Synthesis and Antibacterial Activity of Analogs of 5-Arylidene-3-(4-methylcoumarin-7-yloxyacetylamino)-2-thioxo-1,3-thiazoli-din-4-one

In an effort to develop new antimicrobial agents, 3-(4-methylcoumarin-7-yloxyacetylamino)-2-thioxo-1,3-thiazolidin-4-one (4) was synthesized by reaction of thiocarbonylbisthioglycolic acid with ethyl (4-methyl-2-oxo-2H-chromen-7-yloxy)aceto- hydrazide (3), which was prepared in turn from 7-hydroxy-4...
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Autor*in:	Nguyen Tien Cong [verfasserIn] Huynh Thi Nhan [verfasserIn] Luong Van Hung [verfasserIn] Tran Dinh Thang [verfasserIn] Ping-Chung Kuo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Schlagwörter:	coumarin 2-thioxo-1,3-thiazolidin-4-one spectral elucidation antibacterial activity

Übergeordnetes Werk:	In: Molecules - MDPI AG, 2003, 19(2014), 9, Seite 13577-13586
Übergeordnetes Werk:	volume:19 ; year:2014 ; number:9 ; pages:13577-13586

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/molecules190913577

Katalog-ID:	DOAJ038355671

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source	In Molecules 19(2014), 9, Seite 13577-13586 volume:19 year:2014 number:9 pages:13577-13586
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authorswithroles_txt_mv	Nguyen Tien Cong @@aut@@ Huynh Thi Nhan @@aut@@ Luong Van Hung @@aut@@ Tran Dinh Thang @@aut@@ Ping-Chung Kuo @@aut@@
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callnumber-first	Q - Science
author	Nguyen Tien Cong
spellingShingle	Nguyen Tien Cong misc QD241-441 misc coumarin misc 2-thioxo-1,3-thiazolidin-4-one misc spectral elucidation misc antibacterial activity misc Organic chemistry Synthesis and Antibacterial Activity of Analogs of 5-Arylidene-3-(4-methylcoumarin-7-yloxyacetylamino)-2-thioxo-1,3-thiazoli-din-4-one
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topic_title	QD241-441 Synthesis and Antibacterial Activity of Analogs of 5-Arylidene-3-(4-methylcoumarin-7-yloxyacetylamino)-2-thioxo-1,3-thiazoli-din-4-one coumarin 2-thioxo-1,3-thiazolidin-4-one spectral elucidation antibacterial activity
topic	misc QD241-441 misc coumarin misc 2-thioxo-1,3-thiazolidin-4-one misc spectral elucidation misc antibacterial activity misc Organic chemistry
topic_unstemmed	misc QD241-441 misc coumarin misc 2-thioxo-1,3-thiazolidin-4-one misc spectral elucidation misc antibacterial activity misc Organic chemistry
topic_browse	misc QD241-441 misc coumarin misc 2-thioxo-1,3-thiazolidin-4-one misc spectral elucidation misc antibacterial activity misc Organic chemistry
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title	Synthesis and Antibacterial Activity of Analogs of 5-Arylidene-3-(4-methylcoumarin-7-yloxyacetylamino)-2-thioxo-1,3-thiazoli-din-4-one
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title_full	Synthesis and Antibacterial Activity of Analogs of 5-Arylidene-3-(4-methylcoumarin-7-yloxyacetylamino)-2-thioxo-1,3-thiazoli-din-4-one
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author_browse	Nguyen Tien Cong Huynh Thi Nhan Luong Van Hung Tran Dinh Thang Ping-Chung Kuo
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title_sort	synthesis and antibacterial activity of analogs of 5-arylidene-3-(4-methylcoumarin-7-yloxyacetylamino)-2-thioxo-1,3-thiazoli-din-4-one
callnumber	QD241-441
title_auth	Synthesis and Antibacterial Activity of Analogs of 5-Arylidene-3-(4-methylcoumarin-7-yloxyacetylamino)-2-thioxo-1,3-thiazoli-din-4-one
abstract	In an effort to develop new antimicrobial agents, 3-(4-methylcoumarin-7-yloxyacetylamino)-2-thioxo-1,3-thiazolidin-4-one (4) was synthesized by reaction of thiocarbonylbisthioglycolic acid with ethyl (4-methyl-2-oxo-2H-chromen-7-yloxy)aceto- hydrazide (3), which was prepared in turn from 7-hydroxy-4-methylcoumarin (1). The condensation of compound 4 with different aromatic aldehydes afforded a series of 5-(arylidene)-3-(4-methylcoumarin-7-yloxyacetyl-amino)-2-thioxo-1,3-thiozolidin-4-one analogs 5a–h. The structures of these synthetic compounds were elucidated on the basis of IR, 1H-NMR and 13C-NMR spectral data and ESI-MS spectrometric analysis. Compounds 5a–h were examined for their antibacterial activity against several strains of Gram-positive and Gram-negative bacteria.
abstractGer	In an effort to develop new antimicrobial agents, 3-(4-methylcoumarin-7-yloxyacetylamino)-2-thioxo-1,3-thiazolidin-4-one (4) was synthesized by reaction of thiocarbonylbisthioglycolic acid with ethyl (4-methyl-2-oxo-2H-chromen-7-yloxy)aceto- hydrazide (3), which was prepared in turn from 7-hydroxy-4-methylcoumarin (1). The condensation of compound 4 with different aromatic aldehydes afforded a series of 5-(arylidene)-3-(4-methylcoumarin-7-yloxyacetyl-amino)-2-thioxo-1,3-thiozolidin-4-one analogs 5a–h. The structures of these synthetic compounds were elucidated on the basis of IR, 1H-NMR and 13C-NMR spectral data and ESI-MS spectrometric analysis. Compounds 5a–h were examined for their antibacterial activity against several strains of Gram-positive and Gram-negative bacteria.
abstract_unstemmed	In an effort to develop new antimicrobial agents, 3-(4-methylcoumarin-7-yloxyacetylamino)-2-thioxo-1,3-thiazolidin-4-one (4) was synthesized by reaction of thiocarbonylbisthioglycolic acid with ethyl (4-methyl-2-oxo-2H-chromen-7-yloxy)aceto- hydrazide (3), which was prepared in turn from 7-hydroxy-4-methylcoumarin (1). The condensation of compound 4 with different aromatic aldehydes afforded a series of 5-(arylidene)-3-(4-methylcoumarin-7-yloxyacetyl-amino)-2-thioxo-1,3-thiozolidin-4-one analogs 5a–h. The structures of these synthetic compounds were elucidated on the basis of IR, 1H-NMR and 13C-NMR spectral data and ESI-MS spectrometric analysis. Compounds 5a–h were examined for their antibacterial activity against several strains of Gram-positive and Gram-negative bacteria.
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title_short	Synthesis and Antibacterial Activity of Analogs of 5-Arylidene-3-(4-methylcoumarin-7-yloxyacetylamino)-2-thioxo-1,3-thiazoli-din-4-one
url	https://doi.org/10.3390/molecules190913577 https://doaj.org/article/251269d61ac84a8b975a52a90ad69080 http://www.mdpi.com/1420-3049/19/9/13577 https://doaj.org/toc/1420-3049
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up_date	2024-07-03T17:29:33.708Z
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Synthesis and Antibacterial Activity of Analogs of 5-Arylidene-3-(4-methylcoumarin-7-yloxyacetylamino)-2-thioxo-1,3-thiazoli-din-4-one

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