Advances in Preclinical Research Models of Radiation-Induced Cardiac Toxicity

Radiation therapy (RT) is an important component of cancer therapy, with >50% of cancer patients receiving RT. As the number of cancer survivors increases, the short- and long-term side effects of cancer therapy are of growing concern. Side effects of RT for thoracic tumors, notably cardiac a...
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Gespeichert in:

Autor*in:	Rachel A. Schlaak [verfasserIn] Gopika SenthilKumar [verfasserIn] Marjan Boerma [verfasserIn] Carmen Bergom [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	radiation biology thoracic radiation therapy normal tissue toxicity cardiopulmonary toxicity small animal irradiators image-guided radiotherapy cardiotoxicity radiation-induced heart disease

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 12(2020), 2, p 415
Übergeordnetes Werk:	volume:12 ; year:2020 ; number:2, p 415

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers12020415

Katalog-ID:	DOAJ037974882

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allfieldsSound	10.3390/cancers12020415 doi (DE-627)DOAJ037974882 (DE-599)DOAJbea14c88988d4e63aeba6a38e2fc4994 DE-627 ger DE-627 rakwb eng RC254-282 Rachel A. Schlaak verfasserin aut Advances in Preclinical Research Models of Radiation-Induced Cardiac Toxicity 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Radiation therapy (RT) is an important component of cancer therapy, with >50% of cancer patients receiving RT. As the number of cancer survivors increases, the short- and long-term side effects of cancer therapy are of growing concern. Side effects of RT for thoracic tumors, notably cardiac and pulmonary toxicities, can cause morbidity and mortality in long-term cancer survivors. An understanding of the biological pathways and mechanisms involved in normal tissue toxicity from RT will improve future cancer treatments by reducing the risk of long-term side effects. Many of these mechanistic studies are performed in animal models of radiation exposure. In this area of research, the use of small animal image-guided RT with treatment planning systems that allow more accurate dose determination has the potential to revolutionize knowledge of clinically relevant tumor and normal tissue radiobiology. However, there are still a number of challenges to overcome to optimize such radiation delivery, including dose verification and calibration, determination of doses received by adjacent normal tissues that can affect outcomes, and motion management and identifying variation in doses due to animal heterogeneity. In addition, recent studies have begun to determine how animal strain and sex affect normal tissue radiation injuries. This review article discusses the known and potential benefits and caveats of newer technologies and methods used for small animal radiation delivery, as well as how the choice of animal models, including variables such as species, strain, and age, can alter the severity of cardiac radiation toxicities and impact their clinical relevance. radiation biology thoracic radiation therapy normal tissue toxicity cardiopulmonary toxicity small animal irradiators image-guided radiotherapy cardiotoxicity radiation-induced heart disease Neoplasms. Tumors. Oncology. Including cancer and carcinogens Gopika SenthilKumar verfasserin aut Marjan Boerma verfasserin aut Carmen Bergom verfasserin aut In Cancers MDPI AG, 2010 12(2020), 2, p 415 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:12 year:2020 number:2, p 415 https://doi.org/10.3390/cancers12020415 kostenfrei https://doaj.org/article/bea14c88988d4e63aeba6a38e2fc4994 kostenfrei https://www.mdpi.com/2072-6694/12/2/415 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 2, p 415
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callnumber-first	R - Medicine
author	Rachel A. Schlaak
spellingShingle	Rachel A. Schlaak misc RC254-282 misc radiation biology misc thoracic radiation therapy misc normal tissue toxicity misc cardiopulmonary toxicity misc small animal irradiators misc image-guided radiotherapy misc cardiotoxicity misc radiation-induced heart disease misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Advances in Preclinical Research Models of Radiation-Induced Cardiac Toxicity
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topic_title	RC254-282 Advances in Preclinical Research Models of Radiation-Induced Cardiac Toxicity radiation biology thoracic radiation therapy normal tissue toxicity cardiopulmonary toxicity small animal irradiators image-guided radiotherapy cardiotoxicity radiation-induced heart disease
topic	misc RC254-282 misc radiation biology misc thoracic radiation therapy misc normal tissue toxicity misc cardiopulmonary toxicity misc small animal irradiators misc image-guided radiotherapy misc cardiotoxicity misc radiation-induced heart disease misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc radiation biology misc thoracic radiation therapy misc normal tissue toxicity misc cardiopulmonary toxicity misc small animal irradiators misc image-guided radiotherapy misc cardiotoxicity misc radiation-induced heart disease misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title_sort	advances in preclinical research models of radiation-induced cardiac toxicity
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title_auth	Advances in Preclinical Research Models of Radiation-Induced Cardiac Toxicity
abstract	Radiation therapy (RT) is an important component of cancer therapy, with >50% of cancer patients receiving RT. As the number of cancer survivors increases, the short- and long-term side effects of cancer therapy are of growing concern. Side effects of RT for thoracic tumors, notably cardiac and pulmonary toxicities, can cause morbidity and mortality in long-term cancer survivors. An understanding of the biological pathways and mechanisms involved in normal tissue toxicity from RT will improve future cancer treatments by reducing the risk of long-term side effects. Many of these mechanistic studies are performed in animal models of radiation exposure. In this area of research, the use of small animal image-guided RT with treatment planning systems that allow more accurate dose determination has the potential to revolutionize knowledge of clinically relevant tumor and normal tissue radiobiology. However, there are still a number of challenges to overcome to optimize such radiation delivery, including dose verification and calibration, determination of doses received by adjacent normal tissues that can affect outcomes, and motion management and identifying variation in doses due to animal heterogeneity. In addition, recent studies have begun to determine how animal strain and sex affect normal tissue radiation injuries. This review article discusses the known and potential benefits and caveats of newer technologies and methods used for small animal radiation delivery, as well as how the choice of animal models, including variables such as species, strain, and age, can alter the severity of cardiac radiation toxicities and impact their clinical relevance.
abstractGer	Radiation therapy (RT) is an important component of cancer therapy, with >50% of cancer patients receiving RT. As the number of cancer survivors increases, the short- and long-term side effects of cancer therapy are of growing concern. Side effects of RT for thoracic tumors, notably cardiac and pulmonary toxicities, can cause morbidity and mortality in long-term cancer survivors. An understanding of the biological pathways and mechanisms involved in normal tissue toxicity from RT will improve future cancer treatments by reducing the risk of long-term side effects. Many of these mechanistic studies are performed in animal models of radiation exposure. In this area of research, the use of small animal image-guided RT with treatment planning systems that allow more accurate dose determination has the potential to revolutionize knowledge of clinically relevant tumor and normal tissue radiobiology. However, there are still a number of challenges to overcome to optimize such radiation delivery, including dose verification and calibration, determination of doses received by adjacent normal tissues that can affect outcomes, and motion management and identifying variation in doses due to animal heterogeneity. In addition, recent studies have begun to determine how animal strain and sex affect normal tissue radiation injuries. This review article discusses the known and potential benefits and caveats of newer technologies and methods used for small animal radiation delivery, as well as how the choice of animal models, including variables such as species, strain, and age, can alter the severity of cardiac radiation toxicities and impact their clinical relevance.
abstract_unstemmed	Radiation therapy (RT) is an important component of cancer therapy, with >50% of cancer patients receiving RT. As the number of cancer survivors increases, the short- and long-term side effects of cancer therapy are of growing concern. Side effects of RT for thoracic tumors, notably cardiac and pulmonary toxicities, can cause morbidity and mortality in long-term cancer survivors. An understanding of the biological pathways and mechanisms involved in normal tissue toxicity from RT will improve future cancer treatments by reducing the risk of long-term side effects. Many of these mechanistic studies are performed in animal models of radiation exposure. In this area of research, the use of small animal image-guided RT with treatment planning systems that allow more accurate dose determination has the potential to revolutionize knowledge of clinically relevant tumor and normal tissue radiobiology. However, there are still a number of challenges to overcome to optimize such radiation delivery, including dose verification and calibration, determination of doses received by adjacent normal tissues that can affect outcomes, and motion management and identifying variation in doses due to animal heterogeneity. In addition, recent studies have begun to determine how animal strain and sex affect normal tissue radiation injuries. This review article discusses the known and potential benefits and caveats of newer technologies and methods used for small animal radiation delivery, as well as how the choice of animal models, including variables such as species, strain, and age, can alter the severity of cardiac radiation toxicities and impact their clinical relevance.
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