Novel Treatment of Allergic Fungal Sinusitis Using Omalizumab

A case report of recalcitrant allergic fungal sinusitis (AFS) refractory to systemic corticosteroids and multiple functional endoscopic sinus surgeries (FESSs) treated with anti-IgE antibody omalizumab is reported. AFS is often classified with chronic rhinosinusitis (CRS). Although similar symptoms...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Martin Oman Evans D.O. [verfasserIn] Christopher Albert Coop M.D. [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Übergeordnetes Werk:	In: Allergy & Rhinology - SAGE Publishing, 2018, 5(2014)
Übergeordnetes Werk:	volume:5 ; year:2014

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.2500/ar.2014.5.0098

Katalog-ID:	DOAJ039393917

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callnumber-first	R - Medicine
author	Martin Oman Evans D.O.
spellingShingle	Martin Oman Evans D.O. misc RF1-547 misc RC581-607 misc Otorhinolaryngology misc Immunologic diseases. Allergy Novel Treatment of Allergic Fungal Sinusitis Using Omalizumab
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topic_title	RF1-547 RC581-607 Novel Treatment of Allergic Fungal Sinusitis Using Omalizumab
topic	misc RF1-547 misc RC581-607 misc Otorhinolaryngology misc Immunologic diseases. Allergy
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title	Novel Treatment of Allergic Fungal Sinusitis Using Omalizumab
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title_sort	novel treatment of allergic fungal sinusitis using omalizumab
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title_auth	Novel Treatment of Allergic Fungal Sinusitis Using Omalizumab
abstract	A case report of recalcitrant allergic fungal sinusitis (AFS) refractory to systemic corticosteroids and multiple functional endoscopic sinus surgeries (FESSs) treated with anti-IgE antibody omalizumab is reported. AFS is often classified with chronic rhinosinusitis (CRS). Although similar symptoms are among the two diseases, AFS has a unique pathophysiology. Patients with AFS demonstrate type 1 hypersensitivity to fungal allergens, increased total serum IgE, increased CD8 + T-cell prevalence, and IL-4 and IL-5 response. Omalizumab should be considered in the treatment of AFS.
abstractGer	A case report of recalcitrant allergic fungal sinusitis (AFS) refractory to systemic corticosteroids and multiple functional endoscopic sinus surgeries (FESSs) treated with anti-IgE antibody omalizumab is reported. AFS is often classified with chronic rhinosinusitis (CRS). Although similar symptoms are among the two diseases, AFS has a unique pathophysiology. Patients with AFS demonstrate type 1 hypersensitivity to fungal allergens, increased total serum IgE, increased CD8 + T-cell prevalence, and IL-4 and IL-5 response. Omalizumab should be considered in the treatment of AFS.
abstract_unstemmed	A case report of recalcitrant allergic fungal sinusitis (AFS) refractory to systemic corticosteroids and multiple functional endoscopic sinus surgeries (FESSs) treated with anti-IgE antibody omalizumab is reported. AFS is often classified with chronic rhinosinusitis (CRS). Although similar symptoms are among the two diseases, AFS has a unique pathophysiology. Patients with AFS demonstrate type 1 hypersensitivity to fungal allergens, increased total serum IgE, increased CD8 + T-cell prevalence, and IL-4 and IL-5 response. Omalizumab should be considered in the treatment of AFS.
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title_short	Novel Treatment of Allergic Fungal Sinusitis Using Omalizumab
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