Structural organisation of femoral bones of white laboratory rats associated with aminophosphonates and aminobisphosphonates

Background. In recent years, the total amount of atypical forms of inflammatory processes of the jaw in a group of patients exposed to psychotropic substances significantly increased. Objective. To evaluate the degree of peculiarities of morphological changes in proximal epiphysis of femoral bone of white laboratory rats under influence of non-opioid branded equivalent of “tweak” and aminophosphonate drug “Pamired” (pamidronic acid). Methods. 30 white laboratory rats were used in the research and 3 groups of animals were formed with 10 animals in each group. Control group of animals received 1.0 ml of distilled water intragastrically and 1.0 ml of normal saline intraperitoneally once a day during 3 months. Experimental rats received aminobiphosphonate drug “Pamired” and 63 mg/kg of non-opioid branded equivalent of “tweak” (aminophosphonate substance) during three month. External and internal surface of proximal epiphysis of femoral bone were studied with scanning electron microscopy and light microscopy. Results. Animals that received aminobiphosphonate drug “Pamired” had high mineralization of collagen matrix. As a result growth plate became more narrow (dystrophy), size of foramina nutricia and branches of Volkmann canals became smaller during intense bone growth. Animals that received non-opioid branded equivalent of “tweak” had the highest degree of mineralization and visual breaking of growth plate. Size of foramina nutricia decreased and number of branches of Volkmann canals also decreased; it leads to degenerative processes in the bone. Conclusion. Administration of non-opioid branded equivalent of “tweak” in dose 63 mg/kg and aminobiphosphonate drug “Pamired” during 3 month cause bone hypermineralization and lead to structural disorders of femoral proximal epiphyses in white laboratory rats. Structural disorders due to administration of non-opioid branded equivalent of “tweak” are more intensive. Citation: Mostovoy SO, Ostapenko OV, Kutya SA, Demchuk NI. [Structural organisation of femoral bones of white la-boratory rats associated with aminophosphonates and aminobisphosphonates]. Morphologia. 2014;8(3):50-6. Russian. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Mostovoy S.O. [verfasserIn] Ostapenko O.V. [verfasserIn] Kutya S.A. [verfasserIn] Demchuk N.I. [verfasserIn]

Format:	E-Artikel
Sprache:	Russisch ; Ukrainisch

Erschienen:	2014

Schlagwörter:	aminobisphosphonate aminosphosphonate growth plate tweak

Übergeordnetes Werk:	In: Морфологія - Ministry of Health of Ukraine. Dnipropetrovsk Medical Academy, 2018, 8(2014), 3, Seite 50-56
Übergeordnetes Werk:	volume:8 ; year:2014 ; number:3 ; pages:50-56

Links:	Link aufrufen Link aufrufen Journal toc Journal toc

Katalog-ID:	DOAJ039079724

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allfields	(DE-627)DOAJ039079724 (DE-599)DOAJdd5a9ff809654e399697b46b16562bca DE-627 ger DE-627 rakwb rus ukr QH301-705.5 Mostovoy S.O. verfasserin aut Structural organisation of femoral bones of white laboratory rats associated with aminophosphonates and aminobisphosphonates 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background. In recent years, the total amount of atypical forms of inflammatory processes of the jaw in a group of patients exposed to psychotropic substances significantly increased. Objective. To evaluate the degree of peculiarities of morphological changes in proximal epiphysis of femoral bone of white laboratory rats under influence of non-opioid branded equivalent of “tweak” and aminophosphonate drug “Pamired” (pamidronic acid). Methods. 30 white laboratory rats were used in the research and 3 groups of animals were formed with 10 animals in each group. Control group of animals received 1.0 ml of distilled water intragastrically and 1.0 ml of normal saline intraperitoneally once a day during 3 months. Experimental rats received aminobiphosphonate drug “Pamired” and 63 mg/kg of non-opioid branded equivalent of “tweak” (aminophosphonate substance) during three month. External and internal surface of proximal epiphysis of femoral bone were studied with scanning electron microscopy and light microscopy. Results. Animals that received aminobiphosphonate drug “Pamired” had high mineralization of collagen matrix. As a result growth plate became more narrow (dystrophy), size of foramina nutricia and branches of Volkmann canals became smaller during intense bone growth. Animals that received non-opioid branded equivalent of “tweak” had the highest degree of mineralization and visual breaking of growth plate. Size of foramina nutricia decreased and number of branches of Volkmann canals also decreased; it leads to degenerative processes in the bone. Conclusion. Administration of non-opioid branded equivalent of “tweak” in dose 63 mg/kg and aminobiphosphonate drug “Pamired” during 3 month cause bone hypermineralization and lead to structural disorders of femoral proximal epiphyses in white laboratory rats. Structural disorders due to administration of non-opioid branded equivalent of “tweak” are more intensive. Citation: Mostovoy SO, Ostapenko OV, Kutya SA, Demchuk NI. [Structural organisation of femoral bones of white la-boratory rats associated with aminophosphonates and aminobisphosphonates]. Morphologia. 2014;8(3):50-6. Russian. aminobisphosphonate aminosphosphonate growth plate tweak Biology (General) Ostapenko O.V. verfasserin aut Kutya S.A. verfasserin aut Demchuk N.I. verfasserin aut In Морфологія Ministry of Health of Ukraine. Dnipropetrovsk Medical Academy, 2018 8(2014), 3, Seite 50-56 (DE-627)598790535 (DE-600)2491710-2 19979665 nnns volume:8 year:2014 number:3 pages:50-56 https://doaj.org/article/dd5a9ff809654e399697b46b16562bca kostenfrei http://www.morphology.dp.ua/_pub/MORPHO-2014-08-03/14msoaag.pdf kostenfrei https://doaj.org/toc/1997-9665 Journal toc kostenfrei https://doaj.org/toc/1997-9665 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2014 3 50-56
spelling	(DE-627)DOAJ039079724 (DE-599)DOAJdd5a9ff809654e399697b46b16562bca DE-627 ger DE-627 rakwb rus ukr QH301-705.5 Mostovoy S.O. verfasserin aut Structural organisation of femoral bones of white laboratory rats associated with aminophosphonates and aminobisphosphonates 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background. In recent years, the total amount of atypical forms of inflammatory processes of the jaw in a group of patients exposed to psychotropic substances significantly increased. Objective. To evaluate the degree of peculiarities of morphological changes in proximal epiphysis of femoral bone of white laboratory rats under influence of non-opioid branded equivalent of “tweak” and aminophosphonate drug “Pamired” (pamidronic acid). Methods. 30 white laboratory rats were used in the research and 3 groups of animals were formed with 10 animals in each group. Control group of animals received 1.0 ml of distilled water intragastrically and 1.0 ml of normal saline intraperitoneally once a day during 3 months. Experimental rats received aminobiphosphonate drug “Pamired” and 63 mg/kg of non-opioid branded equivalent of “tweak” (aminophosphonate substance) during three month. External and internal surface of proximal epiphysis of femoral bone were studied with scanning electron microscopy and light microscopy. Results. Animals that received aminobiphosphonate drug “Pamired” had high mineralization of collagen matrix. As a result growth plate became more narrow (dystrophy), size of foramina nutricia and branches of Volkmann canals became smaller during intense bone growth. Animals that received non-opioid branded equivalent of “tweak” had the highest degree of mineralization and visual breaking of growth plate. Size of foramina nutricia decreased and number of branches of Volkmann canals also decreased; it leads to degenerative processes in the bone. Conclusion. Administration of non-opioid branded equivalent of “tweak” in dose 63 mg/kg and aminobiphosphonate drug “Pamired” during 3 month cause bone hypermineralization and lead to structural disorders of femoral proximal epiphyses in white laboratory rats. Structural disorders due to administration of non-opioid branded equivalent of “tweak” are more intensive. Citation: Mostovoy SO, Ostapenko OV, Kutya SA, Demchuk NI. [Structural organisation of femoral bones of white la-boratory rats associated with aminophosphonates and aminobisphosphonates]. Morphologia. 2014;8(3):50-6. Russian. aminobisphosphonate aminosphosphonate growth plate tweak Biology (General) Ostapenko O.V. verfasserin aut Kutya S.A. verfasserin aut Demchuk N.I. verfasserin aut In Морфологія Ministry of Health of Ukraine. Dnipropetrovsk Medical Academy, 2018 8(2014), 3, Seite 50-56 (DE-627)598790535 (DE-600)2491710-2 19979665 nnns volume:8 year:2014 number:3 pages:50-56 https://doaj.org/article/dd5a9ff809654e399697b46b16562bca kostenfrei http://www.morphology.dp.ua/_pub/MORPHO-2014-08-03/14msoaag.pdf kostenfrei https://doaj.org/toc/1997-9665 Journal toc kostenfrei https://doaj.org/toc/1997-9665 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2014 3 50-56
allfields_unstemmed	(DE-627)DOAJ039079724 (DE-599)DOAJdd5a9ff809654e399697b46b16562bca DE-627 ger DE-627 rakwb rus ukr QH301-705.5 Mostovoy S.O. verfasserin aut Structural organisation of femoral bones of white laboratory rats associated with aminophosphonates and aminobisphosphonates 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background. In recent years, the total amount of atypical forms of inflammatory processes of the jaw in a group of patients exposed to psychotropic substances significantly increased. Objective. To evaluate the degree of peculiarities of morphological changes in proximal epiphysis of femoral bone of white laboratory rats under influence of non-opioid branded equivalent of “tweak” and aminophosphonate drug “Pamired” (pamidronic acid). Methods. 30 white laboratory rats were used in the research and 3 groups of animals were formed with 10 animals in each group. Control group of animals received 1.0 ml of distilled water intragastrically and 1.0 ml of normal saline intraperitoneally once a day during 3 months. Experimental rats received aminobiphosphonate drug “Pamired” and 63 mg/kg of non-opioid branded equivalent of “tweak” (aminophosphonate substance) during three month. External and internal surface of proximal epiphysis of femoral bone were studied with scanning electron microscopy and light microscopy. Results. Animals that received aminobiphosphonate drug “Pamired” had high mineralization of collagen matrix. As a result growth plate became more narrow (dystrophy), size of foramina nutricia and branches of Volkmann canals became smaller during intense bone growth. Animals that received non-opioid branded equivalent of “tweak” had the highest degree of mineralization and visual breaking of growth plate. Size of foramina nutricia decreased and number of branches of Volkmann canals also decreased; it leads to degenerative processes in the bone. Conclusion. Administration of non-opioid branded equivalent of “tweak” in dose 63 mg/kg and aminobiphosphonate drug “Pamired” during 3 month cause bone hypermineralization and lead to structural disorders of femoral proximal epiphyses in white laboratory rats. Structural disorders due to administration of non-opioid branded equivalent of “tweak” are more intensive. Citation: Mostovoy SO, Ostapenko OV, Kutya SA, Demchuk NI. [Structural organisation of femoral bones of white la-boratory rats associated with aminophosphonates and aminobisphosphonates]. Morphologia. 2014;8(3):50-6. Russian. aminobisphosphonate aminosphosphonate growth plate tweak Biology (General) Ostapenko O.V. verfasserin aut Kutya S.A. verfasserin aut Demchuk N.I. verfasserin aut In Морфологія Ministry of Health of Ukraine. Dnipropetrovsk Medical Academy, 2018 8(2014), 3, Seite 50-56 (DE-627)598790535 (DE-600)2491710-2 19979665 nnns volume:8 year:2014 number:3 pages:50-56 https://doaj.org/article/dd5a9ff809654e399697b46b16562bca kostenfrei http://www.morphology.dp.ua/_pub/MORPHO-2014-08-03/14msoaag.pdf kostenfrei https://doaj.org/toc/1997-9665 Journal toc kostenfrei https://doaj.org/toc/1997-9665 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2014 3 50-56
allfieldsGer	(DE-627)DOAJ039079724 (DE-599)DOAJdd5a9ff809654e399697b46b16562bca DE-627 ger DE-627 rakwb rus ukr QH301-705.5 Mostovoy S.O. verfasserin aut Structural organisation of femoral bones of white laboratory rats associated with aminophosphonates and aminobisphosphonates 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background. In recent years, the total amount of atypical forms of inflammatory processes of the jaw in a group of patients exposed to psychotropic substances significantly increased. Objective. To evaluate the degree of peculiarities of morphological changes in proximal epiphysis of femoral bone of white laboratory rats under influence of non-opioid branded equivalent of “tweak” and aminophosphonate drug “Pamired” (pamidronic acid). Methods. 30 white laboratory rats were used in the research and 3 groups of animals were formed with 10 animals in each group. Control group of animals received 1.0 ml of distilled water intragastrically and 1.0 ml of normal saline intraperitoneally once a day during 3 months. Experimental rats received aminobiphosphonate drug “Pamired” and 63 mg/kg of non-opioid branded equivalent of “tweak” (aminophosphonate substance) during three month. External and internal surface of proximal epiphysis of femoral bone were studied with scanning electron microscopy and light microscopy. Results. Animals that received aminobiphosphonate drug “Pamired” had high mineralization of collagen matrix. As a result growth plate became more narrow (dystrophy), size of foramina nutricia and branches of Volkmann canals became smaller during intense bone growth. Animals that received non-opioid branded equivalent of “tweak” had the highest degree of mineralization and visual breaking of growth plate. Size of foramina nutricia decreased and number of branches of Volkmann canals also decreased; it leads to degenerative processes in the bone. Conclusion. Administration of non-opioid branded equivalent of “tweak” in dose 63 mg/kg and aminobiphosphonate drug “Pamired” during 3 month cause bone hypermineralization and lead to structural disorders of femoral proximal epiphyses in white laboratory rats. Structural disorders due to administration of non-opioid branded equivalent of “tweak” are more intensive. Citation: Mostovoy SO, Ostapenko OV, Kutya SA, Demchuk NI. [Structural organisation of femoral bones of white la-boratory rats associated with aminophosphonates and aminobisphosphonates]. Morphologia. 2014;8(3):50-6. Russian. aminobisphosphonate aminosphosphonate growth plate tweak Biology (General) Ostapenko O.V. verfasserin aut Kutya S.A. verfasserin aut Demchuk N.I. verfasserin aut In Морфологія Ministry of Health of Ukraine. Dnipropetrovsk Medical Academy, 2018 8(2014), 3, Seite 50-56 (DE-627)598790535 (DE-600)2491710-2 19979665 nnns volume:8 year:2014 number:3 pages:50-56 https://doaj.org/article/dd5a9ff809654e399697b46b16562bca kostenfrei http://www.morphology.dp.ua/_pub/MORPHO-2014-08-03/14msoaag.pdf kostenfrei https://doaj.org/toc/1997-9665 Journal toc kostenfrei https://doaj.org/toc/1997-9665 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2014 3 50-56
allfieldsSound	(DE-627)DOAJ039079724 (DE-599)DOAJdd5a9ff809654e399697b46b16562bca DE-627 ger DE-627 rakwb rus ukr QH301-705.5 Mostovoy S.O. verfasserin aut Structural organisation of femoral bones of white laboratory rats associated with aminophosphonates and aminobisphosphonates 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background. In recent years, the total amount of atypical forms of inflammatory processes of the jaw in a group of patients exposed to psychotropic substances significantly increased. Objective. To evaluate the degree of peculiarities of morphological changes in proximal epiphysis of femoral bone of white laboratory rats under influence of non-opioid branded equivalent of “tweak” and aminophosphonate drug “Pamired” (pamidronic acid). Methods. 30 white laboratory rats were used in the research and 3 groups of animals were formed with 10 animals in each group. Control group of animals received 1.0 ml of distilled water intragastrically and 1.0 ml of normal saline intraperitoneally once a day during 3 months. Experimental rats received aminobiphosphonate drug “Pamired” and 63 mg/kg of non-opioid branded equivalent of “tweak” (aminophosphonate substance) during three month. External and internal surface of proximal epiphysis of femoral bone were studied with scanning electron microscopy and light microscopy. Results. Animals that received aminobiphosphonate drug “Pamired” had high mineralization of collagen matrix. As a result growth plate became more narrow (dystrophy), size of foramina nutricia and branches of Volkmann canals became smaller during intense bone growth. Animals that received non-opioid branded equivalent of “tweak” had the highest degree of mineralization and visual breaking of growth plate. Size of foramina nutricia decreased and number of branches of Volkmann canals also decreased; it leads to degenerative processes in the bone. Conclusion. Administration of non-opioid branded equivalent of “tweak” in dose 63 mg/kg and aminobiphosphonate drug “Pamired” during 3 month cause bone hypermineralization and lead to structural disorders of femoral proximal epiphyses in white laboratory rats. Structural disorders due to administration of non-opioid branded equivalent of “tweak” are more intensive. Citation: Mostovoy SO, Ostapenko OV, Kutya SA, Demchuk NI. [Structural organisation of femoral bones of white la-boratory rats associated with aminophosphonates and aminobisphosphonates]. Morphologia. 2014;8(3):50-6. Russian. aminobisphosphonate aminosphosphonate growth plate tweak Biology (General) Ostapenko O.V. verfasserin aut Kutya S.A. verfasserin aut Demchuk N.I. verfasserin aut In Морфологія Ministry of Health of Ukraine. Dnipropetrovsk Medical Academy, 2018 8(2014), 3, Seite 50-56 (DE-627)598790535 (DE-600)2491710-2 19979665 nnns volume:8 year:2014 number:3 pages:50-56 https://doaj.org/article/dd5a9ff809654e399697b46b16562bca kostenfrei http://www.morphology.dp.ua/_pub/MORPHO-2014-08-03/14msoaag.pdf kostenfrei https://doaj.org/toc/1997-9665 Journal toc kostenfrei https://doaj.org/toc/1997-9665 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2014 3 50-56
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title	Structural organisation of femoral bones of white laboratory rats associated with aminophosphonates and aminobisphosphonates
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author_browse	Mostovoy S.O. Ostapenko O.V. Kutya S.A. Demchuk N.I.
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title_sort	structural organisation of femoral bones of white laboratory rats associated with aminophosphonates and aminobisphosphonates
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title_auth	Structural organisation of femoral bones of white laboratory rats associated with aminophosphonates and aminobisphosphonates
abstract	Background. In recent years, the total amount of atypical forms of inflammatory processes of the jaw in a group of patients exposed to psychotropic substances significantly increased. Objective. To evaluate the degree of peculiarities of morphological changes in proximal epiphysis of femoral bone of white laboratory rats under influence of non-opioid branded equivalent of “tweak” and aminophosphonate drug “Pamired” (pamidronic acid). Methods. 30 white laboratory rats were used in the research and 3 groups of animals were formed with 10 animals in each group. Control group of animals received 1.0 ml of distilled water intragastrically and 1.0 ml of normal saline intraperitoneally once a day during 3 months. Experimental rats received aminobiphosphonate drug “Pamired” and 63 mg/kg of non-opioid branded equivalent of “tweak” (aminophosphonate substance) during three month. External and internal surface of proximal epiphysis of femoral bone were studied with scanning electron microscopy and light microscopy. Results. Animals that received aminobiphosphonate drug “Pamired” had high mineralization of collagen matrix. As a result growth plate became more narrow (dystrophy), size of foramina nutricia and branches of Volkmann canals became smaller during intense bone growth. Animals that received non-opioid branded equivalent of “tweak” had the highest degree of mineralization and visual breaking of growth plate. Size of foramina nutricia decreased and number of branches of Volkmann canals also decreased; it leads to degenerative processes in the bone. Conclusion. Administration of non-opioid branded equivalent of “tweak” in dose 63 mg/kg and aminobiphosphonate drug “Pamired” during 3 month cause bone hypermineralization and lead to structural disorders of femoral proximal epiphyses in white laboratory rats. Structural disorders due to administration of non-opioid branded equivalent of “tweak” are more intensive. Citation: Mostovoy SO, Ostapenko OV, Kutya SA, Demchuk NI. [Structural organisation of femoral bones of white la-boratory rats associated with aminophosphonates and aminobisphosphonates]. Morphologia. 2014;8(3):50-6. Russian.
abstractGer	Background. In recent years, the total amount of atypical forms of inflammatory processes of the jaw in a group of patients exposed to psychotropic substances significantly increased. Objective. To evaluate the degree of peculiarities of morphological changes in proximal epiphysis of femoral bone of white laboratory rats under influence of non-opioid branded equivalent of “tweak” and aminophosphonate drug “Pamired” (pamidronic acid). Methods. 30 white laboratory rats were used in the research and 3 groups of animals were formed with 10 animals in each group. Control group of animals received 1.0 ml of distilled water intragastrically and 1.0 ml of normal saline intraperitoneally once a day during 3 months. Experimental rats received aminobiphosphonate drug “Pamired” and 63 mg/kg of non-opioid branded equivalent of “tweak” (aminophosphonate substance) during three month. External and internal surface of proximal epiphysis of femoral bone were studied with scanning electron microscopy and light microscopy. Results. Animals that received aminobiphosphonate drug “Pamired” had high mineralization of collagen matrix. As a result growth plate became more narrow (dystrophy), size of foramina nutricia and branches of Volkmann canals became smaller during intense bone growth. Animals that received non-opioid branded equivalent of “tweak” had the highest degree of mineralization and visual breaking of growth plate. Size of foramina nutricia decreased and number of branches of Volkmann canals also decreased; it leads to degenerative processes in the bone. Conclusion. Administration of non-opioid branded equivalent of “tweak” in dose 63 mg/kg and aminobiphosphonate drug “Pamired” during 3 month cause bone hypermineralization and lead to structural disorders of femoral proximal epiphyses in white laboratory rats. Structural disorders due to administration of non-opioid branded equivalent of “tweak” are more intensive. Citation: Mostovoy SO, Ostapenko OV, Kutya SA, Demchuk NI. [Structural organisation of femoral bones of white la-boratory rats associated with aminophosphonates and aminobisphosphonates]. Morphologia. 2014;8(3):50-6. Russian.
abstract_unstemmed	Background. In recent years, the total amount of atypical forms of inflammatory processes of the jaw in a group of patients exposed to psychotropic substances significantly increased. Objective. To evaluate the degree of peculiarities of morphological changes in proximal epiphysis of femoral bone of white laboratory rats under influence of non-opioid branded equivalent of “tweak” and aminophosphonate drug “Pamired” (pamidronic acid). Methods. 30 white laboratory rats were used in the research and 3 groups of animals were formed with 10 animals in each group. Control group of animals received 1.0 ml of distilled water intragastrically and 1.0 ml of normal saline intraperitoneally once a day during 3 months. Experimental rats received aminobiphosphonate drug “Pamired” and 63 mg/kg of non-opioid branded equivalent of “tweak” (aminophosphonate substance) during three month. External and internal surface of proximal epiphysis of femoral bone were studied with scanning electron microscopy and light microscopy. Results. Animals that received aminobiphosphonate drug “Pamired” had high mineralization of collagen matrix. As a result growth plate became more narrow (dystrophy), size of foramina nutricia and branches of Volkmann canals became smaller during intense bone growth. Animals that received non-opioid branded equivalent of “tweak” had the highest degree of mineralization and visual breaking of growth plate. Size of foramina nutricia decreased and number of branches of Volkmann canals also decreased; it leads to degenerative processes in the bone. Conclusion. Administration of non-opioid branded equivalent of “tweak” in dose 63 mg/kg and aminobiphosphonate drug “Pamired” during 3 month cause bone hypermineralization and lead to structural disorders of femoral proximal epiphyses in white laboratory rats. Structural disorders due to administration of non-opioid branded equivalent of “tweak” are more intensive. Citation: Mostovoy SO, Ostapenko OV, Kutya SA, Demchuk NI. [Structural organisation of femoral bones of white la-boratory rats associated with aminophosphonates and aminobisphosphonates]. Morphologia. 2014;8(3):50-6. Russian.
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title_short	Structural organisation of femoral bones of white laboratory rats associated with aminophosphonates and aminobisphosphonates
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