Angiotensin I-converting enzyme gene plays a crucial role in the pathology of carcinomas in colorectal cancer

Angiotensin I-Converting Enzyme (ACE, CD143) Gene plays a crucial role in the pathology of carcinomas in many cancers including colorectal cancer (CRC). However, the methylation of ACE was rarely reported. In this study, our purpose was to investigate the methylation status of ACE and explored its p...
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Autor*in:	Keqian Zhang [verfasserIn] Tianqi Mao [verfasserIn] Zhicheng He [verfasserIn] Xiaojiao Wu [verfasserIn] Yu Peng [verfasserIn] Yanrong Chen [verfasserIn] Yan Dong [verfasserIn] Zhihua Ruan [verfasserIn] Zhe Wang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	ACE hypomethylation colorectal cancer cell growth prognosis

Übergeordnetes Werk:	In: Artificial Cells, Nanomedicine, and Biotechnology - Taylor & Francis Group, 2019, 47(2019), 1, Seite 2500-2506
Übergeordnetes Werk:	volume:47 ; year:2019 ; number:1 ; pages:2500-2506

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1080/21691401.2019.1626402

Katalog-ID:	DOAJ038286157

Internformat


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allfields	10.1080/21691401.2019.1626402 doi (DE-627)DOAJ038286157 (DE-599)DOAJf8cd7dda1a784ef99390902a57965e9d DE-627 ger DE-627 rakwb eng TP248.13-248.65 R855-855.5 Keqian Zhang verfasserin aut Angiotensin I-converting enzyme gene plays a crucial role in the pathology of carcinomas in colorectal cancer 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Angiotensin I-Converting Enzyme (ACE, CD143) Gene plays a crucial role in the pathology of carcinomas in many cancers including colorectal cancer (CRC). However, the methylation of ACE was rarely reported. In this study, our purpose was to investigate the methylation status of ACE and explored its prognostic value in CRC. The expression of ACE was detected by quantitative real-time polymerase chain reaction (qRT-PCR) analysis while the methylation status of ACE was measured via methylation-specific polymerase chain reaction (MSP). The result demonstrated that ACE expression was up-regulated in tumour tissues and HT-29 cells compared with the controls. ACE was also confirmed to be hypomethylated in CRC. Next, we evaluated the influence of ACE hypomethylation on cell growth. It was proved to be a favourable factor for the cell proliferation, cell colony forming, but an inhibitor for the cell apoptosis of CRC cells according to MST assay, colony forming assay and flow cytometry assay. ACE hypomethylation was also considered to be related to the prognosis of CRC through Cox regression analysis. Taken together, the over-expression of ACE was regulated by its hypomethylation and the ACE hypomethylation might be an independent prognostic indicator in CRC. ACE hypomethylation colorectal cancer cell growth prognosis Biotechnology Medical technology Tianqi Mao verfasserin aut Zhicheng He verfasserin aut Xiaojiao Wu verfasserin aut Yu Peng verfasserin aut Yanrong Chen verfasserin aut Yan Dong verfasserin aut Zhihua Ruan verfasserin aut Zhe Wang verfasserin aut In Artificial Cells, Nanomedicine, and Biotechnology Taylor & Francis Group, 2019 47(2019), 1, Seite 2500-2506 (DE-627)742222489 (DE-600)2711415-6 2169141X nnns volume:47 year:2019 number:1 pages:2500-2506 https://doi.org/10.1080/21691401.2019.1626402 kostenfrei https://doaj.org/article/f8cd7dda1a784ef99390902a57965e9d kostenfrei https://www.tandfonline.com/doi/10.1080/21691401.2019.1626402 kostenfrei https://doaj.org/toc/2169-1401 Journal toc kostenfrei https://doaj.org/toc/2169-141X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 47 2019 1 2500-2506
spelling	10.1080/21691401.2019.1626402 doi (DE-627)DOAJ038286157 (DE-599)DOAJf8cd7dda1a784ef99390902a57965e9d DE-627 ger DE-627 rakwb eng TP248.13-248.65 R855-855.5 Keqian Zhang verfasserin aut Angiotensin I-converting enzyme gene plays a crucial role in the pathology of carcinomas in colorectal cancer 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Angiotensin I-Converting Enzyme (ACE, CD143) Gene plays a crucial role in the pathology of carcinomas in many cancers including colorectal cancer (CRC). However, the methylation of ACE was rarely reported. In this study, our purpose was to investigate the methylation status of ACE and explored its prognostic value in CRC. The expression of ACE was detected by quantitative real-time polymerase chain reaction (qRT-PCR) analysis while the methylation status of ACE was measured via methylation-specific polymerase chain reaction (MSP). The result demonstrated that ACE expression was up-regulated in tumour tissues and HT-29 cells compared with the controls. ACE was also confirmed to be hypomethylated in CRC. Next, we evaluated the influence of ACE hypomethylation on cell growth. It was proved to be a favourable factor for the cell proliferation, cell colony forming, but an inhibitor for the cell apoptosis of CRC cells according to MST assay, colony forming assay and flow cytometry assay. ACE hypomethylation was also considered to be related to the prognosis of CRC through Cox regression analysis. Taken together, the over-expression of ACE was regulated by its hypomethylation and the ACE hypomethylation might be an independent prognostic indicator in CRC. ACE hypomethylation colorectal cancer cell growth prognosis Biotechnology Medical technology Tianqi Mao verfasserin aut Zhicheng He verfasserin aut Xiaojiao Wu verfasserin aut Yu Peng verfasserin aut Yanrong Chen verfasserin aut Yan Dong verfasserin aut Zhihua Ruan verfasserin aut Zhe Wang verfasserin aut In Artificial Cells, Nanomedicine, and Biotechnology Taylor & Francis Group, 2019 47(2019), 1, Seite 2500-2506 (DE-627)742222489 (DE-600)2711415-6 2169141X nnns volume:47 year:2019 number:1 pages:2500-2506 https://doi.org/10.1080/21691401.2019.1626402 kostenfrei https://doaj.org/article/f8cd7dda1a784ef99390902a57965e9d kostenfrei https://www.tandfonline.com/doi/10.1080/21691401.2019.1626402 kostenfrei https://doaj.org/toc/2169-1401 Journal toc kostenfrei https://doaj.org/toc/2169-141X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 47 2019 1 2500-2506
allfields_unstemmed	10.1080/21691401.2019.1626402 doi (DE-627)DOAJ038286157 (DE-599)DOAJf8cd7dda1a784ef99390902a57965e9d DE-627 ger DE-627 rakwb eng TP248.13-248.65 R855-855.5 Keqian Zhang verfasserin aut Angiotensin I-converting enzyme gene plays a crucial role in the pathology of carcinomas in colorectal cancer 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Angiotensin I-Converting Enzyme (ACE, CD143) Gene plays a crucial role in the pathology of carcinomas in many cancers including colorectal cancer (CRC). However, the methylation of ACE was rarely reported. In this study, our purpose was to investigate the methylation status of ACE and explored its prognostic value in CRC. The expression of ACE was detected by quantitative real-time polymerase chain reaction (qRT-PCR) analysis while the methylation status of ACE was measured via methylation-specific polymerase chain reaction (MSP). The result demonstrated that ACE expression was up-regulated in tumour tissues and HT-29 cells compared with the controls. ACE was also confirmed to be hypomethylated in CRC. Next, we evaluated the influence of ACE hypomethylation on cell growth. It was proved to be a favourable factor for the cell proliferation, cell colony forming, but an inhibitor for the cell apoptosis of CRC cells according to MST assay, colony forming assay and flow cytometry assay. ACE hypomethylation was also considered to be related to the prognosis of CRC through Cox regression analysis. Taken together, the over-expression of ACE was regulated by its hypomethylation and the ACE hypomethylation might be an independent prognostic indicator in CRC. ACE hypomethylation colorectal cancer cell growth prognosis Biotechnology Medical technology Tianqi Mao verfasserin aut Zhicheng He verfasserin aut Xiaojiao Wu verfasserin aut Yu Peng verfasserin aut Yanrong Chen verfasserin aut Yan Dong verfasserin aut Zhihua Ruan verfasserin aut Zhe Wang verfasserin aut In Artificial Cells, Nanomedicine, and Biotechnology Taylor & Francis Group, 2019 47(2019), 1, Seite 2500-2506 (DE-627)742222489 (DE-600)2711415-6 2169141X nnns volume:47 year:2019 number:1 pages:2500-2506 https://doi.org/10.1080/21691401.2019.1626402 kostenfrei https://doaj.org/article/f8cd7dda1a784ef99390902a57965e9d kostenfrei https://www.tandfonline.com/doi/10.1080/21691401.2019.1626402 kostenfrei https://doaj.org/toc/2169-1401 Journal toc kostenfrei https://doaj.org/toc/2169-141X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 47 2019 1 2500-2506
allfieldsGer	10.1080/21691401.2019.1626402 doi (DE-627)DOAJ038286157 (DE-599)DOAJf8cd7dda1a784ef99390902a57965e9d DE-627 ger DE-627 rakwb eng TP248.13-248.65 R855-855.5 Keqian Zhang verfasserin aut Angiotensin I-converting enzyme gene plays a crucial role in the pathology of carcinomas in colorectal cancer 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Angiotensin I-Converting Enzyme (ACE, CD143) Gene plays a crucial role in the pathology of carcinomas in many cancers including colorectal cancer (CRC). However, the methylation of ACE was rarely reported. In this study, our purpose was to investigate the methylation status of ACE and explored its prognostic value in CRC. The expression of ACE was detected by quantitative real-time polymerase chain reaction (qRT-PCR) analysis while the methylation status of ACE was measured via methylation-specific polymerase chain reaction (MSP). The result demonstrated that ACE expression was up-regulated in tumour tissues and HT-29 cells compared with the controls. ACE was also confirmed to be hypomethylated in CRC. Next, we evaluated the influence of ACE hypomethylation on cell growth. It was proved to be a favourable factor for the cell proliferation, cell colony forming, but an inhibitor for the cell apoptosis of CRC cells according to MST assay, colony forming assay and flow cytometry assay. ACE hypomethylation was also considered to be related to the prognosis of CRC through Cox regression analysis. Taken together, the over-expression of ACE was regulated by its hypomethylation and the ACE hypomethylation might be an independent prognostic indicator in CRC. ACE hypomethylation colorectal cancer cell growth prognosis Biotechnology Medical technology Tianqi Mao verfasserin aut Zhicheng He verfasserin aut Xiaojiao Wu verfasserin aut Yu Peng verfasserin aut Yanrong Chen verfasserin aut Yan Dong verfasserin aut Zhihua Ruan verfasserin aut Zhe Wang verfasserin aut In Artificial Cells, Nanomedicine, and Biotechnology Taylor & Francis Group, 2019 47(2019), 1, Seite 2500-2506 (DE-627)742222489 (DE-600)2711415-6 2169141X nnns volume:47 year:2019 number:1 pages:2500-2506 https://doi.org/10.1080/21691401.2019.1626402 kostenfrei https://doaj.org/article/f8cd7dda1a784ef99390902a57965e9d kostenfrei https://www.tandfonline.com/doi/10.1080/21691401.2019.1626402 kostenfrei https://doaj.org/toc/2169-1401 Journal toc kostenfrei https://doaj.org/toc/2169-141X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 47 2019 1 2500-2506
allfieldsSound	10.1080/21691401.2019.1626402 doi (DE-627)DOAJ038286157 (DE-599)DOAJf8cd7dda1a784ef99390902a57965e9d DE-627 ger DE-627 rakwb eng TP248.13-248.65 R855-855.5 Keqian Zhang verfasserin aut Angiotensin I-converting enzyme gene plays a crucial role in the pathology of carcinomas in colorectal cancer 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Angiotensin I-Converting Enzyme (ACE, CD143) Gene plays a crucial role in the pathology of carcinomas in many cancers including colorectal cancer (CRC). However, the methylation of ACE was rarely reported. In this study, our purpose was to investigate the methylation status of ACE and explored its prognostic value in CRC. The expression of ACE was detected by quantitative real-time polymerase chain reaction (qRT-PCR) analysis while the methylation status of ACE was measured via methylation-specific polymerase chain reaction (MSP). The result demonstrated that ACE expression was up-regulated in tumour tissues and HT-29 cells compared with the controls. ACE was also confirmed to be hypomethylated in CRC. Next, we evaluated the influence of ACE hypomethylation on cell growth. It was proved to be a favourable factor for the cell proliferation, cell colony forming, but an inhibitor for the cell apoptosis of CRC cells according to MST assay, colony forming assay and flow cytometry assay. ACE hypomethylation was also considered to be related to the prognosis of CRC through Cox regression analysis. Taken together, the over-expression of ACE was regulated by its hypomethylation and the ACE hypomethylation might be an independent prognostic indicator in CRC. ACE hypomethylation colorectal cancer cell growth prognosis Biotechnology Medical technology Tianqi Mao verfasserin aut Zhicheng He verfasserin aut Xiaojiao Wu verfasserin aut Yu Peng verfasserin aut Yanrong Chen verfasserin aut Yan Dong verfasserin aut Zhihua Ruan verfasserin aut Zhe Wang verfasserin aut In Artificial Cells, Nanomedicine, and Biotechnology Taylor & Francis Group, 2019 47(2019), 1, Seite 2500-2506 (DE-627)742222489 (DE-600)2711415-6 2169141X nnns volume:47 year:2019 number:1 pages:2500-2506 https://doi.org/10.1080/21691401.2019.1626402 kostenfrei https://doaj.org/article/f8cd7dda1a784ef99390902a57965e9d kostenfrei https://www.tandfonline.com/doi/10.1080/21691401.2019.1626402 kostenfrei https://doaj.org/toc/2169-1401 Journal toc kostenfrei https://doaj.org/toc/2169-141X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 47 2019 1 2500-2506
language	English
source	In Artificial Cells, Nanomedicine, and Biotechnology 47(2019), 1, Seite 2500-2506 volume:47 year:2019 number:1 pages:2500-2506
sourceStr	In Artificial Cells, Nanomedicine, and Biotechnology 47(2019), 1, Seite 2500-2506 volume:47 year:2019 number:1 pages:2500-2506
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	ACE hypomethylation colorectal cancer cell growth prognosis Biotechnology Medical technology
isfreeaccess_bool	true
container_title	Artificial Cells, Nanomedicine, and Biotechnology
authorswithroles_txt_mv	Keqian Zhang @@aut@@ Tianqi Mao @@aut@@ Zhicheng He @@aut@@ Xiaojiao Wu @@aut@@ Yu Peng @@aut@@ Yanrong Chen @@aut@@ Yan Dong @@aut@@ Zhihua Ruan @@aut@@ Zhe Wang @@aut@@
publishDateDaySort_date	2019-01-01T00:00:00Z
hierarchy_top_id	742222489
id	DOAJ038286157
language_de	englisch
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callnumber-first	T - Technology
author	Keqian Zhang
spellingShingle	Keqian Zhang misc TP248.13-248.65 misc R855-855.5 misc ACE hypomethylation misc colorectal cancer misc cell growth misc prognosis misc Biotechnology misc Medical technology Angiotensin I-converting enzyme gene plays a crucial role in the pathology of carcinomas in colorectal cancer
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topic_title	TP248.13-248.65 R855-855.5 Angiotensin I-converting enzyme gene plays a crucial role in the pathology of carcinomas in colorectal cancer ACE hypomethylation colorectal cancer cell growth prognosis
topic	misc TP248.13-248.65 misc R855-855.5 misc ACE hypomethylation misc colorectal cancer misc cell growth misc prognosis misc Biotechnology misc Medical technology
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title	Angiotensin I-converting enzyme gene plays a crucial role in the pathology of carcinomas in colorectal cancer
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title_full	Angiotensin I-converting enzyme gene plays a crucial role in the pathology of carcinomas in colorectal cancer
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title_sort	angiotensin i-converting enzyme gene plays a crucial role in the pathology of carcinomas in colorectal cancer
callnumber	TP248.13-248.65
title_auth	Angiotensin I-converting enzyme gene plays a crucial role in the pathology of carcinomas in colorectal cancer
abstract	Angiotensin I-Converting Enzyme (ACE, CD143) Gene plays a crucial role in the pathology of carcinomas in many cancers including colorectal cancer (CRC). However, the methylation of ACE was rarely reported. In this study, our purpose was to investigate the methylation status of ACE and explored its prognostic value in CRC. The expression of ACE was detected by quantitative real-time polymerase chain reaction (qRT-PCR) analysis while the methylation status of ACE was measured via methylation-specific polymerase chain reaction (MSP). The result demonstrated that ACE expression was up-regulated in tumour tissues and HT-29 cells compared with the controls. ACE was also confirmed to be hypomethylated in CRC. Next, we evaluated the influence of ACE hypomethylation on cell growth. It was proved to be a favourable factor for the cell proliferation, cell colony forming, but an inhibitor for the cell apoptosis of CRC cells according to MST assay, colony forming assay and flow cytometry assay. ACE hypomethylation was also considered to be related to the prognosis of CRC through Cox regression analysis. Taken together, the over-expression of ACE was regulated by its hypomethylation and the ACE hypomethylation might be an independent prognostic indicator in CRC.
abstractGer	Angiotensin I-Converting Enzyme (ACE, CD143) Gene plays a crucial role in the pathology of carcinomas in many cancers including colorectal cancer (CRC). However, the methylation of ACE was rarely reported. In this study, our purpose was to investigate the methylation status of ACE and explored its prognostic value in CRC. The expression of ACE was detected by quantitative real-time polymerase chain reaction (qRT-PCR) analysis while the methylation status of ACE was measured via methylation-specific polymerase chain reaction (MSP). The result demonstrated that ACE expression was up-regulated in tumour tissues and HT-29 cells compared with the controls. ACE was also confirmed to be hypomethylated in CRC. Next, we evaluated the influence of ACE hypomethylation on cell growth. It was proved to be a favourable factor for the cell proliferation, cell colony forming, but an inhibitor for the cell apoptosis of CRC cells according to MST assay, colony forming assay and flow cytometry assay. ACE hypomethylation was also considered to be related to the prognosis of CRC through Cox regression analysis. Taken together, the over-expression of ACE was regulated by its hypomethylation and the ACE hypomethylation might be an independent prognostic indicator in CRC.
abstract_unstemmed	Angiotensin I-Converting Enzyme (ACE, CD143) Gene plays a crucial role in the pathology of carcinomas in many cancers including colorectal cancer (CRC). However, the methylation of ACE was rarely reported. In this study, our purpose was to investigate the methylation status of ACE and explored its prognostic value in CRC. The expression of ACE was detected by quantitative real-time polymerase chain reaction (qRT-PCR) analysis while the methylation status of ACE was measured via methylation-specific polymerase chain reaction (MSP). The result demonstrated that ACE expression was up-regulated in tumour tissues and HT-29 cells compared with the controls. ACE was also confirmed to be hypomethylated in CRC. Next, we evaluated the influence of ACE hypomethylation on cell growth. It was proved to be a favourable factor for the cell proliferation, cell colony forming, but an inhibitor for the cell apoptosis of CRC cells according to MST assay, colony forming assay and flow cytometry assay. ACE hypomethylation was also considered to be related to the prognosis of CRC through Cox regression analysis. Taken together, the over-expression of ACE was regulated by its hypomethylation and the ACE hypomethylation might be an independent prognostic indicator in CRC.
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title_short	Angiotensin I-converting enzyme gene plays a crucial role in the pathology of carcinomas in colorectal cancer
url	https://doi.org/10.1080/21691401.2019.1626402 https://doaj.org/article/f8cd7dda1a784ef99390902a57965e9d https://www.tandfonline.com/doi/10.1080/21691401.2019.1626402 https://doaj.org/toc/2169-1401 https://doaj.org/toc/2169-141X
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Angiotensin I-converting enzyme gene plays a crucial role in the pathology of carcinomas in colorectal cancer

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