Biologics in severe asthma: the role of real-world evidence from registries
Asthma is one of the most common noncommunicable diseases; in the majority of patients it is well controlled with inhaled bronchodilators and inhaled corticosteroids, but the management of severe asthma has been a significant challenge historically. The introduction of novel biologic drugs in the pa...
Ausführliche Beschreibung
Autor*in: |
Giovanni Paoletti [verfasserIn] Jack Pepys [verfasserIn] Marta Casini [verfasserIn] Danilo Di Bona [verfasserIn] Enrico Heffler [verfasserIn] Celine Y.Y. Goh [verfasserIn] David B. Price [verfasserIn] Giorgio Walter Canonica [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2022 |
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Übergeordnetes Werk: |
In: European Respiratory Review - European Respiratory Society, 2009, 31(2022), 164 |
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Übergeordnetes Werk: |
volume:31 ; year:2022 ; number:164 |
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Link aufrufen |
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DOI / URN: |
10.1183/16000617.0278-2021 |
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Katalog-ID: |
DOAJ03907692X |
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10.1183/16000617.0278-2021 doi (DE-627)DOAJ03907692X (DE-599)DOAJ61b232e1626744bd96776b861423b068 DE-627 ger DE-627 rakwb eng RC705-779 Giovanni Paoletti verfasserin aut Biologics in severe asthma: the role of real-world evidence from registries 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Asthma is one of the most common noncommunicable diseases; in the majority of patients it is well controlled with inhaled bronchodilators and inhaled corticosteroids, but the management of severe asthma has been a significant challenge historically. The introduction of novel biologic drugs in the past few decades has revolutionised the field, presenting physicians with a variety of biologic drugs with different mechanisms for the treatment of severe asthma. It is of crucial importance to evaluate the effectiveness of these drugs by following their “real-life” effectiveness rather than relying solely on their efficacy, established in carefully designed clinical trials, which therefore do not necessarily match the profile of the real-life patient. Understanding the actual effectiveness of the specific drugs in real-life patients is a crucial part of tailoring the right drugs to the right patients. Registries serve as an important tool in obtaining real-life evidence, since they are in effect observational studies, following the entire patient population. Diseases of the respiratory system Jack Pepys verfasserin aut Marta Casini verfasserin aut Danilo Di Bona verfasserin aut Enrico Heffler verfasserin aut Celine Y.Y. Goh verfasserin aut David B. Price verfasserin aut Giorgio Walter Canonica verfasserin aut In European Respiratory Review European Respiratory Society, 2009 31(2022), 164 (DE-627)500021430 (DE-600)2202947-3 16000617 nnns volume:31 year:2022 number:164 https://doi.org/10.1183/16000617.0278-2021 kostenfrei https://doaj.org/article/61b232e1626744bd96776b861423b068 kostenfrei http://err.ersjournals.com/content/31/164/210278.full kostenfrei https://doaj.org/toc/0905-9180 Journal toc kostenfrei https://doaj.org/toc/1600-0617 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 31 2022 164 |
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10.1183/16000617.0278-2021 doi (DE-627)DOAJ03907692X (DE-599)DOAJ61b232e1626744bd96776b861423b068 DE-627 ger DE-627 rakwb eng RC705-779 Giovanni Paoletti verfasserin aut Biologics in severe asthma: the role of real-world evidence from registries 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Asthma is one of the most common noncommunicable diseases; in the majority of patients it is well controlled with inhaled bronchodilators and inhaled corticosteroids, but the management of severe asthma has been a significant challenge historically. The introduction of novel biologic drugs in the past few decades has revolutionised the field, presenting physicians with a variety of biologic drugs with different mechanisms for the treatment of severe asthma. It is of crucial importance to evaluate the effectiveness of these drugs by following their “real-life” effectiveness rather than relying solely on their efficacy, established in carefully designed clinical trials, which therefore do not necessarily match the profile of the real-life patient. Understanding the actual effectiveness of the specific drugs in real-life patients is a crucial part of tailoring the right drugs to the right patients. Registries serve as an important tool in obtaining real-life evidence, since they are in effect observational studies, following the entire patient population. Diseases of the respiratory system Jack Pepys verfasserin aut Marta Casini verfasserin aut Danilo Di Bona verfasserin aut Enrico Heffler verfasserin aut Celine Y.Y. Goh verfasserin aut David B. Price verfasserin aut Giorgio Walter Canonica verfasserin aut In European Respiratory Review European Respiratory Society, 2009 31(2022), 164 (DE-627)500021430 (DE-600)2202947-3 16000617 nnns volume:31 year:2022 number:164 https://doi.org/10.1183/16000617.0278-2021 kostenfrei https://doaj.org/article/61b232e1626744bd96776b861423b068 kostenfrei http://err.ersjournals.com/content/31/164/210278.full kostenfrei https://doaj.org/toc/0905-9180 Journal toc kostenfrei https://doaj.org/toc/1600-0617 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 31 2022 164 |
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10.1183/16000617.0278-2021 doi (DE-627)DOAJ03907692X (DE-599)DOAJ61b232e1626744bd96776b861423b068 DE-627 ger DE-627 rakwb eng RC705-779 Giovanni Paoletti verfasserin aut Biologics in severe asthma: the role of real-world evidence from registries 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Asthma is one of the most common noncommunicable diseases; in the majority of patients it is well controlled with inhaled bronchodilators and inhaled corticosteroids, but the management of severe asthma has been a significant challenge historically. The introduction of novel biologic drugs in the past few decades has revolutionised the field, presenting physicians with a variety of biologic drugs with different mechanisms for the treatment of severe asthma. It is of crucial importance to evaluate the effectiveness of these drugs by following their “real-life” effectiveness rather than relying solely on their efficacy, established in carefully designed clinical trials, which therefore do not necessarily match the profile of the real-life patient. Understanding the actual effectiveness of the specific drugs in real-life patients is a crucial part of tailoring the right drugs to the right patients. Registries serve as an important tool in obtaining real-life evidence, since they are in effect observational studies, following the entire patient population. Diseases of the respiratory system Jack Pepys verfasserin aut Marta Casini verfasserin aut Danilo Di Bona verfasserin aut Enrico Heffler verfasserin aut Celine Y.Y. Goh verfasserin aut David B. Price verfasserin aut Giorgio Walter Canonica verfasserin aut In European Respiratory Review European Respiratory Society, 2009 31(2022), 164 (DE-627)500021430 (DE-600)2202947-3 16000617 nnns volume:31 year:2022 number:164 https://doi.org/10.1183/16000617.0278-2021 kostenfrei https://doaj.org/article/61b232e1626744bd96776b861423b068 kostenfrei http://err.ersjournals.com/content/31/164/210278.full kostenfrei https://doaj.org/toc/0905-9180 Journal toc kostenfrei https://doaj.org/toc/1600-0617 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 31 2022 164 |
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10.1183/16000617.0278-2021 doi (DE-627)DOAJ03907692X (DE-599)DOAJ61b232e1626744bd96776b861423b068 DE-627 ger DE-627 rakwb eng RC705-779 Giovanni Paoletti verfasserin aut Biologics in severe asthma: the role of real-world evidence from registries 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Asthma is one of the most common noncommunicable diseases; in the majority of patients it is well controlled with inhaled bronchodilators and inhaled corticosteroids, but the management of severe asthma has been a significant challenge historically. The introduction of novel biologic drugs in the past few decades has revolutionised the field, presenting physicians with a variety of biologic drugs with different mechanisms for the treatment of severe asthma. It is of crucial importance to evaluate the effectiveness of these drugs by following their “real-life” effectiveness rather than relying solely on their efficacy, established in carefully designed clinical trials, which therefore do not necessarily match the profile of the real-life patient. Understanding the actual effectiveness of the specific drugs in real-life patients is a crucial part of tailoring the right drugs to the right patients. Registries serve as an important tool in obtaining real-life evidence, since they are in effect observational studies, following the entire patient population. Diseases of the respiratory system Jack Pepys verfasserin aut Marta Casini verfasserin aut Danilo Di Bona verfasserin aut Enrico Heffler verfasserin aut Celine Y.Y. Goh verfasserin aut David B. Price verfasserin aut Giorgio Walter Canonica verfasserin aut In European Respiratory Review European Respiratory Society, 2009 31(2022), 164 (DE-627)500021430 (DE-600)2202947-3 16000617 nnns volume:31 year:2022 number:164 https://doi.org/10.1183/16000617.0278-2021 kostenfrei https://doaj.org/article/61b232e1626744bd96776b861423b068 kostenfrei http://err.ersjournals.com/content/31/164/210278.full kostenfrei https://doaj.org/toc/0905-9180 Journal toc kostenfrei https://doaj.org/toc/1600-0617 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 31 2022 164 |
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Asthma is one of the most common noncommunicable diseases; in the majority of patients it is well controlled with inhaled bronchodilators and inhaled corticosteroids, but the management of severe asthma has been a significant challenge historically. The introduction of novel biologic drugs in the past few decades has revolutionised the field, presenting physicians with a variety of biologic drugs with different mechanisms for the treatment of severe asthma. It is of crucial importance to evaluate the effectiveness of these drugs by following their “real-life” effectiveness rather than relying solely on their efficacy, established in carefully designed clinical trials, which therefore do not necessarily match the profile of the real-life patient. Understanding the actual effectiveness of the specific drugs in real-life patients is a crucial part of tailoring the right drugs to the right patients. Registries serve as an important tool in obtaining real-life evidence, since they are in effect observational studies, following the entire patient population. |
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Asthma is one of the most common noncommunicable diseases; in the majority of patients it is well controlled with inhaled bronchodilators and inhaled corticosteroids, but the management of severe asthma has been a significant challenge historically. The introduction of novel biologic drugs in the past few decades has revolutionised the field, presenting physicians with a variety of biologic drugs with different mechanisms for the treatment of severe asthma. It is of crucial importance to evaluate the effectiveness of these drugs by following their “real-life” effectiveness rather than relying solely on their efficacy, established in carefully designed clinical trials, which therefore do not necessarily match the profile of the real-life patient. Understanding the actual effectiveness of the specific drugs in real-life patients is a crucial part of tailoring the right drugs to the right patients. Registries serve as an important tool in obtaining real-life evidence, since they are in effect observational studies, following the entire patient population. |
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Asthma is one of the most common noncommunicable diseases; in the majority of patients it is well controlled with inhaled bronchodilators and inhaled corticosteroids, but the management of severe asthma has been a significant challenge historically. The introduction of novel biologic drugs in the past few decades has revolutionised the field, presenting physicians with a variety of biologic drugs with different mechanisms for the treatment of severe asthma. It is of crucial importance to evaluate the effectiveness of these drugs by following their “real-life” effectiveness rather than relying solely on their efficacy, established in carefully designed clinical trials, which therefore do not necessarily match the profile of the real-life patient. Understanding the actual effectiveness of the specific drugs in real-life patients is a crucial part of tailoring the right drugs to the right patients. Registries serve as an important tool in obtaining real-life evidence, since they are in effect observational studies, following the entire patient population. |
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