Establishment of a subcutaneous adipogenesis model and distinct roles of LKB1 regulation on adipocyte lipid accumulation in high-altitude Bos grunniens

The domestic yak was regarded as a valuable model to explore the molecular mechanism of high-altitude animal adaptation, including the extreme tolerance of starvation and cold stress, which is closely associated with specifically seasonal deposition and metabolism of subcutaneous adipose tissue. How...
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Autor*in:	Yongqi Yue [verfasserIn] Yonglin Hua [verfasserIn] Jing Zhang [verfasserIn] Yu Guo [verfasserIn] Dan Zhao [verfasserIn] Wentao Huo [verfasserIn] Yan Xiong [verfasserIn] Fenfen Chen [verfasserIn] Yaqiu Lin [verfasserIn] Xianrong Xiong [verfasserIn] Jian Li [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	yak adipogenesis adipocyte lipid accumulation liver kinase B1

Übergeordnetes Werk:	In: Journal of Applied Animal Research - Taylor & Francis Group, 2018, 50(2022), 1, Seite 167-176
Übergeordnetes Werk:	volume:50 ; year:2022 ; number:1 ; pages:167-176

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1080/09712119.2022.2042001

Katalog-ID:	DOAJ03915064X

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allfields	10.1080/09712119.2022.2042001 doi (DE-627)DOAJ03915064X (DE-599)DOAJ94ac5ce376d449e5abeccbb399380b8a DE-627 ger DE-627 rakwb eng SF600-1100 Yongqi Yue verfasserin aut Establishment of a subcutaneous adipogenesis model and distinct roles of LKB1 regulation on adipocyte lipid accumulation in high-altitude Bos grunniens 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The domestic yak was regarded as a valuable model to explore the molecular mechanism of high-altitude animal adaptation, including the extreme tolerance of starvation and cold stress, which is closely associated with specifically seasonal deposition and metabolism of subcutaneous adipose tissue. However, the key regulators for these processes remain largely unknown. Here, the yak adipogenesis model in vitro was established and liver kinase b1 (LKB1) was regarded as a key negative regulator involved in yak adipocytes lipid accumulation. First, the mRNA level of LKB1 in adipose tissue of yaks from the cold season is significantly higher than that of yaks from the warm season. Interestingly, overexpression of LKB1 significantly inhibited adipocytes lipid accumulation. Consistently, LKB1 overexpression dramatically suppressed mRNA levels of adipogenic transcriptional factors, including C/EBPα, C/EBPβ and PPARγ, and subsequently significantly decreased levels of lipid accumulation related genes (FABP4 and FAS) compared with those of control. In contrast, overexpression of LKB1 promoted thermogenic and lipolysis related genes in yak adipocyte, including PGC1α, PPARα, UCP1, ATGL, HSL and LPL. Therefore, these results would provide new insights to decipher the network for domestic yak adipose deposition, and LKB1 might be as a new molecular target for animal environmental-resistant breeding. yak adipogenesis adipocyte lipid accumulation liver kinase B1 Veterinary medicine Yonglin Hua verfasserin aut Jing Zhang verfasserin aut Yu Guo verfasserin aut Dan Zhao verfasserin aut Wentao Huo verfasserin aut Yan Xiong verfasserin aut Fenfen Chen verfasserin aut Yaqiu Lin verfasserin aut Xianrong Xiong verfasserin aut Jian Li verfasserin aut In Journal of Applied Animal Research Taylor & Francis Group, 2018 50(2022), 1, Seite 167-176 (DE-627)620142308 (DE-600)2541051-9 09741844 nnns volume:50 year:2022 number:1 pages:167-176 https://doi.org/10.1080/09712119.2022.2042001 kostenfrei https://doaj.org/article/94ac5ce376d449e5abeccbb399380b8a kostenfrei https://www.tandfonline.com/doi/10.1080/09712119.2022.2042001 kostenfrei https://doaj.org/toc/0971-2119 Journal toc kostenfrei https://doaj.org/toc/0974-1844 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4367 GBV_ILN_4700 AR 50 2022 1 167-176
spelling	10.1080/09712119.2022.2042001 doi (DE-627)DOAJ03915064X (DE-599)DOAJ94ac5ce376d449e5abeccbb399380b8a DE-627 ger DE-627 rakwb eng SF600-1100 Yongqi Yue verfasserin aut Establishment of a subcutaneous adipogenesis model and distinct roles of LKB1 regulation on adipocyte lipid accumulation in high-altitude Bos grunniens 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The domestic yak was regarded as a valuable model to explore the molecular mechanism of high-altitude animal adaptation, including the extreme tolerance of starvation and cold stress, which is closely associated with specifically seasonal deposition and metabolism of subcutaneous adipose tissue. However, the key regulators for these processes remain largely unknown. Here, the yak adipogenesis model in vitro was established and liver kinase b1 (LKB1) was regarded as a key negative regulator involved in yak adipocytes lipid accumulation. First, the mRNA level of LKB1 in adipose tissue of yaks from the cold season is significantly higher than that of yaks from the warm season. Interestingly, overexpression of LKB1 significantly inhibited adipocytes lipid accumulation. Consistently, LKB1 overexpression dramatically suppressed mRNA levels of adipogenic transcriptional factors, including C/EBPα, C/EBPβ and PPARγ, and subsequently significantly decreased levels of lipid accumulation related genes (FABP4 and FAS) compared with those of control. In contrast, overexpression of LKB1 promoted thermogenic and lipolysis related genes in yak adipocyte, including PGC1α, PPARα, UCP1, ATGL, HSL and LPL. Therefore, these results would provide new insights to decipher the network for domestic yak adipose deposition, and LKB1 might be as a new molecular target for animal environmental-resistant breeding. yak adipogenesis adipocyte lipid accumulation liver kinase B1 Veterinary medicine Yonglin Hua verfasserin aut Jing Zhang verfasserin aut Yu Guo verfasserin aut Dan Zhao verfasserin aut Wentao Huo verfasserin aut Yan Xiong verfasserin aut Fenfen Chen verfasserin aut Yaqiu Lin verfasserin aut Xianrong Xiong verfasserin aut Jian Li verfasserin aut In Journal of Applied Animal Research Taylor & Francis Group, 2018 50(2022), 1, Seite 167-176 (DE-627)620142308 (DE-600)2541051-9 09741844 nnns volume:50 year:2022 number:1 pages:167-176 https://doi.org/10.1080/09712119.2022.2042001 kostenfrei https://doaj.org/article/94ac5ce376d449e5abeccbb399380b8a kostenfrei https://www.tandfonline.com/doi/10.1080/09712119.2022.2042001 kostenfrei https://doaj.org/toc/0971-2119 Journal toc kostenfrei https://doaj.org/toc/0974-1844 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4367 GBV_ILN_4700 AR 50 2022 1 167-176
allfields_unstemmed	10.1080/09712119.2022.2042001 doi (DE-627)DOAJ03915064X (DE-599)DOAJ94ac5ce376d449e5abeccbb399380b8a DE-627 ger DE-627 rakwb eng SF600-1100 Yongqi Yue verfasserin aut Establishment of a subcutaneous adipogenesis model and distinct roles of LKB1 regulation on adipocyte lipid accumulation in high-altitude Bos grunniens 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The domestic yak was regarded as a valuable model to explore the molecular mechanism of high-altitude animal adaptation, including the extreme tolerance of starvation and cold stress, which is closely associated with specifically seasonal deposition and metabolism of subcutaneous adipose tissue. However, the key regulators for these processes remain largely unknown. Here, the yak adipogenesis model in vitro was established and liver kinase b1 (LKB1) was regarded as a key negative regulator involved in yak adipocytes lipid accumulation. First, the mRNA level of LKB1 in adipose tissue of yaks from the cold season is significantly higher than that of yaks from the warm season. Interestingly, overexpression of LKB1 significantly inhibited adipocytes lipid accumulation. Consistently, LKB1 overexpression dramatically suppressed mRNA levels of adipogenic transcriptional factors, including C/EBPα, C/EBPβ and PPARγ, and subsequently significantly decreased levels of lipid accumulation related genes (FABP4 and FAS) compared with those of control. In contrast, overexpression of LKB1 promoted thermogenic and lipolysis related genes in yak adipocyte, including PGC1α, PPARα, UCP1, ATGL, HSL and LPL. Therefore, these results would provide new insights to decipher the network for domestic yak adipose deposition, and LKB1 might be as a new molecular target for animal environmental-resistant breeding. yak adipogenesis adipocyte lipid accumulation liver kinase B1 Veterinary medicine Yonglin Hua verfasserin aut Jing Zhang verfasserin aut Yu Guo verfasserin aut Dan Zhao verfasserin aut Wentao Huo verfasserin aut Yan Xiong verfasserin aut Fenfen Chen verfasserin aut Yaqiu Lin verfasserin aut Xianrong Xiong verfasserin aut Jian Li verfasserin aut In Journal of Applied Animal Research Taylor & Francis Group, 2018 50(2022), 1, Seite 167-176 (DE-627)620142308 (DE-600)2541051-9 09741844 nnns volume:50 year:2022 number:1 pages:167-176 https://doi.org/10.1080/09712119.2022.2042001 kostenfrei https://doaj.org/article/94ac5ce376d449e5abeccbb399380b8a kostenfrei https://www.tandfonline.com/doi/10.1080/09712119.2022.2042001 kostenfrei https://doaj.org/toc/0971-2119 Journal toc kostenfrei https://doaj.org/toc/0974-1844 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4367 GBV_ILN_4700 AR 50 2022 1 167-176
allfieldsGer	10.1080/09712119.2022.2042001 doi (DE-627)DOAJ03915064X (DE-599)DOAJ94ac5ce376d449e5abeccbb399380b8a DE-627 ger DE-627 rakwb eng SF600-1100 Yongqi Yue verfasserin aut Establishment of a subcutaneous adipogenesis model and distinct roles of LKB1 regulation on adipocyte lipid accumulation in high-altitude Bos grunniens 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The domestic yak was regarded as a valuable model to explore the molecular mechanism of high-altitude animal adaptation, including the extreme tolerance of starvation and cold stress, which is closely associated with specifically seasonal deposition and metabolism of subcutaneous adipose tissue. However, the key regulators for these processes remain largely unknown. Here, the yak adipogenesis model in vitro was established and liver kinase b1 (LKB1) was regarded as a key negative regulator involved in yak adipocytes lipid accumulation. First, the mRNA level of LKB1 in adipose tissue of yaks from the cold season is significantly higher than that of yaks from the warm season. Interestingly, overexpression of LKB1 significantly inhibited adipocytes lipid accumulation. Consistently, LKB1 overexpression dramatically suppressed mRNA levels of adipogenic transcriptional factors, including C/EBPα, C/EBPβ and PPARγ, and subsequently significantly decreased levels of lipid accumulation related genes (FABP4 and FAS) compared with those of control. In contrast, overexpression of LKB1 promoted thermogenic and lipolysis related genes in yak adipocyte, including PGC1α, PPARα, UCP1, ATGL, HSL and LPL. Therefore, these results would provide new insights to decipher the network for domestic yak adipose deposition, and LKB1 might be as a new molecular target for animal environmental-resistant breeding. yak adipogenesis adipocyte lipid accumulation liver kinase B1 Veterinary medicine Yonglin Hua verfasserin aut Jing Zhang verfasserin aut Yu Guo verfasserin aut Dan Zhao verfasserin aut Wentao Huo verfasserin aut Yan Xiong verfasserin aut Fenfen Chen verfasserin aut Yaqiu Lin verfasserin aut Xianrong Xiong verfasserin aut Jian Li verfasserin aut In Journal of Applied Animal Research Taylor & Francis Group, 2018 50(2022), 1, Seite 167-176 (DE-627)620142308 (DE-600)2541051-9 09741844 nnns volume:50 year:2022 number:1 pages:167-176 https://doi.org/10.1080/09712119.2022.2042001 kostenfrei https://doaj.org/article/94ac5ce376d449e5abeccbb399380b8a kostenfrei https://www.tandfonline.com/doi/10.1080/09712119.2022.2042001 kostenfrei https://doaj.org/toc/0971-2119 Journal toc kostenfrei https://doaj.org/toc/0974-1844 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4367 GBV_ILN_4700 AR 50 2022 1 167-176
allfieldsSound	10.1080/09712119.2022.2042001 doi (DE-627)DOAJ03915064X (DE-599)DOAJ94ac5ce376d449e5abeccbb399380b8a DE-627 ger DE-627 rakwb eng SF600-1100 Yongqi Yue verfasserin aut Establishment of a subcutaneous adipogenesis model and distinct roles of LKB1 regulation on adipocyte lipid accumulation in high-altitude Bos grunniens 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The domestic yak was regarded as a valuable model to explore the molecular mechanism of high-altitude animal adaptation, including the extreme tolerance of starvation and cold stress, which is closely associated with specifically seasonal deposition and metabolism of subcutaneous adipose tissue. However, the key regulators for these processes remain largely unknown. Here, the yak adipogenesis model in vitro was established and liver kinase b1 (LKB1) was regarded as a key negative regulator involved in yak adipocytes lipid accumulation. First, the mRNA level of LKB1 in adipose tissue of yaks from the cold season is significantly higher than that of yaks from the warm season. Interestingly, overexpression of LKB1 significantly inhibited adipocytes lipid accumulation. Consistently, LKB1 overexpression dramatically suppressed mRNA levels of adipogenic transcriptional factors, including C/EBPα, C/EBPβ and PPARγ, and subsequently significantly decreased levels of lipid accumulation related genes (FABP4 and FAS) compared with those of control. In contrast, overexpression of LKB1 promoted thermogenic and lipolysis related genes in yak adipocyte, including PGC1α, PPARα, UCP1, ATGL, HSL and LPL. Therefore, these results would provide new insights to decipher the network for domestic yak adipose deposition, and LKB1 might be as a new molecular target for animal environmental-resistant breeding. yak adipogenesis adipocyte lipid accumulation liver kinase B1 Veterinary medicine Yonglin Hua verfasserin aut Jing Zhang verfasserin aut Yu Guo verfasserin aut Dan Zhao verfasserin aut Wentao Huo verfasserin aut Yan Xiong verfasserin aut Fenfen Chen verfasserin aut Yaqiu Lin verfasserin aut Xianrong Xiong verfasserin aut Jian Li verfasserin aut In Journal of Applied Animal Research Taylor & Francis Group, 2018 50(2022), 1, Seite 167-176 (DE-627)620142308 (DE-600)2541051-9 09741844 nnns volume:50 year:2022 number:1 pages:167-176 https://doi.org/10.1080/09712119.2022.2042001 kostenfrei https://doaj.org/article/94ac5ce376d449e5abeccbb399380b8a kostenfrei https://www.tandfonline.com/doi/10.1080/09712119.2022.2042001 kostenfrei https://doaj.org/toc/0971-2119 Journal toc kostenfrei https://doaj.org/toc/0974-1844 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4367 GBV_ILN_4700 AR 50 2022 1 167-176
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callnumber-first	S - Agriculture
author	Yongqi Yue
spellingShingle	Yongqi Yue misc SF600-1100 misc yak misc adipogenesis misc adipocyte misc lipid accumulation misc liver kinase B1 misc Veterinary medicine Establishment of a subcutaneous adipogenesis model and distinct roles of LKB1 regulation on adipocyte lipid accumulation in high-altitude Bos grunniens
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topic_title	SF600-1100 Establishment of a subcutaneous adipogenesis model and distinct roles of LKB1 regulation on adipocyte lipid accumulation in high-altitude Bos grunniens yak adipogenesis adipocyte lipid accumulation liver kinase B1
topic	misc SF600-1100 misc yak misc adipogenesis misc adipocyte misc lipid accumulation misc liver kinase B1 misc Veterinary medicine
topic_unstemmed	misc SF600-1100 misc yak misc adipogenesis misc adipocyte misc lipid accumulation misc liver kinase B1 misc Veterinary medicine
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title	Establishment of a subcutaneous adipogenesis model and distinct roles of LKB1 regulation on adipocyte lipid accumulation in high-altitude Bos grunniens
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title_full	Establishment of a subcutaneous adipogenesis model and distinct roles of LKB1 regulation on adipocyte lipid accumulation in high-altitude Bos grunniens
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author_browse	Yongqi Yue Yonglin Hua Jing Zhang Yu Guo Dan Zhao Wentao Huo Yan Xiong Fenfen Chen Yaqiu Lin Xianrong Xiong Jian Li
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title_sort	establishment of a subcutaneous adipogenesis model and distinct roles of lkb1 regulation on adipocyte lipid accumulation in high-altitude bos grunniens
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title_auth	Establishment of a subcutaneous adipogenesis model and distinct roles of LKB1 regulation on adipocyte lipid accumulation in high-altitude Bos grunniens
abstract	The domestic yak was regarded as a valuable model to explore the molecular mechanism of high-altitude animal adaptation, including the extreme tolerance of starvation and cold stress, which is closely associated with specifically seasonal deposition and metabolism of subcutaneous adipose tissue. However, the key regulators for these processes remain largely unknown. Here, the yak adipogenesis model in vitro was established and liver kinase b1 (LKB1) was regarded as a key negative regulator involved in yak adipocytes lipid accumulation. First, the mRNA level of LKB1 in adipose tissue of yaks from the cold season is significantly higher than that of yaks from the warm season. Interestingly, overexpression of LKB1 significantly inhibited adipocytes lipid accumulation. Consistently, LKB1 overexpression dramatically suppressed mRNA levels of adipogenic transcriptional factors, including C/EBPα, C/EBPβ and PPARγ, and subsequently significantly decreased levels of lipid accumulation related genes (FABP4 and FAS) compared with those of control. In contrast, overexpression of LKB1 promoted thermogenic and lipolysis related genes in yak adipocyte, including PGC1α, PPARα, UCP1, ATGL, HSL and LPL. Therefore, these results would provide new insights to decipher the network for domestic yak adipose deposition, and LKB1 might be as a new molecular target for animal environmental-resistant breeding.
abstractGer	The domestic yak was regarded as a valuable model to explore the molecular mechanism of high-altitude animal adaptation, including the extreme tolerance of starvation and cold stress, which is closely associated with specifically seasonal deposition and metabolism of subcutaneous adipose tissue. However, the key regulators for these processes remain largely unknown. Here, the yak adipogenesis model in vitro was established and liver kinase b1 (LKB1) was regarded as a key negative regulator involved in yak adipocytes lipid accumulation. First, the mRNA level of LKB1 in adipose tissue of yaks from the cold season is significantly higher than that of yaks from the warm season. Interestingly, overexpression of LKB1 significantly inhibited adipocytes lipid accumulation. Consistently, LKB1 overexpression dramatically suppressed mRNA levels of adipogenic transcriptional factors, including C/EBPα, C/EBPβ and PPARγ, and subsequently significantly decreased levels of lipid accumulation related genes (FABP4 and FAS) compared with those of control. In contrast, overexpression of LKB1 promoted thermogenic and lipolysis related genes in yak adipocyte, including PGC1α, PPARα, UCP1, ATGL, HSL and LPL. Therefore, these results would provide new insights to decipher the network for domestic yak adipose deposition, and LKB1 might be as a new molecular target for animal environmental-resistant breeding.
abstract_unstemmed	The domestic yak was regarded as a valuable model to explore the molecular mechanism of high-altitude animal adaptation, including the extreme tolerance of starvation and cold stress, which is closely associated with specifically seasonal deposition and metabolism of subcutaneous adipose tissue. However, the key regulators for these processes remain largely unknown. Here, the yak adipogenesis model in vitro was established and liver kinase b1 (LKB1) was regarded as a key negative regulator involved in yak adipocytes lipid accumulation. First, the mRNA level of LKB1 in adipose tissue of yaks from the cold season is significantly higher than that of yaks from the warm season. Interestingly, overexpression of LKB1 significantly inhibited adipocytes lipid accumulation. Consistently, LKB1 overexpression dramatically suppressed mRNA levels of adipogenic transcriptional factors, including C/EBPα, C/EBPβ and PPARγ, and subsequently significantly decreased levels of lipid accumulation related genes (FABP4 and FAS) compared with those of control. In contrast, overexpression of LKB1 promoted thermogenic and lipolysis related genes in yak adipocyte, including PGC1α, PPARα, UCP1, ATGL, HSL and LPL. Therefore, these results would provide new insights to decipher the network for domestic yak adipose deposition, and LKB1 might be as a new molecular target for animal environmental-resistant breeding.
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title_short	Establishment of a subcutaneous adipogenesis model and distinct roles of LKB1 regulation on adipocyte lipid accumulation in high-altitude Bos grunniens
url	https://doi.org/10.1080/09712119.2022.2042001 https://doaj.org/article/94ac5ce376d449e5abeccbb399380b8a https://www.tandfonline.com/doi/10.1080/09712119.2022.2042001 https://doaj.org/toc/0971-2119 https://doaj.org/toc/0974-1844
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author2	Yonglin Hua Jing Zhang Yu Guo Dan Zhao Wentao Huo Yan Xiong Fenfen Chen Yaqiu Lin Xianrong Xiong Jian Li
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up_date	2024-07-03T21:53:19.492Z
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However, the key regulators for these processes remain largely unknown. Here, the yak adipogenesis model in vitro was established and liver kinase b1 (LKB1) was regarded as a key negative regulator involved in yak adipocytes lipid accumulation. First, the mRNA level of LKB1 in adipose tissue of yaks from the cold season is significantly higher than that of yaks from the warm season. Interestingly, overexpression of LKB1 significantly inhibited adipocytes lipid accumulation. Consistently, LKB1 overexpression dramatically suppressed mRNA levels of adipogenic transcriptional factors, including C/EBPα, C/EBPβ and PPARγ, and subsequently significantly decreased levels of lipid accumulation related genes (FABP4 and FAS) compared with those of control. In contrast, overexpression of LKB1 promoted thermogenic and lipolysis related genes in yak adipocyte, including PGC1α, PPARα, UCP1, ATGL, HSL and LPL. 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Establishment of a subcutaneous adipogenesis model and distinct roles of LKB1 regulation on adipocyte lipid accumulation in high-altitude Bos grunniens

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