Proteomics in Schizophrenia: A Gateway to Discover Potential Biomarkers of Psychoneuroimmune Pathways

Schizophrenia is a severe and disabling psychiatric disorder with a complex and multifactorial etiology. The lack of consensus regarding the multifaceted dysfunction of this ailment has increased the need to explore new research lines. This research makes use of proteomics data to discover possible...
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Autor*in:	Daniela Rodrigues-Amorim [verfasserIn] Tania Rivera-Baltanás [verfasserIn] María del Carmen Vallejo-Curto [verfasserIn] Cynthia Rodriguez-Jamardo [verfasserIn] Elena de las Heras [verfasserIn] Carolina Barreiro-Villar [verfasserIn] María Blanco-Formoso [verfasserIn] Patricia Fernández-Palleiro [verfasserIn] María Álvarez-Ariza [verfasserIn] Marta López [verfasserIn] Alejandro García-Caballero [verfasserIn] José Manuel Olivares [verfasserIn] Carlos Spuch [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	schizophrenia proteomics liquid chromatography–tandem mass spectrometry Rab3 GTPase-activating protein catalytic subunit glia maturation factor beta brain-derived neurotrophic factor

Übergeordnetes Werk:	In: Frontiers in Psychiatry - Frontiers Media S.A., 2010, 10(2019)
Übergeordnetes Werk:	volume:10 ; year:2019

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fpsyt.2019.00885

Katalog-ID:	DOAJ037457071

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allfieldsSound	10.3389/fpsyt.2019.00885 doi (DE-627)DOAJ037457071 (DE-599)DOAJ3152ca832f1b4e9884c93a9c54fee2a4 DE-627 ger DE-627 rakwb eng RC435-571 Daniela Rodrigues-Amorim verfasserin aut Proteomics in Schizophrenia: A Gateway to Discover Potential Biomarkers of Psychoneuroimmune Pathways 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Schizophrenia is a severe and disabling psychiatric disorder with a complex and multifactorial etiology. The lack of consensus regarding the multifaceted dysfunction of this ailment has increased the need to explore new research lines. This research makes use of proteomics data to discover possible analytes associated with psychoneuroimmune signaling pathways in schizophrenia. Thus, we analyze plasma of 45 patients [10 patients with first-episode schizophrenia (FES) and 35 patients with chronic schizophrenia] and 43 healthy subjects by label-free liquid chromatography–tandem mass spectrometry. The analysis revealed a significant reduction in the levels of glia maturation factor beta (GMF-β), the brain-derived neurotrophic factor (BDNF), and the 115-kDa isoform of the Rab3 GTPase-activating protein catalytic subunit (RAB3GAP1) in patients with schizophrenia as compared to healthy volunteers. In conclusion, GMF-β, BDNF, and 115-kDa isoform of RAB3GAP1 showed significantly reduced levels in plasma of patients with schizophrenia, thus making them potential biomarkers in schizophrenia. schizophrenia proteomics liquid chromatography–tandem mass spectrometry Rab3 GTPase-activating protein catalytic subunit glia maturation factor beta brain-derived neurotrophic factor Psychiatry Tania Rivera-Baltanás verfasserin aut María del Carmen Vallejo-Curto verfasserin aut Cynthia Rodriguez-Jamardo verfasserin aut Elena de las Heras verfasserin aut Carolina Barreiro-Villar verfasserin aut María Blanco-Formoso verfasserin aut Patricia Fernández-Palleiro verfasserin aut María Álvarez-Ariza verfasserin aut Marta López verfasserin aut Alejandro García-Caballero verfasserin aut Alejandro García-Caballero verfasserin aut José Manuel Olivares verfasserin aut Carlos Spuch verfasserin aut In Frontiers in Psychiatry Frontiers Media S.A., 2010 10(2019) (DE-627)631498796 (DE-600)2564218-2 16640640 nnns volume:10 year:2019 https://doi.org/10.3389/fpsyt.2019.00885 kostenfrei https://doaj.org/article/3152ca832f1b4e9884c93a9c54fee2a4 kostenfrei https://www.frontiersin.org/article/10.3389/fpsyt.2019.00885/full kostenfrei https://doaj.org/toc/1664-0640 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2019
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callnumber-first	R - Medicine
author	Daniela Rodrigues-Amorim
spellingShingle	Daniela Rodrigues-Amorim misc RC435-571 misc schizophrenia misc proteomics misc liquid chromatography–tandem mass spectrometry misc Rab3 GTPase-activating protein catalytic subunit misc glia maturation factor beta misc brain-derived neurotrophic factor misc Psychiatry Proteomics in Schizophrenia: A Gateway to Discover Potential Biomarkers of Psychoneuroimmune Pathways
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topic_title	RC435-571 Proteomics in Schizophrenia: A Gateway to Discover Potential Biomarkers of Psychoneuroimmune Pathways schizophrenia proteomics liquid chromatography–tandem mass spectrometry Rab3 GTPase-activating protein catalytic subunit glia maturation factor beta brain-derived neurotrophic factor
topic	misc RC435-571 misc schizophrenia misc proteomics misc liquid chromatography–tandem mass spectrometry misc Rab3 GTPase-activating protein catalytic subunit misc glia maturation factor beta misc brain-derived neurotrophic factor misc Psychiatry
topic_unstemmed	misc RC435-571 misc schizophrenia misc proteomics misc liquid chromatography–tandem mass spectrometry misc Rab3 GTPase-activating protein catalytic subunit misc glia maturation factor beta misc brain-derived neurotrophic factor misc Psychiatry
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title	Proteomics in Schizophrenia: A Gateway to Discover Potential Biomarkers of Psychoneuroimmune Pathways
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title_full	Proteomics in Schizophrenia: A Gateway to Discover Potential Biomarkers of Psychoneuroimmune Pathways
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author_browse	Daniela Rodrigues-Amorim Tania Rivera-Baltanás María del Carmen Vallejo-Curto Cynthia Rodriguez-Jamardo Elena de las Heras Carolina Barreiro-Villar María Blanco-Formoso Patricia Fernández-Palleiro María Álvarez-Ariza Marta López Alejandro García-Caballero José Manuel Olivares Carlos Spuch
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title_sort	proteomics in schizophrenia: a gateway to discover potential biomarkers of psychoneuroimmune pathways
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title_auth	Proteomics in Schizophrenia: A Gateway to Discover Potential Biomarkers of Psychoneuroimmune Pathways
abstract	Schizophrenia is a severe and disabling psychiatric disorder with a complex and multifactorial etiology. The lack of consensus regarding the multifaceted dysfunction of this ailment has increased the need to explore new research lines. This research makes use of proteomics data to discover possible analytes associated with psychoneuroimmune signaling pathways in schizophrenia. Thus, we analyze plasma of 45 patients [10 patients with first-episode schizophrenia (FES) and 35 patients with chronic schizophrenia] and 43 healthy subjects by label-free liquid chromatography–tandem mass spectrometry. The analysis revealed a significant reduction in the levels of glia maturation factor beta (GMF-β), the brain-derived neurotrophic factor (BDNF), and the 115-kDa isoform of the Rab3 GTPase-activating protein catalytic subunit (RAB3GAP1) in patients with schizophrenia as compared to healthy volunteers. In conclusion, GMF-β, BDNF, and 115-kDa isoform of RAB3GAP1 showed significantly reduced levels in plasma of patients with schizophrenia, thus making them potential biomarkers in schizophrenia.
abstractGer	Schizophrenia is a severe and disabling psychiatric disorder with a complex and multifactorial etiology. The lack of consensus regarding the multifaceted dysfunction of this ailment has increased the need to explore new research lines. This research makes use of proteomics data to discover possible analytes associated with psychoneuroimmune signaling pathways in schizophrenia. Thus, we analyze plasma of 45 patients [10 patients with first-episode schizophrenia (FES) and 35 patients with chronic schizophrenia] and 43 healthy subjects by label-free liquid chromatography–tandem mass spectrometry. The analysis revealed a significant reduction in the levels of glia maturation factor beta (GMF-β), the brain-derived neurotrophic factor (BDNF), and the 115-kDa isoform of the Rab3 GTPase-activating protein catalytic subunit (RAB3GAP1) in patients with schizophrenia as compared to healthy volunteers. In conclusion, GMF-β, BDNF, and 115-kDa isoform of RAB3GAP1 showed significantly reduced levels in plasma of patients with schizophrenia, thus making them potential biomarkers in schizophrenia.
abstract_unstemmed	Schizophrenia is a severe and disabling psychiatric disorder with a complex and multifactorial etiology. The lack of consensus regarding the multifaceted dysfunction of this ailment has increased the need to explore new research lines. This research makes use of proteomics data to discover possible analytes associated with psychoneuroimmune signaling pathways in schizophrenia. Thus, we analyze plasma of 45 patients [10 patients with first-episode schizophrenia (FES) and 35 patients with chronic schizophrenia] and 43 healthy subjects by label-free liquid chromatography–tandem mass spectrometry. The analysis revealed a significant reduction in the levels of glia maturation factor beta (GMF-β), the brain-derived neurotrophic factor (BDNF), and the 115-kDa isoform of the Rab3 GTPase-activating protein catalytic subunit (RAB3GAP1) in patients with schizophrenia as compared to healthy volunteers. In conclusion, GMF-β, BDNF, and 115-kDa isoform of RAB3GAP1 showed significantly reduced levels in plasma of patients with schizophrenia, thus making them potential biomarkers in schizophrenia.
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title_short	Proteomics in Schizophrenia: A Gateway to Discover Potential Biomarkers of Psychoneuroimmune Pathways
url	https://doi.org/10.3389/fpsyt.2019.00885 https://doaj.org/article/3152ca832f1b4e9884c93a9c54fee2a4 https://www.frontiersin.org/article/10.3389/fpsyt.2019.00885/full https://doaj.org/toc/1664-0640
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author2	Tania Rivera-Baltanás María del Carmen Vallejo-Curto Cynthia Rodriguez-Jamardo Elena de las Heras Carolina Barreiro-Villar María Blanco-Formoso Patricia Fernández-Palleiro María Álvarez-Ariza Marta López Alejandro García-Caballero José Manuel Olivares Carlos Spuch
author2Str	Tania Rivera-Baltanás María del Carmen Vallejo-Curto Cynthia Rodriguez-Jamardo Elena de las Heras Carolina Barreiro-Villar María Blanco-Formoso Patricia Fernández-Palleiro María Álvarez-Ariza Marta López Alejandro García-Caballero José Manuel Olivares Carlos Spuch
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doi_str	10.3389/fpsyt.2019.00885
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up_date	2024-07-04T01:17:31.529Z
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The lack of consensus regarding the multifaceted dysfunction of this ailment has increased the need to explore new research lines. This research makes use of proteomics data to discover possible analytes associated with psychoneuroimmune signaling pathways in schizophrenia. Thus, we analyze plasma of 45 patients [10 patients with first-episode schizophrenia (FES) and 35 patients with chronic schizophrenia] and 43 healthy subjects by label-free liquid chromatography–tandem mass spectrometry. The analysis revealed a significant reduction in the levels of glia maturation factor beta (GMF-β), the brain-derived neurotrophic factor (BDNF), and the 115-kDa isoform of the Rab3 GTPase-activating protein catalytic subunit (RAB3GAP1) in patients with schizophrenia as compared to healthy volunteers. 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