First-in-man intravenous implantation of stromal vascular fraction in psoriasis: a case study
Kristin Comella,1 Michelle Parlo,2 Rosemary Daly,2 Kellie Dominessy2 1US Stem Cell, Inc., Sunrise, FL, USA; 2US Stem Cell Clinic, Sunrise, FL, USA Background: Stromal vascular fraction (SVF) is a mixture of adipose-derived stem cells/mesenchymal stem cells, endothelial/progenitors, pericytes, fibro...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Comella K [verfasserIn] Parlo M [verfasserIn] Daly R [verfasserIn] Dominessy K [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2018 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: International Medical Case Reports Journal - Dove Medical Press, 2009, (2018), Seite 59-64 |
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| Übergeordnetes Werk: |
year:2018 ; pages:59-64 |
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DOAJ037774956 |
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| 520 | |a Kristin Comella,1 Michelle Parlo,2 Rosemary Daly,2 Kellie Dominessy2 1US Stem Cell, Inc., Sunrise, FL, USA; 2US Stem Cell Clinic, Sunrise, FL, USA Background: Stromal vascular fraction (SVF) is a mixture of adipose-derived stem cells/mesenchymal stem cells, endothelial/progenitors, pericytes, fibroblasts, and other cells obtained from fat tissue. A small sample of fat or adipose tissue can be obtained under local anesthesia using a cannula. After an enzymatic digestion and centrifugation, the adipocytes (fat cells) are removed to obtain an SVF. Here, we describe the rationale and, to our knowledge, the first clinical implementation of SVF intravenously in a patient with severe psoriasis. Methods: Adipose tissue (60 mL) was collected under local anesthesia via a mini-lipoaspirate procedure. The SVF was separated from the adipocytes via centrifugation after an enzymatic digestion. The cells were resuspended in normal saline and injected via bolus push intravenous. The subject was monitored over a period of 12 months for safety (adverse events), medication changes, and quality of life parameters. Results: The patient did not report any safety concerns and did not experience any severe adverse events. The patient demonstrated a significant decrease in symptoms with a noticeable difference in skin quality appearance. Psoriasis area and severity index score went from 50.4 at baseline to 0.3 at 1 month follow-up. Conclusion: Overall, the patient reported improved quality of life and willingness to continue treatments. This successful initial case study demonstrates that this may be a feasible treatment plan for patients suffering from psoriasis. Keywords: adipose tissue, adipose-derived stromal/stem cells, autoimmune disease, cell therapy, mesenchymal stem cells, psoriasis, stem cells, stromal vascular fraction | ||
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(DE-627)DOAJ037774956 (DE-599)DOAJa8762de1f98b46948b997ccf3c705609 DE-627 ger DE-627 rakwb eng R5-920 Comella K verfasserin aut First-in-man intravenous implantation of stromal vascular fraction in psoriasis: a case study 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Kristin Comella,1 Michelle Parlo,2 Rosemary Daly,2 Kellie Dominessy2 1US Stem Cell, Inc., Sunrise, FL, USA; 2US Stem Cell Clinic, Sunrise, FL, USA Background: Stromal vascular fraction (SVF) is a mixture of adipose-derived stem cells/mesenchymal stem cells, endothelial/progenitors, pericytes, fibroblasts, and other cells obtained from fat tissue. A small sample of fat or adipose tissue can be obtained under local anesthesia using a cannula. After an enzymatic digestion and centrifugation, the adipocytes (fat cells) are removed to obtain an SVF. Here, we describe the rationale and, to our knowledge, the first clinical implementation of SVF intravenously in a patient with severe psoriasis. Methods: Adipose tissue (60 mL) was collected under local anesthesia via a mini-lipoaspirate procedure. The SVF was separated from the adipocytes via centrifugation after an enzymatic digestion. The cells were resuspended in normal saline and injected via bolus push intravenous. The subject was monitored over a period of 12 months for safety (adverse events), medication changes, and quality of life parameters. Results: The patient did not report any safety concerns and did not experience any severe adverse events. The patient demonstrated a significant decrease in symptoms with a noticeable difference in skin quality appearance. Psoriasis area and severity index score went from 50.4 at baseline to 0.3 at 1 month follow-up. Conclusion: Overall, the patient reported improved quality of life and willingness to continue treatments. This successful initial case study demonstrates that this may be a feasible treatment plan for patients suffering from psoriasis. Keywords: adipose tissue, adipose-derived stromal/stem cells, autoimmune disease, cell therapy, mesenchymal stem cells, psoriasis, stem cells, stromal vascular fraction adipose tissue adipose derived stromal/stem cells (ADSCs) autoimmune disease cell therapy mesenchymal stem cells (MSCs) psoriasis stem cells stromal vascular fraction (SVF) Medicine (General) Parlo M verfasserin aut Daly R verfasserin aut Dominessy K verfasserin aut In International Medical Case Reports Journal Dove Medical Press, 2009 (2018), Seite 59-64 (DE-627)60030731X (DE-600)2495077-4 1179142X nnns year:2018 pages:59-64 https://doaj.org/article/a8762de1f98b46948b997ccf3c705609 kostenfrei https://www.dovepress.com/first-in-man-intravenous-implantation-of-stromal-vascular-fraction-in--peer-reviewed-article-IMCRJ kostenfrei https://doaj.org/toc/1179-142X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2018 59-64 |
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(DE-627)DOAJ037774956 (DE-599)DOAJa8762de1f98b46948b997ccf3c705609 DE-627 ger DE-627 rakwb eng R5-920 Comella K verfasserin aut First-in-man intravenous implantation of stromal vascular fraction in psoriasis: a case study 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Kristin Comella,1 Michelle Parlo,2 Rosemary Daly,2 Kellie Dominessy2 1US Stem Cell, Inc., Sunrise, FL, USA; 2US Stem Cell Clinic, Sunrise, FL, USA Background: Stromal vascular fraction (SVF) is a mixture of adipose-derived stem cells/mesenchymal stem cells, endothelial/progenitors, pericytes, fibroblasts, and other cells obtained from fat tissue. A small sample of fat or adipose tissue can be obtained under local anesthesia using a cannula. After an enzymatic digestion and centrifugation, the adipocytes (fat cells) are removed to obtain an SVF. Here, we describe the rationale and, to our knowledge, the first clinical implementation of SVF intravenously in a patient with severe psoriasis. Methods: Adipose tissue (60 mL) was collected under local anesthesia via a mini-lipoaspirate procedure. The SVF was separated from the adipocytes via centrifugation after an enzymatic digestion. The cells were resuspended in normal saline and injected via bolus push intravenous. The subject was monitored over a period of 12 months for safety (adverse events), medication changes, and quality of life parameters. Results: The patient did not report any safety concerns and did not experience any severe adverse events. The patient demonstrated a significant decrease in symptoms with a noticeable difference in skin quality appearance. Psoriasis area and severity index score went from 50.4 at baseline to 0.3 at 1 month follow-up. Conclusion: Overall, the patient reported improved quality of life and willingness to continue treatments. This successful initial case study demonstrates that this may be a feasible treatment plan for patients suffering from psoriasis. Keywords: adipose tissue, adipose-derived stromal/stem cells, autoimmune disease, cell therapy, mesenchymal stem cells, psoriasis, stem cells, stromal vascular fraction adipose tissue adipose derived stromal/stem cells (ADSCs) autoimmune disease cell therapy mesenchymal stem cells (MSCs) psoriasis stem cells stromal vascular fraction (SVF) Medicine (General) Parlo M verfasserin aut Daly R verfasserin aut Dominessy K verfasserin aut In International Medical Case Reports Journal Dove Medical Press, 2009 (2018), Seite 59-64 (DE-627)60030731X (DE-600)2495077-4 1179142X nnns year:2018 pages:59-64 https://doaj.org/article/a8762de1f98b46948b997ccf3c705609 kostenfrei https://www.dovepress.com/first-in-man-intravenous-implantation-of-stromal-vascular-fraction-in--peer-reviewed-article-IMCRJ kostenfrei https://doaj.org/toc/1179-142X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2018 59-64 |
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(DE-627)DOAJ037774956 (DE-599)DOAJa8762de1f98b46948b997ccf3c705609 DE-627 ger DE-627 rakwb eng R5-920 Comella K verfasserin aut First-in-man intravenous implantation of stromal vascular fraction in psoriasis: a case study 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Kristin Comella,1 Michelle Parlo,2 Rosemary Daly,2 Kellie Dominessy2 1US Stem Cell, Inc., Sunrise, FL, USA; 2US Stem Cell Clinic, Sunrise, FL, USA Background: Stromal vascular fraction (SVF) is a mixture of adipose-derived stem cells/mesenchymal stem cells, endothelial/progenitors, pericytes, fibroblasts, and other cells obtained from fat tissue. A small sample of fat or adipose tissue can be obtained under local anesthesia using a cannula. After an enzymatic digestion and centrifugation, the adipocytes (fat cells) are removed to obtain an SVF. Here, we describe the rationale and, to our knowledge, the first clinical implementation of SVF intravenously in a patient with severe psoriasis. Methods: Adipose tissue (60 mL) was collected under local anesthesia via a mini-lipoaspirate procedure. The SVF was separated from the adipocytes via centrifugation after an enzymatic digestion. The cells were resuspended in normal saline and injected via bolus push intravenous. The subject was monitored over a period of 12 months for safety (adverse events), medication changes, and quality of life parameters. Results: The patient did not report any safety concerns and did not experience any severe adverse events. The patient demonstrated a significant decrease in symptoms with a noticeable difference in skin quality appearance. Psoriasis area and severity index score went from 50.4 at baseline to 0.3 at 1 month follow-up. Conclusion: Overall, the patient reported improved quality of life and willingness to continue treatments. This successful initial case study demonstrates that this may be a feasible treatment plan for patients suffering from psoriasis. Keywords: adipose tissue, adipose-derived stromal/stem cells, autoimmune disease, cell therapy, mesenchymal stem cells, psoriasis, stem cells, stromal vascular fraction adipose tissue adipose derived stromal/stem cells (ADSCs) autoimmune disease cell therapy mesenchymal stem cells (MSCs) psoriasis stem cells stromal vascular fraction (SVF) Medicine (General) Parlo M verfasserin aut Daly R verfasserin aut Dominessy K verfasserin aut In International Medical Case Reports Journal Dove Medical Press, 2009 (2018), Seite 59-64 (DE-627)60030731X (DE-600)2495077-4 1179142X nnns year:2018 pages:59-64 https://doaj.org/article/a8762de1f98b46948b997ccf3c705609 kostenfrei https://www.dovepress.com/first-in-man-intravenous-implantation-of-stromal-vascular-fraction-in--peer-reviewed-article-IMCRJ kostenfrei https://doaj.org/toc/1179-142X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2018 59-64 |
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(DE-627)DOAJ037774956 (DE-599)DOAJa8762de1f98b46948b997ccf3c705609 DE-627 ger DE-627 rakwb eng R5-920 Comella K verfasserin aut First-in-man intravenous implantation of stromal vascular fraction in psoriasis: a case study 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Kristin Comella,1 Michelle Parlo,2 Rosemary Daly,2 Kellie Dominessy2 1US Stem Cell, Inc., Sunrise, FL, USA; 2US Stem Cell Clinic, Sunrise, FL, USA Background: Stromal vascular fraction (SVF) is a mixture of adipose-derived stem cells/mesenchymal stem cells, endothelial/progenitors, pericytes, fibroblasts, and other cells obtained from fat tissue. A small sample of fat or adipose tissue can be obtained under local anesthesia using a cannula. After an enzymatic digestion and centrifugation, the adipocytes (fat cells) are removed to obtain an SVF. Here, we describe the rationale and, to our knowledge, the first clinical implementation of SVF intravenously in a patient with severe psoriasis. Methods: Adipose tissue (60 mL) was collected under local anesthesia via a mini-lipoaspirate procedure. The SVF was separated from the adipocytes via centrifugation after an enzymatic digestion. The cells were resuspended in normal saline and injected via bolus push intravenous. The subject was monitored over a period of 12 months for safety (adverse events), medication changes, and quality of life parameters. Results: The patient did not report any safety concerns and did not experience any severe adverse events. The patient demonstrated a significant decrease in symptoms with a noticeable difference in skin quality appearance. Psoriasis area and severity index score went from 50.4 at baseline to 0.3 at 1 month follow-up. Conclusion: Overall, the patient reported improved quality of life and willingness to continue treatments. This successful initial case study demonstrates that this may be a feasible treatment plan for patients suffering from psoriasis. Keywords: adipose tissue, adipose-derived stromal/stem cells, autoimmune disease, cell therapy, mesenchymal stem cells, psoriasis, stem cells, stromal vascular fraction adipose tissue adipose derived stromal/stem cells (ADSCs) autoimmune disease cell therapy mesenchymal stem cells (MSCs) psoriasis stem cells stromal vascular fraction (SVF) Medicine (General) Parlo M verfasserin aut Daly R verfasserin aut Dominessy K verfasserin aut In International Medical Case Reports Journal Dove Medical Press, 2009 (2018), Seite 59-64 (DE-627)60030731X (DE-600)2495077-4 1179142X nnns year:2018 pages:59-64 https://doaj.org/article/a8762de1f98b46948b997ccf3c705609 kostenfrei https://www.dovepress.com/first-in-man-intravenous-implantation-of-stromal-vascular-fraction-in--peer-reviewed-article-IMCRJ kostenfrei https://doaj.org/toc/1179-142X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2018 59-64 |
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(DE-627)DOAJ037774956 (DE-599)DOAJa8762de1f98b46948b997ccf3c705609 DE-627 ger DE-627 rakwb eng R5-920 Comella K verfasserin aut First-in-man intravenous implantation of stromal vascular fraction in psoriasis: a case study 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Kristin Comella,1 Michelle Parlo,2 Rosemary Daly,2 Kellie Dominessy2 1US Stem Cell, Inc., Sunrise, FL, USA; 2US Stem Cell Clinic, Sunrise, FL, USA Background: Stromal vascular fraction (SVF) is a mixture of adipose-derived stem cells/mesenchymal stem cells, endothelial/progenitors, pericytes, fibroblasts, and other cells obtained from fat tissue. A small sample of fat or adipose tissue can be obtained under local anesthesia using a cannula. After an enzymatic digestion and centrifugation, the adipocytes (fat cells) are removed to obtain an SVF. Here, we describe the rationale and, to our knowledge, the first clinical implementation of SVF intravenously in a patient with severe psoriasis. Methods: Adipose tissue (60 mL) was collected under local anesthesia via a mini-lipoaspirate procedure. The SVF was separated from the adipocytes via centrifugation after an enzymatic digestion. The cells were resuspended in normal saline and injected via bolus push intravenous. The subject was monitored over a period of 12 months for safety (adverse events), medication changes, and quality of life parameters. Results: The patient did not report any safety concerns and did not experience any severe adverse events. The patient demonstrated a significant decrease in symptoms with a noticeable difference in skin quality appearance. Psoriasis area and severity index score went from 50.4 at baseline to 0.3 at 1 month follow-up. Conclusion: Overall, the patient reported improved quality of life and willingness to continue treatments. This successful initial case study demonstrates that this may be a feasible treatment plan for patients suffering from psoriasis. Keywords: adipose tissue, adipose-derived stromal/stem cells, autoimmune disease, cell therapy, mesenchymal stem cells, psoriasis, stem cells, stromal vascular fraction adipose tissue adipose derived stromal/stem cells (ADSCs) autoimmune disease cell therapy mesenchymal stem cells (MSCs) psoriasis stem cells stromal vascular fraction (SVF) Medicine (General) Parlo M verfasserin aut Daly R verfasserin aut Dominessy K verfasserin aut In International Medical Case Reports Journal Dove Medical Press, 2009 (2018), Seite 59-64 (DE-627)60030731X (DE-600)2495077-4 1179142X nnns year:2018 pages:59-64 https://doaj.org/article/a8762de1f98b46948b997ccf3c705609 kostenfrei https://www.dovepress.com/first-in-man-intravenous-implantation-of-stromal-vascular-fraction-in--peer-reviewed-article-IMCRJ kostenfrei https://doaj.org/toc/1179-142X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2018 59-64 |
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First-in-man intravenous implantation of stromal vascular fraction in psoriasis: a case study |
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Kristin Comella,1 Michelle Parlo,2 Rosemary Daly,2 Kellie Dominessy2 1US Stem Cell, Inc., Sunrise, FL, USA; 2US Stem Cell Clinic, Sunrise, FL, USA Background: Stromal vascular fraction (SVF) is a mixture of adipose-derived stem cells/mesenchymal stem cells, endothelial/progenitors, pericytes, fibroblasts, and other cells obtained from fat tissue. A small sample of fat or adipose tissue can be obtained under local anesthesia using a cannula. After an enzymatic digestion and centrifugation, the adipocytes (fat cells) are removed to obtain an SVF. Here, we describe the rationale and, to our knowledge, the first clinical implementation of SVF intravenously in a patient with severe psoriasis. Methods: Adipose tissue (60 mL) was collected under local anesthesia via a mini-lipoaspirate procedure. The SVF was separated from the adipocytes via centrifugation after an enzymatic digestion. The cells were resuspended in normal saline and injected via bolus push intravenous. The subject was monitored over a period of 12 months for safety (adverse events), medication changes, and quality of life parameters. Results: The patient did not report any safety concerns and did not experience any severe adverse events. The patient demonstrated a significant decrease in symptoms with a noticeable difference in skin quality appearance. Psoriasis area and severity index score went from 50.4 at baseline to 0.3 at 1 month follow-up. Conclusion: Overall, the patient reported improved quality of life and willingness to continue treatments. This successful initial case study demonstrates that this may be a feasible treatment plan for patients suffering from psoriasis. Keywords: adipose tissue, adipose-derived stromal/stem cells, autoimmune disease, cell therapy, mesenchymal stem cells, psoriasis, stem cells, stromal vascular fraction |
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Kristin Comella,1 Michelle Parlo,2 Rosemary Daly,2 Kellie Dominessy2 1US Stem Cell, Inc., Sunrise, FL, USA; 2US Stem Cell Clinic, Sunrise, FL, USA Background: Stromal vascular fraction (SVF) is a mixture of adipose-derived stem cells/mesenchymal stem cells, endothelial/progenitors, pericytes, fibroblasts, and other cells obtained from fat tissue. A small sample of fat or adipose tissue can be obtained under local anesthesia using a cannula. After an enzymatic digestion and centrifugation, the adipocytes (fat cells) are removed to obtain an SVF. Here, we describe the rationale and, to our knowledge, the first clinical implementation of SVF intravenously in a patient with severe psoriasis. Methods: Adipose tissue (60 mL) was collected under local anesthesia via a mini-lipoaspirate procedure. The SVF was separated from the adipocytes via centrifugation after an enzymatic digestion. The cells were resuspended in normal saline and injected via bolus push intravenous. The subject was monitored over a period of 12 months for safety (adverse events), medication changes, and quality of life parameters. Results: The patient did not report any safety concerns and did not experience any severe adverse events. The patient demonstrated a significant decrease in symptoms with a noticeable difference in skin quality appearance. Psoriasis area and severity index score went from 50.4 at baseline to 0.3 at 1 month follow-up. Conclusion: Overall, the patient reported improved quality of life and willingness to continue treatments. This successful initial case study demonstrates that this may be a feasible treatment plan for patients suffering from psoriasis. Keywords: adipose tissue, adipose-derived stromal/stem cells, autoimmune disease, cell therapy, mesenchymal stem cells, psoriasis, stem cells, stromal vascular fraction |
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Kristin Comella,1 Michelle Parlo,2 Rosemary Daly,2 Kellie Dominessy2 1US Stem Cell, Inc., Sunrise, FL, USA; 2US Stem Cell Clinic, Sunrise, FL, USA Background: Stromal vascular fraction (SVF) is a mixture of adipose-derived stem cells/mesenchymal stem cells, endothelial/progenitors, pericytes, fibroblasts, and other cells obtained from fat tissue. A small sample of fat or adipose tissue can be obtained under local anesthesia using a cannula. After an enzymatic digestion and centrifugation, the adipocytes (fat cells) are removed to obtain an SVF. Here, we describe the rationale and, to our knowledge, the first clinical implementation of SVF intravenously in a patient with severe psoriasis. Methods: Adipose tissue (60 mL) was collected under local anesthesia via a mini-lipoaspirate procedure. The SVF was separated from the adipocytes via centrifugation after an enzymatic digestion. The cells were resuspended in normal saline and injected via bolus push intravenous. The subject was monitored over a period of 12 months for safety (adverse events), medication changes, and quality of life parameters. Results: The patient did not report any safety concerns and did not experience any severe adverse events. The patient demonstrated a significant decrease in symptoms with a noticeable difference in skin quality appearance. Psoriasis area and severity index score went from 50.4 at baseline to 0.3 at 1 month follow-up. Conclusion: Overall, the patient reported improved quality of life and willingness to continue treatments. This successful initial case study demonstrates that this may be a feasible treatment plan for patients suffering from psoriasis. Keywords: adipose tissue, adipose-derived stromal/stem cells, autoimmune disease, cell therapy, mesenchymal stem cells, psoriasis, stem cells, stromal vascular fraction |
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Psoriasis area and severity index score went from 50.4 at baseline to 0.3 at 1 month follow-up. Conclusion: Overall, the patient reported improved quality of life and willingness to continue treatments. This successful initial case study demonstrates that this may be a feasible treatment plan for patients suffering from psoriasis. 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