptor (TCR). Despite this built-in TCR variability, individuals can mount immune responses against viral epitopes by using identical or highly related TCRs expressed on CD8+ T cells. Characterization of these TCRs has extended our understanding of the molecular mechanisms that govern the recognition of peptide-HLA. However, few examples exist for CD4+ T cells. Here, we investigate CD4+ T cell responses to the internal proteins of the influenza A virus that correlate with protective immunity. We identify five internal epitopes that are commonly recognized by CD4+ T cells in five HLA-DR1+ subjects and show conservation across viral strains and zoonotic reservoirs. TCR repertoire analysis demonstrates several shared gene usage biases underpinned by complementary biochemical features evident in a structural comparison. These epitopes are attractive targets for vaccination and other T cell therapies. influenza CD4 T cells HLA class II peptide epitopes pHLA mutlimer T cell receptor Biology (General) Meriem Attaf verfasserin aut Bruce J. MacLachlan verfasserin aut Thomas Whalley verfasserin aut Cristina Rius verfasserin aut Aaron Wall verfasserin aut Angharad Lloyd verfasserin aut Hywel Hughes verfasserin aut Kathryn E. Strange verfasserin aut Georgina H. Mason verfasserin aut Andrea J. Schauenburg verfasserin aut Sarah L. Hulin-Curtis verfasserin aut James Geary verfasserin aut Yuan Chen verfasserin aut Sarah N. Lauder verfasserin aut Kathryn Smart verfasserin aut Dhanasekaran Vijaykrishna verfasserin aut Miguel L. Grau verfasserin aut Mikhail Shugay verfasserin aut Robert Andrews verfasserin aut Garry Dolton verfasserin aut Pierre J. Rizkallah verfasserin aut Awen M. Gallimore verfasserin aut Andrew K. Sewell verfasserin aut Andrew J. Godkin verfasserin aut David K. Cole verfasserin aut In Cell Reports Elsevier, 2015 32(2020), 2, Seite 107885- (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:32 year:2020 number:2 pages:107885- https://doi.org/10.1016/j.celrep.2020.107885 kostenfrei https://doaj.org/article/ac1881b0cc804226bb104e9cab830657 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124720308664 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 32 2020 2 107885- |
| spelling |
10.1016/j.celrep.2020.107885 doi (DE-627)DOAJ03741366X (DE-599)DOAJac1881b0cc804226bb104e9cab830657 DE-627 ger DE-627 rakwb eng QH301-705.5 Alexander Greenshields-Watson verfasserin aut CD4+ T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: T cell recognition of peptides presented by human leukocyte antigens (HLAs) is mediated by the highly variable T cell receptor (TCR). Despite this built-in TCR variability, individuals can mount immune responses against viral epitopes by using identical or highly related TCRs expressed on CD8+ T cells. Characterization of these TCRs has extended our understanding of the molecular mechanisms that govern the recognition of peptide-HLA. However, few examples exist for CD4+ T cells. Here, we investigate CD4+ T cell responses to the internal proteins of the influenza A virus that correlate with protective immunity. We identify five internal epitopes that are commonly recognized by CD4+ T cells in five HLA-DR1+ subjects and show conservation across viral strains and zoonotic reservoirs. TCR repertoire analysis demonstrates several shared gene usage biases underpinned by complementary biochemical features evident in a structural comparison. These epitopes are attractive targets for vaccination and other T cell therapies. influenza CD4 T cells HLA class II peptide epitopes pHLA mutlimer T cell receptor Biology (General) Meriem Attaf verfasserin aut Bruce J. MacLachlan verfasserin aut Thomas Whalley verfasserin aut Cristina Rius verfasserin aut Aaron Wall verfasserin aut Angharad Lloyd verfasserin aut Hywel Hughes verfasserin aut Kathryn E. Strange verfasserin aut Georgina H. Mason verfasserin aut Andrea J. Schauenburg verfasserin aut Sarah L. Hulin-Curtis verfasserin aut James Geary verfasserin aut Yuan Chen verfasserin aut Sarah N. Lauder verfasserin aut Kathryn Smart verfasserin aut Dhanasekaran Vijaykrishna verfasserin aut Miguel L. Grau verfasserin aut Mikhail Shugay verfasserin aut Robert Andrews verfasserin aut Garry Dolton verfasserin aut Pierre J. Rizkallah verfasserin aut Awen M. Gallimore verfasserin aut Andrew K. Sewell verfasserin aut Andrew J. Godkin verfasserin aut David K. Cole verfasserin aut In Cell Reports Elsevier, 2015 32(2020), 2, Seite 107885- (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:32 year:2020 number:2 pages:107885- https://doi.org/10.1016/j.celrep.2020.107885 kostenfrei https://doaj.org/article/ac1881b0cc804226bb104e9cab830657 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124720308664 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 32 2020 2 107885- |
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10.1016/j.celrep.2020.107885 doi (DE-627)DOAJ03741366X (DE-599)DOAJac1881b0cc804226bb104e9cab830657 DE-627 ger DE-627 rakwb eng QH301-705.5 Alexander Greenshields-Watson verfasserin aut CD4+ T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: T cell recognition of peptides presented by human leukocyte antigens (HLAs) is mediated by the highly variable T cell receptor (TCR). Despite this built-in TCR variability, individuals can mount immune responses against viral epitopes by using identical or highly related TCRs expressed on CD8+ T cells. Characterization of these TCRs has extended our understanding of the molecular mechanisms that govern the recognition of peptide-HLA. However, few examples exist for CD4+ T cells. Here, we investigate CD4+ T cell responses to the internal proteins of the influenza A virus that correlate with protective immunity. We identify five internal epitopes that are commonly recognized by CD4+ T cells in five HLA-DR1+ subjects and show conservation across viral strains and zoonotic reservoirs. TCR repertoire analysis demonstrates several shared gene usage biases underpinned by complementary biochemical features evident in a structural comparison. These epitopes are attractive targets for vaccination and other T cell therapies. influenza CD4 T cells HLA class II peptide epitopes pHLA mutlimer T cell receptor Biology (General) Meriem Attaf verfasserin aut Bruce J. MacLachlan verfasserin aut Thomas Whalley verfasserin aut Cristina Rius verfasserin aut Aaron Wall verfasserin aut Angharad Lloyd verfasserin aut Hywel Hughes verfasserin aut Kathryn E. Strange verfasserin aut Georgina H. Mason verfasserin aut Andrea J. Schauenburg verfasserin aut Sarah L. Hulin-Curtis verfasserin aut James Geary verfasserin aut Yuan Chen verfasserin aut Sarah N. Lauder verfasserin aut Kathryn Smart verfasserin aut Dhanasekaran Vijaykrishna verfasserin aut Miguel L. Grau verfasserin aut Mikhail Shugay verfasserin aut Robert Andrews verfasserin aut Garry Dolton verfasserin aut Pierre J. Rizkallah verfasserin aut Awen M. Gallimore verfasserin aut Andrew K. Sewell verfasserin aut Andrew J. Godkin verfasserin aut David K. Cole verfasserin aut In Cell Reports Elsevier, 2015 32(2020), 2, Seite 107885- (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:32 year:2020 number:2 pages:107885- https://doi.org/10.1016/j.celrep.2020.107885 kostenfrei https://doaj.org/article/ac1881b0cc804226bb104e9cab830657 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124720308664 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 32 2020 2 107885- |
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10.1016/j.celrep.2020.107885 doi (DE-627)DOAJ03741366X (DE-599)DOAJac1881b0cc804226bb104e9cab830657 DE-627 ger DE-627 rakwb eng QH301-705.5 Alexander Greenshields-Watson verfasserin aut CD4+ T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: T cell recognition of peptides presented by human leukocyte antigens (HLAs) is mediated by the highly variable T cell receptor (TCR). Despite this built-in TCR variability, individuals can mount immune responses against viral epitopes by using identical or highly related TCRs expressed on CD8+ T cells. Characterization of these TCRs has extended our understanding of the molecular mechanisms that govern the recognition of peptide-HLA. However, few examples exist for CD4+ T cells. Here, we investigate CD4+ T cell responses to the internal proteins of the influenza A virus that correlate with protective immunity. We identify five internal epitopes that are commonly recognized by CD4+ T cells in five HLA-DR1+ subjects and show conservation across viral strains and zoonotic reservoirs. TCR repertoire analysis demonstrates several shared gene usage biases underpinned by complementary biochemical features evident in a structural comparison. These epitopes are attractive targets for vaccination and other T cell therapies. influenza CD4 T cells HLA class II peptide epitopes pHLA mutlimer T cell receptor Biology (General) Meriem Attaf verfasserin aut Bruce J. MacLachlan verfasserin aut Thomas Whalley verfasserin aut Cristina Rius verfasserin aut Aaron Wall verfasserin aut Angharad Lloyd verfasserin aut Hywel Hughes verfasserin aut Kathryn E. Strange verfasserin aut Georgina H. Mason verfasserin aut Andrea J. Schauenburg verfasserin aut Sarah L. Hulin-Curtis verfasserin aut James Geary verfasserin aut Yuan Chen verfasserin aut Sarah N. Lauder verfasserin aut Kathryn Smart verfasserin aut Dhanasekaran Vijaykrishna verfasserin aut Miguel L. Grau verfasserin aut Mikhail Shugay verfasserin aut Robert Andrews verfasserin aut Garry Dolton verfasserin aut Pierre J. Rizkallah verfasserin aut Awen M. Gallimore verfasserin aut Andrew K. Sewell verfasserin aut Andrew J. Godkin verfasserin aut David K. Cole verfasserin aut In Cell Reports Elsevier, 2015 32(2020), 2, Seite 107885- (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:32 year:2020 number:2 pages:107885- https://doi.org/10.1016/j.celrep.2020.107885 kostenfrei https://doaj.org/article/ac1881b0cc804226bb104e9cab830657 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124720308664 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 32 2020 2 107885- |
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10.1016/j.celrep.2020.107885 doi (DE-627)DOAJ03741366X (DE-599)DOAJac1881b0cc804226bb104e9cab830657 DE-627 ger DE-627 rakwb eng QH301-705.5 Alexander Greenshields-Watson verfasserin aut CD4+ T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: T cell recognition of peptides presented by human leukocyte antigens (HLAs) is mediated by the highly variable T cell receptor (TCR). Despite this built-in TCR variability, individuals can mount immune responses against viral epitopes by using identical or highly related TCRs expressed on CD8+ T cells. Characterization of these TCRs has extended our understanding of the molecular mechanisms that govern the recognition of peptide-HLA. However, few examples exist for CD4+ T cells. Here, we investigate CD4+ T cell responses to the internal proteins of the influenza A virus that correlate with protective immunity. We identify five internal epitopes that are commonly recognized by CD4+ T cells in five HLA-DR1+ subjects and show conservation across viral strains and zoonotic reservoirs. TCR repertoire analysis demonstrates several shared gene usage biases underpinned by complementary biochemical features evident in a structural comparison. These epitopes are attractive targets for vaccination and other T cell therapies. influenza CD4 T cells HLA class II peptide epitopes pHLA mutlimer T cell receptor Biology (General) Meriem Attaf verfasserin aut Bruce J. MacLachlan verfasserin aut Thomas Whalley verfasserin aut Cristina Rius verfasserin aut Aaron Wall verfasserin aut Angharad Lloyd verfasserin aut Hywel Hughes verfasserin aut Kathryn E. Strange verfasserin aut Georgina H. Mason verfasserin aut Andrea J. Schauenburg verfasserin aut Sarah L. Hulin-Curtis verfasserin aut James Geary verfasserin aut Yuan Chen verfasserin aut Sarah N. Lauder verfasserin aut Kathryn Smart verfasserin aut Dhanasekaran Vijaykrishna verfasserin aut Miguel L. Grau verfasserin aut Mikhail Shugay verfasserin aut Robert Andrews verfasserin aut Garry Dolton verfasserin aut Pierre J. Rizkallah verfasserin aut Awen M. Gallimore verfasserin aut Andrew K. Sewell verfasserin aut Andrew J. Godkin verfasserin aut David K. Cole verfasserin aut In Cell Reports Elsevier, 2015 32(2020), 2, Seite 107885- (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:32 year:2020 number:2 pages:107885- https://doi.org/10.1016/j.celrep.2020.107885 kostenfrei https://doaj.org/article/ac1881b0cc804226bb104e9cab830657 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124720308664 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 32 2020 2 107885- |
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Alexander Greenshields-Watson @@aut@@ Meriem Attaf @@aut@@ Bruce J. MacLachlan @@aut@@ Thomas Whalley @@aut@@ Cristina Rius @@aut@@ Aaron Wall @@aut@@ Angharad Lloyd @@aut@@ Hywel Hughes @@aut@@ Kathryn E. Strange @@aut@@ Georgina H. Mason @@aut@@ Andrea J. Schauenburg @@aut@@ Sarah L. Hulin-Curtis @@aut@@ James Geary @@aut@@ Yuan Chen @@aut@@ Sarah N. Lauder @@aut@@ Kathryn Smart @@aut@@ Dhanasekaran Vijaykrishna @@aut@@ Miguel L. Grau @@aut@@ Mikhail Shugay @@aut@@ Robert Andrews @@aut@@ Garry Dolton @@aut@@ Pierre J. Rizkallah @@aut@@ Awen M. Gallimore @@aut@@ Andrew K. Sewell @@aut@@ Andrew J. Godkin @@aut@@ David K. Cole @@aut@@ |
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Alexander Greenshields-Watson |
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Alexander Greenshields-Watson misc QH301-705.5 misc influenza misc CD4 T cells misc HLA class II misc peptide epitopes misc pHLA mutlimer misc T cell receptor misc Biology (General) CD4+ T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features |
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QH301-705.5 CD4+ T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features influenza CD4 T cells HLA class II peptide epitopes pHLA mutlimer T cell receptor |
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CD4+ T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features |
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CD4+ T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features |
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Alexander Greenshields-Watson Meriem Attaf Bruce J. MacLachlan Thomas Whalley Cristina Rius Aaron Wall Angharad Lloyd Hywel Hughes Kathryn E. Strange Georgina H. Mason Andrea J. Schauenburg Sarah L. Hulin-Curtis James Geary Yuan Chen Sarah N. Lauder Kathryn Smart Dhanasekaran Vijaykrishna Miguel L. Grau Mikhail Shugay Robert Andrews Garry Dolton Pierre J. Rizkallah Awen M. Gallimore Andrew K. Sewell Andrew J. Godkin David K. Cole |
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cd4+ t cells recognize conserved influenza a epitopes through shared patterns of v-gene usage and complementary biochemical features |
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CD4+ T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features |
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Summary: T cell recognition of peptides presented by human leukocyte antigens (HLAs) is mediated by the highly variable T cell receptor (TCR). Despite this built-in TCR variability, individuals can mount immune responses against viral epitopes by using identical or highly related TCRs expressed on CD8+ T cells. Characterization of these TCRs has extended our understanding of the molecular mechanisms that govern the recognition of peptide-HLA. However, few examples exist for CD4+ T cells. Here, we investigate CD4+ T cell responses to the internal proteins of the influenza A virus that correlate with protective immunity. We identify five internal epitopes that are commonly recognized by CD4+ T cells in five HLA-DR1+ subjects and show conservation across viral strains and zoonotic reservoirs. TCR repertoire analysis demonstrates several shared gene usage biases underpinned by complementary biochemical features evident in a structural comparison. These epitopes are attractive targets for vaccination and other T cell therapies. |
| abstractGer |
Summary: T cell recognition of peptides presented by human leukocyte antigens (HLAs) is mediated by the highly variable T cell receptor (TCR). Despite this built-in TCR variability, individuals can mount immune responses against viral epitopes by using identical or highly related TCRs expressed on CD8+ T cells. Characterization of these TCRs has extended our understanding of the molecular mechanisms that govern the recognition of peptide-HLA. However, few examples exist for CD4+ T cells. Here, we investigate CD4+ T cell responses to the internal proteins of the influenza A virus that correlate with protective immunity. We identify five internal epitopes that are commonly recognized by CD4+ T cells in five HLA-DR1+ subjects and show conservation across viral strains and zoonotic reservoirs. TCR repertoire analysis demonstrates several shared gene usage biases underpinned by complementary biochemical features evident in a structural comparison. These epitopes are attractive targets for vaccination and other T cell therapies. |
| abstract_unstemmed |
Summary: T cell recognition of peptides presented by human leukocyte antigens (HLAs) is mediated by the highly variable T cell receptor (TCR). Despite this built-in TCR variability, individuals can mount immune responses against viral epitopes by using identical or highly related TCRs expressed on CD8+ T cells. Characterization of these TCRs has extended our understanding of the molecular mechanisms that govern the recognition of peptide-HLA. However, few examples exist for CD4+ T cells. Here, we investigate CD4+ T cell responses to the internal proteins of the influenza A virus that correlate with protective immunity. We identify five internal epitopes that are commonly recognized by CD4+ T cells in five HLA-DR1+ subjects and show conservation across viral strains and zoonotic reservoirs. TCR repertoire analysis demonstrates several shared gene usage biases underpinned by complementary biochemical features evident in a structural comparison. These epitopes are attractive targets for vaccination and other T cell therapies. |
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CD4+ T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ03741366X</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230308005953.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230227s2020 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.celrep.2020.107885</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ03741366X</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJac1881b0cc804226bb104e9cab830657</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QH301-705.5</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Alexander Greenshields-Watson</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">CD4+ T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Summary: T cell recognition of peptides presented by human leukocyte antigens (HLAs) is mediated by the highly variable T cell receptor (TCR). 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