Associations of Plasma Fatty Acid Patterns during Pregnancy with Respiratory and Allergy Outcomes at School Age

Fatty acids might play a role in asthma and allergy development as they can modulate immune responses. We examined among 4260 mother-child pairs participating in a population-based cohort the associations of maternal plasma fatty acid patterns during pregnancy with a child’s respiratory and allergy...
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Autor*in:	Sara M. Mensink-Bout [verfasserIn] Trudy Voortman [verfasserIn] Marsela Dervishaj [verfasserIn] Irwin K. M. Reiss [verfasserIn] Johan C. De Jongste [verfasserIn] Vincent W. V. Jaddoe [verfasserIn] Liesbeth Duijts [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	fatty acids child inhalant allergic sensitization and allergy pulmonary function prospective cohort study

Übergeordnetes Werk:	In: Nutrients - MDPI AG, 2009, 12(2020), 10, p 3057
Übergeordnetes Werk:	volume:12 ; year:2020 ; number:10, p 3057

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/nu12103057

Katalog-ID:	DOAJ038608200

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authorswithroles_txt_mv	Sara M. Mensink-Bout @@aut@@ Trudy Voortman @@aut@@ Marsela Dervishaj @@aut@@ Irwin K. M. Reiss @@aut@@ Johan C. De Jongste @@aut@@ Vincent W. V. Jaddoe @@aut@@ Liesbeth Duijts @@aut@@
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callnumber-first	T - Technology
author	Sara M. Mensink-Bout
spellingShingle	Sara M. Mensink-Bout misc TX341-641 misc fatty acids misc child misc inhalant allergic sensitization and allergy misc pulmonary function misc prospective cohort study misc Nutrition. Foods and food supply Associations of Plasma Fatty Acid Patterns during Pregnancy with Respiratory and Allergy Outcomes at School Age
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topic_title	TX341-641 Associations of Plasma Fatty Acid Patterns during Pregnancy with Respiratory and Allergy Outcomes at School Age fatty acids child inhalant allergic sensitization and allergy pulmonary function prospective cohort study
topic	misc TX341-641 misc fatty acids misc child misc inhalant allergic sensitization and allergy misc pulmonary function misc prospective cohort study misc Nutrition. Foods and food supply
topic_unstemmed	misc TX341-641 misc fatty acids misc child misc inhalant allergic sensitization and allergy misc pulmonary function misc prospective cohort study misc Nutrition. Foods and food supply
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title	Associations of Plasma Fatty Acid Patterns during Pregnancy with Respiratory and Allergy Outcomes at School Age
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title_full	Associations of Plasma Fatty Acid Patterns during Pregnancy with Respiratory and Allergy Outcomes at School Age
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author_browse	Sara M. Mensink-Bout Trudy Voortman Marsela Dervishaj Irwin K. M. Reiss Johan C. De Jongste Vincent W. V. Jaddoe Liesbeth Duijts
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title_sort	associations of plasma fatty acid patterns during pregnancy with respiratory and allergy outcomes at school age
callnumber	TX341-641
title_auth	Associations of Plasma Fatty Acid Patterns during Pregnancy with Respiratory and Allergy Outcomes at School Age
abstract	Fatty acids might play a role in asthma and allergy development as they can modulate immune responses. We examined among 4260 mother-child pairs participating in a population-based cohort the associations of maternal plasma fatty acid patterns during pregnancy with a child’s respiratory and allergy outcomes at school-age. In mid-pregnancy, 22 individual fatty acids were measured from maternal blood. Three patterns were previously identified by principal component analysis: A ‘high n-6 polyunsaturated fatty acid (PUFA)’, a ‘monounsaturated and saturated fatty acid’, and a ‘high n-3 PUFA’ pattern. At the age of 10 years, a child’s lung function was assessed by spirometry, current asthma and physician-diagnosed inhalant allergy by questionnaire, and inhalant allergic sensitization by skin prick tests. A higher ‘high n-6 PUFA’ pattern was associated with a higher forced expiratory volume in 1 s/forced vital capacity and forced expiratory flow after exhaling 75% of forced vital capacity (Z-score difference (95% CI) 0.04 (0, 0.07) and 0.04 (0.01, 0.07), respectively, per SD increase in the fatty acid pattern). We observed no associations of maternal fatty acid patterns with a child’s asthma or allergy outcomes. Our results showed limited associations of maternal patterns of high n-6 PUFA concentrations in pregnancy with a better lung function in school-aged children.
abstractGer	Fatty acids might play a role in asthma and allergy development as they can modulate immune responses. We examined among 4260 mother-child pairs participating in a population-based cohort the associations of maternal plasma fatty acid patterns during pregnancy with a child’s respiratory and allergy outcomes at school-age. In mid-pregnancy, 22 individual fatty acids were measured from maternal blood. Three patterns were previously identified by principal component analysis: A ‘high n-6 polyunsaturated fatty acid (PUFA)’, a ‘monounsaturated and saturated fatty acid’, and a ‘high n-3 PUFA’ pattern. At the age of 10 years, a child’s lung function was assessed by spirometry, current asthma and physician-diagnosed inhalant allergy by questionnaire, and inhalant allergic sensitization by skin prick tests. A higher ‘high n-6 PUFA’ pattern was associated with a higher forced expiratory volume in 1 s/forced vital capacity and forced expiratory flow after exhaling 75% of forced vital capacity (Z-score difference (95% CI) 0.04 (0, 0.07) and 0.04 (0.01, 0.07), respectively, per SD increase in the fatty acid pattern). We observed no associations of maternal fatty acid patterns with a child’s asthma or allergy outcomes. Our results showed limited associations of maternal patterns of high n-6 PUFA concentrations in pregnancy with a better lung function in school-aged children.
abstract_unstemmed	Fatty acids might play a role in asthma and allergy development as they can modulate immune responses. We examined among 4260 mother-child pairs participating in a population-based cohort the associations of maternal plasma fatty acid patterns during pregnancy with a child’s respiratory and allergy outcomes at school-age. In mid-pregnancy, 22 individual fatty acids were measured from maternal blood. Three patterns were previously identified by principal component analysis: A ‘high n-6 polyunsaturated fatty acid (PUFA)’, a ‘monounsaturated and saturated fatty acid’, and a ‘high n-3 PUFA’ pattern. At the age of 10 years, a child’s lung function was assessed by spirometry, current asthma and physician-diagnosed inhalant allergy by questionnaire, and inhalant allergic sensitization by skin prick tests. A higher ‘high n-6 PUFA’ pattern was associated with a higher forced expiratory volume in 1 s/forced vital capacity and forced expiratory flow after exhaling 75% of forced vital capacity (Z-score difference (95% CI) 0.04 (0, 0.07) and 0.04 (0.01, 0.07), respectively, per SD increase in the fatty acid pattern). We observed no associations of maternal fatty acid patterns with a child’s asthma or allergy outcomes. Our results showed limited associations of maternal patterns of high n-6 PUFA concentrations in pregnancy with a better lung function in school-aged children.
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title_short	Associations of Plasma Fatty Acid Patterns during Pregnancy with Respiratory and Allergy Outcomes at School Age
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Associations of Plasma Fatty Acid Patterns during Pregnancy with Respiratory and Allergy Outcomes at School Age

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