Insulin resistance and the metabolic syndrome are related to the severity of steatosis in the pediatric population with obesity
Background: To determine the factors associated with an increased risk for severe steatosis (SS) and establish the Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) as a screening tool. Methods: A cross-sectional study was performed in obese children to assess the relationship between the me...
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| Autor*in: |
Esther Ubiña-Aznar [verfasserIn] Leopoldo Tapia-Ceballos [verfasserIn] José Miguel Rosales-Zabal [verfasserIn] Rocío Porcel-Chacón [verfasserIn] Francisco Poveda-Gómez [verfasserIn] Carmen Lozano-Calero [verfasserIn] Carmen Ortiz-Cuevas [verfasserIn] Francisco Rivas-Ruiz [verfasserIn] Andrés Sánchez-Cantos [verfasserIn] Jose María Navarro-Jarabo [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch ; Spanisch |
| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Revista Espanola de Enfermedades Digestivas - Aran Ediciones, 2004 |
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| Links: |
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| DOI / URN: |
10.17235/reed.2017.4898/2017 |
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| Katalog-ID: |
DOAJ03777512X |
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| 245 | 1 | 0 | |a Insulin resistance and the metabolic syndrome are related to the severity of steatosis in the pediatric population with obesity |
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| 520 | |a Background: To determine the factors associated with an increased risk for severe steatosis (SS) and establish the Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) as a screening tool. Methods: A cross-sectional study was performed in obese children to assess the relationship between the metabolic syndrome (MetS) and glucose metabolism alterations (GMA) and the risk for severe steatosis. Results: A total of 94 children (51 males) aged from six to 14 years were included. Thirteen children (14.8%) had severe steatosis (SS). The anthropometric variables associated with SS included body mass index (BMI) (SS 34.1 vs non-SS 29.7, p = 0.005), waist circumference (cm) (100 vs 92.5, p = 0.015) and hip circumference (cm) (108 vs 100, p = 0.018). The blood parameters included alanine aminotransferase (ALT) (UI/dl) (27 vs 21, p = 0.002), gamma-glutamil transpeptidase (GGT) (UI/dl) (16 vs 15, p = 0.017), fasting glycemia (mg/dl) (96 vs 88, p = 0.006), fasting insulin (UI/dl) (25 vs 15.3, p < 0.001) and HOMA-IR score (7.1 vs 3.7, p < 0.001). Eighteen children with MetS were found to be at an increased risk for severe steatosis (odds ratio [OR] 11.36, p < 0.001). After receiver operating characteristic (ROC) curve analysis, the best area under the curve (AUC) was obtained for HOMA-R of 0.862. The HOMA-R 4.9 cut-off value had a 100% sensitivity (CI 95%: 96.2-100) and 67.9% specificity (CI 95%: 57.1-78.7) for severe steatosis. Conclusions: The presence of MetS and glucose metabolism alterations are risk factors for severe steatosis. The 4.9 cut-off value for HOMA-IR may be a risk factor for severe steatosis in obese children. | ||
| 650 | 4 | |a Non-alcoholic fatty liver disease | |
| 650 | 4 | |a Non-alcoholic steatohepatitis | |
| 650 | 4 | |a Liver steatosis | |
| 650 | 4 | |a Pediatric obesity | |
| 650 | 4 | |a Metabolic syndrome | |
| 650 | 4 | |a Insulin resistance | |
| 653 | 0 | |a Diseases of the digestive system. Gastroenterology | |
| 700 | 0 | |a Leopoldo Tapia-Ceballos |e verfasserin |4 aut | |
| 700 | 0 | |a José Miguel Rosales-Zabal |e verfasserin |4 aut | |
| 700 | 0 | |a Rocío Porcel-Chacón |e verfasserin |4 aut | |
| 700 | 0 | |a Francisco Poveda-Gómez |e verfasserin |4 aut | |
| 700 | 0 | |a Carmen Lozano-Calero |e verfasserin |4 aut | |
| 700 | 0 | |a Carmen Ortiz-Cuevas |e verfasserin |4 aut | |
| 700 | 0 | |a Francisco Rivas-Ruiz |e verfasserin |4 aut | |
| 700 | 0 | |a Andrés Sánchez-Cantos |e verfasserin |4 aut | |
| 700 | 0 | |a Jose María Navarro-Jarabo |e verfasserin |4 aut | |
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10.17235/reed.2017.4898/2017 doi (DE-627)DOAJ03777512X (DE-599)DOAJ94e4a76955754ff6aa4011562cb59296 DE-627 ger DE-627 rakwb eng spa RC799-869 Esther Ubiña-Aznar verfasserin aut Insulin resistance and the metabolic syndrome are related to the severity of steatosis in the pediatric population with obesity Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: To determine the factors associated with an increased risk for severe steatosis (SS) and establish the Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) as a screening tool. Methods: A cross-sectional study was performed in obese children to assess the relationship between the metabolic syndrome (MetS) and glucose metabolism alterations (GMA) and the risk for severe steatosis. Results: A total of 94 children (51 males) aged from six to 14 years were included. Thirteen children (14.8%) had severe steatosis (SS). The anthropometric variables associated with SS included body mass index (BMI) (SS 34.1 vs non-SS 29.7, p = 0.005), waist circumference (cm) (100 vs 92.5, p = 0.015) and hip circumference (cm) (108 vs 100, p = 0.018). The blood parameters included alanine aminotransferase (ALT) (UI/dl) (27 vs 21, p = 0.002), gamma-glutamil transpeptidase (GGT) (UI/dl) (16 vs 15, p = 0.017), fasting glycemia (mg/dl) (96 vs 88, p = 0.006), fasting insulin (UI/dl) (25 vs 15.3, p < 0.001) and HOMA-IR score (7.1 vs 3.7, p < 0.001). Eighteen children with MetS were found to be at an increased risk for severe steatosis (odds ratio [OR] 11.36, p < 0.001). After receiver operating characteristic (ROC) curve analysis, the best area under the curve (AUC) was obtained for HOMA-R of 0.862. The HOMA-R 4.9 cut-off value had a 100% sensitivity (CI 95%: 96.2-100) and 67.9% specificity (CI 95%: 57.1-78.7) for severe steatosis. Conclusions: The presence of MetS and glucose metabolism alterations are risk factors for severe steatosis. The 4.9 cut-off value for HOMA-IR may be a risk factor for severe steatosis in obese children. Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Liver steatosis Pediatric obesity Metabolic syndrome Insulin resistance Diseases of the digestive system. Gastroenterology Leopoldo Tapia-Ceballos verfasserin aut José Miguel Rosales-Zabal verfasserin aut Rocío Porcel-Chacón verfasserin aut Francisco Poveda-Gómez verfasserin aut Carmen Lozano-Calero verfasserin aut Carmen Ortiz-Cuevas verfasserin aut Francisco Rivas-Ruiz verfasserin aut Andrés Sánchez-Cantos verfasserin aut Jose María Navarro-Jarabo verfasserin aut In Revista Espanola de Enfermedades Digestivas Aran Ediciones, 2004 (DE-627)334927528 (DE-600)2058594-9 11300108 nnns https://doi.org/10.17235/reed.2017.4898/2017 kostenfrei https://doaj.org/article/94e4a76955754ff6aa4011562cb59296 kostenfrei http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082017001100007&lng=en&tlng=en kostenfrei https://doaj.org/toc/1130-0108 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
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10.17235/reed.2017.4898/2017 doi (DE-627)DOAJ03777512X (DE-599)DOAJ94e4a76955754ff6aa4011562cb59296 DE-627 ger DE-627 rakwb eng spa RC799-869 Esther Ubiña-Aznar verfasserin aut Insulin resistance and the metabolic syndrome are related to the severity of steatosis in the pediatric population with obesity Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: To determine the factors associated with an increased risk for severe steatosis (SS) and establish the Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) as a screening tool. Methods: A cross-sectional study was performed in obese children to assess the relationship between the metabolic syndrome (MetS) and glucose metabolism alterations (GMA) and the risk for severe steatosis. Results: A total of 94 children (51 males) aged from six to 14 years were included. Thirteen children (14.8%) had severe steatosis (SS). The anthropometric variables associated with SS included body mass index (BMI) (SS 34.1 vs non-SS 29.7, p = 0.005), waist circumference (cm) (100 vs 92.5, p = 0.015) and hip circumference (cm) (108 vs 100, p = 0.018). The blood parameters included alanine aminotransferase (ALT) (UI/dl) (27 vs 21, p = 0.002), gamma-glutamil transpeptidase (GGT) (UI/dl) (16 vs 15, p = 0.017), fasting glycemia (mg/dl) (96 vs 88, p = 0.006), fasting insulin (UI/dl) (25 vs 15.3, p < 0.001) and HOMA-IR score (7.1 vs 3.7, p < 0.001). Eighteen children with MetS were found to be at an increased risk for severe steatosis (odds ratio [OR] 11.36, p < 0.001). After receiver operating characteristic (ROC) curve analysis, the best area under the curve (AUC) was obtained for HOMA-R of 0.862. The HOMA-R 4.9 cut-off value had a 100% sensitivity (CI 95%: 96.2-100) and 67.9% specificity (CI 95%: 57.1-78.7) for severe steatosis. Conclusions: The presence of MetS and glucose metabolism alterations are risk factors for severe steatosis. The 4.9 cut-off value for HOMA-IR may be a risk factor for severe steatosis in obese children. Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Liver steatosis Pediatric obesity Metabolic syndrome Insulin resistance Diseases of the digestive system. Gastroenterology Leopoldo Tapia-Ceballos verfasserin aut José Miguel Rosales-Zabal verfasserin aut Rocío Porcel-Chacón verfasserin aut Francisco Poveda-Gómez verfasserin aut Carmen Lozano-Calero verfasserin aut Carmen Ortiz-Cuevas verfasserin aut Francisco Rivas-Ruiz verfasserin aut Andrés Sánchez-Cantos verfasserin aut Jose María Navarro-Jarabo verfasserin aut In Revista Espanola de Enfermedades Digestivas Aran Ediciones, 2004 (DE-627)334927528 (DE-600)2058594-9 11300108 nnns https://doi.org/10.17235/reed.2017.4898/2017 kostenfrei https://doaj.org/article/94e4a76955754ff6aa4011562cb59296 kostenfrei http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082017001100007&lng=en&tlng=en kostenfrei https://doaj.org/toc/1130-0108 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
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10.17235/reed.2017.4898/2017 doi (DE-627)DOAJ03777512X (DE-599)DOAJ94e4a76955754ff6aa4011562cb59296 DE-627 ger DE-627 rakwb eng spa RC799-869 Esther Ubiña-Aznar verfasserin aut Insulin resistance and the metabolic syndrome are related to the severity of steatosis in the pediatric population with obesity Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: To determine the factors associated with an increased risk for severe steatosis (SS) and establish the Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) as a screening tool. Methods: A cross-sectional study was performed in obese children to assess the relationship between the metabolic syndrome (MetS) and glucose metabolism alterations (GMA) and the risk for severe steatosis. Results: A total of 94 children (51 males) aged from six to 14 years were included. Thirteen children (14.8%) had severe steatosis (SS). The anthropometric variables associated with SS included body mass index (BMI) (SS 34.1 vs non-SS 29.7, p = 0.005), waist circumference (cm) (100 vs 92.5, p = 0.015) and hip circumference (cm) (108 vs 100, p = 0.018). The blood parameters included alanine aminotransferase (ALT) (UI/dl) (27 vs 21, p = 0.002), gamma-glutamil transpeptidase (GGT) (UI/dl) (16 vs 15, p = 0.017), fasting glycemia (mg/dl) (96 vs 88, p = 0.006), fasting insulin (UI/dl) (25 vs 15.3, p < 0.001) and HOMA-IR score (7.1 vs 3.7, p < 0.001). Eighteen children with MetS were found to be at an increased risk for severe steatosis (odds ratio [OR] 11.36, p < 0.001). After receiver operating characteristic (ROC) curve analysis, the best area under the curve (AUC) was obtained for HOMA-R of 0.862. The HOMA-R 4.9 cut-off value had a 100% sensitivity (CI 95%: 96.2-100) and 67.9% specificity (CI 95%: 57.1-78.7) for severe steatosis. Conclusions: The presence of MetS and glucose metabolism alterations are risk factors for severe steatosis. The 4.9 cut-off value for HOMA-IR may be a risk factor for severe steatosis in obese children. Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Liver steatosis Pediatric obesity Metabolic syndrome Insulin resistance Diseases of the digestive system. Gastroenterology Leopoldo Tapia-Ceballos verfasserin aut José Miguel Rosales-Zabal verfasserin aut Rocío Porcel-Chacón verfasserin aut Francisco Poveda-Gómez verfasserin aut Carmen Lozano-Calero verfasserin aut Carmen Ortiz-Cuevas verfasserin aut Francisco Rivas-Ruiz verfasserin aut Andrés Sánchez-Cantos verfasserin aut Jose María Navarro-Jarabo verfasserin aut In Revista Espanola de Enfermedades Digestivas Aran Ediciones, 2004 (DE-627)334927528 (DE-600)2058594-9 11300108 nnns https://doi.org/10.17235/reed.2017.4898/2017 kostenfrei https://doaj.org/article/94e4a76955754ff6aa4011562cb59296 kostenfrei http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082017001100007&lng=en&tlng=en kostenfrei https://doaj.org/toc/1130-0108 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
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10.17235/reed.2017.4898/2017 doi (DE-627)DOAJ03777512X (DE-599)DOAJ94e4a76955754ff6aa4011562cb59296 DE-627 ger DE-627 rakwb eng spa RC799-869 Esther Ubiña-Aznar verfasserin aut Insulin resistance and the metabolic syndrome are related to the severity of steatosis in the pediatric population with obesity Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: To determine the factors associated with an increased risk for severe steatosis (SS) and establish the Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) as a screening tool. Methods: A cross-sectional study was performed in obese children to assess the relationship between the metabolic syndrome (MetS) and glucose metabolism alterations (GMA) and the risk for severe steatosis. Results: A total of 94 children (51 males) aged from six to 14 years were included. Thirteen children (14.8%) had severe steatosis (SS). The anthropometric variables associated with SS included body mass index (BMI) (SS 34.1 vs non-SS 29.7, p = 0.005), waist circumference (cm) (100 vs 92.5, p = 0.015) and hip circumference (cm) (108 vs 100, p = 0.018). The blood parameters included alanine aminotransferase (ALT) (UI/dl) (27 vs 21, p = 0.002), gamma-glutamil transpeptidase (GGT) (UI/dl) (16 vs 15, p = 0.017), fasting glycemia (mg/dl) (96 vs 88, p = 0.006), fasting insulin (UI/dl) (25 vs 15.3, p < 0.001) and HOMA-IR score (7.1 vs 3.7, p < 0.001). Eighteen children with MetS were found to be at an increased risk for severe steatosis (odds ratio [OR] 11.36, p < 0.001). After receiver operating characteristic (ROC) curve analysis, the best area under the curve (AUC) was obtained for HOMA-R of 0.862. The HOMA-R 4.9 cut-off value had a 100% sensitivity (CI 95%: 96.2-100) and 67.9% specificity (CI 95%: 57.1-78.7) for severe steatosis. Conclusions: The presence of MetS and glucose metabolism alterations are risk factors for severe steatosis. The 4.9 cut-off value for HOMA-IR may be a risk factor for severe steatosis in obese children. Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Liver steatosis Pediatric obesity Metabolic syndrome Insulin resistance Diseases of the digestive system. Gastroenterology Leopoldo Tapia-Ceballos verfasserin aut José Miguel Rosales-Zabal verfasserin aut Rocío Porcel-Chacón verfasserin aut Francisco Poveda-Gómez verfasserin aut Carmen Lozano-Calero verfasserin aut Carmen Ortiz-Cuevas verfasserin aut Francisco Rivas-Ruiz verfasserin aut Andrés Sánchez-Cantos verfasserin aut Jose María Navarro-Jarabo verfasserin aut In Revista Espanola de Enfermedades Digestivas Aran Ediciones, 2004 (DE-627)334927528 (DE-600)2058594-9 11300108 nnns https://doi.org/10.17235/reed.2017.4898/2017 kostenfrei https://doaj.org/article/94e4a76955754ff6aa4011562cb59296 kostenfrei http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082017001100007&lng=en&tlng=en kostenfrei https://doaj.org/toc/1130-0108 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
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10.17235/reed.2017.4898/2017 doi (DE-627)DOAJ03777512X (DE-599)DOAJ94e4a76955754ff6aa4011562cb59296 DE-627 ger DE-627 rakwb eng spa RC799-869 Esther Ubiña-Aznar verfasserin aut Insulin resistance and the metabolic syndrome are related to the severity of steatosis in the pediatric population with obesity Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: To determine the factors associated with an increased risk for severe steatosis (SS) and establish the Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) as a screening tool. Methods: A cross-sectional study was performed in obese children to assess the relationship between the metabolic syndrome (MetS) and glucose metabolism alterations (GMA) and the risk for severe steatosis. Results: A total of 94 children (51 males) aged from six to 14 years were included. Thirteen children (14.8%) had severe steatosis (SS). The anthropometric variables associated with SS included body mass index (BMI) (SS 34.1 vs non-SS 29.7, p = 0.005), waist circumference (cm) (100 vs 92.5, p = 0.015) and hip circumference (cm) (108 vs 100, p = 0.018). The blood parameters included alanine aminotransferase (ALT) (UI/dl) (27 vs 21, p = 0.002), gamma-glutamil transpeptidase (GGT) (UI/dl) (16 vs 15, p = 0.017), fasting glycemia (mg/dl) (96 vs 88, p = 0.006), fasting insulin (UI/dl) (25 vs 15.3, p < 0.001) and HOMA-IR score (7.1 vs 3.7, p < 0.001). Eighteen children with MetS were found to be at an increased risk for severe steatosis (odds ratio [OR] 11.36, p < 0.001). After receiver operating characteristic (ROC) curve analysis, the best area under the curve (AUC) was obtained for HOMA-R of 0.862. The HOMA-R 4.9 cut-off value had a 100% sensitivity (CI 95%: 96.2-100) and 67.9% specificity (CI 95%: 57.1-78.7) for severe steatosis. Conclusions: The presence of MetS and glucose metabolism alterations are risk factors for severe steatosis. The 4.9 cut-off value for HOMA-IR may be a risk factor for severe steatosis in obese children. Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Liver steatosis Pediatric obesity Metabolic syndrome Insulin resistance Diseases of the digestive system. Gastroenterology Leopoldo Tapia-Ceballos verfasserin aut José Miguel Rosales-Zabal verfasserin aut Rocío Porcel-Chacón verfasserin aut Francisco Poveda-Gómez verfasserin aut Carmen Lozano-Calero verfasserin aut Carmen Ortiz-Cuevas verfasserin aut Francisco Rivas-Ruiz verfasserin aut Andrés Sánchez-Cantos verfasserin aut Jose María Navarro-Jarabo verfasserin aut In Revista Espanola de Enfermedades Digestivas Aran Ediciones, 2004 (DE-627)334927528 (DE-600)2058594-9 11300108 nnns https://doi.org/10.17235/reed.2017.4898/2017 kostenfrei https://doaj.org/article/94e4a76955754ff6aa4011562cb59296 kostenfrei http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082017001100007&lng=en&tlng=en kostenfrei https://doaj.org/toc/1130-0108 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
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Esther Ubiña-Aznar |
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Esther Ubiña-Aznar misc RC799-869 misc Non-alcoholic fatty liver disease misc Non-alcoholic steatohepatitis misc Liver steatosis misc Pediatric obesity misc Metabolic syndrome misc Insulin resistance misc Diseases of the digestive system. Gastroenterology Insulin resistance and the metabolic syndrome are related to the severity of steatosis in the pediatric population with obesity |
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RC799-869 Insulin resistance and the metabolic syndrome are related to the severity of steatosis in the pediatric population with obesity Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Liver steatosis Pediatric obesity Metabolic syndrome Insulin resistance |
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misc RC799-869 misc Non-alcoholic fatty liver disease misc Non-alcoholic steatohepatitis misc Liver steatosis misc Pediatric obesity misc Metabolic syndrome misc Insulin resistance misc Diseases of the digestive system. Gastroenterology |
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Esther Ubiña-Aznar Leopoldo Tapia-Ceballos José Miguel Rosales-Zabal Rocío Porcel-Chacón Francisco Poveda-Gómez Carmen Lozano-Calero Carmen Ortiz-Cuevas Francisco Rivas-Ruiz Andrés Sánchez-Cantos Jose María Navarro-Jarabo |
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insulin resistance and the metabolic syndrome are related to the severity of steatosis in the pediatric population with obesity |
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Insulin resistance and the metabolic syndrome are related to the severity of steatosis in the pediatric population with obesity |
| abstract |
Background: To determine the factors associated with an increased risk for severe steatosis (SS) and establish the Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) as a screening tool. Methods: A cross-sectional study was performed in obese children to assess the relationship between the metabolic syndrome (MetS) and glucose metabolism alterations (GMA) and the risk for severe steatosis. Results: A total of 94 children (51 males) aged from six to 14 years were included. Thirteen children (14.8%) had severe steatosis (SS). The anthropometric variables associated with SS included body mass index (BMI) (SS 34.1 vs non-SS 29.7, p = 0.005), waist circumference (cm) (100 vs 92.5, p = 0.015) and hip circumference (cm) (108 vs 100, p = 0.018). The blood parameters included alanine aminotransferase (ALT) (UI/dl) (27 vs 21, p = 0.002), gamma-glutamil transpeptidase (GGT) (UI/dl) (16 vs 15, p = 0.017), fasting glycemia (mg/dl) (96 vs 88, p = 0.006), fasting insulin (UI/dl) (25 vs 15.3, p < 0.001) and HOMA-IR score (7.1 vs 3.7, p < 0.001). Eighteen children with MetS were found to be at an increased risk for severe steatosis (odds ratio [OR] 11.36, p < 0.001). After receiver operating characteristic (ROC) curve analysis, the best area under the curve (AUC) was obtained for HOMA-R of 0.862. The HOMA-R 4.9 cut-off value had a 100% sensitivity (CI 95%: 96.2-100) and 67.9% specificity (CI 95%: 57.1-78.7) for severe steatosis. Conclusions: The presence of MetS and glucose metabolism alterations are risk factors for severe steatosis. The 4.9 cut-off value for HOMA-IR may be a risk factor for severe steatosis in obese children. |
| abstractGer |
Background: To determine the factors associated with an increased risk for severe steatosis (SS) and establish the Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) as a screening tool. Methods: A cross-sectional study was performed in obese children to assess the relationship between the metabolic syndrome (MetS) and glucose metabolism alterations (GMA) and the risk for severe steatosis. Results: A total of 94 children (51 males) aged from six to 14 years were included. Thirteen children (14.8%) had severe steatosis (SS). The anthropometric variables associated with SS included body mass index (BMI) (SS 34.1 vs non-SS 29.7, p = 0.005), waist circumference (cm) (100 vs 92.5, p = 0.015) and hip circumference (cm) (108 vs 100, p = 0.018). The blood parameters included alanine aminotransferase (ALT) (UI/dl) (27 vs 21, p = 0.002), gamma-glutamil transpeptidase (GGT) (UI/dl) (16 vs 15, p = 0.017), fasting glycemia (mg/dl) (96 vs 88, p = 0.006), fasting insulin (UI/dl) (25 vs 15.3, p < 0.001) and HOMA-IR score (7.1 vs 3.7, p < 0.001). Eighteen children with MetS were found to be at an increased risk for severe steatosis (odds ratio [OR] 11.36, p < 0.001). After receiver operating characteristic (ROC) curve analysis, the best area under the curve (AUC) was obtained for HOMA-R of 0.862. The HOMA-R 4.9 cut-off value had a 100% sensitivity (CI 95%: 96.2-100) and 67.9% specificity (CI 95%: 57.1-78.7) for severe steatosis. Conclusions: The presence of MetS and glucose metabolism alterations are risk factors for severe steatosis. The 4.9 cut-off value for HOMA-IR may be a risk factor for severe steatosis in obese children. |
| abstract_unstemmed |
Background: To determine the factors associated with an increased risk for severe steatosis (SS) and establish the Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) as a screening tool. Methods: A cross-sectional study was performed in obese children to assess the relationship between the metabolic syndrome (MetS) and glucose metabolism alterations (GMA) and the risk for severe steatosis. Results: A total of 94 children (51 males) aged from six to 14 years were included. Thirteen children (14.8%) had severe steatosis (SS). The anthropometric variables associated with SS included body mass index (BMI) (SS 34.1 vs non-SS 29.7, p = 0.005), waist circumference (cm) (100 vs 92.5, p = 0.015) and hip circumference (cm) (108 vs 100, p = 0.018). The blood parameters included alanine aminotransferase (ALT) (UI/dl) (27 vs 21, p = 0.002), gamma-glutamil transpeptidase (GGT) (UI/dl) (16 vs 15, p = 0.017), fasting glycemia (mg/dl) (96 vs 88, p = 0.006), fasting insulin (UI/dl) (25 vs 15.3, p < 0.001) and HOMA-IR score (7.1 vs 3.7, p < 0.001). Eighteen children with MetS were found to be at an increased risk for severe steatosis (odds ratio [OR] 11.36, p < 0.001). After receiver operating characteristic (ROC) curve analysis, the best area under the curve (AUC) was obtained for HOMA-R of 0.862. The HOMA-R 4.9 cut-off value had a 100% sensitivity (CI 95%: 96.2-100) and 67.9% specificity (CI 95%: 57.1-78.7) for severe steatosis. Conclusions: The presence of MetS and glucose metabolism alterations are risk factors for severe steatosis. The 4.9 cut-off value for HOMA-IR may be a risk factor for severe steatosis in obese children. |
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Insulin resistance and the metabolic syndrome are related to the severity of steatosis in the pediatric population with obesity |
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Leopoldo Tapia-Ceballos José Miguel Rosales-Zabal Rocío Porcel-Chacón Francisco Poveda-Gómez Carmen Lozano-Calero Carmen Ortiz-Cuevas Francisco Rivas-Ruiz Andrés Sánchez-Cantos Jose María Navarro-Jarabo |
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After receiver operating characteristic (ROC) curve analysis, the best area under the curve (AUC) was obtained for HOMA-R of 0.862. The HOMA-R 4.9 cut-off value had a 100% sensitivity (CI 95%: 96.2-100) and 67.9% specificity (CI 95%: 57.1-78.7) for severe steatosis. Conclusions: The presence of MetS and glucose metabolism alterations are risk factors for severe steatosis. 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Gastroenterology</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Leopoldo Tapia-Ceballos</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">José Miguel Rosales-Zabal</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rocío Porcel-Chacón</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Francisco Poveda-Gómez</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Carmen Lozano-Calero</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Carmen Ortiz-Cuevas</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Francisco Rivas-Ruiz</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Andrés Sánchez-Cantos</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jose María Navarro-Jarabo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Revista Espanola de Enfermedades Digestivas</subfield><subfield code="d">Aran Ediciones, 2004</subfield><subfield code="w">(DE-627)334927528</subfield><subfield code="w">(DE-600)2058594-9</subfield><subfield code="x">11300108</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.17235/reed.2017.4898/2017</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/94e4a76955754ff6aa4011562cb59296</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082017001100007&lng=en&tlng=en</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/1130-0108</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield></record></collection>
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