Association Between IFN-γ Gene Polymorphisms and IgA Nephropathy in a Chinese Han Population

Background/Aims: IFN-γ was reported to be involved in the development and progression of Immunoglobulin A nephropathy (IgAN), however, few studies have investigated the association between IFN-γ polymorphisms and IgAN. Therefore, we performed a case-control study to assess the association between IF...
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Autor*in:	Jie Gao [verfasserIn] Linting Wei [verfasserIn] Xinghan Liu [verfasserIn] Li Wang [verfasserIn] Dan Niu [verfasserIn] Tianbo Jin [verfasserIn] Ganglian Yao [verfasserIn] Meng Wang [verfasserIn] Qiaoling Yu [verfasserIn] Rongguo Fu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	IgA nephropathy IFN-γ Risk Case-control study

Übergeordnetes Werk:	In: Kidney & Blood Pressure Research - Karger Publishers, 2002, 42(2017), 1, Seite 136-144
Übergeordnetes Werk:	volume:42 ; year:2017 ; number:1 ; pages:136-144

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1159/000473889

Katalog-ID:	DOAJ039238814

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520			\|a Background/Aims: IFN-γ was reported to be involved in the development and progression of Immunoglobulin A nephropathy (IgAN), however, few studies have investigated the association between IFN-γ polymorphisms and IgAN. Therefore, we performed a case-control study to assess the association between IFN-γ polymorphisms and the risk of IgAN. Methods: Sequenom MassARRAY was used to genotype two SNPs (rs1861494 and rs2430561) in 351 patients with IgAN and 310 healthy controls. Associations were evaluated as odd ratios (OR) with 95% confidence intervals (CI). Results: No association was found between IFN-γ rs1861494 and IgAN risk or clinical parameters. For rs2430561, the AA genotype was more common in patients with IgAN, compared with controls (AT vs. AA: OR = 0.57, P = 0.035). IFN-γ-rs2430561 T allele may be a protective factor for IgAN susceptibility (T vs. A: OR = 0.59, P = 0.04). Subgroup analysis based on clinical features revealed no significant association between rs2430561 polymorphism and clinical data such as gender, 24-h urine protein, blood pressure, Oxford classifcation and estimated glomerular fltration rate. IgAN patients had a higher IFN-γ serum level than healthy controls and patients with rs1861494 AA genotype had a higher IFN-γ serum level compared with those with AG/GG genotypes. Conclusions: IFN-γ polymorphisms may be involved in the development and progression of IgAN.
650		4	\|a IgA nephropathy
650		4	\|a IFN-γ
650		4	\|a Risk
650		4	\|a Case-control study
653		0	\|a Dermatology
653		0	\|a Diseases of the circulatory (Cardiovascular) system
653		0	\|a Diseases of the genitourinary system. Urology
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700	0		\|a Rongguo Fu \|e verfasserin \|4 aut
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allfields	10.1159/000473889 doi (DE-627)DOAJ039238814 (DE-599)DOAJ0221b3fc9c854b11937c21bd63c3aa40 DE-627 ger DE-627 rakwb eng RL1-803 RC666-701 RC870-923 Jie Gao verfasserin aut Association Between IFN-γ Gene Polymorphisms and IgA Nephropathy in a Chinese Han Population 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background/Aims: IFN-γ was reported to be involved in the development and progression of Immunoglobulin A nephropathy (IgAN), however, few studies have investigated the association between IFN-γ polymorphisms and IgAN. Therefore, we performed a case-control study to assess the association between IFN-γ polymorphisms and the risk of IgAN. Methods: Sequenom MassARRAY was used to genotype two SNPs (rs1861494 and rs2430561) in 351 patients with IgAN and 310 healthy controls. Associations were evaluated as odd ratios (OR) with 95% confidence intervals (CI). Results: No association was found between IFN-γ rs1861494 and IgAN risk or clinical parameters. For rs2430561, the AA genotype was more common in patients with IgAN, compared with controls (AT vs. AA: OR = 0.57, P = 0.035). IFN-γ-rs2430561 T allele may be a protective factor for IgAN susceptibility (T vs. A: OR = 0.59, P = 0.04). Subgroup analysis based on clinical features revealed no significant association between rs2430561 polymorphism and clinical data such as gender, 24-h urine protein, blood pressure, Oxford classifcation and estimated glomerular fltration rate. IgAN patients had a higher IFN-γ serum level than healthy controls and patients with rs1861494 AA genotype had a higher IFN-γ serum level compared with those with AG/GG genotypes. Conclusions: IFN-γ polymorphisms may be involved in the development and progression of IgAN. IgA nephropathy IFN-γ Risk Case-control study Dermatology Diseases of the circulatory (Cardiovascular) system Diseases of the genitourinary system. Urology Linting Wei verfasserin aut Xinghan Liu verfasserin aut Li Wang verfasserin aut Dan Niu verfasserin aut Tianbo Jin verfasserin aut Ganglian Yao verfasserin aut Meng Wang verfasserin aut Qiaoling Yu verfasserin aut Rongguo Fu verfasserin aut In Kidney & Blood Pressure Research Karger Publishers, 2002 42(2017), 1, Seite 136-144 (DE-627)300593767 (DE-600)1482922-8 14230143 nnns volume:42 year:2017 number:1 pages:136-144 https://doi.org/10.1159/000473889 kostenfrei https://doaj.org/article/0221b3fc9c854b11937c21bd63c3aa40 kostenfrei http://www.karger.com/Article/FullText/473889 kostenfrei https://doaj.org/toc/1420-4096 Journal toc kostenfrei https://doaj.org/toc/1423-0143 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2018 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 42 2017 1 136-144
spelling	10.1159/000473889 doi (DE-627)DOAJ039238814 (DE-599)DOAJ0221b3fc9c854b11937c21bd63c3aa40 DE-627 ger DE-627 rakwb eng RL1-803 RC666-701 RC870-923 Jie Gao verfasserin aut Association Between IFN-γ Gene Polymorphisms and IgA Nephropathy in a Chinese Han Population 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background/Aims: IFN-γ was reported to be involved in the development and progression of Immunoglobulin A nephropathy (IgAN), however, few studies have investigated the association between IFN-γ polymorphisms and IgAN. Therefore, we performed a case-control study to assess the association between IFN-γ polymorphisms and the risk of IgAN. Methods: Sequenom MassARRAY was used to genotype two SNPs (rs1861494 and rs2430561) in 351 patients with IgAN and 310 healthy controls. Associations were evaluated as odd ratios (OR) with 95% confidence intervals (CI). Results: No association was found between IFN-γ rs1861494 and IgAN risk or clinical parameters. For rs2430561, the AA genotype was more common in patients with IgAN, compared with controls (AT vs. AA: OR = 0.57, P = 0.035). IFN-γ-rs2430561 T allele may be a protective factor for IgAN susceptibility (T vs. A: OR = 0.59, P = 0.04). Subgroup analysis based on clinical features revealed no significant association between rs2430561 polymorphism and clinical data such as gender, 24-h urine protein, blood pressure, Oxford classifcation and estimated glomerular fltration rate. IgAN patients had a higher IFN-γ serum level than healthy controls and patients with rs1861494 AA genotype had a higher IFN-γ serum level compared with those with AG/GG genotypes. Conclusions: IFN-γ polymorphisms may be involved in the development and progression of IgAN. IgA nephropathy IFN-γ Risk Case-control study Dermatology Diseases of the circulatory (Cardiovascular) system Diseases of the genitourinary system. Urology Linting Wei verfasserin aut Xinghan Liu verfasserin aut Li Wang verfasserin aut Dan Niu verfasserin aut Tianbo Jin verfasserin aut Ganglian Yao verfasserin aut Meng Wang verfasserin aut Qiaoling Yu verfasserin aut Rongguo Fu verfasserin aut In Kidney & Blood Pressure Research Karger Publishers, 2002 42(2017), 1, Seite 136-144 (DE-627)300593767 (DE-600)1482922-8 14230143 nnns volume:42 year:2017 number:1 pages:136-144 https://doi.org/10.1159/000473889 kostenfrei https://doaj.org/article/0221b3fc9c854b11937c21bd63c3aa40 kostenfrei http://www.karger.com/Article/FullText/473889 kostenfrei https://doaj.org/toc/1420-4096 Journal toc kostenfrei https://doaj.org/toc/1423-0143 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2018 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 42 2017 1 136-144
allfields_unstemmed	10.1159/000473889 doi (DE-627)DOAJ039238814 (DE-599)DOAJ0221b3fc9c854b11937c21bd63c3aa40 DE-627 ger DE-627 rakwb eng RL1-803 RC666-701 RC870-923 Jie Gao verfasserin aut Association Between IFN-γ Gene Polymorphisms and IgA Nephropathy in a Chinese Han Population 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background/Aims: IFN-γ was reported to be involved in the development and progression of Immunoglobulin A nephropathy (IgAN), however, few studies have investigated the association between IFN-γ polymorphisms and IgAN. Therefore, we performed a case-control study to assess the association between IFN-γ polymorphisms and the risk of IgAN. Methods: Sequenom MassARRAY was used to genotype two SNPs (rs1861494 and rs2430561) in 351 patients with IgAN and 310 healthy controls. Associations were evaluated as odd ratios (OR) with 95% confidence intervals (CI). Results: No association was found between IFN-γ rs1861494 and IgAN risk or clinical parameters. For rs2430561, the AA genotype was more common in patients with IgAN, compared with controls (AT vs. AA: OR = 0.57, P = 0.035). IFN-γ-rs2430561 T allele may be a protective factor for IgAN susceptibility (T vs. A: OR = 0.59, P = 0.04). Subgroup analysis based on clinical features revealed no significant association between rs2430561 polymorphism and clinical data such as gender, 24-h urine protein, blood pressure, Oxford classifcation and estimated glomerular fltration rate. IgAN patients had a higher IFN-γ serum level than healthy controls and patients with rs1861494 AA genotype had a higher IFN-γ serum level compared with those with AG/GG genotypes. Conclusions: IFN-γ polymorphisms may be involved in the development and progression of IgAN. IgA nephropathy IFN-γ Risk Case-control study Dermatology Diseases of the circulatory (Cardiovascular) system Diseases of the genitourinary system. Urology Linting Wei verfasserin aut Xinghan Liu verfasserin aut Li Wang verfasserin aut Dan Niu verfasserin aut Tianbo Jin verfasserin aut Ganglian Yao verfasserin aut Meng Wang verfasserin aut Qiaoling Yu verfasserin aut Rongguo Fu verfasserin aut In Kidney & Blood Pressure Research Karger Publishers, 2002 42(2017), 1, Seite 136-144 (DE-627)300593767 (DE-600)1482922-8 14230143 nnns volume:42 year:2017 number:1 pages:136-144 https://doi.org/10.1159/000473889 kostenfrei https://doaj.org/article/0221b3fc9c854b11937c21bd63c3aa40 kostenfrei http://www.karger.com/Article/FullText/473889 kostenfrei https://doaj.org/toc/1420-4096 Journal toc kostenfrei https://doaj.org/toc/1423-0143 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2018 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 42 2017 1 136-144
allfieldsGer	10.1159/000473889 doi (DE-627)DOAJ039238814 (DE-599)DOAJ0221b3fc9c854b11937c21bd63c3aa40 DE-627 ger DE-627 rakwb eng RL1-803 RC666-701 RC870-923 Jie Gao verfasserin aut Association Between IFN-γ Gene Polymorphisms and IgA Nephropathy in a Chinese Han Population 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background/Aims: IFN-γ was reported to be involved in the development and progression of Immunoglobulin A nephropathy (IgAN), however, few studies have investigated the association between IFN-γ polymorphisms and IgAN. Therefore, we performed a case-control study to assess the association between IFN-γ polymorphisms and the risk of IgAN. Methods: Sequenom MassARRAY was used to genotype two SNPs (rs1861494 and rs2430561) in 351 patients with IgAN and 310 healthy controls. Associations were evaluated as odd ratios (OR) with 95% confidence intervals (CI). Results: No association was found between IFN-γ rs1861494 and IgAN risk or clinical parameters. For rs2430561, the AA genotype was more common in patients with IgAN, compared with controls (AT vs. AA: OR = 0.57, P = 0.035). IFN-γ-rs2430561 T allele may be a protective factor for IgAN susceptibility (T vs. A: OR = 0.59, P = 0.04). Subgroup analysis based on clinical features revealed no significant association between rs2430561 polymorphism and clinical data such as gender, 24-h urine protein, blood pressure, Oxford classifcation and estimated glomerular fltration rate. IgAN patients had a higher IFN-γ serum level than healthy controls and patients with rs1861494 AA genotype had a higher IFN-γ serum level compared with those with AG/GG genotypes. Conclusions: IFN-γ polymorphisms may be involved in the development and progression of IgAN. IgA nephropathy IFN-γ Risk Case-control study Dermatology Diseases of the circulatory (Cardiovascular) system Diseases of the genitourinary system. Urology Linting Wei verfasserin aut Xinghan Liu verfasserin aut Li Wang verfasserin aut Dan Niu verfasserin aut Tianbo Jin verfasserin aut Ganglian Yao verfasserin aut Meng Wang verfasserin aut Qiaoling Yu verfasserin aut Rongguo Fu verfasserin aut In Kidney & Blood Pressure Research Karger Publishers, 2002 42(2017), 1, Seite 136-144 (DE-627)300593767 (DE-600)1482922-8 14230143 nnns volume:42 year:2017 number:1 pages:136-144 https://doi.org/10.1159/000473889 kostenfrei https://doaj.org/article/0221b3fc9c854b11937c21bd63c3aa40 kostenfrei http://www.karger.com/Article/FullText/473889 kostenfrei https://doaj.org/toc/1420-4096 Journal toc kostenfrei https://doaj.org/toc/1423-0143 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2018 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 42 2017 1 136-144
allfieldsSound	10.1159/000473889 doi (DE-627)DOAJ039238814 (DE-599)DOAJ0221b3fc9c854b11937c21bd63c3aa40 DE-627 ger DE-627 rakwb eng RL1-803 RC666-701 RC870-923 Jie Gao verfasserin aut Association Between IFN-γ Gene Polymorphisms and IgA Nephropathy in a Chinese Han Population 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background/Aims: IFN-γ was reported to be involved in the development and progression of Immunoglobulin A nephropathy (IgAN), however, few studies have investigated the association between IFN-γ polymorphisms and IgAN. Therefore, we performed a case-control study to assess the association between IFN-γ polymorphisms and the risk of IgAN. Methods: Sequenom MassARRAY was used to genotype two SNPs (rs1861494 and rs2430561) in 351 patients with IgAN and 310 healthy controls. Associations were evaluated as odd ratios (OR) with 95% confidence intervals (CI). Results: No association was found between IFN-γ rs1861494 and IgAN risk or clinical parameters. For rs2430561, the AA genotype was more common in patients with IgAN, compared with controls (AT vs. AA: OR = 0.57, P = 0.035). IFN-γ-rs2430561 T allele may be a protective factor for IgAN susceptibility (T vs. A: OR = 0.59, P = 0.04). Subgroup analysis based on clinical features revealed no significant association between rs2430561 polymorphism and clinical data such as gender, 24-h urine protein, blood pressure, Oxford classifcation and estimated glomerular fltration rate. IgAN patients had a higher IFN-γ serum level than healthy controls and patients with rs1861494 AA genotype had a higher IFN-γ serum level compared with those with AG/GG genotypes. Conclusions: IFN-γ polymorphisms may be involved in the development and progression of IgAN. IgA nephropathy IFN-γ Risk Case-control study Dermatology Diseases of the circulatory (Cardiovascular) system Diseases of the genitourinary system. Urology Linting Wei verfasserin aut Xinghan Liu verfasserin aut Li Wang verfasserin aut Dan Niu verfasserin aut Tianbo Jin verfasserin aut Ganglian Yao verfasserin aut Meng Wang verfasserin aut Qiaoling Yu verfasserin aut Rongguo Fu verfasserin aut In Kidney & Blood Pressure Research Karger Publishers, 2002 42(2017), 1, Seite 136-144 (DE-627)300593767 (DE-600)1482922-8 14230143 nnns volume:42 year:2017 number:1 pages:136-144 https://doi.org/10.1159/000473889 kostenfrei https://doaj.org/article/0221b3fc9c854b11937c21bd63c3aa40 kostenfrei http://www.karger.com/Article/FullText/473889 kostenfrei https://doaj.org/toc/1420-4096 Journal toc kostenfrei https://doaj.org/toc/1423-0143 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2018 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 42 2017 1 136-144
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authorswithroles_txt_mv	Jie Gao @@aut@@ Linting Wei @@aut@@ Xinghan Liu @@aut@@ Li Wang @@aut@@ Dan Niu @@aut@@ Tianbo Jin @@aut@@ Ganglian Yao @@aut@@ Meng Wang @@aut@@ Qiaoling Yu @@aut@@ Rongguo Fu @@aut@@
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callnumber-first	R - Medicine
author	Jie Gao
spellingShingle	Jie Gao misc RL1-803 misc RC666-701 misc RC870-923 misc IgA nephropathy misc IFN-γ misc Risk misc Case-control study misc Dermatology misc Diseases of the circulatory (Cardiovascular) system misc Diseases of the genitourinary system. Urology Association Between IFN-γ Gene Polymorphisms and IgA Nephropathy in a Chinese Han Population
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topic_title	RL1-803 RC666-701 RC870-923 Association Between IFN-γ Gene Polymorphisms and IgA Nephropathy in a Chinese Han Population IgA nephropathy IFN-γ Risk Case-control study
topic	misc RL1-803 misc RC666-701 misc RC870-923 misc IgA nephropathy misc IFN-γ misc Risk misc Case-control study misc Dermatology misc Diseases of the circulatory (Cardiovascular) system misc Diseases of the genitourinary system. Urology
topic_unstemmed	misc RL1-803 misc RC666-701 misc RC870-923 misc IgA nephropathy misc IFN-γ misc Risk misc Case-control study misc Dermatology misc Diseases of the circulatory (Cardiovascular) system misc Diseases of the genitourinary system. Urology
topic_browse	misc RL1-803 misc RC666-701 misc RC870-923 misc IgA nephropathy misc IFN-γ misc Risk misc Case-control study misc Dermatology misc Diseases of the circulatory (Cardiovascular) system misc Diseases of the genitourinary system. Urology
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title	Association Between IFN-γ Gene Polymorphisms and IgA Nephropathy in a Chinese Han Population
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title_full	Association Between IFN-γ Gene Polymorphisms and IgA Nephropathy in a Chinese Han Population
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title_sort	association between ifn-γ gene polymorphisms and iga nephropathy in a chinese han population
callnumber	RL1-803
title_auth	Association Between IFN-γ Gene Polymorphisms and IgA Nephropathy in a Chinese Han Population
abstract	Background/Aims: IFN-γ was reported to be involved in the development and progression of Immunoglobulin A nephropathy (IgAN), however, few studies have investigated the association between IFN-γ polymorphisms and IgAN. Therefore, we performed a case-control study to assess the association between IFN-γ polymorphisms and the risk of IgAN. Methods: Sequenom MassARRAY was used to genotype two SNPs (rs1861494 and rs2430561) in 351 patients with IgAN and 310 healthy controls. Associations were evaluated as odd ratios (OR) with 95% confidence intervals (CI). Results: No association was found between IFN-γ rs1861494 and IgAN risk or clinical parameters. For rs2430561, the AA genotype was more common in patients with IgAN, compared with controls (AT vs. AA: OR = 0.57, P = 0.035). IFN-γ-rs2430561 T allele may be a protective factor for IgAN susceptibility (T vs. A: OR = 0.59, P = 0.04). Subgroup analysis based on clinical features revealed no significant association between rs2430561 polymorphism and clinical data such as gender, 24-h urine protein, blood pressure, Oxford classifcation and estimated glomerular fltration rate. IgAN patients had a higher IFN-γ serum level than healthy controls and patients with rs1861494 AA genotype had a higher IFN-γ serum level compared with those with AG/GG genotypes. Conclusions: IFN-γ polymorphisms may be involved in the development and progression of IgAN.
abstractGer	Background/Aims: IFN-γ was reported to be involved in the development and progression of Immunoglobulin A nephropathy (IgAN), however, few studies have investigated the association between IFN-γ polymorphisms and IgAN. Therefore, we performed a case-control study to assess the association between IFN-γ polymorphisms and the risk of IgAN. Methods: Sequenom MassARRAY was used to genotype two SNPs (rs1861494 and rs2430561) in 351 patients with IgAN and 310 healthy controls. Associations were evaluated as odd ratios (OR) with 95% confidence intervals (CI). Results: No association was found between IFN-γ rs1861494 and IgAN risk or clinical parameters. For rs2430561, the AA genotype was more common in patients with IgAN, compared with controls (AT vs. AA: OR = 0.57, P = 0.035). IFN-γ-rs2430561 T allele may be a protective factor for IgAN susceptibility (T vs. A: OR = 0.59, P = 0.04). Subgroup analysis based on clinical features revealed no significant association between rs2430561 polymorphism and clinical data such as gender, 24-h urine protein, blood pressure, Oxford classifcation and estimated glomerular fltration rate. IgAN patients had a higher IFN-γ serum level than healthy controls and patients with rs1861494 AA genotype had a higher IFN-γ serum level compared with those with AG/GG genotypes. Conclusions: IFN-γ polymorphisms may be involved in the development and progression of IgAN.
abstract_unstemmed	Background/Aims: IFN-γ was reported to be involved in the development and progression of Immunoglobulin A nephropathy (IgAN), however, few studies have investigated the association between IFN-γ polymorphisms and IgAN. Therefore, we performed a case-control study to assess the association between IFN-γ polymorphisms and the risk of IgAN. Methods: Sequenom MassARRAY was used to genotype two SNPs (rs1861494 and rs2430561) in 351 patients with IgAN and 310 healthy controls. Associations were evaluated as odd ratios (OR) with 95% confidence intervals (CI). Results: No association was found between IFN-γ rs1861494 and IgAN risk or clinical parameters. For rs2430561, the AA genotype was more common in patients with IgAN, compared with controls (AT vs. AA: OR = 0.57, P = 0.035). IFN-γ-rs2430561 T allele may be a protective factor for IgAN susceptibility (T vs. A: OR = 0.59, P = 0.04). Subgroup analysis based on clinical features revealed no significant association between rs2430561 polymorphism and clinical data such as gender, 24-h urine protein, blood pressure, Oxford classifcation and estimated glomerular fltration rate. IgAN patients had a higher IFN-γ serum level than healthy controls and patients with rs1861494 AA genotype had a higher IFN-γ serum level compared with those with AG/GG genotypes. Conclusions: IFN-γ polymorphisms may be involved in the development and progression of IgAN.
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title_short	Association Between IFN-γ Gene Polymorphisms and IgA Nephropathy in a Chinese Han Population
url	https://doi.org/10.1159/000473889 https://doaj.org/article/0221b3fc9c854b11937c21bd63c3aa40 http://www.karger.com/Article/FullText/473889 https://doaj.org/toc/1420-4096 https://doaj.org/toc/1423-0143
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">DOAJ039238814</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230308030139.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">230227s2017 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1159/000473889</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ039238814</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ0221b3fc9c854b11937c21bd63c3aa40</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RL1-803</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC666-701</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC870-923</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Jie Gao</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Association Between IFN-γ Gene Polymorphisms and IgA Nephropathy in a Chinese Han Population</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2017</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background/Aims: IFN-γ was reported to be involved in the development and progression of Immunoglobulin A nephropathy (IgAN), however, few studies have investigated the association between IFN-γ polymorphisms and IgAN. Therefore, we performed a case-control study to assess the association between IFN-γ polymorphisms and the risk of IgAN. Methods: Sequenom MassARRAY was used to genotype two SNPs (rs1861494 and rs2430561) in 351 patients with IgAN and 310 healthy controls. Associations were evaluated as odd ratios (OR) with 95% confidence intervals (CI). Results: No association was found between IFN-γ rs1861494 and IgAN risk or clinical parameters. For rs2430561, the AA genotype was more common in patients with IgAN, compared with controls (AT vs. AA: OR = 0.57, P = 0.035). IFN-γ-rs2430561 T allele may be a protective factor for IgAN susceptibility (T vs. A: OR = 0.59, P = 0.04). Subgroup analysis based on clinical features revealed no significant association between rs2430561 polymorphism and clinical data such as gender, 24-h urine protein, blood pressure, Oxford classifcation and estimated glomerular fltration rate. IgAN patients had a higher IFN-γ serum level than healthy controls and patients with rs1861494 AA genotype had a higher IFN-γ serum level compared with those with AG/GG genotypes. Conclusions: IFN-γ polymorphisms may be involved in the development and progression of IgAN.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">IgA nephropathy</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">IFN-γ</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Risk</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Case-control study</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Dermatology</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Diseases of the circulatory (Cardiovascular) system</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Diseases of the genitourinary system. 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Association Between IFN-γ Gene Polymorphisms and IgA Nephropathy in a Chinese Han Population

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