Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

PD-L1 and PD-L2 are ligands for the PD-1 immune inhibiting checkpoint that can be induced in tumors by interferon exposure, leading to immune evasion. This process is important for immunotherapy based on PD-1 blockade. We examined the specific molecules involved in interferon-induced signaling that...
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Autor*in:	Angel Garcia-Diaz [verfasserIn] Daniel Sanghoon Shin [verfasserIn] Blanca Homet Moreno [verfasserIn] Justin Saco [verfasserIn] Helena Escuin-Ordinas [verfasserIn] Gabriel Abril Rodriguez [verfasserIn] Jesse M. Zaretsky [verfasserIn] Lu Sun [verfasserIn] Willy Hugo [verfasserIn] Xiaoyan Wang [verfasserIn] Giulia Parisi [verfasserIn] Cristina Puig Saus [verfasserIn] Davis Y. Torrejon [verfasserIn] Thomas G. Graeber [verfasserIn] Begonya Comin-Anduix [verfasserIn] Siwen Hu-Lieskovan [verfasserIn] Robert Damoiseaux [verfasserIn] Roger S. Lo [verfasserIn] Antoni Ribas [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	PD-1 PD-L1 PD-L2 interferon receptor signaling pathways JAK-STATs IRF1 immunotherapy melanoma

Übergeordnetes Werk:	In: Cell Reports - Elsevier, 2015, 19(2017), 6, Seite 1189-1201
Übergeordnetes Werk:	volume:19 ; year:2017 ; number:6 ; pages:1189-1201

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.celrep.2017.04.031

Katalog-ID:	DOAJ037817965

Internformat


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520			\|a PD-L1 and PD-L2 are ligands for the PD-1 immune inhibiting checkpoint that can be induced in tumors by interferon exposure, leading to immune evasion. This process is important for immunotherapy based on PD-1 blockade. We examined the specific molecules involved in interferon-induced signaling that regulates PD-L1 and PD-L2 expression in melanoma cells. These studies revealed that the interferon-gamma-JAK1/JAK2-STAT1/STAT2/STAT3-IRF1 axis primarily regulates PD-L1 expression, with IRF1 binding to its promoter. PD-L2 responded equally to interferon beta and gamma and is regulated through both IRF1 and STAT3, which bind to the PD-L2 promoter. Analysis of biopsy specimens from patients with melanoma confirmed interferon signature enrichment and upregulation of gene targets for STAT1/STAT2/STAT3 and IRF1 in anti-PD-1-responding tumors. Therefore, these studies map the signaling pathway of interferon-gamma-inducible PD-1 ligand expression.
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allfields	10.1016/j.celrep.2017.04.031 doi (DE-627)DOAJ037817965 (DE-599)DOAJe5b58d91cebc41a38766402ee83a9fa5 DE-627 ger DE-627 rakwb eng QH301-705.5 Angel Garcia-Diaz verfasserin aut Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier PD-L1 and PD-L2 are ligands for the PD-1 immune inhibiting checkpoint that can be induced in tumors by interferon exposure, leading to immune evasion. This process is important for immunotherapy based on PD-1 blockade. We examined the specific molecules involved in interferon-induced signaling that regulates PD-L1 and PD-L2 expression in melanoma cells. These studies revealed that the interferon-gamma-JAK1/JAK2-STAT1/STAT2/STAT3-IRF1 axis primarily regulates PD-L1 expression, with IRF1 binding to its promoter. PD-L2 responded equally to interferon beta and gamma and is regulated through both IRF1 and STAT3, which bind to the PD-L2 promoter. Analysis of biopsy specimens from patients with melanoma confirmed interferon signature enrichment and upregulation of gene targets for STAT1/STAT2/STAT3 and IRF1 in anti-PD-1-responding tumors. Therefore, these studies map the signaling pathway of interferon-gamma-inducible PD-1 ligand expression. PD-1 PD-L1 PD-L2 interferon receptor signaling pathways JAK-STATs IRF1 immunotherapy melanoma Biology (General) Daniel Sanghoon Shin verfasserin aut Blanca Homet Moreno verfasserin aut Justin Saco verfasserin aut Helena Escuin-Ordinas verfasserin aut Gabriel Abril Rodriguez verfasserin aut Jesse M. Zaretsky verfasserin aut Lu Sun verfasserin aut Willy Hugo verfasserin aut Xiaoyan Wang verfasserin aut Giulia Parisi verfasserin aut Cristina Puig Saus verfasserin aut Davis Y. Torrejon verfasserin aut Thomas G. Graeber verfasserin aut Begonya Comin-Anduix verfasserin aut Siwen Hu-Lieskovan verfasserin aut Robert Damoiseaux verfasserin aut Roger S. Lo verfasserin aut Antoni Ribas verfasserin aut In Cell Reports Elsevier, 2015 19(2017), 6, Seite 1189-1201 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:19 year:2017 number:6 pages:1189-1201 https://doi.org/10.1016/j.celrep.2017.04.031 kostenfrei https://doaj.org/article/e5b58d91cebc41a38766402ee83a9fa5 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124717305259 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 19 2017 6 1189-1201
spelling	10.1016/j.celrep.2017.04.031 doi (DE-627)DOAJ037817965 (DE-599)DOAJe5b58d91cebc41a38766402ee83a9fa5 DE-627 ger DE-627 rakwb eng QH301-705.5 Angel Garcia-Diaz verfasserin aut Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier PD-L1 and PD-L2 are ligands for the PD-1 immune inhibiting checkpoint that can be induced in tumors by interferon exposure, leading to immune evasion. This process is important for immunotherapy based on PD-1 blockade. We examined the specific molecules involved in interferon-induced signaling that regulates PD-L1 and PD-L2 expression in melanoma cells. These studies revealed that the interferon-gamma-JAK1/JAK2-STAT1/STAT2/STAT3-IRF1 axis primarily regulates PD-L1 expression, with IRF1 binding to its promoter. PD-L2 responded equally to interferon beta and gamma and is regulated through both IRF1 and STAT3, which bind to the PD-L2 promoter. Analysis of biopsy specimens from patients with melanoma confirmed interferon signature enrichment and upregulation of gene targets for STAT1/STAT2/STAT3 and IRF1 in anti-PD-1-responding tumors. Therefore, these studies map the signaling pathway of interferon-gamma-inducible PD-1 ligand expression. PD-1 PD-L1 PD-L2 interferon receptor signaling pathways JAK-STATs IRF1 immunotherapy melanoma Biology (General) Daniel Sanghoon Shin verfasserin aut Blanca Homet Moreno verfasserin aut Justin Saco verfasserin aut Helena Escuin-Ordinas verfasserin aut Gabriel Abril Rodriguez verfasserin aut Jesse M. Zaretsky verfasserin aut Lu Sun verfasserin aut Willy Hugo verfasserin aut Xiaoyan Wang verfasserin aut Giulia Parisi verfasserin aut Cristina Puig Saus verfasserin aut Davis Y. Torrejon verfasserin aut Thomas G. Graeber verfasserin aut Begonya Comin-Anduix verfasserin aut Siwen Hu-Lieskovan verfasserin aut Robert Damoiseaux verfasserin aut Roger S. Lo verfasserin aut Antoni Ribas verfasserin aut In Cell Reports Elsevier, 2015 19(2017), 6, Seite 1189-1201 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:19 year:2017 number:6 pages:1189-1201 https://doi.org/10.1016/j.celrep.2017.04.031 kostenfrei https://doaj.org/article/e5b58d91cebc41a38766402ee83a9fa5 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124717305259 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 19 2017 6 1189-1201
allfields_unstemmed	10.1016/j.celrep.2017.04.031 doi (DE-627)DOAJ037817965 (DE-599)DOAJe5b58d91cebc41a38766402ee83a9fa5 DE-627 ger DE-627 rakwb eng QH301-705.5 Angel Garcia-Diaz verfasserin aut Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier PD-L1 and PD-L2 are ligands for the PD-1 immune inhibiting checkpoint that can be induced in tumors by interferon exposure, leading to immune evasion. This process is important for immunotherapy based on PD-1 blockade. We examined the specific molecules involved in interferon-induced signaling that regulates PD-L1 and PD-L2 expression in melanoma cells. These studies revealed that the interferon-gamma-JAK1/JAK2-STAT1/STAT2/STAT3-IRF1 axis primarily regulates PD-L1 expression, with IRF1 binding to its promoter. PD-L2 responded equally to interferon beta and gamma and is regulated through both IRF1 and STAT3, which bind to the PD-L2 promoter. Analysis of biopsy specimens from patients with melanoma confirmed interferon signature enrichment and upregulation of gene targets for STAT1/STAT2/STAT3 and IRF1 in anti-PD-1-responding tumors. Therefore, these studies map the signaling pathway of interferon-gamma-inducible PD-1 ligand expression. PD-1 PD-L1 PD-L2 interferon receptor signaling pathways JAK-STATs IRF1 immunotherapy melanoma Biology (General) Daniel Sanghoon Shin verfasserin aut Blanca Homet Moreno verfasserin aut Justin Saco verfasserin aut Helena Escuin-Ordinas verfasserin aut Gabriel Abril Rodriguez verfasserin aut Jesse M. Zaretsky verfasserin aut Lu Sun verfasserin aut Willy Hugo verfasserin aut Xiaoyan Wang verfasserin aut Giulia Parisi verfasserin aut Cristina Puig Saus verfasserin aut Davis Y. Torrejon verfasserin aut Thomas G. Graeber verfasserin aut Begonya Comin-Anduix verfasserin aut Siwen Hu-Lieskovan verfasserin aut Robert Damoiseaux verfasserin aut Roger S. Lo verfasserin aut Antoni Ribas verfasserin aut In Cell Reports Elsevier, 2015 19(2017), 6, Seite 1189-1201 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:19 year:2017 number:6 pages:1189-1201 https://doi.org/10.1016/j.celrep.2017.04.031 kostenfrei https://doaj.org/article/e5b58d91cebc41a38766402ee83a9fa5 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124717305259 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 19 2017 6 1189-1201
allfieldsGer	10.1016/j.celrep.2017.04.031 doi (DE-627)DOAJ037817965 (DE-599)DOAJe5b58d91cebc41a38766402ee83a9fa5 DE-627 ger DE-627 rakwb eng QH301-705.5 Angel Garcia-Diaz verfasserin aut Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier PD-L1 and PD-L2 are ligands for the PD-1 immune inhibiting checkpoint that can be induced in tumors by interferon exposure, leading to immune evasion. This process is important for immunotherapy based on PD-1 blockade. We examined the specific molecules involved in interferon-induced signaling that regulates PD-L1 and PD-L2 expression in melanoma cells. These studies revealed that the interferon-gamma-JAK1/JAK2-STAT1/STAT2/STAT3-IRF1 axis primarily regulates PD-L1 expression, with IRF1 binding to its promoter. PD-L2 responded equally to interferon beta and gamma and is regulated through both IRF1 and STAT3, which bind to the PD-L2 promoter. Analysis of biopsy specimens from patients with melanoma confirmed interferon signature enrichment and upregulation of gene targets for STAT1/STAT2/STAT3 and IRF1 in anti-PD-1-responding tumors. Therefore, these studies map the signaling pathway of interferon-gamma-inducible PD-1 ligand expression. PD-1 PD-L1 PD-L2 interferon receptor signaling pathways JAK-STATs IRF1 immunotherapy melanoma Biology (General) Daniel Sanghoon Shin verfasserin aut Blanca Homet Moreno verfasserin aut Justin Saco verfasserin aut Helena Escuin-Ordinas verfasserin aut Gabriel Abril Rodriguez verfasserin aut Jesse M. Zaretsky verfasserin aut Lu Sun verfasserin aut Willy Hugo verfasserin aut Xiaoyan Wang verfasserin aut Giulia Parisi verfasserin aut Cristina Puig Saus verfasserin aut Davis Y. Torrejon verfasserin aut Thomas G. Graeber verfasserin aut Begonya Comin-Anduix verfasserin aut Siwen Hu-Lieskovan verfasserin aut Robert Damoiseaux verfasserin aut Roger S. Lo verfasserin aut Antoni Ribas verfasserin aut In Cell Reports Elsevier, 2015 19(2017), 6, Seite 1189-1201 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:19 year:2017 number:6 pages:1189-1201 https://doi.org/10.1016/j.celrep.2017.04.031 kostenfrei https://doaj.org/article/e5b58d91cebc41a38766402ee83a9fa5 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124717305259 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 19 2017 6 1189-1201
allfieldsSound	10.1016/j.celrep.2017.04.031 doi (DE-627)DOAJ037817965 (DE-599)DOAJe5b58d91cebc41a38766402ee83a9fa5 DE-627 ger DE-627 rakwb eng QH301-705.5 Angel Garcia-Diaz verfasserin aut Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier PD-L1 and PD-L2 are ligands for the PD-1 immune inhibiting checkpoint that can be induced in tumors by interferon exposure, leading to immune evasion. This process is important for immunotherapy based on PD-1 blockade. We examined the specific molecules involved in interferon-induced signaling that regulates PD-L1 and PD-L2 expression in melanoma cells. These studies revealed that the interferon-gamma-JAK1/JAK2-STAT1/STAT2/STAT3-IRF1 axis primarily regulates PD-L1 expression, with IRF1 binding to its promoter. PD-L2 responded equally to interferon beta and gamma and is regulated through both IRF1 and STAT3, which bind to the PD-L2 promoter. Analysis of biopsy specimens from patients with melanoma confirmed interferon signature enrichment and upregulation of gene targets for STAT1/STAT2/STAT3 and IRF1 in anti-PD-1-responding tumors. Therefore, these studies map the signaling pathway of interferon-gamma-inducible PD-1 ligand expression. PD-1 PD-L1 PD-L2 interferon receptor signaling pathways JAK-STATs IRF1 immunotherapy melanoma Biology (General) Daniel Sanghoon Shin verfasserin aut Blanca Homet Moreno verfasserin aut Justin Saco verfasserin aut Helena Escuin-Ordinas verfasserin aut Gabriel Abril Rodriguez verfasserin aut Jesse M. Zaretsky verfasserin aut Lu Sun verfasserin aut Willy Hugo verfasserin aut Xiaoyan Wang verfasserin aut Giulia Parisi verfasserin aut Cristina Puig Saus verfasserin aut Davis Y. Torrejon verfasserin aut Thomas G. Graeber verfasserin aut Begonya Comin-Anduix verfasserin aut Siwen Hu-Lieskovan verfasserin aut Robert Damoiseaux verfasserin aut Roger S. Lo verfasserin aut Antoni Ribas verfasserin aut In Cell Reports Elsevier, 2015 19(2017), 6, Seite 1189-1201 (DE-627)684964562 (DE-600)2649101-1 22111247 nnns volume:19 year:2017 number:6 pages:1189-1201 https://doi.org/10.1016/j.celrep.2017.04.031 kostenfrei https://doaj.org/article/e5b58d91cebc41a38766402ee83a9fa5 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211124717305259 kostenfrei https://doaj.org/toc/2211-1247 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 19 2017 6 1189-1201
language	English
source	In Cell Reports 19(2017), 6, Seite 1189-1201 volume:19 year:2017 number:6 pages:1189-1201
sourceStr	In Cell Reports 19(2017), 6, Seite 1189-1201 volume:19 year:2017 number:6 pages:1189-1201
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	PD-1 PD-L1 PD-L2 interferon receptor signaling pathways JAK-STATs IRF1 immunotherapy melanoma Biology (General)
isfreeaccess_bool	true
container_title	Cell Reports
authorswithroles_txt_mv	Angel Garcia-Diaz @@aut@@ Daniel Sanghoon Shin @@aut@@ Blanca Homet Moreno @@aut@@ Justin Saco @@aut@@ Helena Escuin-Ordinas @@aut@@ Gabriel Abril Rodriguez @@aut@@ Jesse M. Zaretsky @@aut@@ Lu Sun @@aut@@ Willy Hugo @@aut@@ Xiaoyan Wang @@aut@@ Giulia Parisi @@aut@@ Cristina Puig Saus @@aut@@ Davis Y. Torrejon @@aut@@ Thomas G. Graeber @@aut@@ Begonya Comin-Anduix @@aut@@ Siwen Hu-Lieskovan @@aut@@ Robert Damoiseaux @@aut@@ Roger S. Lo @@aut@@ Antoni Ribas @@aut@@
publishDateDaySort_date	2017-01-01T00:00:00Z
hierarchy_top_id	684964562
id	DOAJ037817965
language_de	englisch
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callnumber-first	Q - Science
author	Angel Garcia-Diaz
spellingShingle	Angel Garcia-Diaz misc QH301-705.5 misc PD-1 misc PD-L1 misc PD-L2 misc interferon receptor signaling pathways misc JAK-STATs misc IRF1 misc immunotherapy misc melanoma misc Biology (General) Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression
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topic_title	QH301-705.5 Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression PD-1 PD-L1 PD-L2 interferon receptor signaling pathways JAK-STATs IRF1 immunotherapy melanoma
topic	misc QH301-705.5 misc PD-1 misc PD-L1 misc PD-L2 misc interferon receptor signaling pathways misc JAK-STATs misc IRF1 misc immunotherapy misc melanoma misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc PD-1 misc PD-L1 misc PD-L2 misc interferon receptor signaling pathways misc JAK-STATs misc IRF1 misc immunotherapy misc melanoma misc Biology (General)
topic_browse	misc QH301-705.5 misc PD-1 misc PD-L1 misc PD-L2 misc interferon receptor signaling pathways misc JAK-STATs misc IRF1 misc immunotherapy misc melanoma misc Biology (General)
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title	Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression
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title_full	Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression
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author_browse	Angel Garcia-Diaz Daniel Sanghoon Shin Blanca Homet Moreno Justin Saco Helena Escuin-Ordinas Gabriel Abril Rodriguez Jesse M. Zaretsky Lu Sun Willy Hugo Xiaoyan Wang Giulia Parisi Cristina Puig Saus Davis Y. Torrejon Thomas G. Graeber Begonya Comin-Anduix Siwen Hu-Lieskovan Robert Damoiseaux Roger S. Lo Antoni Ribas
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title_sort	interferon receptor signaling pathways regulating pd-l1 and pd-l2 expression
callnumber	QH301-705.5
title_auth	Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression
abstract	PD-L1 and PD-L2 are ligands for the PD-1 immune inhibiting checkpoint that can be induced in tumors by interferon exposure, leading to immune evasion. This process is important for immunotherapy based on PD-1 blockade. We examined the specific molecules involved in interferon-induced signaling that regulates PD-L1 and PD-L2 expression in melanoma cells. These studies revealed that the interferon-gamma-JAK1/JAK2-STAT1/STAT2/STAT3-IRF1 axis primarily regulates PD-L1 expression, with IRF1 binding to its promoter. PD-L2 responded equally to interferon beta and gamma and is regulated through both IRF1 and STAT3, which bind to the PD-L2 promoter. Analysis of biopsy specimens from patients with melanoma confirmed interferon signature enrichment and upregulation of gene targets for STAT1/STAT2/STAT3 and IRF1 in anti-PD-1-responding tumors. Therefore, these studies map the signaling pathway of interferon-gamma-inducible PD-1 ligand expression.
abstractGer	PD-L1 and PD-L2 are ligands for the PD-1 immune inhibiting checkpoint that can be induced in tumors by interferon exposure, leading to immune evasion. This process is important for immunotherapy based on PD-1 blockade. We examined the specific molecules involved in interferon-induced signaling that regulates PD-L1 and PD-L2 expression in melanoma cells. These studies revealed that the interferon-gamma-JAK1/JAK2-STAT1/STAT2/STAT3-IRF1 axis primarily regulates PD-L1 expression, with IRF1 binding to its promoter. PD-L2 responded equally to interferon beta and gamma and is regulated through both IRF1 and STAT3, which bind to the PD-L2 promoter. Analysis of biopsy specimens from patients with melanoma confirmed interferon signature enrichment and upregulation of gene targets for STAT1/STAT2/STAT3 and IRF1 in anti-PD-1-responding tumors. Therefore, these studies map the signaling pathway of interferon-gamma-inducible PD-1 ligand expression.
abstract_unstemmed	PD-L1 and PD-L2 are ligands for the PD-1 immune inhibiting checkpoint that can be induced in tumors by interferon exposure, leading to immune evasion. This process is important for immunotherapy based on PD-1 blockade. We examined the specific molecules involved in interferon-induced signaling that regulates PD-L1 and PD-L2 expression in melanoma cells. These studies revealed that the interferon-gamma-JAK1/JAK2-STAT1/STAT2/STAT3-IRF1 axis primarily regulates PD-L1 expression, with IRF1 binding to its promoter. PD-L2 responded equally to interferon beta and gamma and is regulated through both IRF1 and STAT3, which bind to the PD-L2 promoter. Analysis of biopsy specimens from patients with melanoma confirmed interferon signature enrichment and upregulation of gene targets for STAT1/STAT2/STAT3 and IRF1 in anti-PD-1-responding tumors. Therefore, these studies map the signaling pathway of interferon-gamma-inducible PD-1 ligand expression.
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container_issue	6
title_short	Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression
url	https://doi.org/10.1016/j.celrep.2017.04.031 https://doaj.org/article/e5b58d91cebc41a38766402ee83a9fa5 http://www.sciencedirect.com/science/article/pii/S2211124717305259 https://doaj.org/toc/2211-1247
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author2	Daniel Sanghoon Shin Blanca Homet Moreno Justin Saco Helena Escuin-Ordinas Gabriel Abril Rodriguez Jesse M. Zaretsky Lu Sun Willy Hugo Xiaoyan Wang Giulia Parisi Cristina Puig Saus Davis Y. Torrejon Thomas G. Graeber Begonya Comin-Anduix Siwen Hu-Lieskovan Robert Damoiseaux Roger S. Lo Antoni Ribas
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up_date	2024-07-03T14:18:30.439Z
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Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

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