Familial autoimmunity and polyautoimmunity in 60 Brazilian Midwest patients with systemic sclerosis
ABSTRACT Introduction: Systemic sclerosis (SSc) is a connective tissue disease of unknown etiology, characterized by a triad of vascular injury, autoimmunity and tissue fibrosis. It is known that a positive family history is the greatest risk factor already identified for the development of SSc in...
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| Autor*in: |
Alex Magno Coelho Horimoto [verfasserIn] Aida Freitas do Carmo Silveira [verfasserIn] Izaias Pereira da Costa [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch ; Spanisch ; Portugiesisch |
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In: Revista Brasileira de Reumatologia - Sociedade Brasileira de Reumatologia, 2005 |
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| Links: |
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| DOI / URN: |
10.1016/j.rbre.2016.01.003 |
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| Katalog-ID: |
DOAJ038588021 |
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| 520 | |a ABSTRACT Introduction: Systemic sclerosis (SSc) is a connective tissue disease of unknown etiology, characterized by a triad of vascular injury, autoimmunity and tissue fibrosis. It is known that a positive family history is the greatest risk factor already identified for the development of SSc in a given individual. Preliminary observation of a high prevalence of polyautoimmunity and of familial autoimmunity in SSc patients support the idea that different autoimmune phenotypes may share common susceptibility variants. Objectives: To describe the frequency of familial autoimmunity and polyautoimmunity in 60 SSc patients in the Midwest region of Brazil, as well as to report the main autoimmune diseases observed in this association of comorbidities. Methods: A cross-sectional study with recruitment of 60 consecutive patients selected at the Rheumatology Department, University Hospital, Medicine School, Federal University of Mato Grosso do Sul (FMUFMS), as well as interviews of their relatives during the period from February 2013 to March 2014. Results: A frequency of 43.3% of polyautoimmunity and of 51.7% of familial autoimmunity in SSc patients was found. Patients with the presence of polyautoimmunity and familial autoimmunity presented primarily the diffuse form of SSc, but this indicator did not reach statistical significance. The autoimmune diseases most frequently observed in polyautoimmunity patients were: Hashimoto's thyroiditis (53.8%), Sjögren's syndrome (38.5%), and inflammatory myopathy (11.5%). The main autoimmune diseases observed in SSc patients' relatives were: Hashimoto's thyroiditis (32.3%), rheumatoid arthritis (22.6%), and SLE (22.6%). The presence of more than one autoimmune disease in SSc patients did not correlate with disease severity or activity. Conclusions: From the high prevalence of coexisting autoimmune diseases found in SSc patients, we stress the importance of the concept of shared autoimmunity, in order to promote a continued vigilance and promptly diagnose other possible autoimmune disease in patients, or in their kin. | ||
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10.1016/j.rbre.2016.01.003 doi (DE-627)DOAJ038588021 (DE-599)DOAJ0c4591ad77194dde84ee08d81266bfe3 DE-627 ger DE-627 rakwb eng spa por RC925-935 Alex Magno Coelho Horimoto verfasserin aut Familial autoimmunity and polyautoimmunity in 60 Brazilian Midwest patients with systemic sclerosis Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT Introduction: Systemic sclerosis (SSc) is a connective tissue disease of unknown etiology, characterized by a triad of vascular injury, autoimmunity and tissue fibrosis. It is known that a positive family history is the greatest risk factor already identified for the development of SSc in a given individual. Preliminary observation of a high prevalence of polyautoimmunity and of familial autoimmunity in SSc patients support the idea that different autoimmune phenotypes may share common susceptibility variants. Objectives: To describe the frequency of familial autoimmunity and polyautoimmunity in 60 SSc patients in the Midwest region of Brazil, as well as to report the main autoimmune diseases observed in this association of comorbidities. Methods: A cross-sectional study with recruitment of 60 consecutive patients selected at the Rheumatology Department, University Hospital, Medicine School, Federal University of Mato Grosso do Sul (FMUFMS), as well as interviews of their relatives during the period from February 2013 to March 2014. Results: A frequency of 43.3% of polyautoimmunity and of 51.7% of familial autoimmunity in SSc patients was found. Patients with the presence of polyautoimmunity and familial autoimmunity presented primarily the diffuse form of SSc, but this indicator did not reach statistical significance. The autoimmune diseases most frequently observed in polyautoimmunity patients were: Hashimoto's thyroiditis (53.8%), Sjögren's syndrome (38.5%), and inflammatory myopathy (11.5%). The main autoimmune diseases observed in SSc patients' relatives were: Hashimoto's thyroiditis (32.3%), rheumatoid arthritis (22.6%), and SLE (22.6%). The presence of more than one autoimmune disease in SSc patients did not correlate with disease severity or activity. Conclusions: From the high prevalence of coexisting autoimmune diseases found in SSc patients, we stress the importance of the concept of shared autoimmunity, in order to promote a continued vigilance and promptly diagnose other possible autoimmune disease in patients, or in their kin. Autoantibodies Systemic sclerosis Autoimmune disease Polyautoimmunity Familial autoimmunity Diseases of the musculoskeletal system Aida Freitas do Carmo Silveira verfasserin aut Izaias Pereira da Costa verfasserin aut In Revista Brasileira de Reumatologia Sociedade Brasileira de Reumatologia, 2005 (DE-627)508330734 (DE-600)2223192-4 18094570 nnns https://doi.org/10.1016/j.rbre.2016.01.003 kostenfrei https://doaj.org/article/0c4591ad77194dde84ee08d81266bfe3 kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042016000400314&lng=en&tlng=en kostenfrei https://doaj.org/toc/1809-4570 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
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10.1016/j.rbre.2016.01.003 doi (DE-627)DOAJ038588021 (DE-599)DOAJ0c4591ad77194dde84ee08d81266bfe3 DE-627 ger DE-627 rakwb eng spa por RC925-935 Alex Magno Coelho Horimoto verfasserin aut Familial autoimmunity and polyautoimmunity in 60 Brazilian Midwest patients with systemic sclerosis Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT Introduction: Systemic sclerosis (SSc) is a connective tissue disease of unknown etiology, characterized by a triad of vascular injury, autoimmunity and tissue fibrosis. It is known that a positive family history is the greatest risk factor already identified for the development of SSc in a given individual. Preliminary observation of a high prevalence of polyautoimmunity and of familial autoimmunity in SSc patients support the idea that different autoimmune phenotypes may share common susceptibility variants. Objectives: To describe the frequency of familial autoimmunity and polyautoimmunity in 60 SSc patients in the Midwest region of Brazil, as well as to report the main autoimmune diseases observed in this association of comorbidities. Methods: A cross-sectional study with recruitment of 60 consecutive patients selected at the Rheumatology Department, University Hospital, Medicine School, Federal University of Mato Grosso do Sul (FMUFMS), as well as interviews of their relatives during the period from February 2013 to March 2014. Results: A frequency of 43.3% of polyautoimmunity and of 51.7% of familial autoimmunity in SSc patients was found. Patients with the presence of polyautoimmunity and familial autoimmunity presented primarily the diffuse form of SSc, but this indicator did not reach statistical significance. The autoimmune diseases most frequently observed in polyautoimmunity patients were: Hashimoto's thyroiditis (53.8%), Sjögren's syndrome (38.5%), and inflammatory myopathy (11.5%). The main autoimmune diseases observed in SSc patients' relatives were: Hashimoto's thyroiditis (32.3%), rheumatoid arthritis (22.6%), and SLE (22.6%). The presence of more than one autoimmune disease in SSc patients did not correlate with disease severity or activity. Conclusions: From the high prevalence of coexisting autoimmune diseases found in SSc patients, we stress the importance of the concept of shared autoimmunity, in order to promote a continued vigilance and promptly diagnose other possible autoimmune disease in patients, or in their kin. Autoantibodies Systemic sclerosis Autoimmune disease Polyautoimmunity Familial autoimmunity Diseases of the musculoskeletal system Aida Freitas do Carmo Silveira verfasserin aut Izaias Pereira da Costa verfasserin aut In Revista Brasileira de Reumatologia Sociedade Brasileira de Reumatologia, 2005 (DE-627)508330734 (DE-600)2223192-4 18094570 nnns https://doi.org/10.1016/j.rbre.2016.01.003 kostenfrei https://doaj.org/article/0c4591ad77194dde84ee08d81266bfe3 kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042016000400314&lng=en&tlng=en kostenfrei https://doaj.org/toc/1809-4570 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
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10.1016/j.rbre.2016.01.003 doi (DE-627)DOAJ038588021 (DE-599)DOAJ0c4591ad77194dde84ee08d81266bfe3 DE-627 ger DE-627 rakwb eng spa por RC925-935 Alex Magno Coelho Horimoto verfasserin aut Familial autoimmunity and polyautoimmunity in 60 Brazilian Midwest patients with systemic sclerosis Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT Introduction: Systemic sclerosis (SSc) is a connective tissue disease of unknown etiology, characterized by a triad of vascular injury, autoimmunity and tissue fibrosis. It is known that a positive family history is the greatest risk factor already identified for the development of SSc in a given individual. Preliminary observation of a high prevalence of polyautoimmunity and of familial autoimmunity in SSc patients support the idea that different autoimmune phenotypes may share common susceptibility variants. Objectives: To describe the frequency of familial autoimmunity and polyautoimmunity in 60 SSc patients in the Midwest region of Brazil, as well as to report the main autoimmune diseases observed in this association of comorbidities. Methods: A cross-sectional study with recruitment of 60 consecutive patients selected at the Rheumatology Department, University Hospital, Medicine School, Federal University of Mato Grosso do Sul (FMUFMS), as well as interviews of their relatives during the period from February 2013 to March 2014. Results: A frequency of 43.3% of polyautoimmunity and of 51.7% of familial autoimmunity in SSc patients was found. Patients with the presence of polyautoimmunity and familial autoimmunity presented primarily the diffuse form of SSc, but this indicator did not reach statistical significance. The autoimmune diseases most frequently observed in polyautoimmunity patients were: Hashimoto's thyroiditis (53.8%), Sjögren's syndrome (38.5%), and inflammatory myopathy (11.5%). The main autoimmune diseases observed in SSc patients' relatives were: Hashimoto's thyroiditis (32.3%), rheumatoid arthritis (22.6%), and SLE (22.6%). The presence of more than one autoimmune disease in SSc patients did not correlate with disease severity or activity. Conclusions: From the high prevalence of coexisting autoimmune diseases found in SSc patients, we stress the importance of the concept of shared autoimmunity, in order to promote a continued vigilance and promptly diagnose other possible autoimmune disease in patients, or in their kin. Autoantibodies Systemic sclerosis Autoimmune disease Polyautoimmunity Familial autoimmunity Diseases of the musculoskeletal system Aida Freitas do Carmo Silveira verfasserin aut Izaias Pereira da Costa verfasserin aut In Revista Brasileira de Reumatologia Sociedade Brasileira de Reumatologia, 2005 (DE-627)508330734 (DE-600)2223192-4 18094570 nnns https://doi.org/10.1016/j.rbre.2016.01.003 kostenfrei https://doaj.org/article/0c4591ad77194dde84ee08d81266bfe3 kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042016000400314&lng=en&tlng=en kostenfrei https://doaj.org/toc/1809-4570 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
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10.1016/j.rbre.2016.01.003 doi (DE-627)DOAJ038588021 (DE-599)DOAJ0c4591ad77194dde84ee08d81266bfe3 DE-627 ger DE-627 rakwb eng spa por RC925-935 Alex Magno Coelho Horimoto verfasserin aut Familial autoimmunity and polyautoimmunity in 60 Brazilian Midwest patients with systemic sclerosis Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACT Introduction: Systemic sclerosis (SSc) is a connective tissue disease of unknown etiology, characterized by a triad of vascular injury, autoimmunity and tissue fibrosis. It is known that a positive family history is the greatest risk factor already identified for the development of SSc in a given individual. Preliminary observation of a high prevalence of polyautoimmunity and of familial autoimmunity in SSc patients support the idea that different autoimmune phenotypes may share common susceptibility variants. Objectives: To describe the frequency of familial autoimmunity and polyautoimmunity in 60 SSc patients in the Midwest region of Brazil, as well as to report the main autoimmune diseases observed in this association of comorbidities. Methods: A cross-sectional study with recruitment of 60 consecutive patients selected at the Rheumatology Department, University Hospital, Medicine School, Federal University of Mato Grosso do Sul (FMUFMS), as well as interviews of their relatives during the period from February 2013 to March 2014. Results: A frequency of 43.3% of polyautoimmunity and of 51.7% of familial autoimmunity in SSc patients was found. Patients with the presence of polyautoimmunity and familial autoimmunity presented primarily the diffuse form of SSc, but this indicator did not reach statistical significance. The autoimmune diseases most frequently observed in polyautoimmunity patients were: Hashimoto's thyroiditis (53.8%), Sjögren's syndrome (38.5%), and inflammatory myopathy (11.5%). The main autoimmune diseases observed in SSc patients' relatives were: Hashimoto's thyroiditis (32.3%), rheumatoid arthritis (22.6%), and SLE (22.6%). The presence of more than one autoimmune disease in SSc patients did not correlate with disease severity or activity. Conclusions: From the high prevalence of coexisting autoimmune diseases found in SSc patients, we stress the importance of the concept of shared autoimmunity, in order to promote a continued vigilance and promptly diagnose other possible autoimmune disease in patients, or in their kin. Autoantibodies Systemic sclerosis Autoimmune disease Polyautoimmunity Familial autoimmunity Diseases of the musculoskeletal system Aida Freitas do Carmo Silveira verfasserin aut Izaias Pereira da Costa verfasserin aut In Revista Brasileira de Reumatologia Sociedade Brasileira de Reumatologia, 2005 (DE-627)508330734 (DE-600)2223192-4 18094570 nnns https://doi.org/10.1016/j.rbre.2016.01.003 kostenfrei https://doaj.org/article/0c4591ad77194dde84ee08d81266bfe3 kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042016000400314&lng=en&tlng=en kostenfrei https://doaj.org/toc/1809-4570 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR |
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RC925-935 Familial autoimmunity and polyautoimmunity in 60 Brazilian Midwest patients with systemic sclerosis Autoantibodies Systemic sclerosis Autoimmune disease Polyautoimmunity Familial autoimmunity |
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Familial autoimmunity and polyautoimmunity in 60 Brazilian Midwest patients with systemic sclerosis |
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Familial autoimmunity and polyautoimmunity in 60 Brazilian Midwest patients with systemic sclerosis |
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Alex Magno Coelho Horimoto |
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10.1016/j.rbre.2016.01.003 |
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familial autoimmunity and polyautoimmunity in 60 brazilian midwest patients with systemic sclerosis |
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Familial autoimmunity and polyautoimmunity in 60 Brazilian Midwest patients with systemic sclerosis |
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ABSTRACT Introduction: Systemic sclerosis (SSc) is a connective tissue disease of unknown etiology, characterized by a triad of vascular injury, autoimmunity and tissue fibrosis. It is known that a positive family history is the greatest risk factor already identified for the development of SSc in a given individual. Preliminary observation of a high prevalence of polyautoimmunity and of familial autoimmunity in SSc patients support the idea that different autoimmune phenotypes may share common susceptibility variants. Objectives: To describe the frequency of familial autoimmunity and polyautoimmunity in 60 SSc patients in the Midwest region of Brazil, as well as to report the main autoimmune diseases observed in this association of comorbidities. Methods: A cross-sectional study with recruitment of 60 consecutive patients selected at the Rheumatology Department, University Hospital, Medicine School, Federal University of Mato Grosso do Sul (FMUFMS), as well as interviews of their relatives during the period from February 2013 to March 2014. Results: A frequency of 43.3% of polyautoimmunity and of 51.7% of familial autoimmunity in SSc patients was found. Patients with the presence of polyautoimmunity and familial autoimmunity presented primarily the diffuse form of SSc, but this indicator did not reach statistical significance. The autoimmune diseases most frequently observed in polyautoimmunity patients were: Hashimoto's thyroiditis (53.8%), Sjögren's syndrome (38.5%), and inflammatory myopathy (11.5%). The main autoimmune diseases observed in SSc patients' relatives were: Hashimoto's thyroiditis (32.3%), rheumatoid arthritis (22.6%), and SLE (22.6%). The presence of more than one autoimmune disease in SSc patients did not correlate with disease severity or activity. Conclusions: From the high prevalence of coexisting autoimmune diseases found in SSc patients, we stress the importance of the concept of shared autoimmunity, in order to promote a continued vigilance and promptly diagnose other possible autoimmune disease in patients, or in their kin. |
| abstractGer |
ABSTRACT Introduction: Systemic sclerosis (SSc) is a connective tissue disease of unknown etiology, characterized by a triad of vascular injury, autoimmunity and tissue fibrosis. It is known that a positive family history is the greatest risk factor already identified for the development of SSc in a given individual. Preliminary observation of a high prevalence of polyautoimmunity and of familial autoimmunity in SSc patients support the idea that different autoimmune phenotypes may share common susceptibility variants. Objectives: To describe the frequency of familial autoimmunity and polyautoimmunity in 60 SSc patients in the Midwest region of Brazil, as well as to report the main autoimmune diseases observed in this association of comorbidities. Methods: A cross-sectional study with recruitment of 60 consecutive patients selected at the Rheumatology Department, University Hospital, Medicine School, Federal University of Mato Grosso do Sul (FMUFMS), as well as interviews of their relatives during the period from February 2013 to March 2014. Results: A frequency of 43.3% of polyautoimmunity and of 51.7% of familial autoimmunity in SSc patients was found. Patients with the presence of polyautoimmunity and familial autoimmunity presented primarily the diffuse form of SSc, but this indicator did not reach statistical significance. The autoimmune diseases most frequently observed in polyautoimmunity patients were: Hashimoto's thyroiditis (53.8%), Sjögren's syndrome (38.5%), and inflammatory myopathy (11.5%). The main autoimmune diseases observed in SSc patients' relatives were: Hashimoto's thyroiditis (32.3%), rheumatoid arthritis (22.6%), and SLE (22.6%). The presence of more than one autoimmune disease in SSc patients did not correlate with disease severity or activity. Conclusions: From the high prevalence of coexisting autoimmune diseases found in SSc patients, we stress the importance of the concept of shared autoimmunity, in order to promote a continued vigilance and promptly diagnose other possible autoimmune disease in patients, or in their kin. |
| abstract_unstemmed |
ABSTRACT Introduction: Systemic sclerosis (SSc) is a connective tissue disease of unknown etiology, characterized by a triad of vascular injury, autoimmunity and tissue fibrosis. It is known that a positive family history is the greatest risk factor already identified for the development of SSc in a given individual. Preliminary observation of a high prevalence of polyautoimmunity and of familial autoimmunity in SSc patients support the idea that different autoimmune phenotypes may share common susceptibility variants. Objectives: To describe the frequency of familial autoimmunity and polyautoimmunity in 60 SSc patients in the Midwest region of Brazil, as well as to report the main autoimmune diseases observed in this association of comorbidities. Methods: A cross-sectional study with recruitment of 60 consecutive patients selected at the Rheumatology Department, University Hospital, Medicine School, Federal University of Mato Grosso do Sul (FMUFMS), as well as interviews of their relatives during the period from February 2013 to March 2014. Results: A frequency of 43.3% of polyautoimmunity and of 51.7% of familial autoimmunity in SSc patients was found. Patients with the presence of polyautoimmunity and familial autoimmunity presented primarily the diffuse form of SSc, but this indicator did not reach statistical significance. The autoimmune diseases most frequently observed in polyautoimmunity patients were: Hashimoto's thyroiditis (53.8%), Sjögren's syndrome (38.5%), and inflammatory myopathy (11.5%). The main autoimmune diseases observed in SSc patients' relatives were: Hashimoto's thyroiditis (32.3%), rheumatoid arthritis (22.6%), and SLE (22.6%). The presence of more than one autoimmune disease in SSc patients did not correlate with disease severity or activity. Conclusions: From the high prevalence of coexisting autoimmune diseases found in SSc patients, we stress the importance of the concept of shared autoimmunity, in order to promote a continued vigilance and promptly diagnose other possible autoimmune disease in patients, or in their kin. |
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https://doi.org/10.1016/j.rbre.2016.01.003 https://doaj.org/article/0c4591ad77194dde84ee08d81266bfe3 http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042016000400314&lng=en&tlng=en https://doaj.org/toc/1809-4570 |
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