The critical points in induction of experimental autoimmune uveitis

Background: Autoimmune uveitis is a leading cause of visual impairment in developed countries in patients of working age. Animal models of experimental autoimmune uveitis (EAU) have been established to serve as a useful template for novel therapeutic approaches. Methods: Experimental autoimmune uvei...
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Autor*in:	Aneta Klimova [verfasserIn] Petra Seidler Stangova [verfasserIn] Petra Svozilkova [verfasserIn] John V. Forrester [verfasserIn] Izabela Klaska [verfasserIn] Jarmila Heissigerova [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	experimental autoimmune uveitis c57bl/6 mouse strain mouse model induction protocol chronic posterior autoimmune uveitis

Übergeordnetes Werk:	In: Biomedical Papers - Palacký University Olomouc, Faculty of Medicine and Dentistry, 2019, 160(2016), 1, Seite 140-142
Übergeordnetes Werk:	volume:160 ; year:2016 ; number:1 ; pages:140-142

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.5507/bp.2015.056

Katalog-ID:	DOAJ037998870

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spelling	10.5507/bp.2015.056 doi (DE-627)DOAJ037998870 (DE-599)DOAJb4790b3faf2a41dc983162e59710bd95 DE-627 ger DE-627 rakwb eng Aneta Klimova verfasserin aut The critical points in induction of experimental autoimmune uveitis 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Autoimmune uveitis is a leading cause of visual impairment in developed countries in patients of working age. Animal models of experimental autoimmune uveitis (EAU) have been established to serve as a useful template for novel therapeutic approaches. Methods: Experimental autoimmune uveitis is induced in C57BL/6 mice by subcutaneous application of interphotoreceptor retinoid binding protein in complete Freund's adjuvant and pertussis toxin. Clinical and histological grading is used to assess the inflammation intensity of EAU. Results: The protocol of induction of EAU in mice hides several important aspects, which are crucial for developing the disease. These details have to be addressed to ensure reproducible disease induction. We describe our experience in establishing the model by pointing out the critical steps in EAU protocol which we found important. Conclusion: The mouse model of EAU has practical value for preclinical studies, is robust and well established. However, the induction of inflammation of the eye can be quite challenging when important details of the protocol are not recognized and adhered to. experimental autoimmune uveitis c57bl/6 mouse strain mouse model induction protocol chronic posterior autoimmune uveitis Medicine R Petra Seidler Stangova verfasserin aut Petra Svozilkova verfasserin aut John V. Forrester verfasserin aut Izabela Klaska verfasserin aut Jarmila Heissigerova verfasserin aut In Biomedical Papers Palacký University Olomouc, Faculty of Medicine and Dentistry, 2019 160(2016), 1, Seite 140-142 (DE-627)50107788X (DE-600)2205906-4 18047521 nnns volume:160 year:2016 number:1 pages:140-142 https://doi.org/10.5507/bp.2015.056 kostenfrei https://doaj.org/article/b4790b3faf2a41dc983162e59710bd95 kostenfrei https://biomed.papers.upol.cz/artkey/bio-201601-0019_The_critical_points_in_induction_of_experimental_autoimmune_uveitis.php kostenfrei https://doaj.org/toc/1213-8118 Journal toc kostenfrei https://doaj.org/toc/1804-7521 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 160 2016 1 140-142
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allfieldsGer	10.5507/bp.2015.056 doi (DE-627)DOAJ037998870 (DE-599)DOAJb4790b3faf2a41dc983162e59710bd95 DE-627 ger DE-627 rakwb eng Aneta Klimova verfasserin aut The critical points in induction of experimental autoimmune uveitis 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Autoimmune uveitis is a leading cause of visual impairment in developed countries in patients of working age. Animal models of experimental autoimmune uveitis (EAU) have been established to serve as a useful template for novel therapeutic approaches. Methods: Experimental autoimmune uveitis is induced in C57BL/6 mice by subcutaneous application of interphotoreceptor retinoid binding protein in complete Freund's adjuvant and pertussis toxin. Clinical and histological grading is used to assess the inflammation intensity of EAU. Results: The protocol of induction of EAU in mice hides several important aspects, which are crucial for developing the disease. These details have to be addressed to ensure reproducible disease induction. We describe our experience in establishing the model by pointing out the critical steps in EAU protocol which we found important. Conclusion: The mouse model of EAU has practical value for preclinical studies, is robust and well established. However, the induction of inflammation of the eye can be quite challenging when important details of the protocol are not recognized and adhered to. experimental autoimmune uveitis c57bl/6 mouse strain mouse model induction protocol chronic posterior autoimmune uveitis Medicine R Petra Seidler Stangova verfasserin aut Petra Svozilkova verfasserin aut John V. Forrester verfasserin aut Izabela Klaska verfasserin aut Jarmila Heissigerova verfasserin aut In Biomedical Papers Palacký University Olomouc, Faculty of Medicine and Dentistry, 2019 160(2016), 1, Seite 140-142 (DE-627)50107788X (DE-600)2205906-4 18047521 nnns volume:160 year:2016 number:1 pages:140-142 https://doi.org/10.5507/bp.2015.056 kostenfrei https://doaj.org/article/b4790b3faf2a41dc983162e59710bd95 kostenfrei https://biomed.papers.upol.cz/artkey/bio-201601-0019_The_critical_points_in_induction_of_experimental_autoimmune_uveitis.php kostenfrei https://doaj.org/toc/1213-8118 Journal toc kostenfrei https://doaj.org/toc/1804-7521 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 160 2016 1 140-142
allfieldsSound	10.5507/bp.2015.056 doi (DE-627)DOAJ037998870 (DE-599)DOAJb4790b3faf2a41dc983162e59710bd95 DE-627 ger DE-627 rakwb eng Aneta Klimova verfasserin aut The critical points in induction of experimental autoimmune uveitis 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Autoimmune uveitis is a leading cause of visual impairment in developed countries in patients of working age. Animal models of experimental autoimmune uveitis (EAU) have been established to serve as a useful template for novel therapeutic approaches. Methods: Experimental autoimmune uveitis is induced in C57BL/6 mice by subcutaneous application of interphotoreceptor retinoid binding protein in complete Freund's adjuvant and pertussis toxin. Clinical and histological grading is used to assess the inflammation intensity of EAU. Results: The protocol of induction of EAU in mice hides several important aspects, which are crucial for developing the disease. These details have to be addressed to ensure reproducible disease induction. We describe our experience in establishing the model by pointing out the critical steps in EAU protocol which we found important. Conclusion: The mouse model of EAU has practical value for preclinical studies, is robust and well established. However, the induction of inflammation of the eye can be quite challenging when important details of the protocol are not recognized and adhered to. experimental autoimmune uveitis c57bl/6 mouse strain mouse model induction protocol chronic posterior autoimmune uveitis Medicine R Petra Seidler Stangova verfasserin aut Petra Svozilkova verfasserin aut John V. Forrester verfasserin aut Izabela Klaska verfasserin aut Jarmila Heissigerova verfasserin aut In Biomedical Papers Palacký University Olomouc, Faculty of Medicine and Dentistry, 2019 160(2016), 1, Seite 140-142 (DE-627)50107788X (DE-600)2205906-4 18047521 nnns volume:160 year:2016 number:1 pages:140-142 https://doi.org/10.5507/bp.2015.056 kostenfrei https://doaj.org/article/b4790b3faf2a41dc983162e59710bd95 kostenfrei https://biomed.papers.upol.cz/artkey/bio-201601-0019_The_critical_points_in_induction_of_experimental_autoimmune_uveitis.php kostenfrei https://doaj.org/toc/1213-8118 Journal toc kostenfrei https://doaj.org/toc/1804-7521 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 160 2016 1 140-142
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source	In Biomedical Papers 160(2016), 1, Seite 140-142 volume:160 year:2016 number:1 pages:140-142
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authorswithroles_txt_mv	Aneta Klimova @@aut@@ Petra Seidler Stangova @@aut@@ Petra Svozilkova @@aut@@ John V. Forrester @@aut@@ Izabela Klaska @@aut@@ Jarmila Heissigerova @@aut@@
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author	Aneta Klimova
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topic_title	The critical points in induction of experimental autoimmune uveitis experimental autoimmune uveitis c57bl/6 mouse strain mouse model induction protocol chronic posterior autoimmune uveitis
topic	misc experimental autoimmune uveitis misc c57bl/6 mouse strain misc mouse model misc induction protocol misc chronic posterior autoimmune uveitis misc Medicine misc R
topic_unstemmed	misc experimental autoimmune uveitis misc c57bl/6 mouse strain misc mouse model misc induction protocol misc chronic posterior autoimmune uveitis misc Medicine misc R
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title	The critical points in induction of experimental autoimmune uveitis
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title_sort	critical points in induction of experimental autoimmune uveitis
title_auth	The critical points in induction of experimental autoimmune uveitis
abstract	Background: Autoimmune uveitis is a leading cause of visual impairment in developed countries in patients of working age. Animal models of experimental autoimmune uveitis (EAU) have been established to serve as a useful template for novel therapeutic approaches. Methods: Experimental autoimmune uveitis is induced in C57BL/6 mice by subcutaneous application of interphotoreceptor retinoid binding protein in complete Freund's adjuvant and pertussis toxin. Clinical and histological grading is used to assess the inflammation intensity of EAU. Results: The protocol of induction of EAU in mice hides several important aspects, which are crucial for developing the disease. These details have to be addressed to ensure reproducible disease induction. We describe our experience in establishing the model by pointing out the critical steps in EAU protocol which we found important. Conclusion: The mouse model of EAU has practical value for preclinical studies, is robust and well established. However, the induction of inflammation of the eye can be quite challenging when important details of the protocol are not recognized and adhered to.
abstractGer	Background: Autoimmune uveitis is a leading cause of visual impairment in developed countries in patients of working age. Animal models of experimental autoimmune uveitis (EAU) have been established to serve as a useful template for novel therapeutic approaches. Methods: Experimental autoimmune uveitis is induced in C57BL/6 mice by subcutaneous application of interphotoreceptor retinoid binding protein in complete Freund's adjuvant and pertussis toxin. Clinical and histological grading is used to assess the inflammation intensity of EAU. Results: The protocol of induction of EAU in mice hides several important aspects, which are crucial for developing the disease. These details have to be addressed to ensure reproducible disease induction. We describe our experience in establishing the model by pointing out the critical steps in EAU protocol which we found important. Conclusion: The mouse model of EAU has practical value for preclinical studies, is robust and well established. However, the induction of inflammation of the eye can be quite challenging when important details of the protocol are not recognized and adhered to.
abstract_unstemmed	Background: Autoimmune uveitis is a leading cause of visual impairment in developed countries in patients of working age. Animal models of experimental autoimmune uveitis (EAU) have been established to serve as a useful template for novel therapeutic approaches. Methods: Experimental autoimmune uveitis is induced in C57BL/6 mice by subcutaneous application of interphotoreceptor retinoid binding protein in complete Freund's adjuvant and pertussis toxin. Clinical and histological grading is used to assess the inflammation intensity of EAU. Results: The protocol of induction of EAU in mice hides several important aspects, which are crucial for developing the disease. These details have to be addressed to ensure reproducible disease induction. We describe our experience in establishing the model by pointing out the critical steps in EAU protocol which we found important. Conclusion: The mouse model of EAU has practical value for preclinical studies, is robust and well established. However, the induction of inflammation of the eye can be quite challenging when important details of the protocol are not recognized and adhered to.
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title_short	The critical points in induction of experimental autoimmune uveitis
url	https://doi.org/10.5507/bp.2015.056 https://doaj.org/article/b4790b3faf2a41dc983162e59710bd95 https://biomed.papers.upol.cz/artkey/bio-201601-0019_The_critical_points_in_induction_of_experimental_autoimmune_uveitis.php https://doaj.org/toc/1213-8118 https://doaj.org/toc/1804-7521
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The critical points in induction of experimental autoimmune uveitis

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