Przyczyny niepowodzeń leczenia chorych na raka trzonu macicy poddanych pooperacyjnej radioterapii
Introduction: The treatment of choice for patients with early clinical stage uterine cancer is surgical intervention.In complementary treatment in standard use is radiotherapy (teletherapy and brachytherapy). In case of onset of disease recurrence, salvage treatment frequently proves ineffective, wh...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Michał Spych [verfasserIn] Leszek Gottwald [verfasserIn] Emilia Jesień-Lewandowicz [verfasserIn] Justyna Chałubińska [verfasserIn] Janusz Sobotkowski [verfasserIn] Jacek Fijuth [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2010 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Menopause Review - Termedia Publishing House, 2011, 14(2010), 1, Seite 32-37 |
|---|---|
| Übergeordnetes Werk: |
volume:14 ; year:2010 ; number:1 ; pages:32-37 |
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DOAJ037482033 |
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| 520 | |a Introduction: The treatment of choice for patients with early clinical stage uterine cancer is surgical intervention.In complementary treatment in standard use is radiotherapy (teletherapy and brachytherapy). In case of onset of disease recurrence, salvage treatment frequently proves ineffective, which is connected with a highpercent of deaths in this group of patients. The aim was to evaluate the causes of treatment failure in patients with endometrial cancer treated withpostoperative radiotherapy. Material and methods: Twenty-eight patients aged between 49 and 84 years were enrolled in the study,in whom for the period from 2002 until 2004 postoperative radiotherapy was applied, and in whom during theperiod of five years after treatment termination disease recurrence was observed. Results: In the analyzed group of patients the 2- and 4-year disease-free survival (DFS) was 41% and 11%respectively. The 2- and 5-year overall survival (OS) was 67% and 13%. Locoregional failures occurred in 5 (17.7%)patients. Distant metastases were detected in 15 (63.6%) patients. In 8 (28.6%) patients, distant metastases occurredsimultaneously with local relapse. Neither of the treatment methods after disease recurrence significantlyextended the survival of patients (p = 0.82). Patients’ age was the sole prognostic factor which has a statisticallysignificant impact on DFS. On the other hand an adverse affect on overall survival was demonstrated for thevariable of the time of disease recurrence. In the group of patients in whom the recurrence was demonstratedearlier than 6 months after treatment termination the OS was significantly shorter (p = 0.001). Conclusions: Distant metastases are the main cause of failures of patients’ treatment for endometrioidendometrial cancer. Neither of the treatment methods after disease recurrence significantly extended the survivalof patients. Shorter time to disease recurrence is a negative prognostic factor with reference to overallsurvival. | ||
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(DE-627)DOAJ037482033 (DE-599)DOAJ41d86023e5494c8496aebac3f713aae6 DE-627 ger DE-627 rakwb eng Michał Spych verfasserin aut Przyczyny niepowodzeń leczenia chorych na raka trzonu macicy poddanych pooperacyjnej radioterapii 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: The treatment of choice for patients with early clinical stage uterine cancer is surgical intervention.In complementary treatment in standard use is radiotherapy (teletherapy and brachytherapy). In case of onset of disease recurrence, salvage treatment frequently proves ineffective, which is connected with a highpercent of deaths in this group of patients. The aim was to evaluate the causes of treatment failure in patients with endometrial cancer treated withpostoperative radiotherapy. Material and methods: Twenty-eight patients aged between 49 and 84 years were enrolled in the study,in whom for the period from 2002 until 2004 postoperative radiotherapy was applied, and in whom during theperiod of five years after treatment termination disease recurrence was observed. Results: In the analyzed group of patients the 2- and 4-year disease-free survival (DFS) was 41% and 11%respectively. The 2- and 5-year overall survival (OS) was 67% and 13%. Locoregional failures occurred in 5 (17.7%)patients. Distant metastases were detected in 15 (63.6%) patients. In 8 (28.6%) patients, distant metastases occurredsimultaneously with local relapse. Neither of the treatment methods after disease recurrence significantlyextended the survival of patients (p = 0.82). Patients’ age was the sole prognostic factor which has a statisticallysignificant impact on DFS. On the other hand an adverse affect on overall survival was demonstrated for thevariable of the time of disease recurrence. In the group of patients in whom the recurrence was demonstratedearlier than 6 months after treatment termination the OS was significantly shorter (p = 0.001). Conclusions: Distant metastases are the main cause of failures of patients’ treatment for endometrioidendometrial cancer. Neither of the treatment methods after disease recurrence significantly extended the survivalof patients. Shorter time to disease recurrence is a negative prognostic factor with reference to overallsurvival. endometrial cancer recurrence causes of failures disease-free survival overall survival Medicine R Leszek Gottwald verfasserin aut Emilia Jesień-Lewandowicz verfasserin aut Justyna Chałubińska verfasserin aut Janusz Sobotkowski verfasserin aut Jacek Fijuth verfasserin aut In Menopause Review Termedia Publishing House, 2011 14(2010), 1, Seite 32-37 (DE-627)647656515 (DE-600)2596140-8 22990038 nnns volume:14 year:2010 number:1 pages:32-37 https://doaj.org/article/41d86023e5494c8496aebac3f713aae6 kostenfrei http://www.termedia.pl/Przyczyny-niepowodzen-leczenia-chorych-na-raka-trzonu-macicy-poddanych-pooperacyjnej-radioterapii,4,14205,1,0.html kostenfrei https://doaj.org/toc/1643-8876 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2010 1 32-37 |
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(DE-627)DOAJ037482033 (DE-599)DOAJ41d86023e5494c8496aebac3f713aae6 DE-627 ger DE-627 rakwb eng Michał Spych verfasserin aut Przyczyny niepowodzeń leczenia chorych na raka trzonu macicy poddanych pooperacyjnej radioterapii 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: The treatment of choice for patients with early clinical stage uterine cancer is surgical intervention.In complementary treatment in standard use is radiotherapy (teletherapy and brachytherapy). In case of onset of disease recurrence, salvage treatment frequently proves ineffective, which is connected with a highpercent of deaths in this group of patients. The aim was to evaluate the causes of treatment failure in patients with endometrial cancer treated withpostoperative radiotherapy. Material and methods: Twenty-eight patients aged between 49 and 84 years were enrolled in the study,in whom for the period from 2002 until 2004 postoperative radiotherapy was applied, and in whom during theperiod of five years after treatment termination disease recurrence was observed. Results: In the analyzed group of patients the 2- and 4-year disease-free survival (DFS) was 41% and 11%respectively. The 2- and 5-year overall survival (OS) was 67% and 13%. Locoregional failures occurred in 5 (17.7%)patients. Distant metastases were detected in 15 (63.6%) patients. In 8 (28.6%) patients, distant metastases occurredsimultaneously with local relapse. Neither of the treatment methods after disease recurrence significantlyextended the survival of patients (p = 0.82). Patients’ age was the sole prognostic factor which has a statisticallysignificant impact on DFS. On the other hand an adverse affect on overall survival was demonstrated for thevariable of the time of disease recurrence. In the group of patients in whom the recurrence was demonstratedearlier than 6 months after treatment termination the OS was significantly shorter (p = 0.001). Conclusions: Distant metastases are the main cause of failures of patients’ treatment for endometrioidendometrial cancer. Neither of the treatment methods after disease recurrence significantly extended the survivalof patients. Shorter time to disease recurrence is a negative prognostic factor with reference to overallsurvival. endometrial cancer recurrence causes of failures disease-free survival overall survival Medicine R Leszek Gottwald verfasserin aut Emilia Jesień-Lewandowicz verfasserin aut Justyna Chałubińska verfasserin aut Janusz Sobotkowski verfasserin aut Jacek Fijuth verfasserin aut In Menopause Review Termedia Publishing House, 2011 14(2010), 1, Seite 32-37 (DE-627)647656515 (DE-600)2596140-8 22990038 nnns volume:14 year:2010 number:1 pages:32-37 https://doaj.org/article/41d86023e5494c8496aebac3f713aae6 kostenfrei http://www.termedia.pl/Przyczyny-niepowodzen-leczenia-chorych-na-raka-trzonu-macicy-poddanych-pooperacyjnej-radioterapii,4,14205,1,0.html kostenfrei https://doaj.org/toc/1643-8876 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2010 1 32-37 |
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(DE-627)DOAJ037482033 (DE-599)DOAJ41d86023e5494c8496aebac3f713aae6 DE-627 ger DE-627 rakwb eng Michał Spych verfasserin aut Przyczyny niepowodzeń leczenia chorych na raka trzonu macicy poddanych pooperacyjnej radioterapii 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: The treatment of choice for patients with early clinical stage uterine cancer is surgical intervention.In complementary treatment in standard use is radiotherapy (teletherapy and brachytherapy). In case of onset of disease recurrence, salvage treatment frequently proves ineffective, which is connected with a highpercent of deaths in this group of patients. The aim was to evaluate the causes of treatment failure in patients with endometrial cancer treated withpostoperative radiotherapy. Material and methods: Twenty-eight patients aged between 49 and 84 years were enrolled in the study,in whom for the period from 2002 until 2004 postoperative radiotherapy was applied, and in whom during theperiod of five years after treatment termination disease recurrence was observed. Results: In the analyzed group of patients the 2- and 4-year disease-free survival (DFS) was 41% and 11%respectively. The 2- and 5-year overall survival (OS) was 67% and 13%. Locoregional failures occurred in 5 (17.7%)patients. Distant metastases were detected in 15 (63.6%) patients. In 8 (28.6%) patients, distant metastases occurredsimultaneously with local relapse. Neither of the treatment methods after disease recurrence significantlyextended the survival of patients (p = 0.82). Patients’ age was the sole prognostic factor which has a statisticallysignificant impact on DFS. On the other hand an adverse affect on overall survival was demonstrated for thevariable of the time of disease recurrence. In the group of patients in whom the recurrence was demonstratedearlier than 6 months after treatment termination the OS was significantly shorter (p = 0.001). Conclusions: Distant metastases are the main cause of failures of patients’ treatment for endometrioidendometrial cancer. Neither of the treatment methods after disease recurrence significantly extended the survivalof patients. Shorter time to disease recurrence is a negative prognostic factor with reference to overallsurvival. endometrial cancer recurrence causes of failures disease-free survival overall survival Medicine R Leszek Gottwald verfasserin aut Emilia Jesień-Lewandowicz verfasserin aut Justyna Chałubińska verfasserin aut Janusz Sobotkowski verfasserin aut Jacek Fijuth verfasserin aut In Menopause Review Termedia Publishing House, 2011 14(2010), 1, Seite 32-37 (DE-627)647656515 (DE-600)2596140-8 22990038 nnns volume:14 year:2010 number:1 pages:32-37 https://doaj.org/article/41d86023e5494c8496aebac3f713aae6 kostenfrei http://www.termedia.pl/Przyczyny-niepowodzen-leczenia-chorych-na-raka-trzonu-macicy-poddanych-pooperacyjnej-radioterapii,4,14205,1,0.html kostenfrei https://doaj.org/toc/1643-8876 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2010 1 32-37 |
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(DE-627)DOAJ037482033 (DE-599)DOAJ41d86023e5494c8496aebac3f713aae6 DE-627 ger DE-627 rakwb eng Michał Spych verfasserin aut Przyczyny niepowodzeń leczenia chorych na raka trzonu macicy poddanych pooperacyjnej radioterapii 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: The treatment of choice for patients with early clinical stage uterine cancer is surgical intervention.In complementary treatment in standard use is radiotherapy (teletherapy and brachytherapy). In case of onset of disease recurrence, salvage treatment frequently proves ineffective, which is connected with a highpercent of deaths in this group of patients. The aim was to evaluate the causes of treatment failure in patients with endometrial cancer treated withpostoperative radiotherapy. Material and methods: Twenty-eight patients aged between 49 and 84 years were enrolled in the study,in whom for the period from 2002 until 2004 postoperative radiotherapy was applied, and in whom during theperiod of five years after treatment termination disease recurrence was observed. Results: In the analyzed group of patients the 2- and 4-year disease-free survival (DFS) was 41% and 11%respectively. The 2- and 5-year overall survival (OS) was 67% and 13%. Locoregional failures occurred in 5 (17.7%)patients. Distant metastases were detected in 15 (63.6%) patients. In 8 (28.6%) patients, distant metastases occurredsimultaneously with local relapse. Neither of the treatment methods after disease recurrence significantlyextended the survival of patients (p = 0.82). Patients’ age was the sole prognostic factor which has a statisticallysignificant impact on DFS. On the other hand an adverse affect on overall survival was demonstrated for thevariable of the time of disease recurrence. In the group of patients in whom the recurrence was demonstratedearlier than 6 months after treatment termination the OS was significantly shorter (p = 0.001). Conclusions: Distant metastases are the main cause of failures of patients’ treatment for endometrioidendometrial cancer. Neither of the treatment methods after disease recurrence significantly extended the survivalof patients. Shorter time to disease recurrence is a negative prognostic factor with reference to overallsurvival. endometrial cancer recurrence causes of failures disease-free survival overall survival Medicine R Leszek Gottwald verfasserin aut Emilia Jesień-Lewandowicz verfasserin aut Justyna Chałubińska verfasserin aut Janusz Sobotkowski verfasserin aut Jacek Fijuth verfasserin aut In Menopause Review Termedia Publishing House, 2011 14(2010), 1, Seite 32-37 (DE-627)647656515 (DE-600)2596140-8 22990038 nnns volume:14 year:2010 number:1 pages:32-37 https://doaj.org/article/41d86023e5494c8496aebac3f713aae6 kostenfrei http://www.termedia.pl/Przyczyny-niepowodzen-leczenia-chorych-na-raka-trzonu-macicy-poddanych-pooperacyjnej-radioterapii,4,14205,1,0.html kostenfrei https://doaj.org/toc/1643-8876 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2010 1 32-37 |
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(DE-627)DOAJ037482033 (DE-599)DOAJ41d86023e5494c8496aebac3f713aae6 DE-627 ger DE-627 rakwb eng Michał Spych verfasserin aut Przyczyny niepowodzeń leczenia chorych na raka trzonu macicy poddanych pooperacyjnej radioterapii 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: The treatment of choice for patients with early clinical stage uterine cancer is surgical intervention.In complementary treatment in standard use is radiotherapy (teletherapy and brachytherapy). In case of onset of disease recurrence, salvage treatment frequently proves ineffective, which is connected with a highpercent of deaths in this group of patients. The aim was to evaluate the causes of treatment failure in patients with endometrial cancer treated withpostoperative radiotherapy. Material and methods: Twenty-eight patients aged between 49 and 84 years were enrolled in the study,in whom for the period from 2002 until 2004 postoperative radiotherapy was applied, and in whom during theperiod of five years after treatment termination disease recurrence was observed. Results: In the analyzed group of patients the 2- and 4-year disease-free survival (DFS) was 41% and 11%respectively. The 2- and 5-year overall survival (OS) was 67% and 13%. Locoregional failures occurred in 5 (17.7%)patients. Distant metastases were detected in 15 (63.6%) patients. In 8 (28.6%) patients, distant metastases occurredsimultaneously with local relapse. Neither of the treatment methods after disease recurrence significantlyextended the survival of patients (p = 0.82). Patients’ age was the sole prognostic factor which has a statisticallysignificant impact on DFS. On the other hand an adverse affect on overall survival was demonstrated for thevariable of the time of disease recurrence. In the group of patients in whom the recurrence was demonstratedearlier than 6 months after treatment termination the OS was significantly shorter (p = 0.001). Conclusions: Distant metastases are the main cause of failures of patients’ treatment for endometrioidendometrial cancer. Neither of the treatment methods after disease recurrence significantly extended the survivalof patients. Shorter time to disease recurrence is a negative prognostic factor with reference to overallsurvival. endometrial cancer recurrence causes of failures disease-free survival overall survival Medicine R Leszek Gottwald verfasserin aut Emilia Jesień-Lewandowicz verfasserin aut Justyna Chałubińska verfasserin aut Janusz Sobotkowski verfasserin aut Jacek Fijuth verfasserin aut In Menopause Review Termedia Publishing House, 2011 14(2010), 1, Seite 32-37 (DE-627)647656515 (DE-600)2596140-8 22990038 nnns volume:14 year:2010 number:1 pages:32-37 https://doaj.org/article/41d86023e5494c8496aebac3f713aae6 kostenfrei http://www.termedia.pl/Przyczyny-niepowodzen-leczenia-chorych-na-raka-trzonu-macicy-poddanych-pooperacyjnej-radioterapii,4,14205,1,0.html kostenfrei https://doaj.org/toc/1643-8876 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2010 1 32-37 |
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Przyczyny niepowodzeń leczenia chorych na raka trzonu macicy poddanych pooperacyjnej radioterapii |
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Introduction: The treatment of choice for patients with early clinical stage uterine cancer is surgical intervention.In complementary treatment in standard use is radiotherapy (teletherapy and brachytherapy). In case of onset of disease recurrence, salvage treatment frequently proves ineffective, which is connected with a highpercent of deaths in this group of patients. The aim was to evaluate the causes of treatment failure in patients with endometrial cancer treated withpostoperative radiotherapy. Material and methods: Twenty-eight patients aged between 49 and 84 years were enrolled in the study,in whom for the period from 2002 until 2004 postoperative radiotherapy was applied, and in whom during theperiod of five years after treatment termination disease recurrence was observed. Results: In the analyzed group of patients the 2- and 4-year disease-free survival (DFS) was 41% and 11%respectively. The 2- and 5-year overall survival (OS) was 67% and 13%. Locoregional failures occurred in 5 (17.7%)patients. Distant metastases were detected in 15 (63.6%) patients. In 8 (28.6%) patients, distant metastases occurredsimultaneously with local relapse. Neither of the treatment methods after disease recurrence significantlyextended the survival of patients (p = 0.82). Patients’ age was the sole prognostic factor which has a statisticallysignificant impact on DFS. On the other hand an adverse affect on overall survival was demonstrated for thevariable of the time of disease recurrence. In the group of patients in whom the recurrence was demonstratedearlier than 6 months after treatment termination the OS was significantly shorter (p = 0.001). Conclusions: Distant metastases are the main cause of failures of patients’ treatment for endometrioidendometrial cancer. Neither of the treatment methods after disease recurrence significantly extended the survivalof patients. Shorter time to disease recurrence is a negative prognostic factor with reference to overallsurvival. |
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Introduction: The treatment of choice for patients with early clinical stage uterine cancer is surgical intervention.In complementary treatment in standard use is radiotherapy (teletherapy and brachytherapy). In case of onset of disease recurrence, salvage treatment frequently proves ineffective, which is connected with a highpercent of deaths in this group of patients. The aim was to evaluate the causes of treatment failure in patients with endometrial cancer treated withpostoperative radiotherapy. Material and methods: Twenty-eight patients aged between 49 and 84 years were enrolled in the study,in whom for the period from 2002 until 2004 postoperative radiotherapy was applied, and in whom during theperiod of five years after treatment termination disease recurrence was observed. Results: In the analyzed group of patients the 2- and 4-year disease-free survival (DFS) was 41% and 11%respectively. The 2- and 5-year overall survival (OS) was 67% and 13%. Locoregional failures occurred in 5 (17.7%)patients. Distant metastases were detected in 15 (63.6%) patients. In 8 (28.6%) patients, distant metastases occurredsimultaneously with local relapse. Neither of the treatment methods after disease recurrence significantlyextended the survival of patients (p = 0.82). Patients’ age was the sole prognostic factor which has a statisticallysignificant impact on DFS. On the other hand an adverse affect on overall survival was demonstrated for thevariable of the time of disease recurrence. In the group of patients in whom the recurrence was demonstratedearlier than 6 months after treatment termination the OS was significantly shorter (p = 0.001). Conclusions: Distant metastases are the main cause of failures of patients’ treatment for endometrioidendometrial cancer. Neither of the treatment methods after disease recurrence significantly extended the survivalof patients. Shorter time to disease recurrence is a negative prognostic factor with reference to overallsurvival. |
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Introduction: The treatment of choice for patients with early clinical stage uterine cancer is surgical intervention.In complementary treatment in standard use is radiotherapy (teletherapy and brachytherapy). In case of onset of disease recurrence, salvage treatment frequently proves ineffective, which is connected with a highpercent of deaths in this group of patients. The aim was to evaluate the causes of treatment failure in patients with endometrial cancer treated withpostoperative radiotherapy. Material and methods: Twenty-eight patients aged between 49 and 84 years were enrolled in the study,in whom for the period from 2002 until 2004 postoperative radiotherapy was applied, and in whom during theperiod of five years after treatment termination disease recurrence was observed. Results: In the analyzed group of patients the 2- and 4-year disease-free survival (DFS) was 41% and 11%respectively. The 2- and 5-year overall survival (OS) was 67% and 13%. Locoregional failures occurred in 5 (17.7%)patients. Distant metastases were detected in 15 (63.6%) patients. In 8 (28.6%) patients, distant metastases occurredsimultaneously with local relapse. Neither of the treatment methods after disease recurrence significantlyextended the survival of patients (p = 0.82). Patients’ age was the sole prognostic factor which has a statisticallysignificant impact on DFS. On the other hand an adverse affect on overall survival was demonstrated for thevariable of the time of disease recurrence. In the group of patients in whom the recurrence was demonstratedearlier than 6 months after treatment termination the OS was significantly shorter (p = 0.001). Conclusions: Distant metastases are the main cause of failures of patients’ treatment for endometrioidendometrial cancer. Neither of the treatment methods after disease recurrence significantly extended the survivalof patients. Shorter time to disease recurrence is a negative prognostic factor with reference to overallsurvival. |
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In case of onset of disease recurrence, salvage treatment frequently proves ineffective, which is connected with a highpercent of deaths in this group of patients. The aim was to evaluate the causes of treatment failure in patients with endometrial cancer treated withpostoperative radiotherapy. Material and methods: Twenty-eight patients aged between 49 and 84 years were enrolled in the study,in whom for the period from 2002 until 2004 postoperative radiotherapy was applied, and in whom during theperiod of five years after treatment termination disease recurrence was observed. Results: In the analyzed group of patients the 2- and 4-year disease-free survival (DFS) was 41% and 11%respectively. The 2- and 5-year overall survival (OS) was 67% and 13%. Locoregional failures occurred in 5 (17.7%)patients. Distant metastases were detected in 15 (63.6%) patients. In 8 (28.6%) patients, distant metastases occurredsimultaneously with local relapse. Neither of the treatment methods after disease recurrence significantlyextended the survival of patients (p = 0.82). Patients’ age was the sole prognostic factor which has a statisticallysignificant impact on DFS. On the other hand an adverse affect on overall survival was demonstrated for thevariable of the time of disease recurrence. In the group of patients in whom the recurrence was demonstratedearlier than 6 months after treatment termination the OS was significantly shorter (p = 0.001). Conclusions: Distant metastases are the main cause of failures of patients’ treatment for endometrioidendometrial cancer. Neither of the treatment methods after disease recurrence significantly extended the survivalof patients. 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