Is intracranial volume a suitable proxy for brain reserve?

Abstract Background Brain reserve is a concept introduced to explain why Alzheimer’s disease (AD) patients with a greater brain volume prior to onset of pathology generally have better clinical outcomes. In this review, we provide a historical background of the emergence of brain reserve and discuss...
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Autor*in:	Anna Catharina van Loenhoud [verfasserIn] Colin Groot [verfasserIn] Jacob William Vogel [verfasserIn] Wiesje Maria van der Flier [verfasserIn] Rik Ossenkoppele [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Brain reserve Intracranial volume Alzheimer’s disease Dementia MRI Resilience

Übergeordnetes Werk:	In: Alzheimer’s Research & Therapy - BMC, 2015, 10(2018), 1, Seite 12
Übergeordnetes Werk:	volume:10 ; year:2018 ; number:1 ; pages:12

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s13195-018-0408-5

Katalog-ID:	DOAJ038118041

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source	In Alzheimer’s Research & Therapy 10(2018), 1, Seite 12 volume:10 year:2018 number:1 pages:12
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topic_facet	Brain reserve Intracranial volume Alzheimer’s disease Dementia MRI Resilience Neurosciences. Biological psychiatry. Neuropsychiatry Neurology. Diseases of the nervous system
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callnumber-first	R - Medicine
author	Anna Catharina van Loenhoud
spellingShingle	Anna Catharina van Loenhoud misc RC321-571 misc RC346-429 misc Brain reserve misc Intracranial volume misc Alzheimer’s disease misc Dementia misc MRI misc Resilience misc Neurosciences. Biological psychiatry. Neuropsychiatry misc Neurology. Diseases of the nervous system Is intracranial volume a suitable proxy for brain reserve?
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topic_title	RC321-571 RC346-429 Is intracranial volume a suitable proxy for brain reserve? Brain reserve Intracranial volume Alzheimer’s disease Dementia MRI Resilience
topic	misc RC321-571 misc RC346-429 misc Brain reserve misc Intracranial volume misc Alzheimer’s disease misc Dementia misc MRI misc Resilience misc Neurosciences. Biological psychiatry. Neuropsychiatry misc Neurology. Diseases of the nervous system
topic_unstemmed	misc RC321-571 misc RC346-429 misc Brain reserve misc Intracranial volume misc Alzheimer’s disease misc Dementia misc MRI misc Resilience misc Neurosciences. Biological psychiatry. Neuropsychiatry misc Neurology. Diseases of the nervous system
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title	Is intracranial volume a suitable proxy for brain reserve?
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title_sort	is intracranial volume a suitable proxy for brain reserve?
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title_auth	Is intracranial volume a suitable proxy for brain reserve?
abstract	Abstract Background Brain reserve is a concept introduced to explain why Alzheimer’s disease (AD) patients with a greater brain volume prior to onset of pathology generally have better clinical outcomes. In this review, we provide a historical background of the emergence of brain reserve and discuss several aspects that need further clarification, including the dynamic or static nature of the concept and its underlying mechanisms and clinical effect. We then describe how brain reserve has been operationalized over the years, and critically evaluate the use of intracranial volume (ICV) as the most widely used proxy for brain reserve. Furthermore, we perform a meta-analysis showing that ICV is associated with higher cognitive performance after adjusting for the presence and amount of pathology. Although we acknowledge its imperfections, we conclude that the use of ICV as a proxy for brain reserve is currently warranted. However, further development of more optimal measures of brain reserve as well as a more clearly defined theoretical framework is essential.
abstractGer	Abstract Background Brain reserve is a concept introduced to explain why Alzheimer’s disease (AD) patients with a greater brain volume prior to onset of pathology generally have better clinical outcomes. In this review, we provide a historical background of the emergence of brain reserve and discuss several aspects that need further clarification, including the dynamic or static nature of the concept and its underlying mechanisms and clinical effect. We then describe how brain reserve has been operationalized over the years, and critically evaluate the use of intracranial volume (ICV) as the most widely used proxy for brain reserve. Furthermore, we perform a meta-analysis showing that ICV is associated with higher cognitive performance after adjusting for the presence and amount of pathology. Although we acknowledge its imperfections, we conclude that the use of ICV as a proxy for brain reserve is currently warranted. However, further development of more optimal measures of brain reserve as well as a more clearly defined theoretical framework is essential.
abstract_unstemmed	Abstract Background Brain reserve is a concept introduced to explain why Alzheimer’s disease (AD) patients with a greater brain volume prior to onset of pathology generally have better clinical outcomes. In this review, we provide a historical background of the emergence of brain reserve and discuss several aspects that need further clarification, including the dynamic or static nature of the concept and its underlying mechanisms and clinical effect. We then describe how brain reserve has been operationalized over the years, and critically evaluate the use of intracranial volume (ICV) as the most widely used proxy for brain reserve. Furthermore, we perform a meta-analysis showing that ICV is associated with higher cognitive performance after adjusting for the presence and amount of pathology. Although we acknowledge its imperfections, we conclude that the use of ICV as a proxy for brain reserve is currently warranted. However, further development of more optimal measures of brain reserve as well as a more clearly defined theoretical framework is essential.
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title_short	Is intracranial volume a suitable proxy for brain reserve?
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