The multifaceted role of the SASP in atherosclerosis: from mechanisms to therapeutic opportunities

Abstract Background The global population of older individuals is growing, and ageing is a key risk factor for atherosclerotic cardiovascular diseases. Abnormal accumulation of senescent cells can cause potentially deleterious effects on the organism with age. As a vital marker of cellular senescenc...
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Autor*in:	Yu Sun [verfasserIn] Xia Wang [verfasserIn] Tianwei Liu [verfasserIn] Xiaoyan Zhu [verfasserIn] Xudong Pan [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	SASP Atherosclerosis Senescent cell Inflammation Ageing

Übergeordnetes Werk:	In: Cell & Bioscience - BMC, 2011, 12(2022), 1, Seite 20
Übergeordnetes Werk:	volume:12 ; year:2022 ; number:1 ; pages:20

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s13578-022-00815-5

Katalog-ID:	DOAJ03934360X

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520			\|a Abstract Background The global population of older individuals is growing, and ageing is a key risk factor for atherosclerotic cardiovascular diseases. Abnormal accumulation of senescent cells can cause potentially deleterious effects on the organism with age. As a vital marker of cellular senescence, the senescence-associated secretory phenotype (SASP) is a novel mechanism to link cellular senescence with atherosclerosis. Main body In this review, we concretely describe the characteristics of the SASP and its regulation mechanisms. Importantly, we provide novel perspectives on how the SASP can promote atherosclerosis. The SASP from different types of senescent cells have vital roles in atherosclerosis progression. As a significant mediator of the harmful effects of senescent cells, it can play a pro-atherogenic role by producing inflammation and immune dysfunction. Furthermore, the SASP can deliver senescence signals to the surrounding vascular cells, gradually contributing to the development of atherosclerosis. Finally, we focus on a variety of novel therapeutic strategies aimed to reduce the burden of atherosclerosis in elderly individuals by targeting senescent cells and inhibiting the regulatory mechanisms of the SASP. Conclusion This review systematically summarizes the multiple roles of the SASP in atherosclerosis and can contribute to the exploration of new therapeutic opportunities.
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allfields	10.1186/s13578-022-00815-5 doi (DE-627)DOAJ03934360X (DE-599)DOAJ6c61a24e41144a328d5dd8edf309f3d0 DE-627 ger DE-627 rakwb eng TP248.13-248.65 QH301-705.5 QD415-436 Yu Sun verfasserin aut The multifaceted role of the SASP in atherosclerosis: from mechanisms to therapeutic opportunities 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The global population of older individuals is growing, and ageing is a key risk factor for atherosclerotic cardiovascular diseases. Abnormal accumulation of senescent cells can cause potentially deleterious effects on the organism with age. As a vital marker of cellular senescence, the senescence-associated secretory phenotype (SASP) is a novel mechanism to link cellular senescence with atherosclerosis. Main body In this review, we concretely describe the characteristics of the SASP and its regulation mechanisms. Importantly, we provide novel perspectives on how the SASP can promote atherosclerosis. The SASP from different types of senescent cells have vital roles in atherosclerosis progression. As a significant mediator of the harmful effects of senescent cells, it can play a pro-atherogenic role by producing inflammation and immune dysfunction. Furthermore, the SASP can deliver senescence signals to the surrounding vascular cells, gradually contributing to the development of atherosclerosis. Finally, we focus on a variety of novel therapeutic strategies aimed to reduce the burden of atherosclerosis in elderly individuals by targeting senescent cells and inhibiting the regulatory mechanisms of the SASP. Conclusion This review systematically summarizes the multiple roles of the SASP in atherosclerosis and can contribute to the exploration of new therapeutic opportunities. SASP Atherosclerosis Senescent cell Inflammation Ageing Biotechnology Biology (General) Biochemistry Xia Wang verfasserin aut Tianwei Liu verfasserin aut Xiaoyan Zhu verfasserin aut Xudong Pan verfasserin aut In Cell & Bioscience BMC, 2011 12(2022), 1, Seite 20 (DE-627)646079387 (DE-600)2593367-X 20453701 nnns volume:12 year:2022 number:1 pages:20 https://doi.org/10.1186/s13578-022-00815-5 kostenfrei https://doaj.org/article/6c61a24e41144a328d5dd8edf309f3d0 kostenfrei https://doi.org/10.1186/s13578-022-00815-5 kostenfrei https://doaj.org/toc/2045-3701 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 1 20
spelling	10.1186/s13578-022-00815-5 doi (DE-627)DOAJ03934360X (DE-599)DOAJ6c61a24e41144a328d5dd8edf309f3d0 DE-627 ger DE-627 rakwb eng TP248.13-248.65 QH301-705.5 QD415-436 Yu Sun verfasserin aut The multifaceted role of the SASP in atherosclerosis: from mechanisms to therapeutic opportunities 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The global population of older individuals is growing, and ageing is a key risk factor for atherosclerotic cardiovascular diseases. Abnormal accumulation of senescent cells can cause potentially deleterious effects on the organism with age. As a vital marker of cellular senescence, the senescence-associated secretory phenotype (SASP) is a novel mechanism to link cellular senescence with atherosclerosis. Main body In this review, we concretely describe the characteristics of the SASP and its regulation mechanisms. Importantly, we provide novel perspectives on how the SASP can promote atherosclerosis. The SASP from different types of senescent cells have vital roles in atherosclerosis progression. As a significant mediator of the harmful effects of senescent cells, it can play a pro-atherogenic role by producing inflammation and immune dysfunction. Furthermore, the SASP can deliver senescence signals to the surrounding vascular cells, gradually contributing to the development of atherosclerosis. Finally, we focus on a variety of novel therapeutic strategies aimed to reduce the burden of atherosclerosis in elderly individuals by targeting senescent cells and inhibiting the regulatory mechanisms of the SASP. Conclusion This review systematically summarizes the multiple roles of the SASP in atherosclerosis and can contribute to the exploration of new therapeutic opportunities. SASP Atherosclerosis Senescent cell Inflammation Ageing Biotechnology Biology (General) Biochemistry Xia Wang verfasserin aut Tianwei Liu verfasserin aut Xiaoyan Zhu verfasserin aut Xudong Pan verfasserin aut In Cell & Bioscience BMC, 2011 12(2022), 1, Seite 20 (DE-627)646079387 (DE-600)2593367-X 20453701 nnns volume:12 year:2022 number:1 pages:20 https://doi.org/10.1186/s13578-022-00815-5 kostenfrei https://doaj.org/article/6c61a24e41144a328d5dd8edf309f3d0 kostenfrei https://doi.org/10.1186/s13578-022-00815-5 kostenfrei https://doaj.org/toc/2045-3701 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 1 20
allfields_unstemmed	10.1186/s13578-022-00815-5 doi (DE-627)DOAJ03934360X (DE-599)DOAJ6c61a24e41144a328d5dd8edf309f3d0 DE-627 ger DE-627 rakwb eng TP248.13-248.65 QH301-705.5 QD415-436 Yu Sun verfasserin aut The multifaceted role of the SASP in atherosclerosis: from mechanisms to therapeutic opportunities 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The global population of older individuals is growing, and ageing is a key risk factor for atherosclerotic cardiovascular diseases. Abnormal accumulation of senescent cells can cause potentially deleterious effects on the organism with age. As a vital marker of cellular senescence, the senescence-associated secretory phenotype (SASP) is a novel mechanism to link cellular senescence with atherosclerosis. Main body In this review, we concretely describe the characteristics of the SASP and its regulation mechanisms. Importantly, we provide novel perspectives on how the SASP can promote atherosclerosis. The SASP from different types of senescent cells have vital roles in atherosclerosis progression. As a significant mediator of the harmful effects of senescent cells, it can play a pro-atherogenic role by producing inflammation and immune dysfunction. Furthermore, the SASP can deliver senescence signals to the surrounding vascular cells, gradually contributing to the development of atherosclerosis. Finally, we focus on a variety of novel therapeutic strategies aimed to reduce the burden of atherosclerosis in elderly individuals by targeting senescent cells and inhibiting the regulatory mechanisms of the SASP. Conclusion This review systematically summarizes the multiple roles of the SASP in atherosclerosis and can contribute to the exploration of new therapeutic opportunities. SASP Atherosclerosis Senescent cell Inflammation Ageing Biotechnology Biology (General) Biochemistry Xia Wang verfasserin aut Tianwei Liu verfasserin aut Xiaoyan Zhu verfasserin aut Xudong Pan verfasserin aut In Cell & Bioscience BMC, 2011 12(2022), 1, Seite 20 (DE-627)646079387 (DE-600)2593367-X 20453701 nnns volume:12 year:2022 number:1 pages:20 https://doi.org/10.1186/s13578-022-00815-5 kostenfrei https://doaj.org/article/6c61a24e41144a328d5dd8edf309f3d0 kostenfrei https://doi.org/10.1186/s13578-022-00815-5 kostenfrei https://doaj.org/toc/2045-3701 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 1 20
allfieldsGer	10.1186/s13578-022-00815-5 doi (DE-627)DOAJ03934360X (DE-599)DOAJ6c61a24e41144a328d5dd8edf309f3d0 DE-627 ger DE-627 rakwb eng TP248.13-248.65 QH301-705.5 QD415-436 Yu Sun verfasserin aut The multifaceted role of the SASP in atherosclerosis: from mechanisms to therapeutic opportunities 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The global population of older individuals is growing, and ageing is a key risk factor for atherosclerotic cardiovascular diseases. Abnormal accumulation of senescent cells can cause potentially deleterious effects on the organism with age. As a vital marker of cellular senescence, the senescence-associated secretory phenotype (SASP) is a novel mechanism to link cellular senescence with atherosclerosis. Main body In this review, we concretely describe the characteristics of the SASP and its regulation mechanisms. Importantly, we provide novel perspectives on how the SASP can promote atherosclerosis. The SASP from different types of senescent cells have vital roles in atherosclerosis progression. As a significant mediator of the harmful effects of senescent cells, it can play a pro-atherogenic role by producing inflammation and immune dysfunction. Furthermore, the SASP can deliver senescence signals to the surrounding vascular cells, gradually contributing to the development of atherosclerosis. Finally, we focus on a variety of novel therapeutic strategies aimed to reduce the burden of atherosclerosis in elderly individuals by targeting senescent cells and inhibiting the regulatory mechanisms of the SASP. Conclusion This review systematically summarizes the multiple roles of the SASP in atherosclerosis and can contribute to the exploration of new therapeutic opportunities. SASP Atherosclerosis Senescent cell Inflammation Ageing Biotechnology Biology (General) Biochemistry Xia Wang verfasserin aut Tianwei Liu verfasserin aut Xiaoyan Zhu verfasserin aut Xudong Pan verfasserin aut In Cell & Bioscience BMC, 2011 12(2022), 1, Seite 20 (DE-627)646079387 (DE-600)2593367-X 20453701 nnns volume:12 year:2022 number:1 pages:20 https://doi.org/10.1186/s13578-022-00815-5 kostenfrei https://doaj.org/article/6c61a24e41144a328d5dd8edf309f3d0 kostenfrei https://doi.org/10.1186/s13578-022-00815-5 kostenfrei https://doaj.org/toc/2045-3701 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 1 20
allfieldsSound	10.1186/s13578-022-00815-5 doi (DE-627)DOAJ03934360X (DE-599)DOAJ6c61a24e41144a328d5dd8edf309f3d0 DE-627 ger DE-627 rakwb eng TP248.13-248.65 QH301-705.5 QD415-436 Yu Sun verfasserin aut The multifaceted role of the SASP in atherosclerosis: from mechanisms to therapeutic opportunities 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The global population of older individuals is growing, and ageing is a key risk factor for atherosclerotic cardiovascular diseases. Abnormal accumulation of senescent cells can cause potentially deleterious effects on the organism with age. As a vital marker of cellular senescence, the senescence-associated secretory phenotype (SASP) is a novel mechanism to link cellular senescence with atherosclerosis. Main body In this review, we concretely describe the characteristics of the SASP and its regulation mechanisms. Importantly, we provide novel perspectives on how the SASP can promote atherosclerosis. The SASP from different types of senescent cells have vital roles in atherosclerosis progression. As a significant mediator of the harmful effects of senescent cells, it can play a pro-atherogenic role by producing inflammation and immune dysfunction. Furthermore, the SASP can deliver senescence signals to the surrounding vascular cells, gradually contributing to the development of atherosclerosis. Finally, we focus on a variety of novel therapeutic strategies aimed to reduce the burden of atherosclerosis in elderly individuals by targeting senescent cells and inhibiting the regulatory mechanisms of the SASP. Conclusion This review systematically summarizes the multiple roles of the SASP in atherosclerosis and can contribute to the exploration of new therapeutic opportunities. SASP Atherosclerosis Senescent cell Inflammation Ageing Biotechnology Biology (General) Biochemistry Xia Wang verfasserin aut Tianwei Liu verfasserin aut Xiaoyan Zhu verfasserin aut Xudong Pan verfasserin aut In Cell & Bioscience BMC, 2011 12(2022), 1, Seite 20 (DE-627)646079387 (DE-600)2593367-X 20453701 nnns volume:12 year:2022 number:1 pages:20 https://doi.org/10.1186/s13578-022-00815-5 kostenfrei https://doaj.org/article/6c61a24e41144a328d5dd8edf309f3d0 kostenfrei https://doi.org/10.1186/s13578-022-00815-5 kostenfrei https://doaj.org/toc/2045-3701 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 1 20
language	English
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topic_facet	SASP Atherosclerosis Senescent cell Inflammation Ageing Biotechnology Biology (General) Biochemistry
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authorswithroles_txt_mv	Yu Sun @@aut@@ Xia Wang @@aut@@ Tianwei Liu @@aut@@ Xiaoyan Zhu @@aut@@ Xudong Pan @@aut@@
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Abnormal accumulation of senescent cells can cause potentially deleterious effects on the organism with age. As a vital marker of cellular senescence, the senescence-associated secretory phenotype (SASP) is a novel mechanism to link cellular senescence with atherosclerosis. Main body In this review, we concretely describe the characteristics of the SASP and its regulation mechanisms. Importantly, we provide novel perspectives on how the SASP can promote atherosclerosis. The SASP from different types of senescent cells have vital roles in atherosclerosis progression. As a significant mediator of the harmful effects of senescent cells, it can play a pro-atherogenic role by producing inflammation and immune dysfunction. Furthermore, the SASP can deliver senescence signals to the surrounding vascular cells, gradually contributing to the development of atherosclerosis. Finally, we focus on a variety of novel therapeutic strategies aimed to reduce the burden of atherosclerosis in elderly individuals by targeting senescent cells and inhibiting the regulatory mechanisms of the SASP. 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callnumber-first	T - Technology
author	Yu Sun
spellingShingle	Yu Sun misc TP248.13-248.65 misc QH301-705.5 misc QD415-436 misc SASP misc Atherosclerosis misc Senescent cell misc Inflammation misc Ageing misc Biotechnology misc Biology (General) misc Biochemistry The multifaceted role of the SASP in atherosclerosis: from mechanisms to therapeutic opportunities
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topic_title	TP248.13-248.65 QH301-705.5 QD415-436 The multifaceted role of the SASP in atherosclerosis: from mechanisms to therapeutic opportunities SASP Atherosclerosis Senescent cell Inflammation Ageing
topic	misc TP248.13-248.65 misc QH301-705.5 misc QD415-436 misc SASP misc Atherosclerosis misc Senescent cell misc Inflammation misc Ageing misc Biotechnology misc Biology (General) misc Biochemistry
topic_unstemmed	misc TP248.13-248.65 misc QH301-705.5 misc QD415-436 misc SASP misc Atherosclerosis misc Senescent cell misc Inflammation misc Ageing misc Biotechnology misc Biology (General) misc Biochemistry
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title	The multifaceted role of the SASP in atherosclerosis: from mechanisms to therapeutic opportunities
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title_full	The multifaceted role of the SASP in atherosclerosis: from mechanisms to therapeutic opportunities
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title_sort	multifaceted role of the sasp in atherosclerosis: from mechanisms to therapeutic opportunities
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title_auth	The multifaceted role of the SASP in atherosclerosis: from mechanisms to therapeutic opportunities
abstract	Abstract Background The global population of older individuals is growing, and ageing is a key risk factor for atherosclerotic cardiovascular diseases. Abnormal accumulation of senescent cells can cause potentially deleterious effects on the organism with age. As a vital marker of cellular senescence, the senescence-associated secretory phenotype (SASP) is a novel mechanism to link cellular senescence with atherosclerosis. Main body In this review, we concretely describe the characteristics of the SASP and its regulation mechanisms. Importantly, we provide novel perspectives on how the SASP can promote atherosclerosis. The SASP from different types of senescent cells have vital roles in atherosclerosis progression. As a significant mediator of the harmful effects of senescent cells, it can play a pro-atherogenic role by producing inflammation and immune dysfunction. Furthermore, the SASP can deliver senescence signals to the surrounding vascular cells, gradually contributing to the development of atherosclerosis. Finally, we focus on a variety of novel therapeutic strategies aimed to reduce the burden of atherosclerosis in elderly individuals by targeting senescent cells and inhibiting the regulatory mechanisms of the SASP. Conclusion This review systematically summarizes the multiple roles of the SASP in atherosclerosis and can contribute to the exploration of new therapeutic opportunities.
abstractGer	Abstract Background The global population of older individuals is growing, and ageing is a key risk factor for atherosclerotic cardiovascular diseases. Abnormal accumulation of senescent cells can cause potentially deleterious effects on the organism with age. As a vital marker of cellular senescence, the senescence-associated secretory phenotype (SASP) is a novel mechanism to link cellular senescence with atherosclerosis. Main body In this review, we concretely describe the characteristics of the SASP and its regulation mechanisms. Importantly, we provide novel perspectives on how the SASP can promote atherosclerosis. The SASP from different types of senescent cells have vital roles in atherosclerosis progression. As a significant mediator of the harmful effects of senescent cells, it can play a pro-atherogenic role by producing inflammation and immune dysfunction. Furthermore, the SASP can deliver senescence signals to the surrounding vascular cells, gradually contributing to the development of atherosclerosis. Finally, we focus on a variety of novel therapeutic strategies aimed to reduce the burden of atherosclerosis in elderly individuals by targeting senescent cells and inhibiting the regulatory mechanisms of the SASP. Conclusion This review systematically summarizes the multiple roles of the SASP in atherosclerosis and can contribute to the exploration of new therapeutic opportunities.
abstract_unstemmed	Abstract Background The global population of older individuals is growing, and ageing is a key risk factor for atherosclerotic cardiovascular diseases. Abnormal accumulation of senescent cells can cause potentially deleterious effects on the organism with age. As a vital marker of cellular senescence, the senescence-associated secretory phenotype (SASP) is a novel mechanism to link cellular senescence with atherosclerosis. Main body In this review, we concretely describe the characteristics of the SASP and its regulation mechanisms. Importantly, we provide novel perspectives on how the SASP can promote atherosclerosis. The SASP from different types of senescent cells have vital roles in atherosclerosis progression. As a significant mediator of the harmful effects of senescent cells, it can play a pro-atherogenic role by producing inflammation and immune dysfunction. Furthermore, the SASP can deliver senescence signals to the surrounding vascular cells, gradually contributing to the development of atherosclerosis. Finally, we focus on a variety of novel therapeutic strategies aimed to reduce the burden of atherosclerosis in elderly individuals by targeting senescent cells and inhibiting the regulatory mechanisms of the SASP. Conclusion This review systematically summarizes the multiple roles of the SASP in atherosclerosis and can contribute to the exploration of new therapeutic opportunities.
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title_short	The multifaceted role of the SASP in atherosclerosis: from mechanisms to therapeutic opportunities
url	https://doi.org/10.1186/s13578-022-00815-5 https://doaj.org/article/6c61a24e41144a328d5dd8edf309f3d0 https://doaj.org/toc/2045-3701
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up_date	2024-07-03T22:53:20.316Z
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The multifaceted role of the SASP in atherosclerosis: from mechanisms to therapeutic opportunities

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