Circulating Tumor Cell Clusters: United We Stand Divided We Fall

The presence of circulating tumor cells (CTCs) and CTC clusters, also known as tumor microemboli, in biological fluids has long been described. Intensive research on single CTCs has made a significant contribution in understanding tumor invasion, metastasis tropism, and intra-tumor heterogeneity. Mo...
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Autor*in:	Samuel Amintas [verfasserIn] Aurélie Bedel [verfasserIn] François Moreau-Gaudry [verfasserIn] Julian Boutin [verfasserIn] Louis Buscail [verfasserIn] Jean-Philippe Merlio [verfasserIn] Véronique Vendrely [verfasserIn] Sandrine Dabernat [verfasserIn] Etienne Buscail [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	liquid biopsy circulating tumor cells clusters circulating tumor cells CTC microemboli

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 21(2020), 7, p 2653
Übergeordnetes Werk:	volume:21 ; year:2020 ; number:7, p 2653

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijms21072653

Katalog-ID:	DOAJ037710486

Internformat


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allfields	10.3390/ijms21072653 doi (DE-627)DOAJ037710486 (DE-599)DOAJb55b9e906f8a4afeb112aaf0eade84ad DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Samuel Amintas verfasserin aut Circulating Tumor Cell Clusters: United We Stand Divided We Fall 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The presence of circulating tumor cells (CTCs) and CTC clusters, also known as tumor microemboli, in biological fluids has long been described. Intensive research on single CTCs has made a significant contribution in understanding tumor invasion, metastasis tropism, and intra-tumor heterogeneity. Moreover, their being minimally invasive biomarkers has positioned them for diagnosis, prognosis, and recurrence monitoring tools. Initially, CTC clusters were out of focus, but major recent advances in the knowledge of their biogenesis and dissemination reposition them as critical actors in the pathophysiology of cancer, especially metastasis. Increasing evidence suggests that “united” CTCs, organized in clusters, resist better and carry stronger metastatic capacities than “divided” single CTCs. This review gathers recent insight on CTC cluster origin and dissemination. We will focus on their distinct molecular package necessary to resist multiple cell deaths that all circulating cells normally face. We will describe the molecular basis of their increased metastatic potential as compared to single CTCs. We will consider their clinical relevance as prognostic biomarkers. Finally, we will propose future directions for research and clinical applications in this promising topic in cancer. liquid biopsy circulating tumor cells clusters circulating tumor cells CTC microemboli Biology (General) Chemistry Aurélie Bedel verfasserin aut François Moreau-Gaudry verfasserin aut Julian Boutin verfasserin aut Louis Buscail verfasserin aut Jean-Philippe Merlio verfasserin aut Véronique Vendrely verfasserin aut Sandrine Dabernat verfasserin aut Etienne Buscail verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 21(2020), 7, p 2653 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:21 year:2020 number:7, p 2653 https://doi.org/10.3390/ijms21072653 kostenfrei https://doaj.org/article/b55b9e906f8a4afeb112aaf0eade84ad kostenfrei https://www.mdpi.com/1422-0067/21/7/2653 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2020 7, p 2653
spelling	10.3390/ijms21072653 doi (DE-627)DOAJ037710486 (DE-599)DOAJb55b9e906f8a4afeb112aaf0eade84ad DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Samuel Amintas verfasserin aut Circulating Tumor Cell Clusters: United We Stand Divided We Fall 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The presence of circulating tumor cells (CTCs) and CTC clusters, also known as tumor microemboli, in biological fluids has long been described. Intensive research on single CTCs has made a significant contribution in understanding tumor invasion, metastasis tropism, and intra-tumor heterogeneity. Moreover, their being minimally invasive biomarkers has positioned them for diagnosis, prognosis, and recurrence monitoring tools. Initially, CTC clusters were out of focus, but major recent advances in the knowledge of their biogenesis and dissemination reposition them as critical actors in the pathophysiology of cancer, especially metastasis. Increasing evidence suggests that “united” CTCs, organized in clusters, resist better and carry stronger metastatic capacities than “divided” single CTCs. This review gathers recent insight on CTC cluster origin and dissemination. We will focus on their distinct molecular package necessary to resist multiple cell deaths that all circulating cells normally face. We will describe the molecular basis of their increased metastatic potential as compared to single CTCs. We will consider their clinical relevance as prognostic biomarkers. Finally, we will propose future directions for research and clinical applications in this promising topic in cancer. liquid biopsy circulating tumor cells clusters circulating tumor cells CTC microemboli Biology (General) Chemistry Aurélie Bedel verfasserin aut François Moreau-Gaudry verfasserin aut Julian Boutin verfasserin aut Louis Buscail verfasserin aut Jean-Philippe Merlio verfasserin aut Véronique Vendrely verfasserin aut Sandrine Dabernat verfasserin aut Etienne Buscail verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 21(2020), 7, p 2653 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:21 year:2020 number:7, p 2653 https://doi.org/10.3390/ijms21072653 kostenfrei https://doaj.org/article/b55b9e906f8a4afeb112aaf0eade84ad kostenfrei https://www.mdpi.com/1422-0067/21/7/2653 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2020 7, p 2653
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allfieldsGer	10.3390/ijms21072653 doi (DE-627)DOAJ037710486 (DE-599)DOAJb55b9e906f8a4afeb112aaf0eade84ad DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Samuel Amintas verfasserin aut Circulating Tumor Cell Clusters: United We Stand Divided We Fall 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The presence of circulating tumor cells (CTCs) and CTC clusters, also known as tumor microemboli, in biological fluids has long been described. Intensive research on single CTCs has made a significant contribution in understanding tumor invasion, metastasis tropism, and intra-tumor heterogeneity. Moreover, their being minimally invasive biomarkers has positioned them for diagnosis, prognosis, and recurrence monitoring tools. Initially, CTC clusters were out of focus, but major recent advances in the knowledge of their biogenesis and dissemination reposition them as critical actors in the pathophysiology of cancer, especially metastasis. Increasing evidence suggests that “united” CTCs, organized in clusters, resist better and carry stronger metastatic capacities than “divided” single CTCs. This review gathers recent insight on CTC cluster origin and dissemination. We will focus on their distinct molecular package necessary to resist multiple cell deaths that all circulating cells normally face. We will describe the molecular basis of their increased metastatic potential as compared to single CTCs. We will consider their clinical relevance as prognostic biomarkers. Finally, we will propose future directions for research and clinical applications in this promising topic in cancer. liquid biopsy circulating tumor cells clusters circulating tumor cells CTC microemboli Biology (General) Chemistry Aurélie Bedel verfasserin aut François Moreau-Gaudry verfasserin aut Julian Boutin verfasserin aut Louis Buscail verfasserin aut Jean-Philippe Merlio verfasserin aut Véronique Vendrely verfasserin aut Sandrine Dabernat verfasserin aut Etienne Buscail verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 21(2020), 7, p 2653 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:21 year:2020 number:7, p 2653 https://doi.org/10.3390/ijms21072653 kostenfrei https://doaj.org/article/b55b9e906f8a4afeb112aaf0eade84ad kostenfrei https://www.mdpi.com/1422-0067/21/7/2653 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2020 7, p 2653
allfieldsSound	10.3390/ijms21072653 doi (DE-627)DOAJ037710486 (DE-599)DOAJb55b9e906f8a4afeb112aaf0eade84ad DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Samuel Amintas verfasserin aut Circulating Tumor Cell Clusters: United We Stand Divided We Fall 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The presence of circulating tumor cells (CTCs) and CTC clusters, also known as tumor microemboli, in biological fluids has long been described. Intensive research on single CTCs has made a significant contribution in understanding tumor invasion, metastasis tropism, and intra-tumor heterogeneity. Moreover, their being minimally invasive biomarkers has positioned them for diagnosis, prognosis, and recurrence monitoring tools. Initially, CTC clusters were out of focus, but major recent advances in the knowledge of their biogenesis and dissemination reposition them as critical actors in the pathophysiology of cancer, especially metastasis. Increasing evidence suggests that “united” CTCs, organized in clusters, resist better and carry stronger metastatic capacities than “divided” single CTCs. This review gathers recent insight on CTC cluster origin and dissemination. We will focus on their distinct molecular package necessary to resist multiple cell deaths that all circulating cells normally face. We will describe the molecular basis of their increased metastatic potential as compared to single CTCs. We will consider their clinical relevance as prognostic biomarkers. Finally, we will propose future directions for research and clinical applications in this promising topic in cancer. liquid biopsy circulating tumor cells clusters circulating tumor cells CTC microemboli Biology (General) Chemistry Aurélie Bedel verfasserin aut François Moreau-Gaudry verfasserin aut Julian Boutin verfasserin aut Louis Buscail verfasserin aut Jean-Philippe Merlio verfasserin aut Véronique Vendrely verfasserin aut Sandrine Dabernat verfasserin aut Etienne Buscail verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 21(2020), 7, p 2653 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:21 year:2020 number:7, p 2653 https://doi.org/10.3390/ijms21072653 kostenfrei https://doaj.org/article/b55b9e906f8a4afeb112aaf0eade84ad kostenfrei https://www.mdpi.com/1422-0067/21/7/2653 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2020 7, p 2653
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source	In International Journal of Molecular Sciences 21(2020), 7, p 2653 volume:21 year:2020 number:7, p 2653
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authorswithroles_txt_mv	Samuel Amintas @@aut@@ Aurélie Bedel @@aut@@ François Moreau-Gaudry @@aut@@ Julian Boutin @@aut@@ Louis Buscail @@aut@@ Jean-Philippe Merlio @@aut@@ Véronique Vendrely @@aut@@ Sandrine Dabernat @@aut@@ Etienne Buscail @@aut@@
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callnumber-first	Q - Science
author	Samuel Amintas
spellingShingle	Samuel Amintas misc QH301-705.5 misc QD1-999 misc liquid biopsy misc circulating tumor cells clusters misc circulating tumor cells misc CTC misc microemboli misc Biology (General) misc Chemistry Circulating Tumor Cell Clusters: United We Stand Divided We Fall
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topic_title	QH301-705.5 QD1-999 Circulating Tumor Cell Clusters: United We Stand Divided We Fall liquid biopsy circulating tumor cells clusters circulating tumor cells CTC microemboli
topic	misc QH301-705.5 misc QD1-999 misc liquid biopsy misc circulating tumor cells clusters misc circulating tumor cells misc CTC misc microemboli misc Biology (General) misc Chemistry
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title	Circulating Tumor Cell Clusters: United We Stand Divided We Fall
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title_sort	circulating tumor cell clusters: united we stand divided we fall
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title_auth	Circulating Tumor Cell Clusters: United We Stand Divided We Fall
abstract	The presence of circulating tumor cells (CTCs) and CTC clusters, also known as tumor microemboli, in biological fluids has long been described. Intensive research on single CTCs has made a significant contribution in understanding tumor invasion, metastasis tropism, and intra-tumor heterogeneity. Moreover, their being minimally invasive biomarkers has positioned them for diagnosis, prognosis, and recurrence monitoring tools. Initially, CTC clusters were out of focus, but major recent advances in the knowledge of their biogenesis and dissemination reposition them as critical actors in the pathophysiology of cancer, especially metastasis. Increasing evidence suggests that “united” CTCs, organized in clusters, resist better and carry stronger metastatic capacities than “divided” single CTCs. This review gathers recent insight on CTC cluster origin and dissemination. We will focus on their distinct molecular package necessary to resist multiple cell deaths that all circulating cells normally face. We will describe the molecular basis of their increased metastatic potential as compared to single CTCs. We will consider their clinical relevance as prognostic biomarkers. Finally, we will propose future directions for research and clinical applications in this promising topic in cancer.
abstractGer	The presence of circulating tumor cells (CTCs) and CTC clusters, also known as tumor microemboli, in biological fluids has long been described. Intensive research on single CTCs has made a significant contribution in understanding tumor invasion, metastasis tropism, and intra-tumor heterogeneity. Moreover, their being minimally invasive biomarkers has positioned them for diagnosis, prognosis, and recurrence monitoring tools. Initially, CTC clusters were out of focus, but major recent advances in the knowledge of their biogenesis and dissemination reposition them as critical actors in the pathophysiology of cancer, especially metastasis. Increasing evidence suggests that “united” CTCs, organized in clusters, resist better and carry stronger metastatic capacities than “divided” single CTCs. This review gathers recent insight on CTC cluster origin and dissemination. We will focus on their distinct molecular package necessary to resist multiple cell deaths that all circulating cells normally face. We will describe the molecular basis of their increased metastatic potential as compared to single CTCs. We will consider their clinical relevance as prognostic biomarkers. Finally, we will propose future directions for research and clinical applications in this promising topic in cancer.
abstract_unstemmed	The presence of circulating tumor cells (CTCs) and CTC clusters, also known as tumor microemboli, in biological fluids has long been described. Intensive research on single CTCs has made a significant contribution in understanding tumor invasion, metastasis tropism, and intra-tumor heterogeneity. Moreover, their being minimally invasive biomarkers has positioned them for diagnosis, prognosis, and recurrence monitoring tools. Initially, CTC clusters were out of focus, but major recent advances in the knowledge of their biogenesis and dissemination reposition them as critical actors in the pathophysiology of cancer, especially metastasis. Increasing evidence suggests that “united” CTCs, organized in clusters, resist better and carry stronger metastatic capacities than “divided” single CTCs. This review gathers recent insight on CTC cluster origin and dissemination. We will focus on their distinct molecular package necessary to resist multiple cell deaths that all circulating cells normally face. We will describe the molecular basis of their increased metastatic potential as compared to single CTCs. We will consider their clinical relevance as prognostic biomarkers. Finally, we will propose future directions for research and clinical applications in this promising topic in cancer.
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title_short	Circulating Tumor Cell Clusters: United We Stand Divided We Fall
url	https://doi.org/10.3390/ijms21072653 https://doaj.org/article/b55b9e906f8a4afeb112aaf0eade84ad https://www.mdpi.com/1422-0067/21/7/2653 https://doaj.org/toc/1661-6596 https://doaj.org/toc/1422-0067
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up_date	2024-07-03T13:40:22.198Z
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