Application of sorption technologies for infected burn wounds treatment in the experiment
The frequency of infectious complications in patients with burn is still an actual problem of modern medicine. Endogenous and exogenous intoxication leads to disruption organs and systems functions in general. That's why more attention should be paid to such a direction of medicine as applicati...
Ausführliche Beschreibung
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| Autor*in: |
G. M. Cherniakova [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch ; Russisch ; Ukrainisch |
| Erschienen: |
2017 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Zaporožskij Medicinskij Žurnal - Zaporozhye State Medical University, 2016, (2017), 6, Seite 793-797 |
|---|---|
| Übergeordnetes Werk: |
year:2017 ; number:6 ; pages:793-797 |
| Links: |
Link aufrufen |
|---|
| DOI / URN: |
10.14739/2310-1210.2017.6.115097 |
|---|
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DOAJ039561801 |
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| 520 | |a The frequency of infectious complications in patients with burn is still an actual problem of modern medicine. Endogenous and exogenous intoxication leads to disruption organs and systems functions in general. That's why more attention should be paid to such a direction of medicine as application sorption. Purpose: The aim of this study was the evaluation of antibacterial activity and wound-healing properties of the sorbent applicator based on highly dispersed nanosilica with immobilized antimicrobial mixture for the treatment of experimental Pseudomonas infection. Materials and мethods: The research was carried out on 90 6-month male mice NMRI line weight 18–20 grams. All animals were divided into 5 groups. We used a model of the contact thermal burn. After burning experimental animals were infected by daily agar culture of multidrug resistant clinical strain of P. aeruginosa 3101, obtained from a patient with burns. Microbiological studies of burn wounds were carried out. The rate of wound healing was carried out using the following parameters: the average rate of wound surface decrease (cm² per day) and reduction of wound surface area (percent per day – Popova’s index). Results. It has been found that the application of new original applicator sorbent for 3 days decrease the number of microbial cells in the wound below the critical level (105). In this experimental group the amount of purulent discharge from the wounds, swelling, redness and infiltration of tissues were reduced in comparison with the other groups. Earlier cleansing of wounds and acceleration of reparative processes were observed. Conclusions. The findings suggest that the applicator sorbent exhibits antibacterial and wound healing properties and can be a prospective complex drug for the topical treatment of Pseudomonas infected burns. | ||
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10.14739/2310-1210.2017.6.115097 doi (DE-627)DOAJ039561801 (DE-599)DOAJ645a4d63fbdd4bcca70a9a7575802513 DE-627 ger DE-627 rakwb eng rus ukr G. M. Cherniakova verfasserin aut Application of sorption technologies for infected burn wounds treatment in the experiment 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The frequency of infectious complications in patients with burn is still an actual problem of modern medicine. Endogenous and exogenous intoxication leads to disruption organs and systems functions in general. That's why more attention should be paid to such a direction of medicine as application sorption. Purpose: The aim of this study was the evaluation of antibacterial activity and wound-healing properties of the sorbent applicator based on highly dispersed nanosilica with immobilized antimicrobial mixture for the treatment of experimental Pseudomonas infection. Materials and мethods: The research was carried out on 90 6-month male mice NMRI line weight 18–20 grams. All animals were divided into 5 groups. We used a model of the contact thermal burn. After burning experimental animals were infected by daily agar culture of multidrug resistant clinical strain of P. aeruginosa 3101, obtained from a patient with burns. Microbiological studies of burn wounds were carried out. The rate of wound healing was carried out using the following parameters: the average rate of wound surface decrease (cm² per day) and reduction of wound surface area (percent per day – Popova’s index). Results. It has been found that the application of new original applicator sorbent for 3 days decrease the number of microbial cells in the wound below the critical level (105). In this experimental group the amount of purulent discharge from the wounds, swelling, redness and infiltration of tissues were reduced in comparison with the other groups. Earlier cleansing of wounds and acceleration of reparative processes were observed. Conclusions. The findings suggest that the applicator sorbent exhibits antibacterial and wound healing properties and can be a prospective complex drug for the topical treatment of Pseudomonas infected burns. burns sorbent P. aeruginosa Medicine R In Zaporožskij Medicinskij Žurnal Zaporozhye State Medical University, 2016 (2017), 6, Seite 793-797 (DE-627)176064269X 23101210 nnns year:2017 number:6 pages:793-797 https://doi.org/10.14739/2310-1210.2017.6.115097 kostenfrei https://doaj.org/article/645a4d63fbdd4bcca70a9a7575802513 kostenfrei http://zmj.zsmu.edu.ua/article/view/115097/113468 kostenfrei https://doaj.org/toc/2306-4145 Journal toc kostenfrei https://doaj.org/toc/2310-1210 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 2017 6 793-797 |
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Application of sorption technologies for infected burn wounds treatment in the experiment |
| abstract |
The frequency of infectious complications in patients with burn is still an actual problem of modern medicine. Endogenous and exogenous intoxication leads to disruption organs and systems functions in general. That's why more attention should be paid to such a direction of medicine as application sorption. Purpose: The aim of this study was the evaluation of antibacterial activity and wound-healing properties of the sorbent applicator based on highly dispersed nanosilica with immobilized antimicrobial mixture for the treatment of experimental Pseudomonas infection. Materials and мethods: The research was carried out on 90 6-month male mice NMRI line weight 18–20 grams. All animals were divided into 5 groups. We used a model of the contact thermal burn. After burning experimental animals were infected by daily agar culture of multidrug resistant clinical strain of P. aeruginosa 3101, obtained from a patient with burns. Microbiological studies of burn wounds were carried out. The rate of wound healing was carried out using the following parameters: the average rate of wound surface decrease (cm² per day) and reduction of wound surface area (percent per day – Popova’s index). Results. It has been found that the application of new original applicator sorbent for 3 days decrease the number of microbial cells in the wound below the critical level (105). In this experimental group the amount of purulent discharge from the wounds, swelling, redness and infiltration of tissues were reduced in comparison with the other groups. Earlier cleansing of wounds and acceleration of reparative processes were observed. Conclusions. The findings suggest that the applicator sorbent exhibits antibacterial and wound healing properties and can be a prospective complex drug for the topical treatment of Pseudomonas infected burns. |
| abstractGer |
The frequency of infectious complications in patients with burn is still an actual problem of modern medicine. Endogenous and exogenous intoxication leads to disruption organs and systems functions in general. That's why more attention should be paid to such a direction of medicine as application sorption. Purpose: The aim of this study was the evaluation of antibacterial activity and wound-healing properties of the sorbent applicator based on highly dispersed nanosilica with immobilized antimicrobial mixture for the treatment of experimental Pseudomonas infection. Materials and мethods: The research was carried out on 90 6-month male mice NMRI line weight 18–20 grams. All animals were divided into 5 groups. We used a model of the contact thermal burn. After burning experimental animals were infected by daily agar culture of multidrug resistant clinical strain of P. aeruginosa 3101, obtained from a patient with burns. Microbiological studies of burn wounds were carried out. The rate of wound healing was carried out using the following parameters: the average rate of wound surface decrease (cm² per day) and reduction of wound surface area (percent per day – Popova’s index). Results. It has been found that the application of new original applicator sorbent for 3 days decrease the number of microbial cells in the wound below the critical level (105). In this experimental group the amount of purulent discharge from the wounds, swelling, redness and infiltration of tissues were reduced in comparison with the other groups. Earlier cleansing of wounds and acceleration of reparative processes were observed. Conclusions. The findings suggest that the applicator sorbent exhibits antibacterial and wound healing properties and can be a prospective complex drug for the topical treatment of Pseudomonas infected burns. |
| abstract_unstemmed |
The frequency of infectious complications in patients with burn is still an actual problem of modern medicine. Endogenous and exogenous intoxication leads to disruption organs and systems functions in general. That's why more attention should be paid to such a direction of medicine as application sorption. Purpose: The aim of this study was the evaluation of antibacterial activity and wound-healing properties of the sorbent applicator based on highly dispersed nanosilica with immobilized antimicrobial mixture for the treatment of experimental Pseudomonas infection. Materials and мethods: The research was carried out on 90 6-month male mice NMRI line weight 18–20 grams. All animals were divided into 5 groups. We used a model of the contact thermal burn. After burning experimental animals were infected by daily agar culture of multidrug resistant clinical strain of P. aeruginosa 3101, obtained from a patient with burns. Microbiological studies of burn wounds were carried out. The rate of wound healing was carried out using the following parameters: the average rate of wound surface decrease (cm² per day) and reduction of wound surface area (percent per day – Popova’s index). Results. It has been found that the application of new original applicator sorbent for 3 days decrease the number of microbial cells in the wound below the critical level (105). In this experimental group the amount of purulent discharge from the wounds, swelling, redness and infiltration of tissues were reduced in comparison with the other groups. Earlier cleansing of wounds and acceleration of reparative processes were observed. Conclusions. The findings suggest that the applicator sorbent exhibits antibacterial and wound healing properties and can be a prospective complex drug for the topical treatment of Pseudomonas infected burns. |
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Application of sorption technologies for infected burn wounds treatment in the experiment |
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https://doi.org/10.14739/2310-1210.2017.6.115097 https://doaj.org/article/645a4d63fbdd4bcca70a9a7575802513 http://zmj.zsmu.edu.ua/article/view/115097/113468 https://doaj.org/toc/2306-4145 https://doaj.org/toc/2310-1210 |
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10.14739/2310-1210.2017.6.115097 |
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2024-07-03T23:52:40.800Z |
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