Developing a set of ancestry-sensitive DNA markers reflecting continental origins of humans

<p<Abstract</p< <p<Background</p< <p<The identification and use of Ancestry-Sensitive Markers (ASMs), i.e. genetic polymorphisms facilitating the genetic reconstruction of geographical origins of individuals, is far from straightforward.</p< <p<Results</p...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	den Dunnen Johan T [verfasserIn] Kloosterman Ate D [verfasserIn] van Duijn Kate [verfasserIn] Kersbergen Paula [verfasserIn] Kayser Manfred [verfasserIn] de Knijff Peter [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2009

Übergeordnetes Werk:	In: BMC Genetics - BMC, 2003, 10(2009), 1, p 69
Übergeordnetes Werk:	volume:10 ; year:2009 ; number:1, p 69

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/1471-2156-10-69

Katalog-ID:	DOAJ039296997

Internformat


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allfields	10.1186/1471-2156-10-69 doi (DE-627)DOAJ039296997 (DE-599)DOAJda3dc73bae434ef284902c1fb5d118c9 DE-627 ger DE-627 rakwb eng QH426-470 den Dunnen Johan T verfasserin aut Developing a set of ancestry-sensitive DNA markers reflecting continental origins of humans 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The identification and use of Ancestry-Sensitive Markers (ASMs), i.e. genetic polymorphisms facilitating the genetic reconstruction of geographical origins of individuals, is far from straightforward.</p< <p<Results</p< <p<Here we describe the ascertainment and application of five different sets of 47 single nucleotide polymorphisms (SNPs) allowing the inference of major human groups of different continental origin. For this, we first used 74 cell lines, representing human males from six different geographical areas and screened them with the Affymetrix Mapping 10K assay. In addition to using summary statistics estimating the genetic diversity among multiple groups of individuals defined by geography or language, we also used the program STRUCTURE to detect genetically distinct subgroups. Subsequently, we used a <it<pairwise </it<F<sub<ST </sub<ranking procedure among all pairs of genetic subgroups in order to identify a single best performing set of ASMs. Our initial results were independently confirmed by genotyping this set of ASMs in 22 individuals from Somalia, Afghanistan and Sudan and in 919 samples from the CEPH Human Genome Diversity Panel (HGDP-CEPH)</p< <p<Conclusion</p< <p<By means of our <it<pairwise </it<population F<sub<ST </sub<ranking approach we identified a set of 47 SNPs that could serve as a panel of ASMs at a continental level.</p< Genetics Kloosterman Ate D verfasserin aut van Duijn Kate verfasserin aut Kersbergen Paula verfasserin aut Kayser Manfred verfasserin aut de Knijff Peter verfasserin aut In BMC Genetics BMC, 2003 10(2009), 1, p 69 (DE-627)326644938 (DE-600)2041497-3 14712156 nnns volume:10 year:2009 number:1, p 69 https://doi.org/10.1186/1471-2156-10-69 kostenfrei https://doaj.org/article/da3dc73bae434ef284902c1fb5d118c9 kostenfrei http://www.biomedcentral.com/1471-2156/10/69 kostenfrei https://doaj.org/toc/1471-2156 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2009 1, p 69
spelling	10.1186/1471-2156-10-69 doi (DE-627)DOAJ039296997 (DE-599)DOAJda3dc73bae434ef284902c1fb5d118c9 DE-627 ger DE-627 rakwb eng QH426-470 den Dunnen Johan T verfasserin aut Developing a set of ancestry-sensitive DNA markers reflecting continental origins of humans 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The identification and use of Ancestry-Sensitive Markers (ASMs), i.e. genetic polymorphisms facilitating the genetic reconstruction of geographical origins of individuals, is far from straightforward.</p< <p<Results</p< <p<Here we describe the ascertainment and application of five different sets of 47 single nucleotide polymorphisms (SNPs) allowing the inference of major human groups of different continental origin. For this, we first used 74 cell lines, representing human males from six different geographical areas and screened them with the Affymetrix Mapping 10K assay. In addition to using summary statistics estimating the genetic diversity among multiple groups of individuals defined by geography or language, we also used the program STRUCTURE to detect genetically distinct subgroups. Subsequently, we used a <it<pairwise </it<F<sub<ST </sub<ranking procedure among all pairs of genetic subgroups in order to identify a single best performing set of ASMs. Our initial results were independently confirmed by genotyping this set of ASMs in 22 individuals from Somalia, Afghanistan and Sudan and in 919 samples from the CEPH Human Genome Diversity Panel (HGDP-CEPH)</p< <p<Conclusion</p< <p<By means of our <it<pairwise </it<population F<sub<ST </sub<ranking approach we identified a set of 47 SNPs that could serve as a panel of ASMs at a continental level.</p< Genetics Kloosterman Ate D verfasserin aut van Duijn Kate verfasserin aut Kersbergen Paula verfasserin aut Kayser Manfred verfasserin aut de Knijff Peter verfasserin aut In BMC Genetics BMC, 2003 10(2009), 1, p 69 (DE-627)326644938 (DE-600)2041497-3 14712156 nnns volume:10 year:2009 number:1, p 69 https://doi.org/10.1186/1471-2156-10-69 kostenfrei https://doaj.org/article/da3dc73bae434ef284902c1fb5d118c9 kostenfrei http://www.biomedcentral.com/1471-2156/10/69 kostenfrei https://doaj.org/toc/1471-2156 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2009 1, p 69
allfields_unstemmed	10.1186/1471-2156-10-69 doi (DE-627)DOAJ039296997 (DE-599)DOAJda3dc73bae434ef284902c1fb5d118c9 DE-627 ger DE-627 rakwb eng QH426-470 den Dunnen Johan T verfasserin aut Developing a set of ancestry-sensitive DNA markers reflecting continental origins of humans 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The identification and use of Ancestry-Sensitive Markers (ASMs), i.e. genetic polymorphisms facilitating the genetic reconstruction of geographical origins of individuals, is far from straightforward.</p< <p<Results</p< <p<Here we describe the ascertainment and application of five different sets of 47 single nucleotide polymorphisms (SNPs) allowing the inference of major human groups of different continental origin. For this, we first used 74 cell lines, representing human males from six different geographical areas and screened them with the Affymetrix Mapping 10K assay. In addition to using summary statistics estimating the genetic diversity among multiple groups of individuals defined by geography or language, we also used the program STRUCTURE to detect genetically distinct subgroups. Subsequently, we used a <it<pairwise </it<F<sub<ST </sub<ranking procedure among all pairs of genetic subgroups in order to identify a single best performing set of ASMs. Our initial results were independently confirmed by genotyping this set of ASMs in 22 individuals from Somalia, Afghanistan and Sudan and in 919 samples from the CEPH Human Genome Diversity Panel (HGDP-CEPH)</p< <p<Conclusion</p< <p<By means of our <it<pairwise </it<population F<sub<ST </sub<ranking approach we identified a set of 47 SNPs that could serve as a panel of ASMs at a continental level.</p< Genetics Kloosterman Ate D verfasserin aut van Duijn Kate verfasserin aut Kersbergen Paula verfasserin aut Kayser Manfred verfasserin aut de Knijff Peter verfasserin aut In BMC Genetics BMC, 2003 10(2009), 1, p 69 (DE-627)326644938 (DE-600)2041497-3 14712156 nnns volume:10 year:2009 number:1, p 69 https://doi.org/10.1186/1471-2156-10-69 kostenfrei https://doaj.org/article/da3dc73bae434ef284902c1fb5d118c9 kostenfrei http://www.biomedcentral.com/1471-2156/10/69 kostenfrei https://doaj.org/toc/1471-2156 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2009 1, p 69
allfieldsGer	10.1186/1471-2156-10-69 doi (DE-627)DOAJ039296997 (DE-599)DOAJda3dc73bae434ef284902c1fb5d118c9 DE-627 ger DE-627 rakwb eng QH426-470 den Dunnen Johan T verfasserin aut Developing a set of ancestry-sensitive DNA markers reflecting continental origins of humans 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The identification and use of Ancestry-Sensitive Markers (ASMs), i.e. genetic polymorphisms facilitating the genetic reconstruction of geographical origins of individuals, is far from straightforward.</p< <p<Results</p< <p<Here we describe the ascertainment and application of five different sets of 47 single nucleotide polymorphisms (SNPs) allowing the inference of major human groups of different continental origin. For this, we first used 74 cell lines, representing human males from six different geographical areas and screened them with the Affymetrix Mapping 10K assay. In addition to using summary statistics estimating the genetic diversity among multiple groups of individuals defined by geography or language, we also used the program STRUCTURE to detect genetically distinct subgroups. Subsequently, we used a <it<pairwise </it<F<sub<ST </sub<ranking procedure among all pairs of genetic subgroups in order to identify a single best performing set of ASMs. Our initial results were independently confirmed by genotyping this set of ASMs in 22 individuals from Somalia, Afghanistan and Sudan and in 919 samples from the CEPH Human Genome Diversity Panel (HGDP-CEPH)</p< <p<Conclusion</p< <p<By means of our <it<pairwise </it<population F<sub<ST </sub<ranking approach we identified a set of 47 SNPs that could serve as a panel of ASMs at a continental level.</p< Genetics Kloosterman Ate D verfasserin aut van Duijn Kate verfasserin aut Kersbergen Paula verfasserin aut Kayser Manfred verfasserin aut de Knijff Peter verfasserin aut In BMC Genetics BMC, 2003 10(2009), 1, p 69 (DE-627)326644938 (DE-600)2041497-3 14712156 nnns volume:10 year:2009 number:1, p 69 https://doi.org/10.1186/1471-2156-10-69 kostenfrei https://doaj.org/article/da3dc73bae434ef284902c1fb5d118c9 kostenfrei http://www.biomedcentral.com/1471-2156/10/69 kostenfrei https://doaj.org/toc/1471-2156 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2009 1, p 69
allfieldsSound	10.1186/1471-2156-10-69 doi (DE-627)DOAJ039296997 (DE-599)DOAJda3dc73bae434ef284902c1fb5d118c9 DE-627 ger DE-627 rakwb eng QH426-470 den Dunnen Johan T verfasserin aut Developing a set of ancestry-sensitive DNA markers reflecting continental origins of humans 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <p<Abstract</p< <p<Background</p< <p<The identification and use of Ancestry-Sensitive Markers (ASMs), i.e. genetic polymorphisms facilitating the genetic reconstruction of geographical origins of individuals, is far from straightforward.</p< <p<Results</p< <p<Here we describe the ascertainment and application of five different sets of 47 single nucleotide polymorphisms (SNPs) allowing the inference of major human groups of different continental origin. For this, we first used 74 cell lines, representing human males from six different geographical areas and screened them with the Affymetrix Mapping 10K assay. In addition to using summary statistics estimating the genetic diversity among multiple groups of individuals defined by geography or language, we also used the program STRUCTURE to detect genetically distinct subgroups. Subsequently, we used a <it<pairwise </it<F<sub<ST </sub<ranking procedure among all pairs of genetic subgroups in order to identify a single best performing set of ASMs. Our initial results were independently confirmed by genotyping this set of ASMs in 22 individuals from Somalia, Afghanistan and Sudan and in 919 samples from the CEPH Human Genome Diversity Panel (HGDP-CEPH)</p< <p<Conclusion</p< <p<By means of our <it<pairwise </it<population F<sub<ST </sub<ranking approach we identified a set of 47 SNPs that could serve as a panel of ASMs at a continental level.</p< Genetics Kloosterman Ate D verfasserin aut van Duijn Kate verfasserin aut Kersbergen Paula verfasserin aut Kayser Manfred verfasserin aut de Knijff Peter verfasserin aut In BMC Genetics BMC, 2003 10(2009), 1, p 69 (DE-627)326644938 (DE-600)2041497-3 14712156 nnns volume:10 year:2009 number:1, p 69 https://doi.org/10.1186/1471-2156-10-69 kostenfrei https://doaj.org/article/da3dc73bae434ef284902c1fb5d118c9 kostenfrei http://www.biomedcentral.com/1471-2156/10/69 kostenfrei https://doaj.org/toc/1471-2156 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2009 1, p 69
language	English
source	In BMC Genetics 10(2009), 1, p 69 volume:10 year:2009 number:1, p 69
sourceStr	In BMC Genetics 10(2009), 1, p 69 volume:10 year:2009 number:1, p 69
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Genetics
isfreeaccess_bool	true
container_title	BMC Genetics
authorswithroles_txt_mv	den Dunnen Johan T @@aut@@ Kloosterman Ate D @@aut@@ van Duijn Kate @@aut@@ Kersbergen Paula @@aut@@ Kayser Manfred @@aut@@ de Knijff Peter @@aut@@
publishDateDaySort_date	2009-01-01T00:00:00Z
hierarchy_top_id	326644938
id	DOAJ039296997
language_de	englisch
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author	den Dunnen Johan T
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topic_title	QH426-470 Developing a set of ancestry-sensitive DNA markers reflecting continental origins of humans
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title	Developing a set of ancestry-sensitive DNA markers reflecting continental origins of humans
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title_full	Developing a set of ancestry-sensitive DNA markers reflecting continental origins of humans
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title_sort	developing a set of ancestry-sensitive dna markers reflecting continental origins of humans
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title_auth	Developing a set of ancestry-sensitive DNA markers reflecting continental origins of humans
abstract	<p<Abstract</p< <p<Background</p< <p<The identification and use of Ancestry-Sensitive Markers (ASMs), i.e. genetic polymorphisms facilitating the genetic reconstruction of geographical origins of individuals, is far from straightforward.</p< <p<Results</p< <p<Here we describe the ascertainment and application of five different sets of 47 single nucleotide polymorphisms (SNPs) allowing the inference of major human groups of different continental origin. For this, we first used 74 cell lines, representing human males from six different geographical areas and screened them with the Affymetrix Mapping 10K assay. In addition to using summary statistics estimating the genetic diversity among multiple groups of individuals defined by geography or language, we also used the program STRUCTURE to detect genetically distinct subgroups. Subsequently, we used a <it<pairwise </it<F<sub<ST </sub<ranking procedure among all pairs of genetic subgroups in order to identify a single best performing set of ASMs. Our initial results were independently confirmed by genotyping this set of ASMs in 22 individuals from Somalia, Afghanistan and Sudan and in 919 samples from the CEPH Human Genome Diversity Panel (HGDP-CEPH)</p< <p<Conclusion</p< <p<By means of our <it<pairwise </it<population F<sub<ST </sub<ranking approach we identified a set of 47 SNPs that could serve as a panel of ASMs at a continental level.</p<
abstractGer	<p<Abstract</p< <p<Background</p< <p<The identification and use of Ancestry-Sensitive Markers (ASMs), i.e. genetic polymorphisms facilitating the genetic reconstruction of geographical origins of individuals, is far from straightforward.</p< <p<Results</p< <p<Here we describe the ascertainment and application of five different sets of 47 single nucleotide polymorphisms (SNPs) allowing the inference of major human groups of different continental origin. For this, we first used 74 cell lines, representing human males from six different geographical areas and screened them with the Affymetrix Mapping 10K assay. In addition to using summary statistics estimating the genetic diversity among multiple groups of individuals defined by geography or language, we also used the program STRUCTURE to detect genetically distinct subgroups. Subsequently, we used a <it<pairwise </it<F<sub<ST </sub<ranking procedure among all pairs of genetic subgroups in order to identify a single best performing set of ASMs. Our initial results were independently confirmed by genotyping this set of ASMs in 22 individuals from Somalia, Afghanistan and Sudan and in 919 samples from the CEPH Human Genome Diversity Panel (HGDP-CEPH)</p< <p<Conclusion</p< <p<By means of our <it<pairwise </it<population F<sub<ST </sub<ranking approach we identified a set of 47 SNPs that could serve as a panel of ASMs at a continental level.</p<
abstract_unstemmed	<p<Abstract</p< <p<Background</p< <p<The identification and use of Ancestry-Sensitive Markers (ASMs), i.e. genetic polymorphisms facilitating the genetic reconstruction of geographical origins of individuals, is far from straightforward.</p< <p<Results</p< <p<Here we describe the ascertainment and application of five different sets of 47 single nucleotide polymorphisms (SNPs) allowing the inference of major human groups of different continental origin. For this, we first used 74 cell lines, representing human males from six different geographical areas and screened them with the Affymetrix Mapping 10K assay. In addition to using summary statistics estimating the genetic diversity among multiple groups of individuals defined by geography or language, we also used the program STRUCTURE to detect genetically distinct subgroups. Subsequently, we used a <it<pairwise </it<F<sub<ST </sub<ranking procedure among all pairs of genetic subgroups in order to identify a single best performing set of ASMs. Our initial results were independently confirmed by genotyping this set of ASMs in 22 individuals from Somalia, Afghanistan and Sudan and in 919 samples from the CEPH Human Genome Diversity Panel (HGDP-CEPH)</p< <p<Conclusion</p< <p<By means of our <it<pairwise </it<population F<sub<ST </sub<ranking approach we identified a set of 47 SNPs that could serve as a panel of ASMs at a continental level.</p<
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score	7.3999424

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Developing a set of ancestry-sensitive DNA markers reflecting continental origins of humans

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Zugang & Verfügbarkeit

Vorhandene Bände

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