Effect of Methylphenidate on Orthodontic Tooth Movement and Histological Features of Bone Tissue in Rats: An Experimental Study

Introduction: Methylphenidate is a psychostimulant drug, which is commonly used by children and teenagers. This age group receives most orthodontic treatment. Effect of this drug on tooth movement is unknown. Aim: The aim of this study was to evaluate the effect of methylphenidate on orthodontic too...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Hossein Aghili [verfasserIn] Soghra Yassaei [verfasserIn] Shokouh Taghipour Zahir [verfasserIn] Rahele Arjmandi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	osteoclast psychostimulant drug ritalin

Übergeordnetes Werk:	In: Journal of Clinical and Diagnostic Research - JCDR Research and Publications Private Limited, 2009, 11(2017), 7, Seite ZF01-ZF05
Übergeordnetes Werk:	volume:11 ; year:2017 ; number:7 ; pages:ZF01-ZF05

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.7860/JCDR/2017/26217.10169

Katalog-ID:	DOAJ037742841

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spelling	10.7860/JCDR/2017/26217.10169 doi (DE-627)DOAJ037742841 (DE-599)DOAJe08e8aa6f90148d0a55a085512e29543 DE-627 ger DE-627 rakwb eng Hossein Aghili verfasserin aut Effect of Methylphenidate on Orthodontic Tooth Movement and Histological Features of Bone Tissue in Rats: An Experimental Study 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Methylphenidate is a psychostimulant drug, which is commonly used by children and teenagers. This age group receives most orthodontic treatment. Effect of this drug on tooth movement is unknown. Aim: The aim of this study was to evaluate the effect of methylphenidate on orthodontic tooth movement and histological features of bone tissue in rats. Materials and Methods: Forty-two Wistar rats (male) were selected and divided to three groups, randomly (n=14). The control group (Group 1) received no drug, the experimental Group 2 received a constant dose of methylphenidate daily for 14 days while the experimental Group 3 received increasing doses of methylphenidate daily. To exert force, a NiTi coil spring was placed between the maxillary right first molar and the maxillary right central incisor. At the end of the study period, the amount of tooth movement was measured and then the rats were sacrificed for histological analysis of bone tissue. Differences between the experimental groups were analysed using Kruskal-wallis and Mann–Whitney U tests. Results: No significant differences were found in the amount of orthodontic tooth movement or osteoclasts and lacunae, between the experimental groups (p<0.05). Mann–Whitney U analysis showed significant differences in the depth of resorption lacuna between Group 2 and 3 (p=0.037). Conclusion: Methylphenidate has no significant effect on orthodontic tooth movement or histological features of bone tissue in rats. osteoclast psychostimulant drug ritalin Medicine R Soghra Yassaei verfasserin aut Shokouh Taghipour Zahir verfasserin aut Rahele Arjmandi verfasserin aut In Journal of Clinical and Diagnostic Research JCDR Research and Publications Private Limited, 2009 11(2017), 7, Seite ZF01-ZF05 (DE-627)789478048 (DE-600)2775283-5 0973709X nnns volume:11 year:2017 number:7 pages:ZF01-ZF05 https://doi.org/10.7860/JCDR/2017/26217.10169 kostenfrei https://doaj.org/article/e08e8aa6f90148d0a55a085512e29543 kostenfrei https://jcdr.net/articles/PDF/10169/26217_CE[Ra1]_F(GH)_PF1(SY_SS)_PFA(RU_SY).pdf kostenfrei https://doaj.org/toc/2249-782X Journal toc kostenfrei https://doaj.org/toc/0973-709X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2017 7 ZF01-ZF05
allfields_unstemmed	10.7860/JCDR/2017/26217.10169 doi (DE-627)DOAJ037742841 (DE-599)DOAJe08e8aa6f90148d0a55a085512e29543 DE-627 ger DE-627 rakwb eng Hossein Aghili verfasserin aut Effect of Methylphenidate on Orthodontic Tooth Movement and Histological Features of Bone Tissue in Rats: An Experimental Study 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Methylphenidate is a psychostimulant drug, which is commonly used by children and teenagers. This age group receives most orthodontic treatment. Effect of this drug on tooth movement is unknown. Aim: The aim of this study was to evaluate the effect of methylphenidate on orthodontic tooth movement and histological features of bone tissue in rats. Materials and Methods: Forty-two Wistar rats (male) were selected and divided to three groups, randomly (n=14). The control group (Group 1) received no drug, the experimental Group 2 received a constant dose of methylphenidate daily for 14 days while the experimental Group 3 received increasing doses of methylphenidate daily. To exert force, a NiTi coil spring was placed between the maxillary right first molar and the maxillary right central incisor. At the end of the study period, the amount of tooth movement was measured and then the rats were sacrificed for histological analysis of bone tissue. Differences between the experimental groups were analysed using Kruskal-wallis and Mann–Whitney U tests. Results: No significant differences were found in the amount of orthodontic tooth movement or osteoclasts and lacunae, between the experimental groups (p<0.05). Mann–Whitney U analysis showed significant differences in the depth of resorption lacuna between Group 2 and 3 (p=0.037). Conclusion: Methylphenidate has no significant effect on orthodontic tooth movement or histological features of bone tissue in rats. osteoclast psychostimulant drug ritalin Medicine R Soghra Yassaei verfasserin aut Shokouh Taghipour Zahir verfasserin aut Rahele Arjmandi verfasserin aut In Journal of Clinical and Diagnostic Research JCDR Research and Publications Private Limited, 2009 11(2017), 7, Seite ZF01-ZF05 (DE-627)789478048 (DE-600)2775283-5 0973709X nnns volume:11 year:2017 number:7 pages:ZF01-ZF05 https://doi.org/10.7860/JCDR/2017/26217.10169 kostenfrei https://doaj.org/article/e08e8aa6f90148d0a55a085512e29543 kostenfrei https://jcdr.net/articles/PDF/10169/26217_CE[Ra1]_F(GH)_PF1(SY_SS)_PFA(RU_SY).pdf kostenfrei https://doaj.org/toc/2249-782X Journal toc kostenfrei https://doaj.org/toc/0973-709X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2017 7 ZF01-ZF05
allfieldsGer	10.7860/JCDR/2017/26217.10169 doi (DE-627)DOAJ037742841 (DE-599)DOAJe08e8aa6f90148d0a55a085512e29543 DE-627 ger DE-627 rakwb eng Hossein Aghili verfasserin aut Effect of Methylphenidate on Orthodontic Tooth Movement and Histological Features of Bone Tissue in Rats: An Experimental Study 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Methylphenidate is a psychostimulant drug, which is commonly used by children and teenagers. This age group receives most orthodontic treatment. Effect of this drug on tooth movement is unknown. Aim: The aim of this study was to evaluate the effect of methylphenidate on orthodontic tooth movement and histological features of bone tissue in rats. Materials and Methods: Forty-two Wistar rats (male) were selected and divided to three groups, randomly (n=14). The control group (Group 1) received no drug, the experimental Group 2 received a constant dose of methylphenidate daily for 14 days while the experimental Group 3 received increasing doses of methylphenidate daily. To exert force, a NiTi coil spring was placed between the maxillary right first molar and the maxillary right central incisor. At the end of the study period, the amount of tooth movement was measured and then the rats were sacrificed for histological analysis of bone tissue. Differences between the experimental groups were analysed using Kruskal-wallis and Mann–Whitney U tests. Results: No significant differences were found in the amount of orthodontic tooth movement or osteoclasts and lacunae, between the experimental groups (p<0.05). Mann–Whitney U analysis showed significant differences in the depth of resorption lacuna between Group 2 and 3 (p=0.037). Conclusion: Methylphenidate has no significant effect on orthodontic tooth movement or histological features of bone tissue in rats. osteoclast psychostimulant drug ritalin Medicine R Soghra Yassaei verfasserin aut Shokouh Taghipour Zahir verfasserin aut Rahele Arjmandi verfasserin aut In Journal of Clinical and Diagnostic Research JCDR Research and Publications Private Limited, 2009 11(2017), 7, Seite ZF01-ZF05 (DE-627)789478048 (DE-600)2775283-5 0973709X nnns volume:11 year:2017 number:7 pages:ZF01-ZF05 https://doi.org/10.7860/JCDR/2017/26217.10169 kostenfrei https://doaj.org/article/e08e8aa6f90148d0a55a085512e29543 kostenfrei https://jcdr.net/articles/PDF/10169/26217_CE[Ra1]_F(GH)_PF1(SY_SS)_PFA(RU_SY).pdf kostenfrei https://doaj.org/toc/2249-782X Journal toc kostenfrei https://doaj.org/toc/0973-709X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2017 7 ZF01-ZF05
allfieldsSound	10.7860/JCDR/2017/26217.10169 doi (DE-627)DOAJ037742841 (DE-599)DOAJe08e8aa6f90148d0a55a085512e29543 DE-627 ger DE-627 rakwb eng Hossein Aghili verfasserin aut Effect of Methylphenidate on Orthodontic Tooth Movement and Histological Features of Bone Tissue in Rats: An Experimental Study 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Methylphenidate is a psychostimulant drug, which is commonly used by children and teenagers. This age group receives most orthodontic treatment. Effect of this drug on tooth movement is unknown. Aim: The aim of this study was to evaluate the effect of methylphenidate on orthodontic tooth movement and histological features of bone tissue in rats. Materials and Methods: Forty-two Wistar rats (male) were selected and divided to three groups, randomly (n=14). The control group (Group 1) received no drug, the experimental Group 2 received a constant dose of methylphenidate daily for 14 days while the experimental Group 3 received increasing doses of methylphenidate daily. To exert force, a NiTi coil spring was placed between the maxillary right first molar and the maxillary right central incisor. At the end of the study period, the amount of tooth movement was measured and then the rats were sacrificed for histological analysis of bone tissue. Differences between the experimental groups were analysed using Kruskal-wallis and Mann–Whitney U tests. Results: No significant differences were found in the amount of orthodontic tooth movement or osteoclasts and lacunae, between the experimental groups (p<0.05). Mann–Whitney U analysis showed significant differences in the depth of resorption lacuna between Group 2 and 3 (p=0.037). Conclusion: Methylphenidate has no significant effect on orthodontic tooth movement or histological features of bone tissue in rats. osteoclast psychostimulant drug ritalin Medicine R Soghra Yassaei verfasserin aut Shokouh Taghipour Zahir verfasserin aut Rahele Arjmandi verfasserin aut In Journal of Clinical and Diagnostic Research JCDR Research and Publications Private Limited, 2009 11(2017), 7, Seite ZF01-ZF05 (DE-627)789478048 (DE-600)2775283-5 0973709X nnns volume:11 year:2017 number:7 pages:ZF01-ZF05 https://doi.org/10.7860/JCDR/2017/26217.10169 kostenfrei https://doaj.org/article/e08e8aa6f90148d0a55a085512e29543 kostenfrei https://jcdr.net/articles/PDF/10169/26217_CE[Ra1]_F(GH)_PF1(SY_SS)_PFA(RU_SY).pdf kostenfrei https://doaj.org/toc/2249-782X Journal toc kostenfrei https://doaj.org/toc/0973-709X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2017 7 ZF01-ZF05
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This age group receives most orthodontic treatment. Effect of this drug on tooth movement is unknown. Aim: The aim of this study was to evaluate the effect of methylphenidate on orthodontic tooth movement and histological features of bone tissue in rats. Materials and Methods: Forty-two Wistar rats (male) were selected and divided to three groups, randomly (n=14). The control group (Group 1) received no drug, the experimental Group 2 received a constant dose of methylphenidate daily for 14 days while the experimental Group 3 received increasing doses of methylphenidate daily. To exert force, a NiTi coil spring was placed between the maxillary right first molar and the maxillary right central incisor. At the end of the study period, the amount of tooth movement was measured and then the rats were sacrificed for histological analysis of bone tissue. Differences between the experimental groups were analysed using Kruskal-wallis and Mann–Whitney U tests. Results: No significant differences were found in the amount of orthodontic tooth movement or osteoclasts and lacunae, between the experimental groups (p<0.05). Mann–Whitney U analysis showed significant differences in the depth of resorption lacuna between Group 2 and 3 (p=0.037). 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author	Hossein Aghili
spellingShingle	Hossein Aghili misc osteoclast misc psychostimulant drug misc ritalin misc Medicine misc R Effect of Methylphenidate on Orthodontic Tooth Movement and Histological Features of Bone Tissue in Rats: An Experimental Study
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topic_title	Effect of Methylphenidate on Orthodontic Tooth Movement and Histological Features of Bone Tissue in Rats: An Experimental Study osteoclast psychostimulant drug ritalin
topic	misc osteoclast misc psychostimulant drug misc ritalin misc Medicine misc R
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title	Effect of Methylphenidate on Orthodontic Tooth Movement and Histological Features of Bone Tissue in Rats: An Experimental Study
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title_full	Effect of Methylphenidate on Orthodontic Tooth Movement and Histological Features of Bone Tissue in Rats: An Experimental Study
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author_browse	Hossein Aghili Soghra Yassaei Shokouh Taghipour Zahir Rahele Arjmandi
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title_sort	effect of methylphenidate on orthodontic tooth movement and histological features of bone tissue in rats: an experimental study
title_auth	Effect of Methylphenidate on Orthodontic Tooth Movement and Histological Features of Bone Tissue in Rats: An Experimental Study
abstract	Introduction: Methylphenidate is a psychostimulant drug, which is commonly used by children and teenagers. This age group receives most orthodontic treatment. Effect of this drug on tooth movement is unknown. Aim: The aim of this study was to evaluate the effect of methylphenidate on orthodontic tooth movement and histological features of bone tissue in rats. Materials and Methods: Forty-two Wistar rats (male) were selected and divided to three groups, randomly (n=14). The control group (Group 1) received no drug, the experimental Group 2 received a constant dose of methylphenidate daily for 14 days while the experimental Group 3 received increasing doses of methylphenidate daily. To exert force, a NiTi coil spring was placed between the maxillary right first molar and the maxillary right central incisor. At the end of the study period, the amount of tooth movement was measured and then the rats were sacrificed for histological analysis of bone tissue. Differences between the experimental groups were analysed using Kruskal-wallis and Mann–Whitney U tests. Results: No significant differences were found in the amount of orthodontic tooth movement or osteoclasts and lacunae, between the experimental groups (p<0.05). Mann–Whitney U analysis showed significant differences in the depth of resorption lacuna between Group 2 and 3 (p=0.037). Conclusion: Methylphenidate has no significant effect on orthodontic tooth movement or histological features of bone tissue in rats.
abstractGer	Introduction: Methylphenidate is a psychostimulant drug, which is commonly used by children and teenagers. This age group receives most orthodontic treatment. Effect of this drug on tooth movement is unknown. Aim: The aim of this study was to evaluate the effect of methylphenidate on orthodontic tooth movement and histological features of bone tissue in rats. Materials and Methods: Forty-two Wistar rats (male) were selected and divided to three groups, randomly (n=14). The control group (Group 1) received no drug, the experimental Group 2 received a constant dose of methylphenidate daily for 14 days while the experimental Group 3 received increasing doses of methylphenidate daily. To exert force, a NiTi coil spring was placed between the maxillary right first molar and the maxillary right central incisor. At the end of the study period, the amount of tooth movement was measured and then the rats were sacrificed for histological analysis of bone tissue. Differences between the experimental groups were analysed using Kruskal-wallis and Mann–Whitney U tests. Results: No significant differences were found in the amount of orthodontic tooth movement or osteoclasts and lacunae, between the experimental groups (p<0.05). Mann–Whitney U analysis showed significant differences in the depth of resorption lacuna between Group 2 and 3 (p=0.037). Conclusion: Methylphenidate has no significant effect on orthodontic tooth movement or histological features of bone tissue in rats.
abstract_unstemmed	Introduction: Methylphenidate is a psychostimulant drug, which is commonly used by children and teenagers. This age group receives most orthodontic treatment. Effect of this drug on tooth movement is unknown. Aim: The aim of this study was to evaluate the effect of methylphenidate on orthodontic tooth movement and histological features of bone tissue in rats. Materials and Methods: Forty-two Wistar rats (male) were selected and divided to three groups, randomly (n=14). The control group (Group 1) received no drug, the experimental Group 2 received a constant dose of methylphenidate daily for 14 days while the experimental Group 3 received increasing doses of methylphenidate daily. To exert force, a NiTi coil spring was placed between the maxillary right first molar and the maxillary right central incisor. At the end of the study period, the amount of tooth movement was measured and then the rats were sacrificed for histological analysis of bone tissue. Differences between the experimental groups were analysed using Kruskal-wallis and Mann–Whitney U tests. Results: No significant differences were found in the amount of orthodontic tooth movement or osteoclasts and lacunae, between the experimental groups (p<0.05). Mann–Whitney U analysis showed significant differences in the depth of resorption lacuna between Group 2 and 3 (p=0.037). Conclusion: Methylphenidate has no significant effect on orthodontic tooth movement or histological features of bone tissue in rats.
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title_short	Effect of Methylphenidate on Orthodontic Tooth Movement and Histological Features of Bone Tissue in Rats: An Experimental Study
url	https://doi.org/10.7860/JCDR/2017/26217.10169 https://doaj.org/article/e08e8aa6f90148d0a55a085512e29543 https://jcdr.net/articles/PDF/10169/26217_CE[Ra1]_F(GH)_PF1(SY_SS)_PFA(RU_SY).pdf https://doaj.org/toc/2249-782X https://doaj.org/toc/0973-709X
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author2	Soghra Yassaei Shokouh Taghipour Zahir Rahele Arjmandi
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up_date	2024-07-03T13:51:46.193Z
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Effect of Methylphenidate on Orthodontic Tooth Movement and Histological Features of Bone Tissue in Rats: An Experimental Study

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