Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study

<p<Abstract</p< <p<Background</p< <p<Vitamin E supplements containing tocotrienols are now being recommended for optimum health but its effects are scarcely known. The objective was to determine the effects of Tocotrienol Rich Fraction (TRF) supplementation on lipid pro...
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Autor*in:	Mohd Yusof Yasmin Anum [verfasserIn] Mazlan Musalmah [verfasserIn] Zakaria Zaiton [verfasserIn] Abdul Latiff Azian [verfasserIn] Abdul Hamid Noor Aini [verfasserIn] Makpol Suzana [verfasserIn] Ibahim Johari [verfasserIn] Chin Siok-Fong [verfasserIn] Abdul Karim Aminuddin [verfasserIn] Wan Ngah Wan Zurinah [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2011

Übergeordnetes Werk:	In: Nutrition & Metabolism - BMC, 2004, 8(2011), 1, p 42
Übergeordnetes Werk:	volume:8 ; year:2011 ; number:1, p 42

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/1743-7075-8-42

Katalog-ID:	DOAJ038579057

Internformat


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245	1	0	\|a Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study
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520			\|a <p<Abstract</p< <p<Background</p< <p<Vitamin E supplements containing tocotrienols are now being recommended for optimum health but its effects are scarcely known. The objective was to determine the effects of Tocotrienol Rich Fraction (TRF) supplementation on lipid profile and oxidative status in healthy older individuals at a dose of 160 mg/day for 6 months.</p< <p<Methods</p< <p<Sixty-two subjects were recruited from two age groups: 35-49 years (n = 31) and above 50 years (n = 31), and randomly assigned to receive either TRF or placebo capsules for six months. Blood samples were obtained at 0, 3<sup<rd </sup<and 6<sup<th </sup<months.</p< <p<Results</p< <p<HDL-cholesterol in the TRF-supplemented group was elevated after 6 months (p < 0.01). Protein carbonyl contents were markedly decreased (p < 0.001), whereas AGE levels were lowered in the < 50 year-old group (p < 0.05). Plasma levels of total vitamin E particularly tocopherols were significantly increased in the TRF-supplemented group after 3 months (p < 0.01). Plasma total tocotrienols were only increased in the < 50 year-old group after receiving 6 months of TRF supplementation. Changes in enzyme activities were only observed in the < 50 year-old group. SOD activity was decreased after 3 (p < 0.05) and 6 (p < 0.05) months of TRF supplementation whereas CAT activity was decreased after 3 (p < 0.01) and 6 (p < 0.05) months in the placebo group. GPx activity was increased at 6 months for both treatment and placebo groups (p < 0.05).</p< <p<Conclusion</p< <p<The observed improvement of plasma cholesterol, AGE and antioxidant vitamin levels as well as the reduced protein damage may indicate a restoration of redox balance after TRF supplementation, particularly in individuals over 50 years of age.</p<
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700	0		\|a Mazlan Musalmah \|e verfasserin \|4 aut
700	0		\|a Zakaria Zaiton \|e verfasserin \|4 aut
700	0		\|a Abdul Latiff Azian \|e verfasserin \|4 aut
700	0		\|a Abdul Hamid Noor Aini \|e verfasserin \|4 aut
700	0		\|a Makpol Suzana \|e verfasserin \|4 aut
700	0		\|a Ibahim Johari \|e verfasserin \|4 aut
700	0		\|a Chin Siok-Fong \|e verfasserin \|4 aut
700	0		\|a Abdul Karim Aminuddin \|e verfasserin \|4 aut
700	0		\|a Wan Ngah Wan Zurinah \|e verfasserin \|4 aut
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allfields	10.1186/1743-7075-8-42 doi (DE-627)DOAJ038579057 (DE-599)DOAJ7b233c59b8a84d25a1ece63b3ffdfd96 DE-627 ger DE-627 rakwb eng TX341-641 RC620-627 Mohd Yusof Yasmin Anum verfasserin aut Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Vitamin E supplements containing tocotrienols are now being recommended for optimum health but its effects are scarcely known. The objective was to determine the effects of Tocotrienol Rich Fraction (TRF) supplementation on lipid profile and oxidative status in healthy older individuals at a dose of 160 mg/day for 6 months.</p< <p<Methods</p< <p<Sixty-two subjects were recruited from two age groups: 35-49 years (n = 31) and above 50 years (n = 31), and randomly assigned to receive either TRF or placebo capsules for six months. Blood samples were obtained at 0, 3<sup<rd </sup<and 6<sup<th </sup<months.</p< <p<Results</p< <p<HDL-cholesterol in the TRF-supplemented group was elevated after 6 months (p < 0.01). Protein carbonyl contents were markedly decreased (p < 0.001), whereas AGE levels were lowered in the < 50 year-old group (p < 0.05). Plasma levels of total vitamin E particularly tocopherols were significantly increased in the TRF-supplemented group after 3 months (p < 0.01). Plasma total tocotrienols were only increased in the < 50 year-old group after receiving 6 months of TRF supplementation. Changes in enzyme activities were only observed in the < 50 year-old group. SOD activity was decreased after 3 (p < 0.05) and 6 (p < 0.05) months of TRF supplementation whereas CAT activity was decreased after 3 (p < 0.01) and 6 (p < 0.05) months in the placebo group. GPx activity was increased at 6 months for both treatment and placebo groups (p < 0.05).</p< <p<Conclusion</p< <p<The observed improvement of plasma cholesterol, AGE and antioxidant vitamin levels as well as the reduced protein damage may indicate a restoration of redox balance after TRF supplementation, particularly in individuals over 50 years of age.</p< Nutrition. Foods and food supply Nutritional diseases. Deficiency diseases Mazlan Musalmah verfasserin aut Zakaria Zaiton verfasserin aut Abdul Latiff Azian verfasserin aut Abdul Hamid Noor Aini verfasserin aut Makpol Suzana verfasserin aut Ibahim Johari verfasserin aut Chin Siok-Fong verfasserin aut Abdul Karim Aminuddin verfasserin aut Wan Ngah Wan Zurinah verfasserin aut In Nutrition & Metabolism BMC, 2004 8(2011), 1, p 42 (DE-627)394163419 (DE-600)2160376-5 17437075 nnns volume:8 year:2011 number:1, p 42 https://doi.org/10.1186/1743-7075-8-42 kostenfrei https://doaj.org/article/7b233c59b8a84d25a1ece63b3ffdfd96 kostenfrei http://www.nutritionandmetabolism.com/content/8/1/42 kostenfrei https://doaj.org/toc/1743-7075 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2011 1, p 42
spelling	10.1186/1743-7075-8-42 doi (DE-627)DOAJ038579057 (DE-599)DOAJ7b233c59b8a84d25a1ece63b3ffdfd96 DE-627 ger DE-627 rakwb eng TX341-641 RC620-627 Mohd Yusof Yasmin Anum verfasserin aut Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Vitamin E supplements containing tocotrienols are now being recommended for optimum health but its effects are scarcely known. The objective was to determine the effects of Tocotrienol Rich Fraction (TRF) supplementation on lipid profile and oxidative status in healthy older individuals at a dose of 160 mg/day for 6 months.</p< <p<Methods</p< <p<Sixty-two subjects were recruited from two age groups: 35-49 years (n = 31) and above 50 years (n = 31), and randomly assigned to receive either TRF or placebo capsules for six months. Blood samples were obtained at 0, 3<sup<rd </sup<and 6<sup<th </sup<months.</p< <p<Results</p< <p<HDL-cholesterol in the TRF-supplemented group was elevated after 6 months (p < 0.01). Protein carbonyl contents were markedly decreased (p < 0.001), whereas AGE levels were lowered in the < 50 year-old group (p < 0.05). Plasma levels of total vitamin E particularly tocopherols were significantly increased in the TRF-supplemented group after 3 months (p < 0.01). Plasma total tocotrienols were only increased in the < 50 year-old group after receiving 6 months of TRF supplementation. Changes in enzyme activities were only observed in the < 50 year-old group. SOD activity was decreased after 3 (p < 0.05) and 6 (p < 0.05) months of TRF supplementation whereas CAT activity was decreased after 3 (p < 0.01) and 6 (p < 0.05) months in the placebo group. GPx activity was increased at 6 months for both treatment and placebo groups (p < 0.05).</p< <p<Conclusion</p< <p<The observed improvement of plasma cholesterol, AGE and antioxidant vitamin levels as well as the reduced protein damage may indicate a restoration of redox balance after TRF supplementation, particularly in individuals over 50 years of age.</p< Nutrition. Foods and food supply Nutritional diseases. Deficiency diseases Mazlan Musalmah verfasserin aut Zakaria Zaiton verfasserin aut Abdul Latiff Azian verfasserin aut Abdul Hamid Noor Aini verfasserin aut Makpol Suzana verfasserin aut Ibahim Johari verfasserin aut Chin Siok-Fong verfasserin aut Abdul Karim Aminuddin verfasserin aut Wan Ngah Wan Zurinah verfasserin aut In Nutrition & Metabolism BMC, 2004 8(2011), 1, p 42 (DE-627)394163419 (DE-600)2160376-5 17437075 nnns volume:8 year:2011 number:1, p 42 https://doi.org/10.1186/1743-7075-8-42 kostenfrei https://doaj.org/article/7b233c59b8a84d25a1ece63b3ffdfd96 kostenfrei http://www.nutritionandmetabolism.com/content/8/1/42 kostenfrei https://doaj.org/toc/1743-7075 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2011 1, p 42
allfields_unstemmed	10.1186/1743-7075-8-42 doi (DE-627)DOAJ038579057 (DE-599)DOAJ7b233c59b8a84d25a1ece63b3ffdfd96 DE-627 ger DE-627 rakwb eng TX341-641 RC620-627 Mohd Yusof Yasmin Anum verfasserin aut Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Vitamin E supplements containing tocotrienols are now being recommended for optimum health but its effects are scarcely known. The objective was to determine the effects of Tocotrienol Rich Fraction (TRF) supplementation on lipid profile and oxidative status in healthy older individuals at a dose of 160 mg/day for 6 months.</p< <p<Methods</p< <p<Sixty-two subjects were recruited from two age groups: 35-49 years (n = 31) and above 50 years (n = 31), and randomly assigned to receive either TRF or placebo capsules for six months. Blood samples were obtained at 0, 3<sup<rd </sup<and 6<sup<th </sup<months.</p< <p<Results</p< <p<HDL-cholesterol in the TRF-supplemented group was elevated after 6 months (p < 0.01). Protein carbonyl contents were markedly decreased (p < 0.001), whereas AGE levels were lowered in the < 50 year-old group (p < 0.05). Plasma levels of total vitamin E particularly tocopherols were significantly increased in the TRF-supplemented group after 3 months (p < 0.01). Plasma total tocotrienols were only increased in the < 50 year-old group after receiving 6 months of TRF supplementation. Changes in enzyme activities were only observed in the < 50 year-old group. SOD activity was decreased after 3 (p < 0.05) and 6 (p < 0.05) months of TRF supplementation whereas CAT activity was decreased after 3 (p < 0.01) and 6 (p < 0.05) months in the placebo group. GPx activity was increased at 6 months for both treatment and placebo groups (p < 0.05).</p< <p<Conclusion</p< <p<The observed improvement of plasma cholesterol, AGE and antioxidant vitamin levels as well as the reduced protein damage may indicate a restoration of redox balance after TRF supplementation, particularly in individuals over 50 years of age.</p< Nutrition. Foods and food supply Nutritional diseases. Deficiency diseases Mazlan Musalmah verfasserin aut Zakaria Zaiton verfasserin aut Abdul Latiff Azian verfasserin aut Abdul Hamid Noor Aini verfasserin aut Makpol Suzana verfasserin aut Ibahim Johari verfasserin aut Chin Siok-Fong verfasserin aut Abdul Karim Aminuddin verfasserin aut Wan Ngah Wan Zurinah verfasserin aut In Nutrition & Metabolism BMC, 2004 8(2011), 1, p 42 (DE-627)394163419 (DE-600)2160376-5 17437075 nnns volume:8 year:2011 number:1, p 42 https://doi.org/10.1186/1743-7075-8-42 kostenfrei https://doaj.org/article/7b233c59b8a84d25a1ece63b3ffdfd96 kostenfrei http://www.nutritionandmetabolism.com/content/8/1/42 kostenfrei https://doaj.org/toc/1743-7075 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2011 1, p 42
allfieldsGer	10.1186/1743-7075-8-42 doi (DE-627)DOAJ038579057 (DE-599)DOAJ7b233c59b8a84d25a1ece63b3ffdfd96 DE-627 ger DE-627 rakwb eng TX341-641 RC620-627 Mohd Yusof Yasmin Anum verfasserin aut Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Vitamin E supplements containing tocotrienols are now being recommended for optimum health but its effects are scarcely known. The objective was to determine the effects of Tocotrienol Rich Fraction (TRF) supplementation on lipid profile and oxidative status in healthy older individuals at a dose of 160 mg/day for 6 months.</p< <p<Methods</p< <p<Sixty-two subjects were recruited from two age groups: 35-49 years (n = 31) and above 50 years (n = 31), and randomly assigned to receive either TRF or placebo capsules for six months. Blood samples were obtained at 0, 3<sup<rd </sup<and 6<sup<th </sup<months.</p< <p<Results</p< <p<HDL-cholesterol in the TRF-supplemented group was elevated after 6 months (p < 0.01). Protein carbonyl contents were markedly decreased (p < 0.001), whereas AGE levels were lowered in the < 50 year-old group (p < 0.05). Plasma levels of total vitamin E particularly tocopherols were significantly increased in the TRF-supplemented group after 3 months (p < 0.01). Plasma total tocotrienols were only increased in the < 50 year-old group after receiving 6 months of TRF supplementation. Changes in enzyme activities were only observed in the < 50 year-old group. SOD activity was decreased after 3 (p < 0.05) and 6 (p < 0.05) months of TRF supplementation whereas CAT activity was decreased after 3 (p < 0.01) and 6 (p < 0.05) months in the placebo group. GPx activity was increased at 6 months for both treatment and placebo groups (p < 0.05).</p< <p<Conclusion</p< <p<The observed improvement of plasma cholesterol, AGE and antioxidant vitamin levels as well as the reduced protein damage may indicate a restoration of redox balance after TRF supplementation, particularly in individuals over 50 years of age.</p< Nutrition. Foods and food supply Nutritional diseases. Deficiency diseases Mazlan Musalmah verfasserin aut Zakaria Zaiton verfasserin aut Abdul Latiff Azian verfasserin aut Abdul Hamid Noor Aini verfasserin aut Makpol Suzana verfasserin aut Ibahim Johari verfasserin aut Chin Siok-Fong verfasserin aut Abdul Karim Aminuddin verfasserin aut Wan Ngah Wan Zurinah verfasserin aut In Nutrition & Metabolism BMC, 2004 8(2011), 1, p 42 (DE-627)394163419 (DE-600)2160376-5 17437075 nnns volume:8 year:2011 number:1, p 42 https://doi.org/10.1186/1743-7075-8-42 kostenfrei https://doaj.org/article/7b233c59b8a84d25a1ece63b3ffdfd96 kostenfrei http://www.nutritionandmetabolism.com/content/8/1/42 kostenfrei https://doaj.org/toc/1743-7075 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2011 1, p 42
allfieldsSound	10.1186/1743-7075-8-42 doi (DE-627)DOAJ038579057 (DE-599)DOAJ7b233c59b8a84d25a1ece63b3ffdfd96 DE-627 ger DE-627 rakwb eng TX341-641 RC620-627 Mohd Yusof Yasmin Anum verfasserin aut Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<Vitamin E supplements containing tocotrienols are now being recommended for optimum health but its effects are scarcely known. The objective was to determine the effects of Tocotrienol Rich Fraction (TRF) supplementation on lipid profile and oxidative status in healthy older individuals at a dose of 160 mg/day for 6 months.</p< <p<Methods</p< <p<Sixty-two subjects were recruited from two age groups: 35-49 years (n = 31) and above 50 years (n = 31), and randomly assigned to receive either TRF or placebo capsules for six months. Blood samples were obtained at 0, 3<sup<rd </sup<and 6<sup<th </sup<months.</p< <p<Results</p< <p<HDL-cholesterol in the TRF-supplemented group was elevated after 6 months (p < 0.01). Protein carbonyl contents were markedly decreased (p < 0.001), whereas AGE levels were lowered in the < 50 year-old group (p < 0.05). Plasma levels of total vitamin E particularly tocopherols were significantly increased in the TRF-supplemented group after 3 months (p < 0.01). Plasma total tocotrienols were only increased in the < 50 year-old group after receiving 6 months of TRF supplementation. Changes in enzyme activities were only observed in the < 50 year-old group. SOD activity was decreased after 3 (p < 0.05) and 6 (p < 0.05) months of TRF supplementation whereas CAT activity was decreased after 3 (p < 0.01) and 6 (p < 0.05) months in the placebo group. GPx activity was increased at 6 months for both treatment and placebo groups (p < 0.05).</p< <p<Conclusion</p< <p<The observed improvement of plasma cholesterol, AGE and antioxidant vitamin levels as well as the reduced protein damage may indicate a restoration of redox balance after TRF supplementation, particularly in individuals over 50 years of age.</p< Nutrition. Foods and food supply Nutritional diseases. Deficiency diseases Mazlan Musalmah verfasserin aut Zakaria Zaiton verfasserin aut Abdul Latiff Azian verfasserin aut Abdul Hamid Noor Aini verfasserin aut Makpol Suzana verfasserin aut Ibahim Johari verfasserin aut Chin Siok-Fong verfasserin aut Abdul Karim Aminuddin verfasserin aut Wan Ngah Wan Zurinah verfasserin aut In Nutrition & Metabolism BMC, 2004 8(2011), 1, p 42 (DE-627)394163419 (DE-600)2160376-5 17437075 nnns volume:8 year:2011 number:1, p 42 https://doi.org/10.1186/1743-7075-8-42 kostenfrei https://doaj.org/article/7b233c59b8a84d25a1ece63b3ffdfd96 kostenfrei http://www.nutritionandmetabolism.com/content/8/1/42 kostenfrei https://doaj.org/toc/1743-7075 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2011 1, p 42
language	English
source	In Nutrition & Metabolism 8(2011), 1, p 42 volume:8 year:2011 number:1, p 42
sourceStr	In Nutrition & Metabolism 8(2011), 1, p 42 volume:8 year:2011 number:1, p 42
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Nutrition. Foods and food supply Nutritional diseases. Deficiency diseases
isfreeaccess_bool	true
container_title	Nutrition & Metabolism
authorswithroles_txt_mv	Mohd Yusof Yasmin Anum @@aut@@ Mazlan Musalmah @@aut@@ Zakaria Zaiton @@aut@@ Abdul Latiff Azian @@aut@@ Abdul Hamid Noor Aini @@aut@@ Makpol Suzana @@aut@@ Ibahim Johari @@aut@@ Chin Siok-Fong @@aut@@ Abdul Karim Aminuddin @@aut@@ Wan Ngah Wan Zurinah @@aut@@
publishDateDaySort_date	2011-01-01T00:00:00Z
hierarchy_top_id	394163419
id	DOAJ038579057
language_de	englisch
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callnumber-first	T - Technology
author	Mohd Yusof Yasmin Anum
spellingShingle	Mohd Yusof Yasmin Anum misc TX341-641 misc RC620-627 misc Nutrition. Foods and food supply misc Nutritional diseases. Deficiency diseases Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study
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topic_title	TX341-641 RC620-627 Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study
topic	misc TX341-641 misc RC620-627 misc Nutrition. Foods and food supply misc Nutritional diseases. Deficiency diseases
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title	Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study
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title_full	Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study
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author_browse	Mohd Yusof Yasmin Anum Mazlan Musalmah Zakaria Zaiton Abdul Latiff Azian Abdul Hamid Noor Aini Makpol Suzana Ibahim Johari Chin Siok-Fong Abdul Karim Aminuddin Wan Ngah Wan Zurinah
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title_sort	tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: a randomized controlled study
callnumber	TX341-641
title_auth	Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study
abstract	<p<Abstract</p< <p<Background</p< <p<Vitamin E supplements containing tocotrienols are now being recommended for optimum health but its effects are scarcely known. The objective was to determine the effects of Tocotrienol Rich Fraction (TRF) supplementation on lipid profile and oxidative status in healthy older individuals at a dose of 160 mg/day for 6 months.</p< <p<Methods</p< <p<Sixty-two subjects were recruited from two age groups: 35-49 years (n = 31) and above 50 years (n = 31), and randomly assigned to receive either TRF or placebo capsules for six months. Blood samples were obtained at 0, 3<sup<rd </sup<and 6<sup<th </sup<months.</p< <p<Results</p< <p<HDL-cholesterol in the TRF-supplemented group was elevated after 6 months (p < 0.01). Protein carbonyl contents were markedly decreased (p < 0.001), whereas AGE levels were lowered in the < 50 year-old group (p < 0.05). Plasma levels of total vitamin E particularly tocopherols were significantly increased in the TRF-supplemented group after 3 months (p < 0.01). Plasma total tocotrienols were only increased in the < 50 year-old group after receiving 6 months of TRF supplementation. Changes in enzyme activities were only observed in the < 50 year-old group. SOD activity was decreased after 3 (p < 0.05) and 6 (p < 0.05) months of TRF supplementation whereas CAT activity was decreased after 3 (p < 0.01) and 6 (p < 0.05) months in the placebo group. GPx activity was increased at 6 months for both treatment and placebo groups (p < 0.05).</p< <p<Conclusion</p< <p<The observed improvement of plasma cholesterol, AGE and antioxidant vitamin levels as well as the reduced protein damage may indicate a restoration of redox balance after TRF supplementation, particularly in individuals over 50 years of age.</p<
abstractGer	<p<Abstract</p< <p<Background</p< <p<Vitamin E supplements containing tocotrienols are now being recommended for optimum health but its effects are scarcely known. The objective was to determine the effects of Tocotrienol Rich Fraction (TRF) supplementation on lipid profile and oxidative status in healthy older individuals at a dose of 160 mg/day for 6 months.</p< <p<Methods</p< <p<Sixty-two subjects were recruited from two age groups: 35-49 years (n = 31) and above 50 years (n = 31), and randomly assigned to receive either TRF or placebo capsules for six months. Blood samples were obtained at 0, 3<sup<rd </sup<and 6<sup<th </sup<months.</p< <p<Results</p< <p<HDL-cholesterol in the TRF-supplemented group was elevated after 6 months (p < 0.01). Protein carbonyl contents were markedly decreased (p < 0.001), whereas AGE levels were lowered in the < 50 year-old group (p < 0.05). Plasma levels of total vitamin E particularly tocopherols were significantly increased in the TRF-supplemented group after 3 months (p < 0.01). Plasma total tocotrienols were only increased in the < 50 year-old group after receiving 6 months of TRF supplementation. Changes in enzyme activities were only observed in the < 50 year-old group. SOD activity was decreased after 3 (p < 0.05) and 6 (p < 0.05) months of TRF supplementation whereas CAT activity was decreased after 3 (p < 0.01) and 6 (p < 0.05) months in the placebo group. GPx activity was increased at 6 months for both treatment and placebo groups (p < 0.05).</p< <p<Conclusion</p< <p<The observed improvement of plasma cholesterol, AGE and antioxidant vitamin levels as well as the reduced protein damage may indicate a restoration of redox balance after TRF supplementation, particularly in individuals over 50 years of age.</p<
abstract_unstemmed	<p<Abstract</p< <p<Background</p< <p<Vitamin E supplements containing tocotrienols are now being recommended for optimum health but its effects are scarcely known. The objective was to determine the effects of Tocotrienol Rich Fraction (TRF) supplementation on lipid profile and oxidative status in healthy older individuals at a dose of 160 mg/day for 6 months.</p< <p<Methods</p< <p<Sixty-two subjects were recruited from two age groups: 35-49 years (n = 31) and above 50 years (n = 31), and randomly assigned to receive either TRF or placebo capsules for six months. Blood samples were obtained at 0, 3<sup<rd </sup<and 6<sup<th </sup<months.</p< <p<Results</p< <p<HDL-cholesterol in the TRF-supplemented group was elevated after 6 months (p < 0.01). Protein carbonyl contents were markedly decreased (p < 0.001), whereas AGE levels were lowered in the < 50 year-old group (p < 0.05). Plasma levels of total vitamin E particularly tocopherols were significantly increased in the TRF-supplemented group after 3 months (p < 0.01). Plasma total tocotrienols were only increased in the < 50 year-old group after receiving 6 months of TRF supplementation. Changes in enzyme activities were only observed in the < 50 year-old group. SOD activity was decreased after 3 (p < 0.05) and 6 (p < 0.05) months of TRF supplementation whereas CAT activity was decreased after 3 (p < 0.01) and 6 (p < 0.05) months in the placebo group. GPx activity was increased at 6 months for both treatment and placebo groups (p < 0.05).</p< <p<Conclusion</p< <p<The observed improvement of plasma cholesterol, AGE and antioxidant vitamin levels as well as the reduced protein damage may indicate a restoration of redox balance after TRF supplementation, particularly in individuals over 50 years of age.</p<
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title_short	Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study
url	https://doi.org/10.1186/1743-7075-8-42 https://doaj.org/article/7b233c59b8a84d25a1ece63b3ffdfd96 http://www.nutritionandmetabolism.com/content/8/1/42 https://doaj.org/toc/1743-7075
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The objective was to determine the effects of Tocotrienol Rich Fraction (TRF) supplementation on lipid profile and oxidative status in healthy older individuals at a dose of 160 mg/day for 6 months.</p< <p<Methods</p< <p<Sixty-two subjects were recruited from two age groups: 35-49 years (n = 31) and above 50 years (n = 31), and randomly assigned to receive either TRF or placebo capsules for six months. Blood samples were obtained at 0, 3<sup<rd </sup<and 6<sup<th </sup<months.</p< <p<Results</p< <p<HDL-cholesterol in the TRF-supplemented group was elevated after 6 months (p < 0.01). Protein carbonyl contents were markedly decreased (p < 0.001), whereas AGE levels were lowered in the < 50 year-old group (p < 0.05). Plasma levels of total vitamin E particularly tocopherols were significantly increased in the TRF-supplemented group after 3 months (p < 0.01). Plasma total tocotrienols were only increased in the < 50 year-old group after receiving 6 months of TRF supplementation. Changes in enzyme activities were only observed in the < 50 year-old group. SOD activity was decreased after 3 (p < 0.05) and 6 (p < 0.05) months of TRF supplementation whereas CAT activity was decreased after 3 (p < 0.01) and 6 (p < 0.05) months in the placebo group. GPx activity was increased at 6 months for both treatment and placebo groups (p < 0.05).</p< <p<Conclusion</p< <p<The observed improvement of plasma cholesterol, AGE and antioxidant vitamin levels as well as the reduced protein damage may indicate a restoration of redox balance after TRF supplementation, particularly in individuals over 50 years of age.</p<</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Nutrition. Foods and food supply</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Nutritional diseases. 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Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study

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