Regulation of Autophagy by Kinases

Autophagy is a process of self-degradation that maintains cellular viability during periods of metabolic stress. Although autophagy is considered a survival mechanism when faced with cellular stress, extensive autophagy can also lead to cell death. Aberrations in autophagy are associated with severa...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Savitha Sridharan [verfasserIn] Alakananda Basu [verfasserIn] Kirti Jain [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2011

Schlagwörter:	autophagy protein kinase mTOR p70S6K AMPK PI3K Akt MAPK PKC

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 3(2011), 2, Seite 2630-2654
Übergeordnetes Werk:	volume:3 ; year:2011 ; number:2 ; pages:2630-2654

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers3022630

Katalog-ID:	DOAJ039060497

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allfieldsSound	10.3390/cancers3022630 doi (DE-627)DOAJ039060497 (DE-599)DOAJb55fb9b994034e768fa43676c74b43f5 DE-627 ger DE-627 rakwb eng RC254-282 Savitha Sridharan verfasserin aut Regulation of Autophagy by Kinases 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Autophagy is a process of self-degradation that maintains cellular viability during periods of metabolic stress. Although autophagy is considered a survival mechanism when faced with cellular stress, extensive autophagy can also lead to cell death. Aberrations in autophagy are associated with several diseases, including cancer. Therapeutic exploitation of this process requires a clear understanding of its regulation. Although the core molecular components involved in the execution of autophagy are well studied there is limited information on how cellular signaling pathways, particularly kinases, regulate this complex process. Protein kinases are integral to the autophagy process. Atg1, the first autophagy-related protein identified, is a serine/threonine kinase and it is regulated by another serine/threonine kinase mTOR. Emerging studies suggest the participation of many different kinases in regulating various components/steps of this catabolic process. This review focuses on the regulation of autophagy by several kinases with particular emphasis on serine/threonine protein kinases such as mTOR, AMP-activated kinase, Akt, mitogen-activated protein kinase (ERK, p38 and JNK) and protein kinase C that are often deregulated in cancer and are important therapeutic targets. autophagy protein kinase mTOR p70S6K AMPK PI3K Akt MAPK PKC Neoplasms. Tumors. Oncology. Including cancer and carcinogens Alakananda Basu verfasserin aut Kirti Jain verfasserin aut In Cancers MDPI AG, 2010 3(2011), 2, Seite 2630-2654 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:3 year:2011 number:2 pages:2630-2654 https://doi.org/10.3390/cancers3022630 kostenfrei https://doaj.org/article/b55fb9b994034e768fa43676c74b43f5 kostenfrei http://www.mdpi.com/2072-6694/3/2/2630/ kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2011 2 2630-2654
language	English
source	In Cancers 3(2011), 2, Seite 2630-2654 volume:3 year:2011 number:2 pages:2630-2654
sourceStr	In Cancers 3(2011), 2, Seite 2630-2654 volume:3 year:2011 number:2 pages:2630-2654
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	autophagy protein kinase mTOR p70S6K AMPK PI3K Akt MAPK PKC Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	Cancers
authorswithroles_txt_mv	Savitha Sridharan @@aut@@ Alakananda Basu @@aut@@ Kirti Jain @@aut@@
publishDateDaySort_date	2011-01-01T00:00:00Z
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callnumber-first	R - Medicine
author	Savitha Sridharan
spellingShingle	Savitha Sridharan misc RC254-282 misc autophagy misc protein kinase misc mTOR misc p70S6K misc AMPK misc PI3K misc Akt misc MAPK misc PKC misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Regulation of Autophagy by Kinases
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topic_title	RC254-282 Regulation of Autophagy by Kinases autophagy protein kinase mTOR p70S6K AMPK PI3K Akt MAPK PKC
topic	misc RC254-282 misc autophagy misc protein kinase misc mTOR misc p70S6K misc AMPK misc PI3K misc Akt misc MAPK misc PKC misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc autophagy misc protein kinase misc mTOR misc p70S6K misc AMPK misc PI3K misc Akt misc MAPK misc PKC misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc autophagy misc protein kinase misc mTOR misc p70S6K misc AMPK misc PI3K misc Akt misc MAPK misc PKC misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Regulation of Autophagy by Kinases
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author_browse	Savitha Sridharan Alakananda Basu Kirti Jain
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title_sort	regulation of autophagy by kinases
callnumber	RC254-282
title_auth	Regulation of Autophagy by Kinases
abstract	Autophagy is a process of self-degradation that maintains cellular viability during periods of metabolic stress. Although autophagy is considered a survival mechanism when faced with cellular stress, extensive autophagy can also lead to cell death. Aberrations in autophagy are associated with several diseases, including cancer. Therapeutic exploitation of this process requires a clear understanding of its regulation. Although the core molecular components involved in the execution of autophagy are well studied there is limited information on how cellular signaling pathways, particularly kinases, regulate this complex process. Protein kinases are integral to the autophagy process. Atg1, the first autophagy-related protein identified, is a serine/threonine kinase and it is regulated by another serine/threonine kinase mTOR. Emerging studies suggest the participation of many different kinases in regulating various components/steps of this catabolic process. This review focuses on the regulation of autophagy by several kinases with particular emphasis on serine/threonine protein kinases such as mTOR, AMP-activated kinase, Akt, mitogen-activated protein kinase (ERK, p38 and JNK) and protein kinase C that are often deregulated in cancer and are important therapeutic targets.
abstractGer	Autophagy is a process of self-degradation that maintains cellular viability during periods of metabolic stress. Although autophagy is considered a survival mechanism when faced with cellular stress, extensive autophagy can also lead to cell death. Aberrations in autophagy are associated with several diseases, including cancer. Therapeutic exploitation of this process requires a clear understanding of its regulation. Although the core molecular components involved in the execution of autophagy are well studied there is limited information on how cellular signaling pathways, particularly kinases, regulate this complex process. Protein kinases are integral to the autophagy process. Atg1, the first autophagy-related protein identified, is a serine/threonine kinase and it is regulated by another serine/threonine kinase mTOR. Emerging studies suggest the participation of many different kinases in regulating various components/steps of this catabolic process. This review focuses on the regulation of autophagy by several kinases with particular emphasis on serine/threonine protein kinases such as mTOR, AMP-activated kinase, Akt, mitogen-activated protein kinase (ERK, p38 and JNK) and protein kinase C that are often deregulated in cancer and are important therapeutic targets.
abstract_unstemmed	Autophagy is a process of self-degradation that maintains cellular viability during periods of metabolic stress. Although autophagy is considered a survival mechanism when faced with cellular stress, extensive autophagy can also lead to cell death. Aberrations in autophagy are associated with several diseases, including cancer. Therapeutic exploitation of this process requires a clear understanding of its regulation. Although the core molecular components involved in the execution of autophagy are well studied there is limited information on how cellular signaling pathways, particularly kinases, regulate this complex process. Protein kinases are integral to the autophagy process. Atg1, the first autophagy-related protein identified, is a serine/threonine kinase and it is regulated by another serine/threonine kinase mTOR. Emerging studies suggest the participation of many different kinases in regulating various components/steps of this catabolic process. This review focuses on the regulation of autophagy by several kinases with particular emphasis on serine/threonine protein kinases such as mTOR, AMP-activated kinase, Akt, mitogen-activated protein kinase (ERK, p38 and JNK) and protein kinase C that are often deregulated in cancer and are important therapeutic targets.
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title_short	Regulation of Autophagy by Kinases
url	https://doi.org/10.3390/cancers3022630 https://doaj.org/article/b55fb9b994034e768fa43676c74b43f5 http://www.mdpi.com/2072-6694/3/2/2630/ https://doaj.org/toc/2072-6694
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author2	Alakananda Basu Kirti Jain
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