A comparison of sexual desire in opiate-dependent men receiving methadone and buprenorphine maintenance treatment

Abstract Background Methadone is an effective therapy for opiate dependence. However, one of the commonest side effects is sexual dysfunction among male patients. Buprenorphine is an alternative to methadone. This study aimed to compare sexual desire among opiate-dependent male patients on buprenorp...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Anne Yee [verfasserIn] Huai Seng Loh [verfasserIn] Huai Heng Loh [verfasserIn] Shahrzad Riahi [verfasserIn] Chong Guan Ng [verfasserIn] Ahmad Hatim bin Sulaiman [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Sexual desire Smoking Methadone Buprenorphine Sexual dysfunction

Übergeordnetes Werk:	In: Annals of General Psychiatry - BMC, 2005, 18(2019), 1, Seite 8
Übergeordnetes Werk:	volume:18 ; year:2019 ; number:1 ; pages:8

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12991-019-0249-z

Katalog-ID:	DOAJ038272644

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520			\|a Abstract Background Methadone is an effective therapy for opiate dependence. However, one of the commonest side effects is sexual dysfunction among male patients. Buprenorphine is an alternative to methadone. This study aimed to compare sexual desire among opiate-dependent male patients on buprenorphine (BMT) and methadone maintenance therapy (MMT). Methods This cross-sectional study involved 126 male opiate-dependent patient who were tested for total testosterone (TT) and prolactin levels, and were interviewed and completed the Sexual Desire Inventory-2 (SDI-2), Malay language of International Index of Erectile Function (Mal-IIEF-15) and the Malay version of the self-rated Montgomery-Asberg Depression Rating Scale (MADRS-BM) questionnaires. Results There were 95 (75.4%) patients on MMT and 31 (24.6%) on BMT. Patients on MMT scored significantly lower in the sexual desire domain (Mal-IIEF-15 scores) (p < 0.01), dyadic sexual desire (p = 0.04) and TT plasma level (p < 0.01) when compared to BMT group after controlling all the confounders. Conclusions Patients on MMT are associated with lower sexual desire when compared with patients on BMT. Smoking may further lower testosterone and, hence, sexual desire in those already on methadone.
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allfields	10.1186/s12991-019-0249-z doi (DE-627)DOAJ038272644 (DE-599)DOAJ6c0cdfe5963242da96398e9457156704 DE-627 ger DE-627 rakwb eng RC435-571 Anne Yee verfasserin aut A comparison of sexual desire in opiate-dependent men receiving methadone and buprenorphine maintenance treatment 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Methadone is an effective therapy for opiate dependence. However, one of the commonest side effects is sexual dysfunction among male patients. Buprenorphine is an alternative to methadone. This study aimed to compare sexual desire among opiate-dependent male patients on buprenorphine (BMT) and methadone maintenance therapy (MMT). Methods This cross-sectional study involved 126 male opiate-dependent patient who were tested for total testosterone (TT) and prolactin levels, and were interviewed and completed the Sexual Desire Inventory-2 (SDI-2), Malay language of International Index of Erectile Function (Mal-IIEF-15) and the Malay version of the self-rated Montgomery-Asberg Depression Rating Scale (MADRS-BM) questionnaires. Results There were 95 (75.4%) patients on MMT and 31 (24.6%) on BMT. Patients on MMT scored significantly lower in the sexual desire domain (Mal-IIEF-15 scores) (p < 0.01), dyadic sexual desire (p = 0.04) and TT plasma level (p < 0.01) when compared to BMT group after controlling all the confounders. Conclusions Patients on MMT are associated with lower sexual desire when compared with patients on BMT. Smoking may further lower testosterone and, hence, sexual desire in those already on methadone. Sexual desire Smoking Methadone Buprenorphine Sexual dysfunction Psychiatry Huai Seng Loh verfasserin aut Huai Heng Loh verfasserin aut Shahrzad Riahi verfasserin aut Chong Guan Ng verfasserin aut Ahmad Hatim bin Sulaiman verfasserin aut In Annals of General Psychiatry BMC, 2005 18(2019), 1, Seite 8 (DE-627)355102919 (DE-600)2090401-0 1744859X nnns volume:18 year:2019 number:1 pages:8 https://doi.org/10.1186/s12991-019-0249-z kostenfrei https://doaj.org/article/6c0cdfe5963242da96398e9457156704 kostenfrei http://link.springer.com/article/10.1186/s12991-019-0249-z kostenfrei https://doaj.org/toc/1744-859X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2019 1 8
spelling	10.1186/s12991-019-0249-z doi (DE-627)DOAJ038272644 (DE-599)DOAJ6c0cdfe5963242da96398e9457156704 DE-627 ger DE-627 rakwb eng RC435-571 Anne Yee verfasserin aut A comparison of sexual desire in opiate-dependent men receiving methadone and buprenorphine maintenance treatment 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Methadone is an effective therapy for opiate dependence. However, one of the commonest side effects is sexual dysfunction among male patients. Buprenorphine is an alternative to methadone. This study aimed to compare sexual desire among opiate-dependent male patients on buprenorphine (BMT) and methadone maintenance therapy (MMT). Methods This cross-sectional study involved 126 male opiate-dependent patient who were tested for total testosterone (TT) and prolactin levels, and were interviewed and completed the Sexual Desire Inventory-2 (SDI-2), Malay language of International Index of Erectile Function (Mal-IIEF-15) and the Malay version of the self-rated Montgomery-Asberg Depression Rating Scale (MADRS-BM) questionnaires. Results There were 95 (75.4%) patients on MMT and 31 (24.6%) on BMT. Patients on MMT scored significantly lower in the sexual desire domain (Mal-IIEF-15 scores) (p < 0.01), dyadic sexual desire (p = 0.04) and TT plasma level (p < 0.01) when compared to BMT group after controlling all the confounders. Conclusions Patients on MMT are associated with lower sexual desire when compared with patients on BMT. Smoking may further lower testosterone and, hence, sexual desire in those already on methadone. Sexual desire Smoking Methadone Buprenorphine Sexual dysfunction Psychiatry Huai Seng Loh verfasserin aut Huai Heng Loh verfasserin aut Shahrzad Riahi verfasserin aut Chong Guan Ng verfasserin aut Ahmad Hatim bin Sulaiman verfasserin aut In Annals of General Psychiatry BMC, 2005 18(2019), 1, Seite 8 (DE-627)355102919 (DE-600)2090401-0 1744859X nnns volume:18 year:2019 number:1 pages:8 https://doi.org/10.1186/s12991-019-0249-z kostenfrei https://doaj.org/article/6c0cdfe5963242da96398e9457156704 kostenfrei http://link.springer.com/article/10.1186/s12991-019-0249-z kostenfrei https://doaj.org/toc/1744-859X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2019 1 8
allfields_unstemmed	10.1186/s12991-019-0249-z doi (DE-627)DOAJ038272644 (DE-599)DOAJ6c0cdfe5963242da96398e9457156704 DE-627 ger DE-627 rakwb eng RC435-571 Anne Yee verfasserin aut A comparison of sexual desire in opiate-dependent men receiving methadone and buprenorphine maintenance treatment 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Methadone is an effective therapy for opiate dependence. However, one of the commonest side effects is sexual dysfunction among male patients. Buprenorphine is an alternative to methadone. This study aimed to compare sexual desire among opiate-dependent male patients on buprenorphine (BMT) and methadone maintenance therapy (MMT). Methods This cross-sectional study involved 126 male opiate-dependent patient who were tested for total testosterone (TT) and prolactin levels, and were interviewed and completed the Sexual Desire Inventory-2 (SDI-2), Malay language of International Index of Erectile Function (Mal-IIEF-15) and the Malay version of the self-rated Montgomery-Asberg Depression Rating Scale (MADRS-BM) questionnaires. Results There were 95 (75.4%) patients on MMT and 31 (24.6%) on BMT. Patients on MMT scored significantly lower in the sexual desire domain (Mal-IIEF-15 scores) (p < 0.01), dyadic sexual desire (p = 0.04) and TT plasma level (p < 0.01) when compared to BMT group after controlling all the confounders. Conclusions Patients on MMT are associated with lower sexual desire when compared with patients on BMT. Smoking may further lower testosterone and, hence, sexual desire in those already on methadone. Sexual desire Smoking Methadone Buprenorphine Sexual dysfunction Psychiatry Huai Seng Loh verfasserin aut Huai Heng Loh verfasserin aut Shahrzad Riahi verfasserin aut Chong Guan Ng verfasserin aut Ahmad Hatim bin Sulaiman verfasserin aut In Annals of General Psychiatry BMC, 2005 18(2019), 1, Seite 8 (DE-627)355102919 (DE-600)2090401-0 1744859X nnns volume:18 year:2019 number:1 pages:8 https://doi.org/10.1186/s12991-019-0249-z kostenfrei https://doaj.org/article/6c0cdfe5963242da96398e9457156704 kostenfrei http://link.springer.com/article/10.1186/s12991-019-0249-z kostenfrei https://doaj.org/toc/1744-859X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2019 1 8
allfieldsGer	10.1186/s12991-019-0249-z doi (DE-627)DOAJ038272644 (DE-599)DOAJ6c0cdfe5963242da96398e9457156704 DE-627 ger DE-627 rakwb eng RC435-571 Anne Yee verfasserin aut A comparison of sexual desire in opiate-dependent men receiving methadone and buprenorphine maintenance treatment 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Methadone is an effective therapy for opiate dependence. However, one of the commonest side effects is sexual dysfunction among male patients. Buprenorphine is an alternative to methadone. This study aimed to compare sexual desire among opiate-dependent male patients on buprenorphine (BMT) and methadone maintenance therapy (MMT). Methods This cross-sectional study involved 126 male opiate-dependent patient who were tested for total testosterone (TT) and prolactin levels, and were interviewed and completed the Sexual Desire Inventory-2 (SDI-2), Malay language of International Index of Erectile Function (Mal-IIEF-15) and the Malay version of the self-rated Montgomery-Asberg Depression Rating Scale (MADRS-BM) questionnaires. Results There were 95 (75.4%) patients on MMT and 31 (24.6%) on BMT. Patients on MMT scored significantly lower in the sexual desire domain (Mal-IIEF-15 scores) (p < 0.01), dyadic sexual desire (p = 0.04) and TT plasma level (p < 0.01) when compared to BMT group after controlling all the confounders. Conclusions Patients on MMT are associated with lower sexual desire when compared with patients on BMT. Smoking may further lower testosterone and, hence, sexual desire in those already on methadone. Sexual desire Smoking Methadone Buprenorphine Sexual dysfunction Psychiatry Huai Seng Loh verfasserin aut Huai Heng Loh verfasserin aut Shahrzad Riahi verfasserin aut Chong Guan Ng verfasserin aut Ahmad Hatim bin Sulaiman verfasserin aut In Annals of General Psychiatry BMC, 2005 18(2019), 1, Seite 8 (DE-627)355102919 (DE-600)2090401-0 1744859X nnns volume:18 year:2019 number:1 pages:8 https://doi.org/10.1186/s12991-019-0249-z kostenfrei https://doaj.org/article/6c0cdfe5963242da96398e9457156704 kostenfrei http://link.springer.com/article/10.1186/s12991-019-0249-z kostenfrei https://doaj.org/toc/1744-859X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2019 1 8
allfieldsSound	10.1186/s12991-019-0249-z doi (DE-627)DOAJ038272644 (DE-599)DOAJ6c0cdfe5963242da96398e9457156704 DE-627 ger DE-627 rakwb eng RC435-571 Anne Yee verfasserin aut A comparison of sexual desire in opiate-dependent men receiving methadone and buprenorphine maintenance treatment 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Methadone is an effective therapy for opiate dependence. However, one of the commonest side effects is sexual dysfunction among male patients. Buprenorphine is an alternative to methadone. This study aimed to compare sexual desire among opiate-dependent male patients on buprenorphine (BMT) and methadone maintenance therapy (MMT). Methods This cross-sectional study involved 126 male opiate-dependent patient who were tested for total testosterone (TT) and prolactin levels, and were interviewed and completed the Sexual Desire Inventory-2 (SDI-2), Malay language of International Index of Erectile Function (Mal-IIEF-15) and the Malay version of the self-rated Montgomery-Asberg Depression Rating Scale (MADRS-BM) questionnaires. Results There were 95 (75.4%) patients on MMT and 31 (24.6%) on BMT. Patients on MMT scored significantly lower in the sexual desire domain (Mal-IIEF-15 scores) (p < 0.01), dyadic sexual desire (p = 0.04) and TT plasma level (p < 0.01) when compared to BMT group after controlling all the confounders. Conclusions Patients on MMT are associated with lower sexual desire when compared with patients on BMT. Smoking may further lower testosterone and, hence, sexual desire in those already on methadone. Sexual desire Smoking Methadone Buprenorphine Sexual dysfunction Psychiatry Huai Seng Loh verfasserin aut Huai Heng Loh verfasserin aut Shahrzad Riahi verfasserin aut Chong Guan Ng verfasserin aut Ahmad Hatim bin Sulaiman verfasserin aut In Annals of General Psychiatry BMC, 2005 18(2019), 1, Seite 8 (DE-627)355102919 (DE-600)2090401-0 1744859X nnns volume:18 year:2019 number:1 pages:8 https://doi.org/10.1186/s12991-019-0249-z kostenfrei https://doaj.org/article/6c0cdfe5963242da96398e9457156704 kostenfrei http://link.springer.com/article/10.1186/s12991-019-0249-z kostenfrei https://doaj.org/toc/1744-859X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2019 1 8
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However, one of the commonest side effects is sexual dysfunction among male patients. Buprenorphine is an alternative to methadone. This study aimed to compare sexual desire among opiate-dependent male patients on buprenorphine (BMT) and methadone maintenance therapy (MMT). Methods This cross-sectional study involved 126 male opiate-dependent patient who were tested for total testosterone (TT) and prolactin levels, and were interviewed and completed the Sexual Desire Inventory-2 (SDI-2), Malay language of International Index of Erectile Function (Mal-IIEF-15) and the Malay version of the self-rated Montgomery-Asberg Depression Rating Scale (MADRS-BM) questionnaires. Results There were 95 (75.4%) patients on MMT and 31 (24.6%) on BMT. Patients on MMT scored significantly lower in the sexual desire domain (Mal-IIEF-15 scores) (p < 0.01), dyadic sexual desire (p = 0.04) and TT plasma level (p < 0.01) when compared to BMT group after controlling all the confounders. Conclusions Patients on MMT are associated with lower sexual desire when compared with patients on BMT. 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callnumber-first	R - Medicine
author	Anne Yee
spellingShingle	Anne Yee misc RC435-571 misc Sexual desire misc Smoking misc Methadone misc Buprenorphine misc Sexual dysfunction misc Psychiatry A comparison of sexual desire in opiate-dependent men receiving methadone and buprenorphine maintenance treatment
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topic_title	RC435-571 A comparison of sexual desire in opiate-dependent men receiving methadone and buprenorphine maintenance treatment Sexual desire Smoking Methadone Buprenorphine Sexual dysfunction
topic	misc RC435-571 misc Sexual desire misc Smoking misc Methadone misc Buprenorphine misc Sexual dysfunction misc Psychiatry
topic_unstemmed	misc RC435-571 misc Sexual desire misc Smoking misc Methadone misc Buprenorphine misc Sexual dysfunction misc Psychiatry
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title	A comparison of sexual desire in opiate-dependent men receiving methadone and buprenorphine maintenance treatment
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title_full	A comparison of sexual desire in opiate-dependent men receiving methadone and buprenorphine maintenance treatment
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title_sort	comparison of sexual desire in opiate-dependent men receiving methadone and buprenorphine maintenance treatment
callnumber	RC435-571
title_auth	A comparison of sexual desire in opiate-dependent men receiving methadone and buprenorphine maintenance treatment
abstract	Abstract Background Methadone is an effective therapy for opiate dependence. However, one of the commonest side effects is sexual dysfunction among male patients. Buprenorphine is an alternative to methadone. This study aimed to compare sexual desire among opiate-dependent male patients on buprenorphine (BMT) and methadone maintenance therapy (MMT). Methods This cross-sectional study involved 126 male opiate-dependent patient who were tested for total testosterone (TT) and prolactin levels, and were interviewed and completed the Sexual Desire Inventory-2 (SDI-2), Malay language of International Index of Erectile Function (Mal-IIEF-15) and the Malay version of the self-rated Montgomery-Asberg Depression Rating Scale (MADRS-BM) questionnaires. Results There were 95 (75.4%) patients on MMT and 31 (24.6%) on BMT. Patients on MMT scored significantly lower in the sexual desire domain (Mal-IIEF-15 scores) (p < 0.01), dyadic sexual desire (p = 0.04) and TT plasma level (p < 0.01) when compared to BMT group after controlling all the confounders. Conclusions Patients on MMT are associated with lower sexual desire when compared with patients on BMT. Smoking may further lower testosterone and, hence, sexual desire in those already on methadone.
abstractGer	Abstract Background Methadone is an effective therapy for opiate dependence. However, one of the commonest side effects is sexual dysfunction among male patients. Buprenorphine is an alternative to methadone. This study aimed to compare sexual desire among opiate-dependent male patients on buprenorphine (BMT) and methadone maintenance therapy (MMT). Methods This cross-sectional study involved 126 male opiate-dependent patient who were tested for total testosterone (TT) and prolactin levels, and were interviewed and completed the Sexual Desire Inventory-2 (SDI-2), Malay language of International Index of Erectile Function (Mal-IIEF-15) and the Malay version of the self-rated Montgomery-Asberg Depression Rating Scale (MADRS-BM) questionnaires. Results There were 95 (75.4%) patients on MMT and 31 (24.6%) on BMT. Patients on MMT scored significantly lower in the sexual desire domain (Mal-IIEF-15 scores) (p < 0.01), dyadic sexual desire (p = 0.04) and TT plasma level (p < 0.01) when compared to BMT group after controlling all the confounders. Conclusions Patients on MMT are associated with lower sexual desire when compared with patients on BMT. Smoking may further lower testosterone and, hence, sexual desire in those already on methadone.
abstract_unstemmed	Abstract Background Methadone is an effective therapy for opiate dependence. However, one of the commonest side effects is sexual dysfunction among male patients. Buprenorphine is an alternative to methadone. This study aimed to compare sexual desire among opiate-dependent male patients on buprenorphine (BMT) and methadone maintenance therapy (MMT). Methods This cross-sectional study involved 126 male opiate-dependent patient who were tested for total testosterone (TT) and prolactin levels, and were interviewed and completed the Sexual Desire Inventory-2 (SDI-2), Malay language of International Index of Erectile Function (Mal-IIEF-15) and the Malay version of the self-rated Montgomery-Asberg Depression Rating Scale (MADRS-BM) questionnaires. Results There were 95 (75.4%) patients on MMT and 31 (24.6%) on BMT. Patients on MMT scored significantly lower in the sexual desire domain (Mal-IIEF-15 scores) (p < 0.01), dyadic sexual desire (p = 0.04) and TT plasma level (p < 0.01) when compared to BMT group after controlling all the confounders. Conclusions Patients on MMT are associated with lower sexual desire when compared with patients on BMT. Smoking may further lower testosterone and, hence, sexual desire in those already on methadone.
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title_short	A comparison of sexual desire in opiate-dependent men receiving methadone and buprenorphine maintenance treatment
url	https://doi.org/10.1186/s12991-019-0249-z https://doaj.org/article/6c0cdfe5963242da96398e9457156704 http://link.springer.com/article/10.1186/s12991-019-0249-z https://doaj.org/toc/1744-859X
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author2	Huai Seng Loh Huai Heng Loh Shahrzad Riahi Chong Guan Ng Ahmad Hatim bin Sulaiman
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up_date	2024-07-03T17:01:25.249Z
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However, one of the commonest side effects is sexual dysfunction among male patients. Buprenorphine is an alternative to methadone. This study aimed to compare sexual desire among opiate-dependent male patients on buprenorphine (BMT) and methadone maintenance therapy (MMT). Methods This cross-sectional study involved 126 male opiate-dependent patient who were tested for total testosterone (TT) and prolactin levels, and were interviewed and completed the Sexual Desire Inventory-2 (SDI-2), Malay language of International Index of Erectile Function (Mal-IIEF-15) and the Malay version of the self-rated Montgomery-Asberg Depression Rating Scale (MADRS-BM) questionnaires. Results There were 95 (75.4%) patients on MMT and 31 (24.6%) on BMT. Patients on MMT scored significantly lower in the sexual desire domain (Mal-IIEF-15 scores) (p < 0.01), dyadic sexual desire (p = 0.04) and TT plasma level (p < 0.01) when compared to BMT group after controlling all the confounders. Conclusions Patients on MMT are associated with lower sexual desire when compared with patients on BMT. 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A comparison of sexual desire in opiate-dependent men receiving methadone and buprenorphine maintenance treatment

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