Differential Gene Expression of <i<Mucor lusitanicus</i< under Aerobic and Anaerobic Conditions

<i<Mucor lusitanicus</i< and some other members of the fungal order Mucorales display the phenomenon of morphological dimorphism. This means that these fungi aerobically produce filamentous hyphae, developing a coenocytic mycelium, but they grow in a multipolar yeast-like form under anae...
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Autor*in:	Mónika Homa [verfasserIn] Sandugash Ibragimova [verfasserIn] Csilla Szebenyi [verfasserIn] Gábor Nagy [verfasserIn] Nóra Zsindely [verfasserIn] László Bodai [verfasserIn] Csaba Vágvölgyi [verfasserIn] Tamás Papp [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Mucorales anaerobiosis yeast-like growth dimorphism transporter CAZymes

Übergeordnetes Werk:	In: Journal of Fungi - MDPI AG, 2015, 8(2022), 4, p 404
Übergeordnetes Werk:	volume:8 ; year:2022 ; number:4, p 404

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jof8040404

Katalog-ID:	DOAJ038645572

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520			\|a <i<Mucor lusitanicus</i< and some other members of the fungal order Mucorales display the phenomenon of morphological dimorphism. This means that these fungi aerobically produce filamentous hyphae, developing a coenocytic mycelium, but they grow in a multipolar yeast-like form under anaerobiosis. Revealing the molecular mechanism of the reversible yeast-hyphal transition can be interesting for both the biotechnological application and in the understanding of the pathomechanism of mucormycosis. In the present study, transcriptomic analyses were carried out after cultivating the fungus either aerobically or anaerobically revealing significant changes in gene expression under the two conditions. In total, 539 differentially expressed genes (FDR < 0.05, \|log<sub<2</sub<FC\| ≥ 3) were identified, including 190 upregulated and 349 downregulated transcripts. Within the metabolism-related genes, carbohydrate metabolism was proven to be especially affected. Anaerobiosis also affected the transcription of transporters: among the 14 up- and 42 downregulated transporters, several putative sugar transporters were detected. Moreover, a considerable number of transcripts related to amino acid transport and metabolism, lipid transport and metabolism, and energy production and conversion were proven to be downregulated when the culture had been transferred into an anaerobic atmosphere.
650		4	\|a Mucorales
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spelling	10.3390/jof8040404 doi (DE-627)DOAJ038645572 (DE-599)DOAJdf27673527394cf79bea310c6ad83d4b DE-627 ger DE-627 rakwb eng QH301-705.5 Mónika Homa verfasserin aut Differential Gene Expression of <i<Mucor lusitanicus</i< under Aerobic and Anaerobic Conditions 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Mucor lusitanicus</i< and some other members of the fungal order Mucorales display the phenomenon of morphological dimorphism. This means that these fungi aerobically produce filamentous hyphae, developing a coenocytic mycelium, but they grow in a multipolar yeast-like form under anaerobiosis. Revealing the molecular mechanism of the reversible yeast-hyphal transition can be interesting for both the biotechnological application and in the understanding of the pathomechanism of mucormycosis. In the present study, transcriptomic analyses were carried out after cultivating the fungus either aerobically or anaerobically revealing significant changes in gene expression under the two conditions. In total, 539 differentially expressed genes (FDR < 0.05, \|log<sub<2</sub<FC\| ≥ 3) were identified, including 190 upregulated and 349 downregulated transcripts. Within the metabolism-related genes, carbohydrate metabolism was proven to be especially affected. Anaerobiosis also affected the transcription of transporters: among the 14 up- and 42 downregulated transporters, several putative sugar transporters were detected. Moreover, a considerable number of transcripts related to amino acid transport and metabolism, lipid transport and metabolism, and energy production and conversion were proven to be downregulated when the culture had been transferred into an anaerobic atmosphere. Mucorales anaerobiosis yeast-like growth dimorphism transporter CAZymes Biology (General) Sandugash Ibragimova verfasserin aut Csilla Szebenyi verfasserin aut Gábor Nagy verfasserin aut Nóra Zsindely verfasserin aut László Bodai verfasserin aut Csaba Vágvölgyi verfasserin aut Gábor Nagy verfasserin aut Tamás Papp verfasserin aut In Journal of Fungi MDPI AG, 2015 8(2022), 4, p 404 (DE-627)796588538 (DE-600)2784229-0 2309608X nnns volume:8 year:2022 number:4, p 404 https://doi.org/10.3390/jof8040404 kostenfrei https://doaj.org/article/df27673527394cf79bea310c6ad83d4b kostenfrei https://www.mdpi.com/2309-608X/8/4/404 kostenfrei https://doaj.org/toc/2309-608X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2022 4, p 404
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allfieldsSound	10.3390/jof8040404 doi (DE-627)DOAJ038645572 (DE-599)DOAJdf27673527394cf79bea310c6ad83d4b DE-627 ger DE-627 rakwb eng QH301-705.5 Mónika Homa verfasserin aut Differential Gene Expression of <i<Mucor lusitanicus</i< under Aerobic and Anaerobic Conditions 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Mucor lusitanicus</i< and some other members of the fungal order Mucorales display the phenomenon of morphological dimorphism. This means that these fungi aerobically produce filamentous hyphae, developing a coenocytic mycelium, but they grow in a multipolar yeast-like form under anaerobiosis. Revealing the molecular mechanism of the reversible yeast-hyphal transition can be interesting for both the biotechnological application and in the understanding of the pathomechanism of mucormycosis. In the present study, transcriptomic analyses were carried out after cultivating the fungus either aerobically or anaerobically revealing significant changes in gene expression under the two conditions. In total, 539 differentially expressed genes (FDR < 0.05, \|log<sub<2</sub<FC\| ≥ 3) were identified, including 190 upregulated and 349 downregulated transcripts. Within the metabolism-related genes, carbohydrate metabolism was proven to be especially affected. Anaerobiosis also affected the transcription of transporters: among the 14 up- and 42 downregulated transporters, several putative sugar transporters were detected. Moreover, a considerable number of transcripts related to amino acid transport and metabolism, lipid transport and metabolism, and energy production and conversion were proven to be downregulated when the culture had been transferred into an anaerobic atmosphere. Mucorales anaerobiosis yeast-like growth dimorphism transporter CAZymes Biology (General) Sandugash Ibragimova verfasserin aut Csilla Szebenyi verfasserin aut Gábor Nagy verfasserin aut Nóra Zsindely verfasserin aut László Bodai verfasserin aut Csaba Vágvölgyi verfasserin aut Gábor Nagy verfasserin aut Tamás Papp verfasserin aut In Journal of Fungi MDPI AG, 2015 8(2022), 4, p 404 (DE-627)796588538 (DE-600)2784229-0 2309608X nnns volume:8 year:2022 number:4, p 404 https://doi.org/10.3390/jof8040404 kostenfrei https://doaj.org/article/df27673527394cf79bea310c6ad83d4b kostenfrei https://www.mdpi.com/2309-608X/8/4/404 kostenfrei https://doaj.org/toc/2309-608X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2022 4, p 404
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callnumber-first	Q - Science
author	Mónika Homa
spellingShingle	Mónika Homa misc QH301-705.5 misc Mucorales misc anaerobiosis misc yeast-like growth misc dimorphism misc transporter misc CAZymes misc Biology (General) Differential Gene Expression of <i<Mucor lusitanicus</i< under Aerobic and Anaerobic Conditions
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topic_title	QH301-705.5 Differential Gene Expression of <i<Mucor lusitanicus</i< under Aerobic and Anaerobic Conditions Mucorales anaerobiosis yeast-like growth dimorphism transporter CAZymes
topic	misc QH301-705.5 misc Mucorales misc anaerobiosis misc yeast-like growth misc dimorphism misc transporter misc CAZymes misc Biology (General)
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title	Differential Gene Expression of <i<Mucor lusitanicus</i< under Aerobic and Anaerobic Conditions
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title_full	Differential Gene Expression of <i<Mucor lusitanicus</i< under Aerobic and Anaerobic Conditions
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title_sort	differential gene expression of <i<mucor lusitanicus</i< under aerobic and anaerobic conditions
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title_auth	Differential Gene Expression of <i<Mucor lusitanicus</i< under Aerobic and Anaerobic Conditions
abstract	<i<Mucor lusitanicus</i< and some other members of the fungal order Mucorales display the phenomenon of morphological dimorphism. This means that these fungi aerobically produce filamentous hyphae, developing a coenocytic mycelium, but they grow in a multipolar yeast-like form under anaerobiosis. Revealing the molecular mechanism of the reversible yeast-hyphal transition can be interesting for both the biotechnological application and in the understanding of the pathomechanism of mucormycosis. In the present study, transcriptomic analyses were carried out after cultivating the fungus either aerobically or anaerobically revealing significant changes in gene expression under the two conditions. In total, 539 differentially expressed genes (FDR < 0.05, \|log<sub<2</sub<FC\| ≥ 3) were identified, including 190 upregulated and 349 downregulated transcripts. Within the metabolism-related genes, carbohydrate metabolism was proven to be especially affected. Anaerobiosis also affected the transcription of transporters: among the 14 up- and 42 downregulated transporters, several putative sugar transporters were detected. Moreover, a considerable number of transcripts related to amino acid transport and metabolism, lipid transport and metabolism, and energy production and conversion were proven to be downregulated when the culture had been transferred into an anaerobic atmosphere.
abstractGer	<i<Mucor lusitanicus</i< and some other members of the fungal order Mucorales display the phenomenon of morphological dimorphism. This means that these fungi aerobically produce filamentous hyphae, developing a coenocytic mycelium, but they grow in a multipolar yeast-like form under anaerobiosis. Revealing the molecular mechanism of the reversible yeast-hyphal transition can be interesting for both the biotechnological application and in the understanding of the pathomechanism of mucormycosis. In the present study, transcriptomic analyses were carried out after cultivating the fungus either aerobically or anaerobically revealing significant changes in gene expression under the two conditions. In total, 539 differentially expressed genes (FDR < 0.05, \|log<sub<2</sub<FC\| ≥ 3) were identified, including 190 upregulated and 349 downregulated transcripts. Within the metabolism-related genes, carbohydrate metabolism was proven to be especially affected. Anaerobiosis also affected the transcription of transporters: among the 14 up- and 42 downregulated transporters, several putative sugar transporters were detected. Moreover, a considerable number of transcripts related to amino acid transport and metabolism, lipid transport and metabolism, and energy production and conversion were proven to be downregulated when the culture had been transferred into an anaerobic atmosphere.
abstract_unstemmed	<i<Mucor lusitanicus</i< and some other members of the fungal order Mucorales display the phenomenon of morphological dimorphism. This means that these fungi aerobically produce filamentous hyphae, developing a coenocytic mycelium, but they grow in a multipolar yeast-like form under anaerobiosis. Revealing the molecular mechanism of the reversible yeast-hyphal transition can be interesting for both the biotechnological application and in the understanding of the pathomechanism of mucormycosis. In the present study, transcriptomic analyses were carried out after cultivating the fungus either aerobically or anaerobically revealing significant changes in gene expression under the two conditions. In total, 539 differentially expressed genes (FDR < 0.05, \|log<sub<2</sub<FC\| ≥ 3) were identified, including 190 upregulated and 349 downregulated transcripts. Within the metabolism-related genes, carbohydrate metabolism was proven to be especially affected. Anaerobiosis also affected the transcription of transporters: among the 14 up- and 42 downregulated transporters, several putative sugar transporters were detected. Moreover, a considerable number of transcripts related to amino acid transport and metabolism, lipid transport and metabolism, and energy production and conversion were proven to be downregulated when the culture had been transferred into an anaerobic atmosphere.
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title_short	Differential Gene Expression of <i<Mucor lusitanicus</i< under Aerobic and Anaerobic Conditions
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Differential Gene Expression of <i<Mucor lusitanicus</i< under Aerobic and Anaerobic Conditions

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