Multidirectional Pharma-Toxicological Study on <i<Harpagophytum procumbens</i< DC. ex Meisn.: An IBD-Focused Investigation

In the present study, we investigated the water extract of <i<Harpagophytum procumbens</i< DC. ex Meisn. in an experimental model of inflammatory bowel diseases (IBDs). Additionally, a microbiological investigation was carried out to discriminate the efficacy against bacterial and fungal...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Lucia Recinella [verfasserIn] Annalisa Chiavaroli [verfasserIn] Maurizio Ronci [verfasserIn] Luigi Menghini [verfasserIn] Luigi Brunetti [verfasserIn] Sheila Leone [verfasserIn] Bruno Tirillini [verfasserIn] Paola Angelini [verfasserIn] Stefano Covino [verfasserIn] Roberto Venanzoni [verfasserIn] Gokhan Zengin [verfasserIn] Simonetta Di Simone [verfasserIn] Maria Chiara Ciferri [verfasserIn] Viviana di Giacomo [verfasserIn] Amelia Cataldi [verfasserIn] Monica Rapino [verfasserIn] Valentina Di Valerio [verfasserIn] Giustino Orlando [verfasserIn] Claudio Ferrante [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	ibds oxidative stress inflammation proteomic analysis

Übergeordnetes Werk:	In: Antioxidants - MDPI AG, 2013, 9(2020), 2, p 168
Übergeordnetes Werk:	volume:9 ; year:2020 ; number:2, p 168

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/antiox9020168

Katalog-ID:	DOAJ038595931

Internformat


LEADER	01000caa a22002652 4500
001	DOAJ038595931
003	DE-627
005	20230503055524.0
007	cr uuu---uuuuu
008	230227s2020 xx \|\|\|\|\|o 00\| \|\|eng c
024	7		\|a 10.3390/antiox9020168 \|2 doi
035			\|a (DE-627)DOAJ038595931
035			\|a (DE-599)DOAJ5dd510e1cb864df29e7f5661710810a3
040			\|a DE-627 \|b ger \|c DE-627 \|e rakwb
041			\|a eng
050		0	\|a RM1-950
100	0		\|a Lucia Recinella \|e verfasserin \|4 aut
245	1	0	\|a Multidirectional Pharma-Toxicological Study on <i<Harpagophytum procumbens</i< DC. ex Meisn.: An IBD-Focused Investigation
264		1	\|c 2020
336			\|a Text \|b txt \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
520			\|a In the present study, we investigated the water extract of <i<Harpagophytum procumbens</i< DC. ex Meisn. in an experimental model of inflammatory bowel diseases (IBDs). Additionally, a microbiological investigation was carried out to discriminate the efficacy against bacterial and fungal strains involved in IBDs. Finally, an untargeted proteomic analysis was conducted on more than one hundred colon proteins involved in tissue morphology and metabolism. The extract was effective in blunting the production of oxidative stress and inflammation, including serotonin, prostaglandins, cytokines, and transcription factors. Additionally, the extract inhibited the growth of <i<Candida albicans</i< and <i<C. tropicalis</i<. The extract was also able to exert a pro-homeostatic effect on the levels of a wide plethora of colon proteins, thus corroborating a protective effect. Conversely, the supraphysiological downregulation of cytoskeletal-related proteins involved in tissue morphology and antimicrobial barrier function suggests a warning in the use of food supplements containing <i<H. procumbens</i< extracts.
650		4	\|a <i<harpagophytum procumbens</i<
650		4	\|a ibds
650		4	\|a oxidative stress
650		4	\|a inflammation
650		4	\|a proteomic analysis
653		0	\|a Therapeutics. Pharmacology
700	0		\|a Annalisa Chiavaroli \|e verfasserin \|4 aut
700	0		\|a Maurizio Ronci \|e verfasserin \|4 aut
700	0		\|a Luigi Menghini \|e verfasserin \|4 aut
700	0		\|a Luigi Brunetti \|e verfasserin \|4 aut
700	0		\|a Sheila Leone \|e verfasserin \|4 aut
700	0		\|a Bruno Tirillini \|e verfasserin \|4 aut
700	0		\|a Paola Angelini \|e verfasserin \|4 aut
700	0		\|a Stefano Covino \|e verfasserin \|4 aut
700	0		\|a Roberto Venanzoni \|e verfasserin \|4 aut
700	0		\|a Gokhan Zengin \|e verfasserin \|4 aut
700	0		\|a Simonetta Di Simone \|e verfasserin \|4 aut
700	0		\|a Maria Chiara Ciferri \|e verfasserin \|4 aut
700	0		\|a Viviana di Giacomo \|e verfasserin \|4 aut
700	0		\|a Amelia Cataldi \|e verfasserin \|4 aut
700	0		\|a Monica Rapino \|e verfasserin \|4 aut
700	0		\|a Valentina Di Valerio \|e verfasserin \|4 aut
700	0		\|a Giustino Orlando \|e verfasserin \|4 aut
700	0		\|a Claudio Ferrante \|e verfasserin \|4 aut
773	0	8	\|i In \|t Antioxidants \|d MDPI AG, 2013 \|g 9(2020), 2, p 168 \|w (DE-627)737287578 \|w (DE-600)2704216-9 \|x 20763921 \|7 nnns
773	1	8	\|g volume:9 \|g year:2020 \|g number:2, p 168
856	4	0	\|u https://doi.org/10.3390/antiox9020168 \|z kostenfrei
856	4	0	\|u https://doaj.org/article/5dd510e1cb864df29e7f5661710810a3 \|z kostenfrei
856	4	0	\|u https://www.mdpi.com/2076-3921/9/2/168 \|z kostenfrei
856	4	2	\|u https://doaj.org/toc/2076-3921 \|y Journal toc \|z kostenfrei
912			\|a GBV_USEFLAG_A
912			\|a SYSFLAG_A
912			\|a GBV_DOAJ
912			\|a SSG-OLC-PHA
912			\|a GBV_ILN_20
912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_95
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_206
912			\|a GBV_ILN_213
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_602
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4700
951			\|a AR
952			\|d 9 \|j 2020 \|e 2, p 168

Indexfelder

author_variant	l r lr a c ac m r mr l m lm l b lb s l sl b t bt p a pa s c sc r v rv g z gz s d s sds m c c mcc v d g vdg a c ac m r mr v d v vdv g o go c f cf
matchkey_str	article:20763921:2020----::utdrcinlhraoiooiasuynhraohtmrcmesdemi
hierarchy_sort_str	2020
callnumber-subject-code	RM
publishDate	2020
allfields	10.3390/antiox9020168 doi (DE-627)DOAJ038595931 (DE-599)DOAJ5dd510e1cb864df29e7f5661710810a3 DE-627 ger DE-627 rakwb eng RM1-950 Lucia Recinella verfasserin aut Multidirectional Pharma-Toxicological Study on <i<Harpagophytum procumbens</i< DC. ex Meisn.: An IBD-Focused Investigation 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In the present study, we investigated the water extract of <i<Harpagophytum procumbens</i< DC. ex Meisn. in an experimental model of inflammatory bowel diseases (IBDs). Additionally, a microbiological investigation was carried out to discriminate the efficacy against bacterial and fungal strains involved in IBDs. Finally, an untargeted proteomic analysis was conducted on more than one hundred colon proteins involved in tissue morphology and metabolism. The extract was effective in blunting the production of oxidative stress and inflammation, including serotonin, prostaglandins, cytokines, and transcription factors. Additionally, the extract inhibited the growth of <i<Candida albicans</i< and <i<C. tropicalis</i<. The extract was also able to exert a pro-homeostatic effect on the levels of a wide plethora of colon proteins, thus corroborating a protective effect. Conversely, the supraphysiological downregulation of cytoskeletal-related proteins involved in tissue morphology and antimicrobial barrier function suggests a warning in the use of food supplements containing <i<H. procumbens</i< extracts. <i<harpagophytum procumbens</i< ibds oxidative stress inflammation proteomic analysis Therapeutics. Pharmacology Annalisa Chiavaroli verfasserin aut Maurizio Ronci verfasserin aut Luigi Menghini verfasserin aut Luigi Brunetti verfasserin aut Sheila Leone verfasserin aut Bruno Tirillini verfasserin aut Paola Angelini verfasserin aut Stefano Covino verfasserin aut Roberto Venanzoni verfasserin aut Gokhan Zengin verfasserin aut Simonetta Di Simone verfasserin aut Maria Chiara Ciferri verfasserin aut Viviana di Giacomo verfasserin aut Amelia Cataldi verfasserin aut Monica Rapino verfasserin aut Valentina Di Valerio verfasserin aut Giustino Orlando verfasserin aut Claudio Ferrante verfasserin aut In Antioxidants MDPI AG, 2013 9(2020), 2, p 168 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:9 year:2020 number:2, p 168 https://doi.org/10.3390/antiox9020168 kostenfrei https://doaj.org/article/5dd510e1cb864df29e7f5661710810a3 kostenfrei https://www.mdpi.com/2076-3921/9/2/168 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 2, p 168
spelling	10.3390/antiox9020168 doi (DE-627)DOAJ038595931 (DE-599)DOAJ5dd510e1cb864df29e7f5661710810a3 DE-627 ger DE-627 rakwb eng RM1-950 Lucia Recinella verfasserin aut Multidirectional Pharma-Toxicological Study on <i<Harpagophytum procumbens</i< DC. ex Meisn.: An IBD-Focused Investigation 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In the present study, we investigated the water extract of <i<Harpagophytum procumbens</i< DC. ex Meisn. in an experimental model of inflammatory bowel diseases (IBDs). Additionally, a microbiological investigation was carried out to discriminate the efficacy against bacterial and fungal strains involved in IBDs. Finally, an untargeted proteomic analysis was conducted on more than one hundred colon proteins involved in tissue morphology and metabolism. The extract was effective in blunting the production of oxidative stress and inflammation, including serotonin, prostaglandins, cytokines, and transcription factors. Additionally, the extract inhibited the growth of <i<Candida albicans</i< and <i<C. tropicalis</i<. The extract was also able to exert a pro-homeostatic effect on the levels of a wide plethora of colon proteins, thus corroborating a protective effect. Conversely, the supraphysiological downregulation of cytoskeletal-related proteins involved in tissue morphology and antimicrobial barrier function suggests a warning in the use of food supplements containing <i<H. procumbens</i< extracts. <i<harpagophytum procumbens</i< ibds oxidative stress inflammation proteomic analysis Therapeutics. Pharmacology Annalisa Chiavaroli verfasserin aut Maurizio Ronci verfasserin aut Luigi Menghini verfasserin aut Luigi Brunetti verfasserin aut Sheila Leone verfasserin aut Bruno Tirillini verfasserin aut Paola Angelini verfasserin aut Stefano Covino verfasserin aut Roberto Venanzoni verfasserin aut Gokhan Zengin verfasserin aut Simonetta Di Simone verfasserin aut Maria Chiara Ciferri verfasserin aut Viviana di Giacomo verfasserin aut Amelia Cataldi verfasserin aut Monica Rapino verfasserin aut Valentina Di Valerio verfasserin aut Giustino Orlando verfasserin aut Claudio Ferrante verfasserin aut In Antioxidants MDPI AG, 2013 9(2020), 2, p 168 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:9 year:2020 number:2, p 168 https://doi.org/10.3390/antiox9020168 kostenfrei https://doaj.org/article/5dd510e1cb864df29e7f5661710810a3 kostenfrei https://www.mdpi.com/2076-3921/9/2/168 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 2, p 168
allfields_unstemmed	10.3390/antiox9020168 doi (DE-627)DOAJ038595931 (DE-599)DOAJ5dd510e1cb864df29e7f5661710810a3 DE-627 ger DE-627 rakwb eng RM1-950 Lucia Recinella verfasserin aut Multidirectional Pharma-Toxicological Study on <i<Harpagophytum procumbens</i< DC. ex Meisn.: An IBD-Focused Investigation 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In the present study, we investigated the water extract of <i<Harpagophytum procumbens</i< DC. ex Meisn. in an experimental model of inflammatory bowel diseases (IBDs). Additionally, a microbiological investigation was carried out to discriminate the efficacy against bacterial and fungal strains involved in IBDs. Finally, an untargeted proteomic analysis was conducted on more than one hundred colon proteins involved in tissue morphology and metabolism. The extract was effective in blunting the production of oxidative stress and inflammation, including serotonin, prostaglandins, cytokines, and transcription factors. Additionally, the extract inhibited the growth of <i<Candida albicans</i< and <i<C. tropicalis</i<. The extract was also able to exert a pro-homeostatic effect on the levels of a wide plethora of colon proteins, thus corroborating a protective effect. Conversely, the supraphysiological downregulation of cytoskeletal-related proteins involved in tissue morphology and antimicrobial barrier function suggests a warning in the use of food supplements containing <i<H. procumbens</i< extracts. <i<harpagophytum procumbens</i< ibds oxidative stress inflammation proteomic analysis Therapeutics. Pharmacology Annalisa Chiavaroli verfasserin aut Maurizio Ronci verfasserin aut Luigi Menghini verfasserin aut Luigi Brunetti verfasserin aut Sheila Leone verfasserin aut Bruno Tirillini verfasserin aut Paola Angelini verfasserin aut Stefano Covino verfasserin aut Roberto Venanzoni verfasserin aut Gokhan Zengin verfasserin aut Simonetta Di Simone verfasserin aut Maria Chiara Ciferri verfasserin aut Viviana di Giacomo verfasserin aut Amelia Cataldi verfasserin aut Monica Rapino verfasserin aut Valentina Di Valerio verfasserin aut Giustino Orlando verfasserin aut Claudio Ferrante verfasserin aut In Antioxidants MDPI AG, 2013 9(2020), 2, p 168 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:9 year:2020 number:2, p 168 https://doi.org/10.3390/antiox9020168 kostenfrei https://doaj.org/article/5dd510e1cb864df29e7f5661710810a3 kostenfrei https://www.mdpi.com/2076-3921/9/2/168 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 2, p 168
allfieldsGer	10.3390/antiox9020168 doi (DE-627)DOAJ038595931 (DE-599)DOAJ5dd510e1cb864df29e7f5661710810a3 DE-627 ger DE-627 rakwb eng RM1-950 Lucia Recinella verfasserin aut Multidirectional Pharma-Toxicological Study on <i<Harpagophytum procumbens</i< DC. ex Meisn.: An IBD-Focused Investigation 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In the present study, we investigated the water extract of <i<Harpagophytum procumbens</i< DC. ex Meisn. in an experimental model of inflammatory bowel diseases (IBDs). Additionally, a microbiological investigation was carried out to discriminate the efficacy against bacterial and fungal strains involved in IBDs. Finally, an untargeted proteomic analysis was conducted on more than one hundred colon proteins involved in tissue morphology and metabolism. The extract was effective in blunting the production of oxidative stress and inflammation, including serotonin, prostaglandins, cytokines, and transcription factors. Additionally, the extract inhibited the growth of <i<Candida albicans</i< and <i<C. tropicalis</i<. The extract was also able to exert a pro-homeostatic effect on the levels of a wide plethora of colon proteins, thus corroborating a protective effect. Conversely, the supraphysiological downregulation of cytoskeletal-related proteins involved in tissue morphology and antimicrobial barrier function suggests a warning in the use of food supplements containing <i<H. procumbens</i< extracts. <i<harpagophytum procumbens</i< ibds oxidative stress inflammation proteomic analysis Therapeutics. Pharmacology Annalisa Chiavaroli verfasserin aut Maurizio Ronci verfasserin aut Luigi Menghini verfasserin aut Luigi Brunetti verfasserin aut Sheila Leone verfasserin aut Bruno Tirillini verfasserin aut Paola Angelini verfasserin aut Stefano Covino verfasserin aut Roberto Venanzoni verfasserin aut Gokhan Zengin verfasserin aut Simonetta Di Simone verfasserin aut Maria Chiara Ciferri verfasserin aut Viviana di Giacomo verfasserin aut Amelia Cataldi verfasserin aut Monica Rapino verfasserin aut Valentina Di Valerio verfasserin aut Giustino Orlando verfasserin aut Claudio Ferrante verfasserin aut In Antioxidants MDPI AG, 2013 9(2020), 2, p 168 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:9 year:2020 number:2, p 168 https://doi.org/10.3390/antiox9020168 kostenfrei https://doaj.org/article/5dd510e1cb864df29e7f5661710810a3 kostenfrei https://www.mdpi.com/2076-3921/9/2/168 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 2, p 168
allfieldsSound	10.3390/antiox9020168 doi (DE-627)DOAJ038595931 (DE-599)DOAJ5dd510e1cb864df29e7f5661710810a3 DE-627 ger DE-627 rakwb eng RM1-950 Lucia Recinella verfasserin aut Multidirectional Pharma-Toxicological Study on <i<Harpagophytum procumbens</i< DC. ex Meisn.: An IBD-Focused Investigation 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier In the present study, we investigated the water extract of <i<Harpagophytum procumbens</i< DC. ex Meisn. in an experimental model of inflammatory bowel diseases (IBDs). Additionally, a microbiological investigation was carried out to discriminate the efficacy against bacterial and fungal strains involved in IBDs. Finally, an untargeted proteomic analysis was conducted on more than one hundred colon proteins involved in tissue morphology and metabolism. The extract was effective in blunting the production of oxidative stress and inflammation, including serotonin, prostaglandins, cytokines, and transcription factors. Additionally, the extract inhibited the growth of <i<Candida albicans</i< and <i<C. tropicalis</i<. The extract was also able to exert a pro-homeostatic effect on the levels of a wide plethora of colon proteins, thus corroborating a protective effect. Conversely, the supraphysiological downregulation of cytoskeletal-related proteins involved in tissue morphology and antimicrobial barrier function suggests a warning in the use of food supplements containing <i<H. procumbens</i< extracts. <i<harpagophytum procumbens</i< ibds oxidative stress inflammation proteomic analysis Therapeutics. Pharmacology Annalisa Chiavaroli verfasserin aut Maurizio Ronci verfasserin aut Luigi Menghini verfasserin aut Luigi Brunetti verfasserin aut Sheila Leone verfasserin aut Bruno Tirillini verfasserin aut Paola Angelini verfasserin aut Stefano Covino verfasserin aut Roberto Venanzoni verfasserin aut Gokhan Zengin verfasserin aut Simonetta Di Simone verfasserin aut Maria Chiara Ciferri verfasserin aut Viviana di Giacomo verfasserin aut Amelia Cataldi verfasserin aut Monica Rapino verfasserin aut Valentina Di Valerio verfasserin aut Giustino Orlando verfasserin aut Claudio Ferrante verfasserin aut In Antioxidants MDPI AG, 2013 9(2020), 2, p 168 (DE-627)737287578 (DE-600)2704216-9 20763921 nnns volume:9 year:2020 number:2, p 168 https://doi.org/10.3390/antiox9020168 kostenfrei https://doaj.org/article/5dd510e1cb864df29e7f5661710810a3 kostenfrei https://www.mdpi.com/2076-3921/9/2/168 kostenfrei https://doaj.org/toc/2076-3921 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 2, p 168
language	English
source	In Antioxidants 9(2020), 2, p 168 volume:9 year:2020 number:2, p 168
sourceStr	In Antioxidants 9(2020), 2, p 168 volume:9 year:2020 number:2, p 168
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	<i<harpagophytum procumbens</i< ibds oxidative stress inflammation proteomic analysis Therapeutics. Pharmacology
isfreeaccess_bool	true
container_title	Antioxidants
authorswithroles_txt_mv	Lucia Recinella @@aut@@ Annalisa Chiavaroli @@aut@@ Maurizio Ronci @@aut@@ Luigi Menghini @@aut@@ Luigi Brunetti @@aut@@ Sheila Leone @@aut@@ Bruno Tirillini @@aut@@ Paola Angelini @@aut@@ Stefano Covino @@aut@@ Roberto Venanzoni @@aut@@ Gokhan Zengin @@aut@@ Simonetta Di Simone @@aut@@ Maria Chiara Ciferri @@aut@@ Viviana di Giacomo @@aut@@ Amelia Cataldi @@aut@@ Monica Rapino @@aut@@ Valentina Di Valerio @@aut@@ Giustino Orlando @@aut@@ Claudio Ferrante @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	737287578
id	DOAJ038595931
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ038595931</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230503055524.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230227s2020 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3390/antiox9020168</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ038595931</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ5dd510e1cb864df29e7f5661710810a3</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RM1-950</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Lucia Recinella</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Multidirectional Pharma-Toxicological Study on <i<Harpagophytum procumbens</i< DC. ex Meisn.: An IBD-Focused Investigation</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">In the present study, we investigated the water extract of <i<Harpagophytum procumbens</i< DC. ex Meisn. in an experimental model of inflammatory bowel diseases (IBDs). Additionally, a microbiological investigation was carried out to discriminate the efficacy against bacterial and fungal strains involved in IBDs. Finally, an untargeted proteomic analysis was conducted on more than one hundred colon proteins involved in tissue morphology and metabolism. The extract was effective in blunting the production of oxidative stress and inflammation, including serotonin, prostaglandins, cytokines, and transcription factors. Additionally, the extract inhibited the growth of <i<Candida albicans</i< and <i<C. tropicalis</i<. The extract was also able to exert a pro-homeostatic effect on the levels of a wide plethora of colon proteins, thus corroborating a protective effect. Conversely, the supraphysiological downregulation of cytoskeletal-related proteins involved in tissue morphology and antimicrobial barrier function suggests a warning in the use of food supplements containing <i<H. procumbens</i< extracts.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a"><i<harpagophytum procumbens</i<</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">ibds</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">oxidative stress</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">inflammation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">proteomic analysis</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Therapeutics. Pharmacology</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Annalisa Chiavaroli</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maurizio Ronci</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Luigi Menghini</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Luigi Brunetti</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sheila Leone</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Bruno Tirillini</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Paola Angelini</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Stefano Covino</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Roberto Venanzoni</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gokhan Zengin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Simonetta Di Simone</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maria Chiara Ciferri</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Viviana di Giacomo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Amelia Cataldi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Monica Rapino</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Valentina Di Valerio</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Giustino Orlando</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Claudio Ferrante</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Antioxidants</subfield><subfield code="d">MDPI AG, 2013</subfield><subfield code="g">9(2020), 2, p 168</subfield><subfield code="w">(DE-627)737287578</subfield><subfield code="w">(DE-600)2704216-9</subfield><subfield code="x">20763921</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:9</subfield><subfield code="g">year:2020</subfield><subfield code="g">number:2, p 168</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.3390/antiox9020168</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/5dd510e1cb864df29e7f5661710810a3</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://www.mdpi.com/2076-3921/9/2/168</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2076-3921</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">9</subfield><subfield code="j">2020</subfield><subfield code="e">2, p 168</subfield></datafield></record></collection>
callnumber-first	R - Medicine
author	Lucia Recinella
spellingShingle	Lucia Recinella misc RM1-950 misc <i<harpagophytum procumbens</i< misc ibds misc oxidative stress misc inflammation misc proteomic analysis misc Therapeutics. Pharmacology Multidirectional Pharma-Toxicological Study on <i<Harpagophytum procumbens</i< DC. ex Meisn.: An IBD-Focused Investigation
authorStr	Lucia Recinella
ppnlink_with_tag_str_mv	@@773@@(DE-627)737287578
format	electronic Article
delete_txt_mv	keep
author_role	aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut
collection	DOAJ
remote_str	true
callnumber-label	RM1-950
illustrated	Not Illustrated
issn	20763921
topic_title	RM1-950 Multidirectional Pharma-Toxicological Study on <i<Harpagophytum procumbens</i< DC. ex Meisn.: An IBD-Focused Investigation <i<harpagophytum procumbens</i< ibds oxidative stress inflammation proteomic analysis
topic	misc RM1-950 misc <i<harpagophytum procumbens</i< misc ibds misc oxidative stress misc inflammation misc proteomic analysis misc Therapeutics. Pharmacology
topic_unstemmed	misc RM1-950 misc <i<harpagophytum procumbens</i< misc ibds misc oxidative stress misc inflammation misc proteomic analysis misc Therapeutics. Pharmacology
topic_browse	misc RM1-950 misc <i<harpagophytum procumbens</i< misc ibds misc oxidative stress misc inflammation misc proteomic analysis misc Therapeutics. Pharmacology
format_facet	Elektronische Aufsätze Aufsätze Elektronische Ressource
format_main_str_mv	Text Zeitschrift/Artikel
carriertype_str_mv	cr
hierarchy_parent_title	Antioxidants
hierarchy_parent_id	737287578
hierarchy_top_title	Antioxidants
isfreeaccess_txt	true
familylinks_str_mv	(DE-627)737287578 (DE-600)2704216-9
title	Multidirectional Pharma-Toxicological Study on <i<Harpagophytum procumbens</i< DC. ex Meisn.: An IBD-Focused Investigation
ctrlnum	(DE-627)DOAJ038595931 (DE-599)DOAJ5dd510e1cb864df29e7f5661710810a3
title_full	Multidirectional Pharma-Toxicological Study on <i<Harpagophytum procumbens</i< DC. ex Meisn.: An IBD-Focused Investigation
author_sort	Lucia Recinella
journal	Antioxidants
journalStr	Antioxidants
callnumber-first-code	R
lang_code	eng
isOA_bool	true
recordtype	marc
publishDateSort	2020
contenttype_str_mv	txt
author_browse	Lucia Recinella Annalisa Chiavaroli Maurizio Ronci Luigi Menghini Luigi Brunetti Sheila Leone Bruno Tirillini Paola Angelini Stefano Covino Roberto Venanzoni Gokhan Zengin Simonetta Di Simone Maria Chiara Ciferri Viviana di Giacomo Amelia Cataldi Monica Rapino Valentina Di Valerio Giustino Orlando Claudio Ferrante
container_volume	9
class	RM1-950
format_se	Elektronische Aufsätze
author-letter	Lucia Recinella
doi_str_mv	10.3390/antiox9020168
author2-role	verfasserin
title_sort	multidirectional pharma-toxicological study on <i<harpagophytum procumbens</i< dc. ex meisn.: an ibd-focused investigation
callnumber	RM1-950
title_auth	Multidirectional Pharma-Toxicological Study on <i<Harpagophytum procumbens</i< DC. ex Meisn.: An IBD-Focused Investigation
abstract	In the present study, we investigated the water extract of <i<Harpagophytum procumbens</i< DC. ex Meisn. in an experimental model of inflammatory bowel diseases (IBDs). Additionally, a microbiological investigation was carried out to discriminate the efficacy against bacterial and fungal strains involved in IBDs. Finally, an untargeted proteomic analysis was conducted on more than one hundred colon proteins involved in tissue morphology and metabolism. The extract was effective in blunting the production of oxidative stress and inflammation, including serotonin, prostaglandins, cytokines, and transcription factors. Additionally, the extract inhibited the growth of <i<Candida albicans</i< and <i<C. tropicalis</i<. The extract was also able to exert a pro-homeostatic effect on the levels of a wide plethora of colon proteins, thus corroborating a protective effect. Conversely, the supraphysiological downregulation of cytoskeletal-related proteins involved in tissue morphology and antimicrobial barrier function suggests a warning in the use of food supplements containing <i<H. procumbens</i< extracts.
abstractGer	In the present study, we investigated the water extract of <i<Harpagophytum procumbens</i< DC. ex Meisn. in an experimental model of inflammatory bowel diseases (IBDs). Additionally, a microbiological investigation was carried out to discriminate the efficacy against bacterial and fungal strains involved in IBDs. Finally, an untargeted proteomic analysis was conducted on more than one hundred colon proteins involved in tissue morphology and metabolism. The extract was effective in blunting the production of oxidative stress and inflammation, including serotonin, prostaglandins, cytokines, and transcription factors. Additionally, the extract inhibited the growth of <i<Candida albicans</i< and <i<C. tropicalis</i<. The extract was also able to exert a pro-homeostatic effect on the levels of a wide plethora of colon proteins, thus corroborating a protective effect. Conversely, the supraphysiological downregulation of cytoskeletal-related proteins involved in tissue morphology and antimicrobial barrier function suggests a warning in the use of food supplements containing <i<H. procumbens</i< extracts.
abstract_unstemmed	In the present study, we investigated the water extract of <i<Harpagophytum procumbens</i< DC. ex Meisn. in an experimental model of inflammatory bowel diseases (IBDs). Additionally, a microbiological investigation was carried out to discriminate the efficacy against bacterial and fungal strains involved in IBDs. Finally, an untargeted proteomic analysis was conducted on more than one hundred colon proteins involved in tissue morphology and metabolism. The extract was effective in blunting the production of oxidative stress and inflammation, including serotonin, prostaglandins, cytokines, and transcription factors. Additionally, the extract inhibited the growth of <i<Candida albicans</i< and <i<C. tropicalis</i<. The extract was also able to exert a pro-homeostatic effect on the levels of a wide plethora of colon proteins, thus corroborating a protective effect. Conversely, the supraphysiological downregulation of cytoskeletal-related proteins involved in tissue morphology and antimicrobial barrier function suggests a warning in the use of food supplements containing <i<H. procumbens</i< extracts.
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
container_issue	2, p 168
title_short	Multidirectional Pharma-Toxicological Study on <i<Harpagophytum procumbens</i< DC. ex Meisn.: An IBD-Focused Investigation
url	https://doi.org/10.3390/antiox9020168 https://doaj.org/article/5dd510e1cb864df29e7f5661710810a3 https://www.mdpi.com/2076-3921/9/2/168 https://doaj.org/toc/2076-3921
remote_bool	true
author2	Annalisa Chiavaroli Maurizio Ronci Luigi Menghini Luigi Brunetti Sheila Leone Bruno Tirillini Paola Angelini Stefano Covino Roberto Venanzoni Gokhan Zengin Simonetta Di Simone Maria Chiara Ciferri Viviana di Giacomo Amelia Cataldi Monica Rapino Valentina Di Valerio Giustino Orlando Claudio Ferrante
author2Str	Annalisa Chiavaroli Maurizio Ronci Luigi Menghini Luigi Brunetti Sheila Leone Bruno Tirillini Paola Angelini Stefano Covino Roberto Venanzoni Gokhan Zengin Simonetta Di Simone Maria Chiara Ciferri Viviana di Giacomo Amelia Cataldi Monica Rapino Valentina Di Valerio Giustino Orlando Claudio Ferrante
ppnlink	737287578
callnumber-subject	RM - Therapeutics and Pharmacology
mediatype_str_mv	c
isOA_txt	true
hochschulschrift_bool	false
doi_str	10.3390/antiox9020168
callnumber-a	RM1-950
up_date	2024-07-03T18:48:30.459Z
_version_	1803584809697542144
fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ038595931</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230503055524.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230227s2020 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3390/antiox9020168</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ038595931</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ5dd510e1cb864df29e7f5661710810a3</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RM1-950</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Lucia Recinella</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Multidirectional Pharma-Toxicological Study on <i<Harpagophytum procumbens</i< DC. ex Meisn.: An IBD-Focused Investigation</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2020</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">In the present study, we investigated the water extract of <i<Harpagophytum procumbens</i< DC. ex Meisn. in an experimental model of inflammatory bowel diseases (IBDs). Additionally, a microbiological investigation was carried out to discriminate the efficacy against bacterial and fungal strains involved in IBDs. Finally, an untargeted proteomic analysis was conducted on more than one hundred colon proteins involved in tissue morphology and metabolism. The extract was effective in blunting the production of oxidative stress and inflammation, including serotonin, prostaglandins, cytokines, and transcription factors. Additionally, the extract inhibited the growth of <i<Candida albicans</i< and <i<C. tropicalis</i<. The extract was also able to exert a pro-homeostatic effect on the levels of a wide plethora of colon proteins, thus corroborating a protective effect. Conversely, the supraphysiological downregulation of cytoskeletal-related proteins involved in tissue morphology and antimicrobial barrier function suggests a warning in the use of food supplements containing <i<H. procumbens</i< extracts.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a"><i<harpagophytum procumbens</i<</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">ibds</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">oxidative stress</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">inflammation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">proteomic analysis</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Therapeutics. Pharmacology</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Annalisa Chiavaroli</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maurizio Ronci</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Luigi Menghini</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Luigi Brunetti</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sheila Leone</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Bruno Tirillini</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Paola Angelini</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Stefano Covino</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Roberto Venanzoni</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gokhan Zengin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Simonetta Di Simone</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maria Chiara Ciferri</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Viviana di Giacomo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Amelia Cataldi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Monica Rapino</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Valentina Di Valerio</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Giustino Orlando</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Claudio Ferrante</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Antioxidants</subfield><subfield code="d">MDPI AG, 2013</subfield><subfield code="g">9(2020), 2, p 168</subfield><subfield code="w">(DE-627)737287578</subfield><subfield code="w">(DE-600)2704216-9</subfield><subfield code="x">20763921</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:9</subfield><subfield code="g">year:2020</subfield><subfield code="g">number:2, p 168</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.3390/antiox9020168</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/5dd510e1cb864df29e7f5661710810a3</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://www.mdpi.com/2076-3921/9/2/168</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2076-3921</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">9</subfield><subfield code="j">2020</subfield><subfield code="e">2, p 168</subfield></datafield></record></collection>
score	7.4021673

Nicht das Richtige dabei?

Schreiben Sie uns!

Multidirectional Pharma-Toxicological Study on <i<Harpagophytum procumbens</i< DC. ex Meisn.: An IBD-Focused Investigation

Nicht das Richtige dabei?

Zugang & Verfügbarkeit

Vorhandene Bände

Nicht das Richtige dabei?