Anti-Aging Effect of the Ketone Metabolite β-Hydroxybutyrate in <i<Drosophila</i< Intestinal Stem Cells

Age-related changes in tissue-resident adult stem cells may be closely linked to tissue aging and age-related diseases, such as cancer. β-Hydroxybutyrate is emerging as an important molecule for exhibiting the anti-aging effects of caloric restriction and fasting, which are generally considered to b...
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Autor*in:	Joung-Sun Park [verfasserIn] Yung-Jin Kim [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	β-hydroxybutyrate intestinal stem cell centrosome amplification Niche DNA damage

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 21(2020), 10, p 3497
Übergeordnetes Werk:	volume:21 ; year:2020 ; number:10, p 3497

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijms21103497

Katalog-ID:	DOAJ037917412

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callnumber-first	Q - Science
author	Joung-Sun Park
spellingShingle	Joung-Sun Park misc QH301-705.5 misc QD1-999 misc <i<Drosophila</i< midgut misc β-hydroxybutyrate misc intestinal stem cell misc centrosome amplification misc Niche misc DNA damage misc Biology (General) misc Chemistry Anti-Aging Effect of the Ketone Metabolite β-Hydroxybutyrate in <i<Drosophila</i< Intestinal Stem Cells
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topic_title	QH301-705.5 QD1-999 Anti-Aging Effect of the Ketone Metabolite β-Hydroxybutyrate in <i<Drosophila</i< Intestinal Stem Cells <i<Drosophila</i< midgut β-hydroxybutyrate intestinal stem cell centrosome amplification Niche DNA damage
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title	Anti-Aging Effect of the Ketone Metabolite β-Hydroxybutyrate in <i<Drosophila</i< Intestinal Stem Cells
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title_full	Anti-Aging Effect of the Ketone Metabolite β-Hydroxybutyrate in <i<Drosophila</i< Intestinal Stem Cells
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title_sort	anti-aging effect of the ketone metabolite β-hydroxybutyrate in <i<drosophila</i< intestinal stem cells
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title_auth	Anti-Aging Effect of the Ketone Metabolite β-Hydroxybutyrate in <i<Drosophila</i< Intestinal Stem Cells
abstract	Age-related changes in tissue-resident adult stem cells may be closely linked to tissue aging and age-related diseases, such as cancer. β-Hydroxybutyrate is emerging as an important molecule for exhibiting the anti-aging effects of caloric restriction and fasting, which are generally considered to be beneficial for stem cell maintenance and tissue regeneration. The effects of β-hydroxybutyrate on adult stem cells remain largely unknown. Therefore, this study was undertaken to investigate whether β-hydroxybutyrate supplementation exerts beneficial effects on age-related changes in intestinal stem cells that were derived from the <i<Drosophila</i< midgut. Our results indicate that β-hydroxybutyrate inhibits age- and oxidative stress-induced changes in midgut intestinal stem cells, including centrosome amplification (a hallmark of cancers), hyperproliferation, and DNA damage accumulation. Additionally, β-hydroxybutyrate inhibits age- and oxidative stress-induced heterochromatin instability in enterocytes, an intestinal stem cells niche cells. Our results suggest that β-hydroxybutyrate exerts both intrinsic as well as extrinsic influence in order to maintain stem cell homeostasis.
abstractGer	Age-related changes in tissue-resident adult stem cells may be closely linked to tissue aging and age-related diseases, such as cancer. β-Hydroxybutyrate is emerging as an important molecule for exhibiting the anti-aging effects of caloric restriction and fasting, which are generally considered to be beneficial for stem cell maintenance and tissue regeneration. The effects of β-hydroxybutyrate on adult stem cells remain largely unknown. Therefore, this study was undertaken to investigate whether β-hydroxybutyrate supplementation exerts beneficial effects on age-related changes in intestinal stem cells that were derived from the <i<Drosophila</i< midgut. Our results indicate that β-hydroxybutyrate inhibits age- and oxidative stress-induced changes in midgut intestinal stem cells, including centrosome amplification (a hallmark of cancers), hyperproliferation, and DNA damage accumulation. Additionally, β-hydroxybutyrate inhibits age- and oxidative stress-induced heterochromatin instability in enterocytes, an intestinal stem cells niche cells. Our results suggest that β-hydroxybutyrate exerts both intrinsic as well as extrinsic influence in order to maintain stem cell homeostasis.
abstract_unstemmed	Age-related changes in tissue-resident adult stem cells may be closely linked to tissue aging and age-related diseases, such as cancer. β-Hydroxybutyrate is emerging as an important molecule for exhibiting the anti-aging effects of caloric restriction and fasting, which are generally considered to be beneficial for stem cell maintenance and tissue regeneration. The effects of β-hydroxybutyrate on adult stem cells remain largely unknown. Therefore, this study was undertaken to investigate whether β-hydroxybutyrate supplementation exerts beneficial effects on age-related changes in intestinal stem cells that were derived from the <i<Drosophila</i< midgut. Our results indicate that β-hydroxybutyrate inhibits age- and oxidative stress-induced changes in midgut intestinal stem cells, including centrosome amplification (a hallmark of cancers), hyperproliferation, and DNA damage accumulation. Additionally, β-hydroxybutyrate inhibits age- and oxidative stress-induced heterochromatin instability in enterocytes, an intestinal stem cells niche cells. Our results suggest that β-hydroxybutyrate exerts both intrinsic as well as extrinsic influence in order to maintain stem cell homeostasis.
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title_short	Anti-Aging Effect of the Ketone Metabolite β-Hydroxybutyrate in <i<Drosophila</i< Intestinal Stem Cells
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Anti-Aging Effect of the Ketone Metabolite β-Hydroxybutyrate in <i<Drosophila</i< Intestinal Stem Cells

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