Nonleaching Antibacterial Concept Demonstrated by In Situ Construction of 2D Nanoflakes on Magnesium

Abstract In bone implants, antibacterial biomaterials with nonleaching surfaces are superior to ones based on abrupt release because systemic side effects arising from the latter can be avoided. In this work, a nonleaching antibacterial concept is demonstrated by fabricating 2D nanoflakes in situ on...
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Autor*in:	Guomin Wang [verfasserIn] Wenjuan Jiang [verfasserIn] Shi Mo [verfasserIn] Lingxia Xie [verfasserIn] Qing Liao [verfasserIn] Liangsheng Hu [verfasserIn] Qingdong Ruan [verfasserIn] Kaiwei Tang [verfasserIn] Babak Mehrjou [verfasserIn] Mengting Liu [verfasserIn] Liping Tong [verfasserIn] Huaiyu Wang [verfasserIn] Jie Zhuang [verfasserIn] Guosong Wu [verfasserIn] Paul K. Chu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	antibacterial magnesium nanoflake nonleaching

Übergeordnetes Werk:	In: Advanced Science - Wiley, 2015, 7(2020), 1, Seite n/a-n/a
Übergeordnetes Werk:	volume:7 ; year:2020 ; number:1 ; pages:n/a-n/a

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1002/advs.201902089

Katalog-ID:	DOAJ039001938

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520			\|a Abstract In bone implants, antibacterial biomaterials with nonleaching surfaces are superior to ones based on abrupt release because systemic side effects arising from the latter can be avoided. In this work, a nonleaching antibacterial concept is demonstrated by fabricating 2D nanoflakes in situ on magnesium (Mg). Different from the conventional antibacterial mechanisms that depend on Mg2+ release and pH increase, the nanoflakes exert mechanical tension onto the bacteria membranes to destroy microorganisms on contact and produce intracellular stress via physical interactions, which is also revealed by computational simulations. Moreover, the nanoflake layer decelerates the corrosion process resulting in mitigated Mg2+ release, weaker alkalinity in the vicinity, and less hydrogen evolution, in turn inducing less inflammatory reactions and ensuring the biocompatibility as confirmed by the in vivo study. In this way, bacteria are killed by a mechanical process causing very little side effects. This work provides information and insights pertaining to the design of multifunctional biomaterials.
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700	0		\|a Jie Zhuang \|e verfasserin \|4 aut
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912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_636
912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2006
912			\|a GBV_ILN_2007
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912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
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Indexfelder

author_variant	g w gw w j wj s m sm l x lx q l ql l h lh q r qr k t kt b m bm m l ml l t lt h w hw j z jz g w gw p k c pkc
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publishDate	2020
allfields	10.1002/advs.201902089 doi (DE-627)DOAJ039001938 (DE-599)DOAJ7bcf68770d834d96ba27b738d0e2c2ae DE-627 ger DE-627 rakwb eng Guomin Wang verfasserin aut Nonleaching Antibacterial Concept Demonstrated by In Situ Construction of 2D Nanoflakes on Magnesium 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In bone implants, antibacterial biomaterials with nonleaching surfaces are superior to ones based on abrupt release because systemic side effects arising from the latter can be avoided. In this work, a nonleaching antibacterial concept is demonstrated by fabricating 2D nanoflakes in situ on magnesium (Mg). Different from the conventional antibacterial mechanisms that depend on Mg2+ release and pH increase, the nanoflakes exert mechanical tension onto the bacteria membranes to destroy microorganisms on contact and produce intracellular stress via physical interactions, which is also revealed by computational simulations. Moreover, the nanoflake layer decelerates the corrosion process resulting in mitigated Mg2+ release, weaker alkalinity in the vicinity, and less hydrogen evolution, in turn inducing less inflammatory reactions and ensuring the biocompatibility as confirmed by the in vivo study. In this way, bacteria are killed by a mechanical process causing very little side effects. This work provides information and insights pertaining to the design of multifunctional biomaterials. antibacterial magnesium nanoflake nonleaching Science Q Wenjuan Jiang verfasserin aut Shi Mo verfasserin aut Lingxia Xie verfasserin aut Qing Liao verfasserin aut Liangsheng Hu verfasserin aut Qingdong Ruan verfasserin aut Kaiwei Tang verfasserin aut Babak Mehrjou verfasserin aut Mengting Liu verfasserin aut Liping Tong verfasserin aut Huaiyu Wang verfasserin aut Jie Zhuang verfasserin aut Guosong Wu verfasserin aut Paul K. Chu verfasserin aut In Advanced Science Wiley, 2015 7(2020), 1, Seite n/a-n/a (DE-627)817357777 (DE-600)2808093-2 21983844 nnns volume:7 year:2020 number:1 pages:n/a-n/a https://doi.org/10.1002/advs.201902089 kostenfrei https://doaj.org/article/7bcf68770d834d96ba27b738d0e2c2ae kostenfrei https://doi.org/10.1002/advs.201902089 kostenfrei https://doaj.org/toc/2198-3844 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2020 1 n/a-n/a
spelling	10.1002/advs.201902089 doi (DE-627)DOAJ039001938 (DE-599)DOAJ7bcf68770d834d96ba27b738d0e2c2ae DE-627 ger DE-627 rakwb eng Guomin Wang verfasserin aut Nonleaching Antibacterial Concept Demonstrated by In Situ Construction of 2D Nanoflakes on Magnesium 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In bone implants, antibacterial biomaterials with nonleaching surfaces are superior to ones based on abrupt release because systemic side effects arising from the latter can be avoided. In this work, a nonleaching antibacterial concept is demonstrated by fabricating 2D nanoflakes in situ on magnesium (Mg). Different from the conventional antibacterial mechanisms that depend on Mg2+ release and pH increase, the nanoflakes exert mechanical tension onto the bacteria membranes to destroy microorganisms on contact and produce intracellular stress via physical interactions, which is also revealed by computational simulations. Moreover, the nanoflake layer decelerates the corrosion process resulting in mitigated Mg2+ release, weaker alkalinity in the vicinity, and less hydrogen evolution, in turn inducing less inflammatory reactions and ensuring the biocompatibility as confirmed by the in vivo study. In this way, bacteria are killed by a mechanical process causing very little side effects. This work provides information and insights pertaining to the design of multifunctional biomaterials. antibacterial magnesium nanoflake nonleaching Science Q Wenjuan Jiang verfasserin aut Shi Mo verfasserin aut Lingxia Xie verfasserin aut Qing Liao verfasserin aut Liangsheng Hu verfasserin aut Qingdong Ruan verfasserin aut Kaiwei Tang verfasserin aut Babak Mehrjou verfasserin aut Mengting Liu verfasserin aut Liping Tong verfasserin aut Huaiyu Wang verfasserin aut Jie Zhuang verfasserin aut Guosong Wu verfasserin aut Paul K. Chu verfasserin aut In Advanced Science Wiley, 2015 7(2020), 1, Seite n/a-n/a (DE-627)817357777 (DE-600)2808093-2 21983844 nnns volume:7 year:2020 number:1 pages:n/a-n/a https://doi.org/10.1002/advs.201902089 kostenfrei https://doaj.org/article/7bcf68770d834d96ba27b738d0e2c2ae kostenfrei https://doi.org/10.1002/advs.201902089 kostenfrei https://doaj.org/toc/2198-3844 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2020 1 n/a-n/a
allfields_unstemmed	10.1002/advs.201902089 doi (DE-627)DOAJ039001938 (DE-599)DOAJ7bcf68770d834d96ba27b738d0e2c2ae DE-627 ger DE-627 rakwb eng Guomin Wang verfasserin aut Nonleaching Antibacterial Concept Demonstrated by In Situ Construction of 2D Nanoflakes on Magnesium 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In bone implants, antibacterial biomaterials with nonleaching surfaces are superior to ones based on abrupt release because systemic side effects arising from the latter can be avoided. In this work, a nonleaching antibacterial concept is demonstrated by fabricating 2D nanoflakes in situ on magnesium (Mg). Different from the conventional antibacterial mechanisms that depend on Mg2+ release and pH increase, the nanoflakes exert mechanical tension onto the bacteria membranes to destroy microorganisms on contact and produce intracellular stress via physical interactions, which is also revealed by computational simulations. Moreover, the nanoflake layer decelerates the corrosion process resulting in mitigated Mg2+ release, weaker alkalinity in the vicinity, and less hydrogen evolution, in turn inducing less inflammatory reactions and ensuring the biocompatibility as confirmed by the in vivo study. In this way, bacteria are killed by a mechanical process causing very little side effects. This work provides information and insights pertaining to the design of multifunctional biomaterials. antibacterial magnesium nanoflake nonleaching Science Q Wenjuan Jiang verfasserin aut Shi Mo verfasserin aut Lingxia Xie verfasserin aut Qing Liao verfasserin aut Liangsheng Hu verfasserin aut Qingdong Ruan verfasserin aut Kaiwei Tang verfasserin aut Babak Mehrjou verfasserin aut Mengting Liu verfasserin aut Liping Tong verfasserin aut Huaiyu Wang verfasserin aut Jie Zhuang verfasserin aut Guosong Wu verfasserin aut Paul K. Chu verfasserin aut In Advanced Science Wiley, 2015 7(2020), 1, Seite n/a-n/a (DE-627)817357777 (DE-600)2808093-2 21983844 nnns volume:7 year:2020 number:1 pages:n/a-n/a https://doi.org/10.1002/advs.201902089 kostenfrei https://doaj.org/article/7bcf68770d834d96ba27b738d0e2c2ae kostenfrei https://doi.org/10.1002/advs.201902089 kostenfrei https://doaj.org/toc/2198-3844 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2020 1 n/a-n/a
allfieldsGer	10.1002/advs.201902089 doi (DE-627)DOAJ039001938 (DE-599)DOAJ7bcf68770d834d96ba27b738d0e2c2ae DE-627 ger DE-627 rakwb eng Guomin Wang verfasserin aut Nonleaching Antibacterial Concept Demonstrated by In Situ Construction of 2D Nanoflakes on Magnesium 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In bone implants, antibacterial biomaterials with nonleaching surfaces are superior to ones based on abrupt release because systemic side effects arising from the latter can be avoided. In this work, a nonleaching antibacterial concept is demonstrated by fabricating 2D nanoflakes in situ on magnesium (Mg). Different from the conventional antibacterial mechanisms that depend on Mg2+ release and pH increase, the nanoflakes exert mechanical tension onto the bacteria membranes to destroy microorganisms on contact and produce intracellular stress via physical interactions, which is also revealed by computational simulations. Moreover, the nanoflake layer decelerates the corrosion process resulting in mitigated Mg2+ release, weaker alkalinity in the vicinity, and less hydrogen evolution, in turn inducing less inflammatory reactions and ensuring the biocompatibility as confirmed by the in vivo study. In this way, bacteria are killed by a mechanical process causing very little side effects. This work provides information and insights pertaining to the design of multifunctional biomaterials. antibacterial magnesium nanoflake nonleaching Science Q Wenjuan Jiang verfasserin aut Shi Mo verfasserin aut Lingxia Xie verfasserin aut Qing Liao verfasserin aut Liangsheng Hu verfasserin aut Qingdong Ruan verfasserin aut Kaiwei Tang verfasserin aut Babak Mehrjou verfasserin aut Mengting Liu verfasserin aut Liping Tong verfasserin aut Huaiyu Wang verfasserin aut Jie Zhuang verfasserin aut Guosong Wu verfasserin aut Paul K. Chu verfasserin aut In Advanced Science Wiley, 2015 7(2020), 1, Seite n/a-n/a (DE-627)817357777 (DE-600)2808093-2 21983844 nnns volume:7 year:2020 number:1 pages:n/a-n/a https://doi.org/10.1002/advs.201902089 kostenfrei https://doaj.org/article/7bcf68770d834d96ba27b738d0e2c2ae kostenfrei https://doi.org/10.1002/advs.201902089 kostenfrei https://doaj.org/toc/2198-3844 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2020 1 n/a-n/a
allfieldsSound	10.1002/advs.201902089 doi (DE-627)DOAJ039001938 (DE-599)DOAJ7bcf68770d834d96ba27b738d0e2c2ae DE-627 ger DE-627 rakwb eng Guomin Wang verfasserin aut Nonleaching Antibacterial Concept Demonstrated by In Situ Construction of 2D Nanoflakes on Magnesium 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract In bone implants, antibacterial biomaterials with nonleaching surfaces are superior to ones based on abrupt release because systemic side effects arising from the latter can be avoided. In this work, a nonleaching antibacterial concept is demonstrated by fabricating 2D nanoflakes in situ on magnesium (Mg). Different from the conventional antibacterial mechanisms that depend on Mg2+ release and pH increase, the nanoflakes exert mechanical tension onto the bacteria membranes to destroy microorganisms on contact and produce intracellular stress via physical interactions, which is also revealed by computational simulations. Moreover, the nanoflake layer decelerates the corrosion process resulting in mitigated Mg2+ release, weaker alkalinity in the vicinity, and less hydrogen evolution, in turn inducing less inflammatory reactions and ensuring the biocompatibility as confirmed by the in vivo study. In this way, bacteria are killed by a mechanical process causing very little side effects. This work provides information and insights pertaining to the design of multifunctional biomaterials. antibacterial magnesium nanoflake nonleaching Science Q Wenjuan Jiang verfasserin aut Shi Mo verfasserin aut Lingxia Xie verfasserin aut Qing Liao verfasserin aut Liangsheng Hu verfasserin aut Qingdong Ruan verfasserin aut Kaiwei Tang verfasserin aut Babak Mehrjou verfasserin aut Mengting Liu verfasserin aut Liping Tong verfasserin aut Huaiyu Wang verfasserin aut Jie Zhuang verfasserin aut Guosong Wu verfasserin aut Paul K. Chu verfasserin aut In Advanced Science Wiley, 2015 7(2020), 1, Seite n/a-n/a (DE-627)817357777 (DE-600)2808093-2 21983844 nnns volume:7 year:2020 number:1 pages:n/a-n/a https://doi.org/10.1002/advs.201902089 kostenfrei https://doaj.org/article/7bcf68770d834d96ba27b738d0e2c2ae kostenfrei https://doi.org/10.1002/advs.201902089 kostenfrei https://doaj.org/toc/2198-3844 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2020 1 n/a-n/a
language	English
source	In Advanced Science 7(2020), 1, Seite n/a-n/a volume:7 year:2020 number:1 pages:n/a-n/a
sourceStr	In Advanced Science 7(2020), 1, Seite n/a-n/a volume:7 year:2020 number:1 pages:n/a-n/a
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	antibacterial magnesium nanoflake nonleaching Science Q
isfreeaccess_bool	true
container_title	Advanced Science
authorswithroles_txt_mv	Guomin Wang @@aut@@ Wenjuan Jiang @@aut@@ Shi Mo @@aut@@ Lingxia Xie @@aut@@ Qing Liao @@aut@@ Liangsheng Hu @@aut@@ Qingdong Ruan @@aut@@ Kaiwei Tang @@aut@@ Babak Mehrjou @@aut@@ Mengting Liu @@aut@@ Liping Tong @@aut@@ Huaiyu Wang @@aut@@ Jie Zhuang @@aut@@ Guosong Wu @@aut@@ Paul K. Chu @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
hierarchy_top_id	817357777
id	DOAJ039001938
language_de	englisch
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author	Guomin Wang
spellingShingle	Guomin Wang misc antibacterial misc magnesium misc nanoflake misc nonleaching misc Science misc Q Nonleaching Antibacterial Concept Demonstrated by In Situ Construction of 2D Nanoflakes on Magnesium
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topic_title	Nonleaching Antibacterial Concept Demonstrated by In Situ Construction of 2D Nanoflakes on Magnesium antibacterial magnesium nanoflake nonleaching
topic	misc antibacterial misc magnesium misc nanoflake misc nonleaching misc Science misc Q
topic_unstemmed	misc antibacterial misc magnesium misc nanoflake misc nonleaching misc Science misc Q
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title	Nonleaching Antibacterial Concept Demonstrated by In Situ Construction of 2D Nanoflakes on Magnesium
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title_full	Nonleaching Antibacterial Concept Demonstrated by In Situ Construction of 2D Nanoflakes on Magnesium
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author_browse	Guomin Wang Wenjuan Jiang Shi Mo Lingxia Xie Qing Liao Liangsheng Hu Qingdong Ruan Kaiwei Tang Babak Mehrjou Mengting Liu Liping Tong Huaiyu Wang Jie Zhuang Guosong Wu Paul K. Chu
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title_sort	nonleaching antibacterial concept demonstrated by in situ construction of 2d nanoflakes on magnesium
title_auth	Nonleaching Antibacterial Concept Demonstrated by In Situ Construction of 2D Nanoflakes on Magnesium
abstract	Abstract In bone implants, antibacterial biomaterials with nonleaching surfaces are superior to ones based on abrupt release because systemic side effects arising from the latter can be avoided. In this work, a nonleaching antibacterial concept is demonstrated by fabricating 2D nanoflakes in situ on magnesium (Mg). Different from the conventional antibacterial mechanisms that depend on Mg2+ release and pH increase, the nanoflakes exert mechanical tension onto the bacteria membranes to destroy microorganisms on contact and produce intracellular stress via physical interactions, which is also revealed by computational simulations. Moreover, the nanoflake layer decelerates the corrosion process resulting in mitigated Mg2+ release, weaker alkalinity in the vicinity, and less hydrogen evolution, in turn inducing less inflammatory reactions and ensuring the biocompatibility as confirmed by the in vivo study. In this way, bacteria are killed by a mechanical process causing very little side effects. This work provides information and insights pertaining to the design of multifunctional biomaterials.
abstractGer	Abstract In bone implants, antibacterial biomaterials with nonleaching surfaces are superior to ones based on abrupt release because systemic side effects arising from the latter can be avoided. In this work, a nonleaching antibacterial concept is demonstrated by fabricating 2D nanoflakes in situ on magnesium (Mg). Different from the conventional antibacterial mechanisms that depend on Mg2+ release and pH increase, the nanoflakes exert mechanical tension onto the bacteria membranes to destroy microorganisms on contact and produce intracellular stress via physical interactions, which is also revealed by computational simulations. Moreover, the nanoflake layer decelerates the corrosion process resulting in mitigated Mg2+ release, weaker alkalinity in the vicinity, and less hydrogen evolution, in turn inducing less inflammatory reactions and ensuring the biocompatibility as confirmed by the in vivo study. In this way, bacteria are killed by a mechanical process causing very little side effects. This work provides information and insights pertaining to the design of multifunctional biomaterials.
abstract_unstemmed	Abstract In bone implants, antibacterial biomaterials with nonleaching surfaces are superior to ones based on abrupt release because systemic side effects arising from the latter can be avoided. In this work, a nonleaching antibacterial concept is demonstrated by fabricating 2D nanoflakes in situ on magnesium (Mg). Different from the conventional antibacterial mechanisms that depend on Mg2+ release and pH increase, the nanoflakes exert mechanical tension onto the bacteria membranes to destroy microorganisms on contact and produce intracellular stress via physical interactions, which is also revealed by computational simulations. Moreover, the nanoflake layer decelerates the corrosion process resulting in mitigated Mg2+ release, weaker alkalinity in the vicinity, and less hydrogen evolution, in turn inducing less inflammatory reactions and ensuring the biocompatibility as confirmed by the in vivo study. In this way, bacteria are killed by a mechanical process causing very little side effects. This work provides information and insights pertaining to the design of multifunctional biomaterials.
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title_short	Nonleaching Antibacterial Concept Demonstrated by In Situ Construction of 2D Nanoflakes on Magnesium
url	https://doi.org/10.1002/advs.201902089 https://doaj.org/article/7bcf68770d834d96ba27b738d0e2c2ae https://doaj.org/toc/2198-3844
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up_date	2024-07-03T21:04:36.051Z
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Nonleaching Antibacterial Concept Demonstrated by In Situ Construction of 2D Nanoflakes on Magnesium

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