Topical Application of 0.5% Timolol Maleate Hydrogel for the Treatment of Superficial Infantile Hemangioma

The therapeutic options for infantile hemangiomas (IHs) have been greatly altered since the introduction of oral propranolol for successful treatments of IHs. Recently, there is an increase in the application of topical timolol maleate for treating superficial IHs. In the present study, we developed...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Hai Wei Wu [verfasserIn] Chao Liu [verfasserIn] Xuan Wang [verfasserIn] Ling Zhang [verfasserIn] Weien Yuan [verfasserIn] Jia Wei Zheng [verfasserIn] Li Xin Su [verfasserIn] Xin Dong Fan [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	infantile hemangioma timolol maleate hydrogel topical therapy drug safety

Übergeordnetes Werk:	In: Frontiers in Oncology - Frontiers Media S.A., 2012, 7(2017)
Übergeordnetes Werk:	volume:7 ; year:2017

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fonc.2017.00137

Katalog-ID:	DOAJ039441806

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allfieldsGer	10.3389/fonc.2017.00137 doi (DE-627)DOAJ039441806 (DE-599)DOAJe79cd07641af4b45883503cb3bb9fc9a DE-627 ger DE-627 rakwb eng RC254-282 Hai Wei Wu verfasserin aut Topical Application of 0.5% Timolol Maleate Hydrogel for the Treatment of Superficial Infantile Hemangioma 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The therapeutic options for infantile hemangiomas (IHs) have been greatly altered since the introduction of oral propranolol for successful treatments of IHs. Recently, there is an increase in the application of topical timolol maleate for treating superficial IHs. In the present study, we developed a new formulation of timolol maleate 0.5% hydrogel and treated 321 patients with superficial IHs to evaluate its efficacy and safety in the treatment of superficial IHs. This new timolol hydrogel was applied three times daily with a mean duration of 7.1 months. Response to treatment was assessed according to cosmetic improvement by using visual analog scale (VAS). The average VAS improvement after treatment was 76.4, with 126 patients (39.3%) achieving excellent responses, 159 patients (49.5%) achieving good responses, 33 patients (10.3%) achieving fair responses, and three patients (0.9%) achieving poor responses. Age at treatment initiation (P = 0.0349) and lesion thickness (P = 0.0147) were significantly associated with therapeutic efficacy. No severe side effects were observed in all patients. In conclusion, this new topical timolol maleate 0.5% hydrogel appears to be a proper candidate for treating superficial IHs, and our study provides supportive evidence and experience of topical timolol maleate in treating superficial IHs. infantile hemangioma timolol maleate hydrogel topical therapy drug safety Neoplasms. Tumors. Oncology. Including cancer and carcinogens Chao Liu verfasserin aut Chao Liu verfasserin aut Xuan Wang verfasserin aut Ling Zhang verfasserin aut Weien Yuan verfasserin aut Jia Wei Zheng verfasserin aut Li Xin Su verfasserin aut Xin Dong Fan verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 7(2017) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:7 year:2017 https://doi.org/10.3389/fonc.2017.00137 kostenfrei https://doaj.org/article/e79cd07641af4b45883503cb3bb9fc9a kostenfrei http://journal.frontiersin.org/article/10.3389/fonc.2017.00137/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2017
allfieldsSound	10.3389/fonc.2017.00137 doi (DE-627)DOAJ039441806 (DE-599)DOAJe79cd07641af4b45883503cb3bb9fc9a DE-627 ger DE-627 rakwb eng RC254-282 Hai Wei Wu verfasserin aut Topical Application of 0.5% Timolol Maleate Hydrogel for the Treatment of Superficial Infantile Hemangioma 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The therapeutic options for infantile hemangiomas (IHs) have been greatly altered since the introduction of oral propranolol for successful treatments of IHs. Recently, there is an increase in the application of topical timolol maleate for treating superficial IHs. In the present study, we developed a new formulation of timolol maleate 0.5% hydrogel and treated 321 patients with superficial IHs to evaluate its efficacy and safety in the treatment of superficial IHs. This new timolol hydrogel was applied three times daily with a mean duration of 7.1 months. Response to treatment was assessed according to cosmetic improvement by using visual analog scale (VAS). The average VAS improvement after treatment was 76.4, with 126 patients (39.3%) achieving excellent responses, 159 patients (49.5%) achieving good responses, 33 patients (10.3%) achieving fair responses, and three patients (0.9%) achieving poor responses. Age at treatment initiation (P = 0.0349) and lesion thickness (P = 0.0147) were significantly associated with therapeutic efficacy. No severe side effects were observed in all patients. In conclusion, this new topical timolol maleate 0.5% hydrogel appears to be a proper candidate for treating superficial IHs, and our study provides supportive evidence and experience of topical timolol maleate in treating superficial IHs. infantile hemangioma timolol maleate hydrogel topical therapy drug safety Neoplasms. Tumors. Oncology. Including cancer and carcinogens Chao Liu verfasserin aut Chao Liu verfasserin aut Xuan Wang verfasserin aut Ling Zhang verfasserin aut Weien Yuan verfasserin aut Jia Wei Zheng verfasserin aut Li Xin Su verfasserin aut Xin Dong Fan verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 7(2017) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:7 year:2017 https://doi.org/10.3389/fonc.2017.00137 kostenfrei https://doaj.org/article/e79cd07641af4b45883503cb3bb9fc9a kostenfrei http://journal.frontiersin.org/article/10.3389/fonc.2017.00137/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2017
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container_title	Frontiers in Oncology
authorswithroles_txt_mv	Hai Wei Wu @@aut@@ Chao Liu @@aut@@ Xuan Wang @@aut@@ Ling Zhang @@aut@@ Weien Yuan @@aut@@ Jia Wei Zheng @@aut@@ Li Xin Su @@aut@@ Xin Dong Fan @@aut@@
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callnumber-first	R - Medicine
author	Hai Wei Wu
spellingShingle	Hai Wei Wu misc RC254-282 misc infantile hemangioma misc timolol maleate misc hydrogel misc topical therapy misc drug safety misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Topical Application of 0.5% Timolol Maleate Hydrogel for the Treatment of Superficial Infantile Hemangioma
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topic_title	RC254-282 Topical Application of 0.5% Timolol Maleate Hydrogel for the Treatment of Superficial Infantile Hemangioma infantile hemangioma timolol maleate hydrogel topical therapy drug safety
topic	misc RC254-282 misc infantile hemangioma misc timolol maleate misc hydrogel misc topical therapy misc drug safety misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc infantile hemangioma misc timolol maleate misc hydrogel misc topical therapy misc drug safety misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Topical Application of 0.5% Timolol Maleate Hydrogel for the Treatment of Superficial Infantile Hemangioma
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title_full	Topical Application of 0.5% Timolol Maleate Hydrogel for the Treatment of Superficial Infantile Hemangioma
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title_sort	topical application of 0.5% timolol maleate hydrogel for the treatment of superficial infantile hemangioma
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title_auth	Topical Application of 0.5% Timolol Maleate Hydrogel for the Treatment of Superficial Infantile Hemangioma
abstract	The therapeutic options for infantile hemangiomas (IHs) have been greatly altered since the introduction of oral propranolol for successful treatments of IHs. Recently, there is an increase in the application of topical timolol maleate for treating superficial IHs. In the present study, we developed a new formulation of timolol maleate 0.5% hydrogel and treated 321 patients with superficial IHs to evaluate its efficacy and safety in the treatment of superficial IHs. This new timolol hydrogel was applied three times daily with a mean duration of 7.1 months. Response to treatment was assessed according to cosmetic improvement by using visual analog scale (VAS). The average VAS improvement after treatment was 76.4, with 126 patients (39.3%) achieving excellent responses, 159 patients (49.5%) achieving good responses, 33 patients (10.3%) achieving fair responses, and three patients (0.9%) achieving poor responses. Age at treatment initiation (P = 0.0349) and lesion thickness (P = 0.0147) were significantly associated with therapeutic efficacy. No severe side effects were observed in all patients. In conclusion, this new topical timolol maleate 0.5% hydrogel appears to be a proper candidate for treating superficial IHs, and our study provides supportive evidence and experience of topical timolol maleate in treating superficial IHs.
abstractGer	The therapeutic options for infantile hemangiomas (IHs) have been greatly altered since the introduction of oral propranolol for successful treatments of IHs. Recently, there is an increase in the application of topical timolol maleate for treating superficial IHs. In the present study, we developed a new formulation of timolol maleate 0.5% hydrogel and treated 321 patients with superficial IHs to evaluate its efficacy and safety in the treatment of superficial IHs. This new timolol hydrogel was applied three times daily with a mean duration of 7.1 months. Response to treatment was assessed according to cosmetic improvement by using visual analog scale (VAS). The average VAS improvement after treatment was 76.4, with 126 patients (39.3%) achieving excellent responses, 159 patients (49.5%) achieving good responses, 33 patients (10.3%) achieving fair responses, and three patients (0.9%) achieving poor responses. Age at treatment initiation (P = 0.0349) and lesion thickness (P = 0.0147) were significantly associated with therapeutic efficacy. No severe side effects were observed in all patients. In conclusion, this new topical timolol maleate 0.5% hydrogel appears to be a proper candidate for treating superficial IHs, and our study provides supportive evidence and experience of topical timolol maleate in treating superficial IHs.
abstract_unstemmed	The therapeutic options for infantile hemangiomas (IHs) have been greatly altered since the introduction of oral propranolol for successful treatments of IHs. Recently, there is an increase in the application of topical timolol maleate for treating superficial IHs. In the present study, we developed a new formulation of timolol maleate 0.5% hydrogel and treated 321 patients with superficial IHs to evaluate its efficacy and safety in the treatment of superficial IHs. This new timolol hydrogel was applied three times daily with a mean duration of 7.1 months. Response to treatment was assessed according to cosmetic improvement by using visual analog scale (VAS). The average VAS improvement after treatment was 76.4, with 126 patients (39.3%) achieving excellent responses, 159 patients (49.5%) achieving good responses, 33 patients (10.3%) achieving fair responses, and three patients (0.9%) achieving poor responses. Age at treatment initiation (P = 0.0349) and lesion thickness (P = 0.0147) were significantly associated with therapeutic efficacy. No severe side effects were observed in all patients. In conclusion, this new topical timolol maleate 0.5% hydrogel appears to be a proper candidate for treating superficial IHs, and our study provides supportive evidence and experience of topical timolol maleate in treating superficial IHs.
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title_short	Topical Application of 0.5% Timolol Maleate Hydrogel for the Treatment of Superficial Infantile Hemangioma
url	https://doi.org/10.3389/fonc.2017.00137 https://doaj.org/article/e79cd07641af4b45883503cb3bb9fc9a http://journal.frontiersin.org/article/10.3389/fonc.2017.00137/full https://doaj.org/toc/2234-943X
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up_date	2024-07-03T23:21:52.194Z
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Topical Application of 0.5% Timolol Maleate Hydrogel for the Treatment of Superficial Infantile Hemangioma

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