Natural compounds: A new perspective on targeting polarization and infiltration of tumor-associated macrophages in lung cancer

With the development in tumor immunology, people are gradually understanding the complexity and diversity of the tumor microenvironment immune status and its important effect on tumors. Tumor-associated macrophages (TAMs), an important part of the tumor immune microenvironment, have a double effect...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Xintong Zhou [verfasserIn] Xiaomin Wang [verfasserIn] Qi Sun [verfasserIn] Wenfeng Zhang [verfasserIn] Cun Liu [verfasserIn] Wenzhe Ma [verfasserIn] Changgang Sun [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Natural compounds Lung cancer Tumor associated macrophages Macrophage polarization Macrophage infiltration

Übergeordnetes Werk:	In: Biomedicine & Pharmacotherapy - Elsevier, 2021, 151(2022), Seite 113096-
Übergeordnetes Werk:	volume:151 ; year:2022 ; pages:113096-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.biopha.2022.113096

Katalog-ID:	DOAJ039605299

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allfields	10.1016/j.biopha.2022.113096 doi (DE-627)DOAJ039605299 (DE-599)DOAJ4ba2ce1aebc24a20a6a3f755f2e3ba5d DE-627 ger DE-627 rakwb eng RM1-950 Xintong Zhou verfasserin aut Natural compounds: A new perspective on targeting polarization and infiltration of tumor-associated macrophages in lung cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier With the development in tumor immunology, people are gradually understanding the complexity and diversity of the tumor microenvironment immune status and its important effect on tumors. Tumor-associated macrophages (TAMs), an important part of the tumor immune microenvironment, have a double effect on tumor growth and metastasis. Many studies have focused on lung cancer, especially non-small cell lung cancer and other ''hot tumors'' with typical inflammatory characteristics. The polarization and infiltration of TAMs is an important mechanism in the occurrence and development of malignant tumors, such as lung cancer, and in the tumor immune microenvironment. Therapeutic drugs designed for these reasons are key to targeting TAMs in the treatment of lung cancer. A large number of reports have suggested that natural compounds have a strong potential of affecting immunity by targeting the polarization and infiltration of TAMs to improve the immune microenvironment of lung cancer and exert a natural antitumor effect. This paper discusses the infiltration and polarization effects of natural compounds on lung cancer TAMs, provides a detailed classification and systematic review of natural compounds, and summarizes the bias of different kinds of natural compounds by affecting their antitumor mechanism of TAMs, with the aim of providing new perspectives and potential therapeutic drugs for targeted macrophages in the treatment of lung cancer. Natural compounds Lung cancer Tumor associated macrophages Macrophage polarization Macrophage infiltration Therapeutics. Pharmacology Xiaomin Wang verfasserin aut Qi Sun verfasserin aut Wenfeng Zhang verfasserin aut Cun Liu verfasserin aut Wenzhe Ma verfasserin aut Changgang Sun verfasserin aut In Biomedicine & Pharmacotherapy Elsevier, 2021 151(2022), Seite 113096- (DE-627)306717565 (DE-600)1501510-5 19506007 nnns volume:151 year:2022 pages:113096- https://doi.org/10.1016/j.biopha.2022.113096 kostenfrei https://doaj.org/article/4ba2ce1aebc24a20a6a3f755f2e3ba5d kostenfrei http://www.sciencedirect.com/science/article/pii/S0753332222004851 kostenfrei https://doaj.org/toc/0753-3322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 151 2022 113096-
spelling	10.1016/j.biopha.2022.113096 doi (DE-627)DOAJ039605299 (DE-599)DOAJ4ba2ce1aebc24a20a6a3f755f2e3ba5d DE-627 ger DE-627 rakwb eng RM1-950 Xintong Zhou verfasserin aut Natural compounds: A new perspective on targeting polarization and infiltration of tumor-associated macrophages in lung cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier With the development in tumor immunology, people are gradually understanding the complexity and diversity of the tumor microenvironment immune status and its important effect on tumors. Tumor-associated macrophages (TAMs), an important part of the tumor immune microenvironment, have a double effect on tumor growth and metastasis. Many studies have focused on lung cancer, especially non-small cell lung cancer and other ''hot tumors'' with typical inflammatory characteristics. The polarization and infiltration of TAMs is an important mechanism in the occurrence and development of malignant tumors, such as lung cancer, and in the tumor immune microenvironment. Therapeutic drugs designed for these reasons are key to targeting TAMs in the treatment of lung cancer. A large number of reports have suggested that natural compounds have a strong potential of affecting immunity by targeting the polarization and infiltration of TAMs to improve the immune microenvironment of lung cancer and exert a natural antitumor effect. This paper discusses the infiltration and polarization effects of natural compounds on lung cancer TAMs, provides a detailed classification and systematic review of natural compounds, and summarizes the bias of different kinds of natural compounds by affecting their antitumor mechanism of TAMs, with the aim of providing new perspectives and potential therapeutic drugs for targeted macrophages in the treatment of lung cancer. Natural compounds Lung cancer Tumor associated macrophages Macrophage polarization Macrophage infiltration Therapeutics. Pharmacology Xiaomin Wang verfasserin aut Qi Sun verfasserin aut Wenfeng Zhang verfasserin aut Cun Liu verfasserin aut Wenzhe Ma verfasserin aut Changgang Sun verfasserin aut In Biomedicine & Pharmacotherapy Elsevier, 2021 151(2022), Seite 113096- (DE-627)306717565 (DE-600)1501510-5 19506007 nnns volume:151 year:2022 pages:113096- https://doi.org/10.1016/j.biopha.2022.113096 kostenfrei https://doaj.org/article/4ba2ce1aebc24a20a6a3f755f2e3ba5d kostenfrei http://www.sciencedirect.com/science/article/pii/S0753332222004851 kostenfrei https://doaj.org/toc/0753-3322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 151 2022 113096-
allfields_unstemmed	10.1016/j.biopha.2022.113096 doi (DE-627)DOAJ039605299 (DE-599)DOAJ4ba2ce1aebc24a20a6a3f755f2e3ba5d DE-627 ger DE-627 rakwb eng RM1-950 Xintong Zhou verfasserin aut Natural compounds: A new perspective on targeting polarization and infiltration of tumor-associated macrophages in lung cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier With the development in tumor immunology, people are gradually understanding the complexity and diversity of the tumor microenvironment immune status and its important effect on tumors. Tumor-associated macrophages (TAMs), an important part of the tumor immune microenvironment, have a double effect on tumor growth and metastasis. Many studies have focused on lung cancer, especially non-small cell lung cancer and other ''hot tumors'' with typical inflammatory characteristics. The polarization and infiltration of TAMs is an important mechanism in the occurrence and development of malignant tumors, such as lung cancer, and in the tumor immune microenvironment. Therapeutic drugs designed for these reasons are key to targeting TAMs in the treatment of lung cancer. A large number of reports have suggested that natural compounds have a strong potential of affecting immunity by targeting the polarization and infiltration of TAMs to improve the immune microenvironment of lung cancer and exert a natural antitumor effect. This paper discusses the infiltration and polarization effects of natural compounds on lung cancer TAMs, provides a detailed classification and systematic review of natural compounds, and summarizes the bias of different kinds of natural compounds by affecting their antitumor mechanism of TAMs, with the aim of providing new perspectives and potential therapeutic drugs for targeted macrophages in the treatment of lung cancer. Natural compounds Lung cancer Tumor associated macrophages Macrophage polarization Macrophage infiltration Therapeutics. Pharmacology Xiaomin Wang verfasserin aut Qi Sun verfasserin aut Wenfeng Zhang verfasserin aut Cun Liu verfasserin aut Wenzhe Ma verfasserin aut Changgang Sun verfasserin aut In Biomedicine & Pharmacotherapy Elsevier, 2021 151(2022), Seite 113096- (DE-627)306717565 (DE-600)1501510-5 19506007 nnns volume:151 year:2022 pages:113096- https://doi.org/10.1016/j.biopha.2022.113096 kostenfrei https://doaj.org/article/4ba2ce1aebc24a20a6a3f755f2e3ba5d kostenfrei http://www.sciencedirect.com/science/article/pii/S0753332222004851 kostenfrei https://doaj.org/toc/0753-3322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 151 2022 113096-
allfieldsGer	10.1016/j.biopha.2022.113096 doi (DE-627)DOAJ039605299 (DE-599)DOAJ4ba2ce1aebc24a20a6a3f755f2e3ba5d DE-627 ger DE-627 rakwb eng RM1-950 Xintong Zhou verfasserin aut Natural compounds: A new perspective on targeting polarization and infiltration of tumor-associated macrophages in lung cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier With the development in tumor immunology, people are gradually understanding the complexity and diversity of the tumor microenvironment immune status and its important effect on tumors. Tumor-associated macrophages (TAMs), an important part of the tumor immune microenvironment, have a double effect on tumor growth and metastasis. Many studies have focused on lung cancer, especially non-small cell lung cancer and other ''hot tumors'' with typical inflammatory characteristics. The polarization and infiltration of TAMs is an important mechanism in the occurrence and development of malignant tumors, such as lung cancer, and in the tumor immune microenvironment. Therapeutic drugs designed for these reasons are key to targeting TAMs in the treatment of lung cancer. A large number of reports have suggested that natural compounds have a strong potential of affecting immunity by targeting the polarization and infiltration of TAMs to improve the immune microenvironment of lung cancer and exert a natural antitumor effect. This paper discusses the infiltration and polarization effects of natural compounds on lung cancer TAMs, provides a detailed classification and systematic review of natural compounds, and summarizes the bias of different kinds of natural compounds by affecting their antitumor mechanism of TAMs, with the aim of providing new perspectives and potential therapeutic drugs for targeted macrophages in the treatment of lung cancer. Natural compounds Lung cancer Tumor associated macrophages Macrophage polarization Macrophage infiltration Therapeutics. Pharmacology Xiaomin Wang verfasserin aut Qi Sun verfasserin aut Wenfeng Zhang verfasserin aut Cun Liu verfasserin aut Wenzhe Ma verfasserin aut Changgang Sun verfasserin aut In Biomedicine & Pharmacotherapy Elsevier, 2021 151(2022), Seite 113096- (DE-627)306717565 (DE-600)1501510-5 19506007 nnns volume:151 year:2022 pages:113096- https://doi.org/10.1016/j.biopha.2022.113096 kostenfrei https://doaj.org/article/4ba2ce1aebc24a20a6a3f755f2e3ba5d kostenfrei http://www.sciencedirect.com/science/article/pii/S0753332222004851 kostenfrei https://doaj.org/toc/0753-3322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 151 2022 113096-
allfieldsSound	10.1016/j.biopha.2022.113096 doi (DE-627)DOAJ039605299 (DE-599)DOAJ4ba2ce1aebc24a20a6a3f755f2e3ba5d DE-627 ger DE-627 rakwb eng RM1-950 Xintong Zhou verfasserin aut Natural compounds: A new perspective on targeting polarization and infiltration of tumor-associated macrophages in lung cancer 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier With the development in tumor immunology, people are gradually understanding the complexity and diversity of the tumor microenvironment immune status and its important effect on tumors. Tumor-associated macrophages (TAMs), an important part of the tumor immune microenvironment, have a double effect on tumor growth and metastasis. Many studies have focused on lung cancer, especially non-small cell lung cancer and other ''hot tumors'' with typical inflammatory characteristics. The polarization and infiltration of TAMs is an important mechanism in the occurrence and development of malignant tumors, such as lung cancer, and in the tumor immune microenvironment. Therapeutic drugs designed for these reasons are key to targeting TAMs in the treatment of lung cancer. A large number of reports have suggested that natural compounds have a strong potential of affecting immunity by targeting the polarization and infiltration of TAMs to improve the immune microenvironment of lung cancer and exert a natural antitumor effect. This paper discusses the infiltration and polarization effects of natural compounds on lung cancer TAMs, provides a detailed classification and systematic review of natural compounds, and summarizes the bias of different kinds of natural compounds by affecting their antitumor mechanism of TAMs, with the aim of providing new perspectives and potential therapeutic drugs for targeted macrophages in the treatment of lung cancer. Natural compounds Lung cancer Tumor associated macrophages Macrophage polarization Macrophage infiltration Therapeutics. Pharmacology Xiaomin Wang verfasserin aut Qi Sun verfasserin aut Wenfeng Zhang verfasserin aut Cun Liu verfasserin aut Wenzhe Ma verfasserin aut Changgang Sun verfasserin aut In Biomedicine & Pharmacotherapy Elsevier, 2021 151(2022), Seite 113096- (DE-627)306717565 (DE-600)1501510-5 19506007 nnns volume:151 year:2022 pages:113096- https://doi.org/10.1016/j.biopha.2022.113096 kostenfrei https://doaj.org/article/4ba2ce1aebc24a20a6a3f755f2e3ba5d kostenfrei http://www.sciencedirect.com/science/article/pii/S0753332222004851 kostenfrei https://doaj.org/toc/0753-3322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2025 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 151 2022 113096-
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title	Natural compounds: A new perspective on targeting polarization and infiltration of tumor-associated macrophages in lung cancer
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title_sort	natural compounds: a new perspective on targeting polarization and infiltration of tumor-associated macrophages in lung cancer
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title_auth	Natural compounds: A new perspective on targeting polarization and infiltration of tumor-associated macrophages in lung cancer
abstract	With the development in tumor immunology, people are gradually understanding the complexity and diversity of the tumor microenvironment immune status and its important effect on tumors. Tumor-associated macrophages (TAMs), an important part of the tumor immune microenvironment, have a double effect on tumor growth and metastasis. Many studies have focused on lung cancer, especially non-small cell lung cancer and other ''hot tumors'' with typical inflammatory characteristics. The polarization and infiltration of TAMs is an important mechanism in the occurrence and development of malignant tumors, such as lung cancer, and in the tumor immune microenvironment. Therapeutic drugs designed for these reasons are key to targeting TAMs in the treatment of lung cancer. A large number of reports have suggested that natural compounds have a strong potential of affecting immunity by targeting the polarization and infiltration of TAMs to improve the immune microenvironment of lung cancer and exert a natural antitumor effect. This paper discusses the infiltration and polarization effects of natural compounds on lung cancer TAMs, provides a detailed classification and systematic review of natural compounds, and summarizes the bias of different kinds of natural compounds by affecting their antitumor mechanism of TAMs, with the aim of providing new perspectives and potential therapeutic drugs for targeted macrophages in the treatment of lung cancer.
abstractGer	With the development in tumor immunology, people are gradually understanding the complexity and diversity of the tumor microenvironment immune status and its important effect on tumors. Tumor-associated macrophages (TAMs), an important part of the tumor immune microenvironment, have a double effect on tumor growth and metastasis. Many studies have focused on lung cancer, especially non-small cell lung cancer and other ''hot tumors'' with typical inflammatory characteristics. The polarization and infiltration of TAMs is an important mechanism in the occurrence and development of malignant tumors, such as lung cancer, and in the tumor immune microenvironment. Therapeutic drugs designed for these reasons are key to targeting TAMs in the treatment of lung cancer. A large number of reports have suggested that natural compounds have a strong potential of affecting immunity by targeting the polarization and infiltration of TAMs to improve the immune microenvironment of lung cancer and exert a natural antitumor effect. This paper discusses the infiltration and polarization effects of natural compounds on lung cancer TAMs, provides a detailed classification and systematic review of natural compounds, and summarizes the bias of different kinds of natural compounds by affecting their antitumor mechanism of TAMs, with the aim of providing new perspectives and potential therapeutic drugs for targeted macrophages in the treatment of lung cancer.
abstract_unstemmed	With the development in tumor immunology, people are gradually understanding the complexity and diversity of the tumor microenvironment immune status and its important effect on tumors. Tumor-associated macrophages (TAMs), an important part of the tumor immune microenvironment, have a double effect on tumor growth and metastasis. Many studies have focused on lung cancer, especially non-small cell lung cancer and other ''hot tumors'' with typical inflammatory characteristics. The polarization and infiltration of TAMs is an important mechanism in the occurrence and development of malignant tumors, such as lung cancer, and in the tumor immune microenvironment. Therapeutic drugs designed for these reasons are key to targeting TAMs in the treatment of lung cancer. A large number of reports have suggested that natural compounds have a strong potential of affecting immunity by targeting the polarization and infiltration of TAMs to improve the immune microenvironment of lung cancer and exert a natural antitumor effect. This paper discusses the infiltration and polarization effects of natural compounds on lung cancer TAMs, provides a detailed classification and systematic review of natural compounds, and summarizes the bias of different kinds of natural compounds by affecting their antitumor mechanism of TAMs, with the aim of providing new perspectives and potential therapeutic drugs for targeted macrophages in the treatment of lung cancer.
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title_short	Natural compounds: A new perspective on targeting polarization and infiltration of tumor-associated macrophages in lung cancer
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This paper discusses the infiltration and polarization effects of natural compounds on lung cancer TAMs, provides a detailed classification and systematic review of natural compounds, and summarizes the bias of different kinds of natural compounds by affecting their antitumor mechanism of TAMs, with the aim of providing new perspectives and potential therapeutic drugs for targeted macrophages in the treatment of lung cancer.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Natural compounds</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Lung cancer</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Tumor associated macrophages</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Macrophage polarization</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Macrophage infiltration</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Therapeutics. 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Natural compounds: A new perspective on targeting polarization and infiltration of tumor-associated macrophages in lung cancer

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