Symptomatic gallstones and HIV in black South African women: Changing trends of gallstone disease?
Background: The incidence of metabolic disorders in human immunodeficiency virus (HIV) endemic settings is a prevailing burden in developing countries. Cholesterol homeostasis and fat metabolism are altered by HIV and antiretroviral therapy (ART), thereby possibly contributing to complications such...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Suman Mewa Kinoo [verfasserIn] Savania Nagiah [verfasserIn] Anil Chuturgoon [verfasserIn] Bhugwan Singh [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2021 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Southern African Journal of HIV Medicine - AOSIS, 2016, 22(2021), 1, Seite e1-e7 |
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| Übergeordnetes Werk: |
volume:22 ; year:2021 ; number:1 ; pages:e1-e7 |
| Links: |
Link aufrufen |
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| DOI / URN: |
10.4102/sajhivmed.v22i1.1208 |
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| Katalog-ID: |
DOAJ038776340 |
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| 520 | |a Background: The incidence of metabolic disorders in human immunodeficiency virus (HIV) endemic settings is a prevailing burden in developing countries. Cholesterol homeostasis and fat metabolism are altered by HIV and antiretroviral therapy (ART), thereby possibly contributing to complications such as gallstone formation. Objectives: The aim of this study was to evaluate established risk factors for the formation of cholesterol gallstones in black South African women living with HIV (WLHIV). Method: A case series study was conducted of all black South African women undergoing cholecystectomy for gallstone disease over a 1-year period at King Edward VIII Hospital, Durban, South Africa. Age, body mass index (BMI), family history of gallstones, oestrogen exposure and lipograms were compared between WLHIV and uninfected women. Categorical variables were tested using either the Fisher’s exact test or Pearson’s chi-square test. Means were compared using independent t-tests. For non-normally distributed data, the Mann–Whitney U test was used. Statistical tests were two-sided, and p-values of less than 0.05 were considered statistically significant. Results: A total of 52 patients were assessed, 34 HIV-uninfected and 18 WLHIV. The median age of WLHIV versus the uninfected women was 35 and 50 years, respectively, (p = 0.015). A statistically significant number of uninfected women were in the overweight/obese category (BMI 25 kg/m2) compared to the normal weight category (BMI 25 kg/m2) (p 0.001). The number of obese WLHIV did not reach statistical significance. Conclusion: The age of occurrence of gallstone disease amongst black South African WLHIV was significantly lower and fewer women were obese compared with the uninfected women with gallstone disease. These findings differ from known gallstone risk factors in other populations and in uninfected black South African women. This could be attributed to the metabolic alterations caused by HIV infection itself and/or to the long-term use of ART. Larger cohort studies are required to elucidate the role of HIV and ART in cholestatic disease. | ||
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10.4102/sajhivmed.v22i1.1208 doi (DE-627)DOAJ038776340 (DE-599)DOAJ34f647d8e93a4e4cb5e27bc3540ff878 DE-627 ger DE-627 rakwb eng RA1-1270 RC109-216 Suman Mewa Kinoo verfasserin aut Symptomatic gallstones and HIV in black South African women: Changing trends of gallstone disease? 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The incidence of metabolic disorders in human immunodeficiency virus (HIV) endemic settings is a prevailing burden in developing countries. Cholesterol homeostasis and fat metabolism are altered by HIV and antiretroviral therapy (ART), thereby possibly contributing to complications such as gallstone formation. Objectives: The aim of this study was to evaluate established risk factors for the formation of cholesterol gallstones in black South African women living with HIV (WLHIV). Method: A case series study was conducted of all black South African women undergoing cholecystectomy for gallstone disease over a 1-year period at King Edward VIII Hospital, Durban, South Africa. Age, body mass index (BMI), family history of gallstones, oestrogen exposure and lipograms were compared between WLHIV and uninfected women. Categorical variables were tested using either the Fisher’s exact test or Pearson’s chi-square test. Means were compared using independent t-tests. For non-normally distributed data, the Mann–Whitney U test was used. Statistical tests were two-sided, and p-values of less than 0.05 were considered statistically significant. Results: A total of 52 patients were assessed, 34 HIV-uninfected and 18 WLHIV. The median age of WLHIV versus the uninfected women was 35 and 50 years, respectively, (p = 0.015). A statistically significant number of uninfected women were in the overweight/obese category (BMI 25 kg/m2) compared to the normal weight category (BMI 25 kg/m2) (p 0.001). The number of obese WLHIV did not reach statistical significance. Conclusion: The age of occurrence of gallstone disease amongst black South African WLHIV was significantly lower and fewer women were obese compared with the uninfected women with gallstone disease. These findings differ from known gallstone risk factors in other populations and in uninfected black South African women. This could be attributed to the metabolic alterations caused by HIV infection itself and/or to the long-term use of ART. Larger cohort studies are required to elucidate the role of HIV and ART in cholestatic disease. hiv art gallstone disease cholesterol gallstones hiv-induced cholesterol gallstones arv-induced cholesterol gallstones Public aspects of medicine Infectious and parasitic diseases Savania Nagiah verfasserin aut Anil Chuturgoon verfasserin aut Bhugwan Singh verfasserin aut In Southern African Journal of HIV Medicine AOSIS, 2016 22(2021), 1, Seite e1-e7 (DE-627)521453623 (DE-600)2259791-8 20786751 nnns volume:22 year:2021 number:1 pages:e1-e7 https://doi.org/10.4102/sajhivmed.v22i1.1208 kostenfrei https://doaj.org/article/34f647d8e93a4e4cb5e27bc3540ff878 kostenfrei https://sajhivmed.org.za/index.php/hivmed/article/view/1208 kostenfrei https://doaj.org/toc/1608-9693 Journal toc kostenfrei https://doaj.org/toc/2078-6751 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2021 1 e1-e7 |
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10.4102/sajhivmed.v22i1.1208 doi (DE-627)DOAJ038776340 (DE-599)DOAJ34f647d8e93a4e4cb5e27bc3540ff878 DE-627 ger DE-627 rakwb eng RA1-1270 RC109-216 Suman Mewa Kinoo verfasserin aut Symptomatic gallstones and HIV in black South African women: Changing trends of gallstone disease? 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The incidence of metabolic disorders in human immunodeficiency virus (HIV) endemic settings is a prevailing burden in developing countries. Cholesterol homeostasis and fat metabolism are altered by HIV and antiretroviral therapy (ART), thereby possibly contributing to complications such as gallstone formation. Objectives: The aim of this study was to evaluate established risk factors for the formation of cholesterol gallstones in black South African women living with HIV (WLHIV). Method: A case series study was conducted of all black South African women undergoing cholecystectomy for gallstone disease over a 1-year period at King Edward VIII Hospital, Durban, South Africa. Age, body mass index (BMI), family history of gallstones, oestrogen exposure and lipograms were compared between WLHIV and uninfected women. Categorical variables were tested using either the Fisher’s exact test or Pearson’s chi-square test. Means were compared using independent t-tests. For non-normally distributed data, the Mann–Whitney U test was used. Statistical tests were two-sided, and p-values of less than 0.05 were considered statistically significant. Results: A total of 52 patients were assessed, 34 HIV-uninfected and 18 WLHIV. The median age of WLHIV versus the uninfected women was 35 and 50 years, respectively, (p = 0.015). A statistically significant number of uninfected women were in the overweight/obese category (BMI 25 kg/m2) compared to the normal weight category (BMI 25 kg/m2) (p 0.001). The number of obese WLHIV did not reach statistical significance. Conclusion: The age of occurrence of gallstone disease amongst black South African WLHIV was significantly lower and fewer women were obese compared with the uninfected women with gallstone disease. These findings differ from known gallstone risk factors in other populations and in uninfected black South African women. This could be attributed to the metabolic alterations caused by HIV infection itself and/or to the long-term use of ART. Larger cohort studies are required to elucidate the role of HIV and ART in cholestatic disease. hiv art gallstone disease cholesterol gallstones hiv-induced cholesterol gallstones arv-induced cholesterol gallstones Public aspects of medicine Infectious and parasitic diseases Savania Nagiah verfasserin aut Anil Chuturgoon verfasserin aut Bhugwan Singh verfasserin aut In Southern African Journal of HIV Medicine AOSIS, 2016 22(2021), 1, Seite e1-e7 (DE-627)521453623 (DE-600)2259791-8 20786751 nnns volume:22 year:2021 number:1 pages:e1-e7 https://doi.org/10.4102/sajhivmed.v22i1.1208 kostenfrei https://doaj.org/article/34f647d8e93a4e4cb5e27bc3540ff878 kostenfrei https://sajhivmed.org.za/index.php/hivmed/article/view/1208 kostenfrei https://doaj.org/toc/1608-9693 Journal toc kostenfrei https://doaj.org/toc/2078-6751 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2021 1 e1-e7 |
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10.4102/sajhivmed.v22i1.1208 doi (DE-627)DOAJ038776340 (DE-599)DOAJ34f647d8e93a4e4cb5e27bc3540ff878 DE-627 ger DE-627 rakwb eng RA1-1270 RC109-216 Suman Mewa Kinoo verfasserin aut Symptomatic gallstones and HIV in black South African women: Changing trends of gallstone disease? 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The incidence of metabolic disorders in human immunodeficiency virus (HIV) endemic settings is a prevailing burden in developing countries. Cholesterol homeostasis and fat metabolism are altered by HIV and antiretroviral therapy (ART), thereby possibly contributing to complications such as gallstone formation. Objectives: The aim of this study was to evaluate established risk factors for the formation of cholesterol gallstones in black South African women living with HIV (WLHIV). Method: A case series study was conducted of all black South African women undergoing cholecystectomy for gallstone disease over a 1-year period at King Edward VIII Hospital, Durban, South Africa. Age, body mass index (BMI), family history of gallstones, oestrogen exposure and lipograms were compared between WLHIV and uninfected women. Categorical variables were tested using either the Fisher’s exact test or Pearson’s chi-square test. Means were compared using independent t-tests. For non-normally distributed data, the Mann–Whitney U test was used. Statistical tests were two-sided, and p-values of less than 0.05 were considered statistically significant. Results: A total of 52 patients were assessed, 34 HIV-uninfected and 18 WLHIV. The median age of WLHIV versus the uninfected women was 35 and 50 years, respectively, (p = 0.015). A statistically significant number of uninfected women were in the overweight/obese category (BMI 25 kg/m2) compared to the normal weight category (BMI 25 kg/m2) (p 0.001). The number of obese WLHIV did not reach statistical significance. Conclusion: The age of occurrence of gallstone disease amongst black South African WLHIV was significantly lower and fewer women were obese compared with the uninfected women with gallstone disease. These findings differ from known gallstone risk factors in other populations and in uninfected black South African women. This could be attributed to the metabolic alterations caused by HIV infection itself and/or to the long-term use of ART. Larger cohort studies are required to elucidate the role of HIV and ART in cholestatic disease. hiv art gallstone disease cholesterol gallstones hiv-induced cholesterol gallstones arv-induced cholesterol gallstones Public aspects of medicine Infectious and parasitic diseases Savania Nagiah verfasserin aut Anil Chuturgoon verfasserin aut Bhugwan Singh verfasserin aut In Southern African Journal of HIV Medicine AOSIS, 2016 22(2021), 1, Seite e1-e7 (DE-627)521453623 (DE-600)2259791-8 20786751 nnns volume:22 year:2021 number:1 pages:e1-e7 https://doi.org/10.4102/sajhivmed.v22i1.1208 kostenfrei https://doaj.org/article/34f647d8e93a4e4cb5e27bc3540ff878 kostenfrei https://sajhivmed.org.za/index.php/hivmed/article/view/1208 kostenfrei https://doaj.org/toc/1608-9693 Journal toc kostenfrei https://doaj.org/toc/2078-6751 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2021 1 e1-e7 |
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10.4102/sajhivmed.v22i1.1208 doi (DE-627)DOAJ038776340 (DE-599)DOAJ34f647d8e93a4e4cb5e27bc3540ff878 DE-627 ger DE-627 rakwb eng RA1-1270 RC109-216 Suman Mewa Kinoo verfasserin aut Symptomatic gallstones and HIV in black South African women: Changing trends of gallstone disease? 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The incidence of metabolic disorders in human immunodeficiency virus (HIV) endemic settings is a prevailing burden in developing countries. Cholesterol homeostasis and fat metabolism are altered by HIV and antiretroviral therapy (ART), thereby possibly contributing to complications such as gallstone formation. Objectives: The aim of this study was to evaluate established risk factors for the formation of cholesterol gallstones in black South African women living with HIV (WLHIV). Method: A case series study was conducted of all black South African women undergoing cholecystectomy for gallstone disease over a 1-year period at King Edward VIII Hospital, Durban, South Africa. Age, body mass index (BMI), family history of gallstones, oestrogen exposure and lipograms were compared between WLHIV and uninfected women. Categorical variables were tested using either the Fisher’s exact test or Pearson’s chi-square test. Means were compared using independent t-tests. For non-normally distributed data, the Mann–Whitney U test was used. Statistical tests were two-sided, and p-values of less than 0.05 were considered statistically significant. Results: A total of 52 patients were assessed, 34 HIV-uninfected and 18 WLHIV. The median age of WLHIV versus the uninfected women was 35 and 50 years, respectively, (p = 0.015). A statistically significant number of uninfected women were in the overweight/obese category (BMI 25 kg/m2) compared to the normal weight category (BMI 25 kg/m2) (p 0.001). The number of obese WLHIV did not reach statistical significance. Conclusion: The age of occurrence of gallstone disease amongst black South African WLHIV was significantly lower and fewer women were obese compared with the uninfected women with gallstone disease. These findings differ from known gallstone risk factors in other populations and in uninfected black South African women. This could be attributed to the metabolic alterations caused by HIV infection itself and/or to the long-term use of ART. Larger cohort studies are required to elucidate the role of HIV and ART in cholestatic disease. hiv art gallstone disease cholesterol gallstones hiv-induced cholesterol gallstones arv-induced cholesterol gallstones Public aspects of medicine Infectious and parasitic diseases Savania Nagiah verfasserin aut Anil Chuturgoon verfasserin aut Bhugwan Singh verfasserin aut In Southern African Journal of HIV Medicine AOSIS, 2016 22(2021), 1, Seite e1-e7 (DE-627)521453623 (DE-600)2259791-8 20786751 nnns volume:22 year:2021 number:1 pages:e1-e7 https://doi.org/10.4102/sajhivmed.v22i1.1208 kostenfrei https://doaj.org/article/34f647d8e93a4e4cb5e27bc3540ff878 kostenfrei https://sajhivmed.org.za/index.php/hivmed/article/view/1208 kostenfrei https://doaj.org/toc/1608-9693 Journal toc kostenfrei https://doaj.org/toc/2078-6751 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2021 1 e1-e7 |
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Symptomatic gallstones and HIV in black South African women: Changing trends of gallstone disease? |
| abstract |
Background: The incidence of metabolic disorders in human immunodeficiency virus (HIV) endemic settings is a prevailing burden in developing countries. Cholesterol homeostasis and fat metabolism are altered by HIV and antiretroviral therapy (ART), thereby possibly contributing to complications such as gallstone formation. Objectives: The aim of this study was to evaluate established risk factors for the formation of cholesterol gallstones in black South African women living with HIV (WLHIV). Method: A case series study was conducted of all black South African women undergoing cholecystectomy for gallstone disease over a 1-year period at King Edward VIII Hospital, Durban, South Africa. Age, body mass index (BMI), family history of gallstones, oestrogen exposure and lipograms were compared between WLHIV and uninfected women. Categorical variables were tested using either the Fisher’s exact test or Pearson’s chi-square test. Means were compared using independent t-tests. For non-normally distributed data, the Mann–Whitney U test was used. Statistical tests were two-sided, and p-values of less than 0.05 were considered statistically significant. Results: A total of 52 patients were assessed, 34 HIV-uninfected and 18 WLHIV. The median age of WLHIV versus the uninfected women was 35 and 50 years, respectively, (p = 0.015). A statistically significant number of uninfected women were in the overweight/obese category (BMI 25 kg/m2) compared to the normal weight category (BMI 25 kg/m2) (p 0.001). The number of obese WLHIV did not reach statistical significance. Conclusion: The age of occurrence of gallstone disease amongst black South African WLHIV was significantly lower and fewer women were obese compared with the uninfected women with gallstone disease. These findings differ from known gallstone risk factors in other populations and in uninfected black South African women. This could be attributed to the metabolic alterations caused by HIV infection itself and/or to the long-term use of ART. Larger cohort studies are required to elucidate the role of HIV and ART in cholestatic disease. |
| abstractGer |
Background: The incidence of metabolic disorders in human immunodeficiency virus (HIV) endemic settings is a prevailing burden in developing countries. Cholesterol homeostasis and fat metabolism are altered by HIV and antiretroviral therapy (ART), thereby possibly contributing to complications such as gallstone formation. Objectives: The aim of this study was to evaluate established risk factors for the formation of cholesterol gallstones in black South African women living with HIV (WLHIV). Method: A case series study was conducted of all black South African women undergoing cholecystectomy for gallstone disease over a 1-year period at King Edward VIII Hospital, Durban, South Africa. Age, body mass index (BMI), family history of gallstones, oestrogen exposure and lipograms were compared between WLHIV and uninfected women. Categorical variables were tested using either the Fisher’s exact test or Pearson’s chi-square test. Means were compared using independent t-tests. For non-normally distributed data, the Mann–Whitney U test was used. Statistical tests were two-sided, and p-values of less than 0.05 were considered statistically significant. Results: A total of 52 patients were assessed, 34 HIV-uninfected and 18 WLHIV. The median age of WLHIV versus the uninfected women was 35 and 50 years, respectively, (p = 0.015). A statistically significant number of uninfected women were in the overweight/obese category (BMI 25 kg/m2) compared to the normal weight category (BMI 25 kg/m2) (p 0.001). The number of obese WLHIV did not reach statistical significance. Conclusion: The age of occurrence of gallstone disease amongst black South African WLHIV was significantly lower and fewer women were obese compared with the uninfected women with gallstone disease. These findings differ from known gallstone risk factors in other populations and in uninfected black South African women. This could be attributed to the metabolic alterations caused by HIV infection itself and/or to the long-term use of ART. Larger cohort studies are required to elucidate the role of HIV and ART in cholestatic disease. |
| abstract_unstemmed |
Background: The incidence of metabolic disorders in human immunodeficiency virus (HIV) endemic settings is a prevailing burden in developing countries. Cholesterol homeostasis and fat metabolism are altered by HIV and antiretroviral therapy (ART), thereby possibly contributing to complications such as gallstone formation. Objectives: The aim of this study was to evaluate established risk factors for the formation of cholesterol gallstones in black South African women living with HIV (WLHIV). Method: A case series study was conducted of all black South African women undergoing cholecystectomy for gallstone disease over a 1-year period at King Edward VIII Hospital, Durban, South Africa. Age, body mass index (BMI), family history of gallstones, oestrogen exposure and lipograms were compared between WLHIV and uninfected women. Categorical variables were tested using either the Fisher’s exact test or Pearson’s chi-square test. Means were compared using independent t-tests. For non-normally distributed data, the Mann–Whitney U test was used. Statistical tests were two-sided, and p-values of less than 0.05 were considered statistically significant. Results: A total of 52 patients were assessed, 34 HIV-uninfected and 18 WLHIV. The median age of WLHIV versus the uninfected women was 35 and 50 years, respectively, (p = 0.015). A statistically significant number of uninfected women were in the overweight/obese category (BMI 25 kg/m2) compared to the normal weight category (BMI 25 kg/m2) (p 0.001). The number of obese WLHIV did not reach statistical significance. Conclusion: The age of occurrence of gallstone disease amongst black South African WLHIV was significantly lower and fewer women were obese compared with the uninfected women with gallstone disease. These findings differ from known gallstone risk factors in other populations and in uninfected black South African women. This could be attributed to the metabolic alterations caused by HIV infection itself and/or to the long-term use of ART. Larger cohort studies are required to elucidate the role of HIV and ART in cholestatic disease. |
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| title_short |
Symptomatic gallstones and HIV in black South African women: Changing trends of gallstone disease? |
| url |
https://doi.org/10.4102/sajhivmed.v22i1.1208 https://doaj.org/article/34f647d8e93a4e4cb5e27bc3540ff878 https://sajhivmed.org.za/index.php/hivmed/article/view/1208 https://doaj.org/toc/1608-9693 https://doaj.org/toc/2078-6751 |
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Savania Nagiah Anil Chuturgoon Bhugwan Singh |
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Savania Nagiah Anil Chuturgoon Bhugwan Singh |
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| up_date |
2024-07-03T19:49:12.971Z |
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