Antiulcerogenic activity of Scutia buxifolia on gastric ulcers induced by ethanol in rats

Gastric ulcers affect many people around the world and their development is a result of the imbalance between aggressive and protective factors in the gastric mucosa. Scutia buxifolia, commonly known as coronilha, has attracted the interest of the scientific community due to its pharmacological prop...
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Gespeichert in:

Autor*in:	Aline Augusti Boligon [verfasserIn] Robson Borba de Freitas [verfasserIn] Thiele Faccim de Brum [verfasserIn] Emily Pansera Waczuk [verfasserIn] Cláudia Vargas Klimaczewski [verfasserIn] Daiana Silva de Ávila [verfasserIn] Margareth Linde Athayde [verfasserIn] Liliane de Freitas Bauermann [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Schlagwörter:	Scutia buxifolia Antioxidant Gastric ulcer HPLC

Übergeordnetes Werk:	In: Acta Pharmaceutica Sinica B - Elsevier, 2013, 4(2014), 5, Seite 358-367
Übergeordnetes Werk:	volume:4 ; year:2014 ; number:5 ; pages:358-367

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1016/j.apsb.2014.05.001

Katalog-ID:	DOAJ038976218

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spelling	10.1016/j.apsb.2014.05.001 doi (DE-627)DOAJ038976218 (DE-599)DOAJ2a5288e92c1a407394f4486cd1d37e24 DE-627 ger DE-627 rakwb eng RM1-950 Aline Augusti Boligon verfasserin aut Antiulcerogenic activity of Scutia buxifolia on gastric ulcers induced by ethanol in rats 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gastric ulcers affect many people around the world and their development is a result of the imbalance between aggressive and protective factors in the gastric mucosa. Scutia buxifolia, commonly known as coronilha, has attracted the interest of the scientific community due to its pharmacological properties and its potential therapeutic applications. In this study, the preventive effects of the crude extract of Scutia buxifolia (ceSb) against gastric ulcer induced by 70% ethanol were evaluated in male Wistar rats. In addition, the composition of ceSb was clarified by high-performance liquid chromatography (HPLC). S. buxifolia extract (100, 200 and 400 mg/kg body weight) attenuated oxidative and histopathological features induced by ethanol. Moreover, all evaluated doses of ceSb caused significant (P<0.001 and P<0.0001) and dose-dependent increase in sulfhydryl groups (NPSH) levels, catalase (CAT) and superoxide dismutase (SOD) activities. Furthermore, the administration of ceSb reversed the increase in lipid peroxidation produced by ethanol. The protective effect of the extract could be attributed to antioxidant compounds present in the ceSb, such as flavonoids and phenolic acids, which were quantified by HPLC. Thus, an antioxidant effect of the extract leads to a protection on gastric tissue. These results indicate that S. buxifolia could have a beneficial role against ethanol toxicity by preventing oxidative stress and gastric tissue injury. Scutia buxifolia Antioxidant Gastric ulcer HPLC Therapeutics. Pharmacology Robson Borba de Freitas verfasserin aut Thiele Faccim de Brum verfasserin aut Emily Pansera Waczuk verfasserin aut Cláudia Vargas Klimaczewski verfasserin aut Daiana Silva de Ávila verfasserin aut Margareth Linde Athayde verfasserin aut Liliane de Freitas Bauermann verfasserin aut In Acta Pharmaceutica Sinica B Elsevier, 2013 4(2014), 5, Seite 358-367 (DE-627)670211095 (DE-600)2631779-5 22113843 nnns volume:4 year:2014 number:5 pages:358-367 https://doi.org/10.1016/j.apsb.2014.05.001 kostenfrei https://doaj.org/article/2a5288e92c1a407394f4486cd1d37e24 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211383514000422 kostenfrei https://doaj.org/toc/2211-3835 Journal toc kostenfrei https://doaj.org/toc/2211-3843 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2014 5 358-367
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allfieldsSound	10.1016/j.apsb.2014.05.001 doi (DE-627)DOAJ038976218 (DE-599)DOAJ2a5288e92c1a407394f4486cd1d37e24 DE-627 ger DE-627 rakwb eng RM1-950 Aline Augusti Boligon verfasserin aut Antiulcerogenic activity of Scutia buxifolia on gastric ulcers induced by ethanol in rats 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gastric ulcers affect many people around the world and their development is a result of the imbalance between aggressive and protective factors in the gastric mucosa. Scutia buxifolia, commonly known as coronilha, has attracted the interest of the scientific community due to its pharmacological properties and its potential therapeutic applications. In this study, the preventive effects of the crude extract of Scutia buxifolia (ceSb) against gastric ulcer induced by 70% ethanol were evaluated in male Wistar rats. In addition, the composition of ceSb was clarified by high-performance liquid chromatography (HPLC). S. buxifolia extract (100, 200 and 400 mg/kg body weight) attenuated oxidative and histopathological features induced by ethanol. Moreover, all evaluated doses of ceSb caused significant (P<0.001 and P<0.0001) and dose-dependent increase in sulfhydryl groups (NPSH) levels, catalase (CAT) and superoxide dismutase (SOD) activities. Furthermore, the administration of ceSb reversed the increase in lipid peroxidation produced by ethanol. The protective effect of the extract could be attributed to antioxidant compounds present in the ceSb, such as flavonoids and phenolic acids, which were quantified by HPLC. Thus, an antioxidant effect of the extract leads to a protection on gastric tissue. These results indicate that S. buxifolia could have a beneficial role against ethanol toxicity by preventing oxidative stress and gastric tissue injury. Scutia buxifolia Antioxidant Gastric ulcer HPLC Therapeutics. Pharmacology Robson Borba de Freitas verfasserin aut Thiele Faccim de Brum verfasserin aut Emily Pansera Waczuk verfasserin aut Cláudia Vargas Klimaczewski verfasserin aut Daiana Silva de Ávila verfasserin aut Margareth Linde Athayde verfasserin aut Liliane de Freitas Bauermann verfasserin aut In Acta Pharmaceutica Sinica B Elsevier, 2013 4(2014), 5, Seite 358-367 (DE-627)670211095 (DE-600)2631779-5 22113843 nnns volume:4 year:2014 number:5 pages:358-367 https://doi.org/10.1016/j.apsb.2014.05.001 kostenfrei https://doaj.org/article/2a5288e92c1a407394f4486cd1d37e24 kostenfrei http://www.sciencedirect.com/science/article/pii/S2211383514000422 kostenfrei https://doaj.org/toc/2211-3835 Journal toc kostenfrei https://doaj.org/toc/2211-3843 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2014 5 358-367
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callnumber-first	R - Medicine
author	Aline Augusti Boligon
spellingShingle	Aline Augusti Boligon misc RM1-950 misc Scutia buxifolia misc Antioxidant misc Gastric ulcer misc HPLC misc Therapeutics. Pharmacology Antiulcerogenic activity of Scutia buxifolia on gastric ulcers induced by ethanol in rats
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topic_title	RM1-950 Antiulcerogenic activity of Scutia buxifolia on gastric ulcers induced by ethanol in rats Scutia buxifolia Antioxidant Gastric ulcer HPLC
topic	misc RM1-950 misc Scutia buxifolia misc Antioxidant misc Gastric ulcer misc HPLC misc Therapeutics. Pharmacology
topic_unstemmed	misc RM1-950 misc Scutia buxifolia misc Antioxidant misc Gastric ulcer misc HPLC misc Therapeutics. Pharmacology
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title	Antiulcerogenic activity of Scutia buxifolia on gastric ulcers induced by ethanol in rats
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title_full	Antiulcerogenic activity of Scutia buxifolia on gastric ulcers induced by ethanol in rats
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title_sort	antiulcerogenic activity of scutia buxifolia on gastric ulcers induced by ethanol in rats
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title_auth	Antiulcerogenic activity of Scutia buxifolia on gastric ulcers induced by ethanol in rats
abstract	Gastric ulcers affect many people around the world and their development is a result of the imbalance between aggressive and protective factors in the gastric mucosa. Scutia buxifolia, commonly known as coronilha, has attracted the interest of the scientific community due to its pharmacological properties and its potential therapeutic applications. In this study, the preventive effects of the crude extract of Scutia buxifolia (ceSb) against gastric ulcer induced by 70% ethanol were evaluated in male Wistar rats. In addition, the composition of ceSb was clarified by high-performance liquid chromatography (HPLC). S. buxifolia extract (100, 200 and 400 mg/kg body weight) attenuated oxidative and histopathological features induced by ethanol. Moreover, all evaluated doses of ceSb caused significant (P<0.001 and P<0.0001) and dose-dependent increase in sulfhydryl groups (NPSH) levels, catalase (CAT) and superoxide dismutase (SOD) activities. Furthermore, the administration of ceSb reversed the increase in lipid peroxidation produced by ethanol. The protective effect of the extract could be attributed to antioxidant compounds present in the ceSb, such as flavonoids and phenolic acids, which were quantified by HPLC. Thus, an antioxidant effect of the extract leads to a protection on gastric tissue. These results indicate that S. buxifolia could have a beneficial role against ethanol toxicity by preventing oxidative stress and gastric tissue injury.
abstractGer	Gastric ulcers affect many people around the world and their development is a result of the imbalance between aggressive and protective factors in the gastric mucosa. Scutia buxifolia, commonly known as coronilha, has attracted the interest of the scientific community due to its pharmacological properties and its potential therapeutic applications. In this study, the preventive effects of the crude extract of Scutia buxifolia (ceSb) against gastric ulcer induced by 70% ethanol were evaluated in male Wistar rats. In addition, the composition of ceSb was clarified by high-performance liquid chromatography (HPLC). S. buxifolia extract (100, 200 and 400 mg/kg body weight) attenuated oxidative and histopathological features induced by ethanol. Moreover, all evaluated doses of ceSb caused significant (P<0.001 and P<0.0001) and dose-dependent increase in sulfhydryl groups (NPSH) levels, catalase (CAT) and superoxide dismutase (SOD) activities. Furthermore, the administration of ceSb reversed the increase in lipid peroxidation produced by ethanol. The protective effect of the extract could be attributed to antioxidant compounds present in the ceSb, such as flavonoids and phenolic acids, which were quantified by HPLC. Thus, an antioxidant effect of the extract leads to a protection on gastric tissue. These results indicate that S. buxifolia could have a beneficial role against ethanol toxicity by preventing oxidative stress and gastric tissue injury.
abstract_unstemmed	Gastric ulcers affect many people around the world and their development is a result of the imbalance between aggressive and protective factors in the gastric mucosa. Scutia buxifolia, commonly known as coronilha, has attracted the interest of the scientific community due to its pharmacological properties and its potential therapeutic applications. In this study, the preventive effects of the crude extract of Scutia buxifolia (ceSb) against gastric ulcer induced by 70% ethanol were evaluated in male Wistar rats. In addition, the composition of ceSb was clarified by high-performance liquid chromatography (HPLC). S. buxifolia extract (100, 200 and 400 mg/kg body weight) attenuated oxidative and histopathological features induced by ethanol. Moreover, all evaluated doses of ceSb caused significant (P<0.001 and P<0.0001) and dose-dependent increase in sulfhydryl groups (NPSH) levels, catalase (CAT) and superoxide dismutase (SOD) activities. Furthermore, the administration of ceSb reversed the increase in lipid peroxidation produced by ethanol. The protective effect of the extract could be attributed to antioxidant compounds present in the ceSb, such as flavonoids and phenolic acids, which were quantified by HPLC. Thus, an antioxidant effect of the extract leads to a protection on gastric tissue. These results indicate that S. buxifolia could have a beneficial role against ethanol toxicity by preventing oxidative stress and gastric tissue injury.
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title_short	Antiulcerogenic activity of Scutia buxifolia on gastric ulcers induced by ethanol in rats
url	https://doi.org/10.1016/j.apsb.2014.05.001 https://doaj.org/article/2a5288e92c1a407394f4486cd1d37e24 http://www.sciencedirect.com/science/article/pii/S2211383514000422 https://doaj.org/toc/2211-3835 https://doaj.org/toc/2211-3843
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up_date	2024-07-03T20:56:01.684Z
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Antiulcerogenic activity of Scutia buxifolia on gastric ulcers induced by ethanol in rats

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