Are MTHFR C677T and MTRR A66G Polymorphisms Associated with Overweight/Obesity Risk? From a Case-Control to a Meta-Analysis of 30,327 Subjects

Several studies have examined the associations of methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase reductase (MTRR) A66G polymorphisms with being overweight/obesity. However, the results are still controversial. We therefore conducted a case-control study (517 cases and 741...
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Autor*in:	Shu-Jun Fan [verfasserIn] Bo-Yi Yang [verfasserIn] Xue-Yuan Zhi [verfasserIn] Miao He [verfasserIn] Da Wang [verfasserIn] Yan-Xun Wang [verfasserIn] Yi-Nuo Wang [verfasserIn] Jian Wei [verfasserIn] Quan-Mei Zheng [verfasserIn] Gui-Fan Sun [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	MTHFR MTRR overweight obesity polymorphism

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 16(2015), 6, Seite 11849-11863
Übergeordnetes Werk:	volume:16 ; year:2015 ; number:6 ; pages:11849-11863

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/ijms160611849

Katalog-ID:	DOAJ039686744

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allfields	10.3390/ijms160611849 doi (DE-627)DOAJ039686744 (DE-599)DOAJd40402f6b35e47129b15c673a4feb718 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Shu-Jun Fan verfasserin aut Are MTHFR C677T and MTRR A66G Polymorphisms Associated with Overweight/Obesity Risk? From a Case-Control to a Meta-Analysis of 30,327 Subjects 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Several studies have examined the associations of methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase reductase (MTRR) A66G polymorphisms with being overweight/obesity. However, the results are still controversial. We therefore conducted a case-control study (517 cases and 741 controls) in a Chinese Han population and then performed a meta-analysis by combining previous studies (5431 cases and 24,896 controls). In our case-control study, the MTHFR C677T polymorphism was not significantly associated with being overweight/obesity when examining homozygous codominant, heterozygous codominant, dominant, recessive and allelic genetic models. The following meta-analysis confirmed our case-control results. Heterogeneity was minimal in the overall analysis, and sensitivity analyses and publication bias tests indicated that the meta-analytic results were reliable. Similarly, both the case-control study and meta-analysis found no significant association between the MTRR A66G polymorphism and being overweight/obesity. However, sensitivity analyses showed that the associations between the MTRR A66G polymorphism and being overweight/obesity became significant in the dominant, heterozygous codominant and allelic models after excluding our case-control study. The results from our case-control study and meta-analysis suggest that both of the two polymorphisms are not associated with being overweight/obesity. Further large-scale population-based studies, especially for the MTRR A66G polymorphism, are still needed to confirm or refute our findings. MTHFR MTRR overweight obesity polymorphism Biology (General) Chemistry Bo-Yi Yang verfasserin aut Xue-Yuan Zhi verfasserin aut Miao He verfasserin aut Da Wang verfasserin aut Yan-Xun Wang verfasserin aut Yi-Nuo Wang verfasserin aut Jian Wei verfasserin aut Quan-Mei Zheng verfasserin aut Gui-Fan Sun verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 16(2015), 6, Seite 11849-11863 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:16 year:2015 number:6 pages:11849-11863 https://doi.org/10.3390/ijms160611849 kostenfrei https://doaj.org/article/d40402f6b35e47129b15c673a4feb718 kostenfrei http://www.mdpi.com/1422-0067/16/6/11849 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2015 6 11849-11863
spelling	10.3390/ijms160611849 doi (DE-627)DOAJ039686744 (DE-599)DOAJd40402f6b35e47129b15c673a4feb718 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Shu-Jun Fan verfasserin aut Are MTHFR C677T and MTRR A66G Polymorphisms Associated with Overweight/Obesity Risk? From a Case-Control to a Meta-Analysis of 30,327 Subjects 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Several studies have examined the associations of methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase reductase (MTRR) A66G polymorphisms with being overweight/obesity. However, the results are still controversial. We therefore conducted a case-control study (517 cases and 741 controls) in a Chinese Han population and then performed a meta-analysis by combining previous studies (5431 cases and 24,896 controls). In our case-control study, the MTHFR C677T polymorphism was not significantly associated with being overweight/obesity when examining homozygous codominant, heterozygous codominant, dominant, recessive and allelic genetic models. The following meta-analysis confirmed our case-control results. Heterogeneity was minimal in the overall analysis, and sensitivity analyses and publication bias tests indicated that the meta-analytic results were reliable. Similarly, both the case-control study and meta-analysis found no significant association between the MTRR A66G polymorphism and being overweight/obesity. However, sensitivity analyses showed that the associations between the MTRR A66G polymorphism and being overweight/obesity became significant in the dominant, heterozygous codominant and allelic models after excluding our case-control study. The results from our case-control study and meta-analysis suggest that both of the two polymorphisms are not associated with being overweight/obesity. Further large-scale population-based studies, especially for the MTRR A66G polymorphism, are still needed to confirm or refute our findings. MTHFR MTRR overweight obesity polymorphism Biology (General) Chemistry Bo-Yi Yang verfasserin aut Xue-Yuan Zhi verfasserin aut Miao He verfasserin aut Da Wang verfasserin aut Yan-Xun Wang verfasserin aut Yi-Nuo Wang verfasserin aut Jian Wei verfasserin aut Quan-Mei Zheng verfasserin aut Gui-Fan Sun verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 16(2015), 6, Seite 11849-11863 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:16 year:2015 number:6 pages:11849-11863 https://doi.org/10.3390/ijms160611849 kostenfrei https://doaj.org/article/d40402f6b35e47129b15c673a4feb718 kostenfrei http://www.mdpi.com/1422-0067/16/6/11849 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2015 6 11849-11863
allfields_unstemmed	10.3390/ijms160611849 doi (DE-627)DOAJ039686744 (DE-599)DOAJd40402f6b35e47129b15c673a4feb718 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Shu-Jun Fan verfasserin aut Are MTHFR C677T and MTRR A66G Polymorphisms Associated with Overweight/Obesity Risk? From a Case-Control to a Meta-Analysis of 30,327 Subjects 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Several studies have examined the associations of methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase reductase (MTRR) A66G polymorphisms with being overweight/obesity. However, the results are still controversial. We therefore conducted a case-control study (517 cases and 741 controls) in a Chinese Han population and then performed a meta-analysis by combining previous studies (5431 cases and 24,896 controls). In our case-control study, the MTHFR C677T polymorphism was not significantly associated with being overweight/obesity when examining homozygous codominant, heterozygous codominant, dominant, recessive and allelic genetic models. The following meta-analysis confirmed our case-control results. Heterogeneity was minimal in the overall analysis, and sensitivity analyses and publication bias tests indicated that the meta-analytic results were reliable. Similarly, both the case-control study and meta-analysis found no significant association between the MTRR A66G polymorphism and being overweight/obesity. However, sensitivity analyses showed that the associations between the MTRR A66G polymorphism and being overweight/obesity became significant in the dominant, heterozygous codominant and allelic models after excluding our case-control study. The results from our case-control study and meta-analysis suggest that both of the two polymorphisms are not associated with being overweight/obesity. Further large-scale population-based studies, especially for the MTRR A66G polymorphism, are still needed to confirm or refute our findings. MTHFR MTRR overweight obesity polymorphism Biology (General) Chemistry Bo-Yi Yang verfasserin aut Xue-Yuan Zhi verfasserin aut Miao He verfasserin aut Da Wang verfasserin aut Yan-Xun Wang verfasserin aut Yi-Nuo Wang verfasserin aut Jian Wei verfasserin aut Quan-Mei Zheng verfasserin aut Gui-Fan Sun verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 16(2015), 6, Seite 11849-11863 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:16 year:2015 number:6 pages:11849-11863 https://doi.org/10.3390/ijms160611849 kostenfrei https://doaj.org/article/d40402f6b35e47129b15c673a4feb718 kostenfrei http://www.mdpi.com/1422-0067/16/6/11849 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2015 6 11849-11863
allfieldsGer	10.3390/ijms160611849 doi (DE-627)DOAJ039686744 (DE-599)DOAJd40402f6b35e47129b15c673a4feb718 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Shu-Jun Fan verfasserin aut Are MTHFR C677T and MTRR A66G Polymorphisms Associated with Overweight/Obesity Risk? From a Case-Control to a Meta-Analysis of 30,327 Subjects 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Several studies have examined the associations of methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase reductase (MTRR) A66G polymorphisms with being overweight/obesity. However, the results are still controversial. We therefore conducted a case-control study (517 cases and 741 controls) in a Chinese Han population and then performed a meta-analysis by combining previous studies (5431 cases and 24,896 controls). In our case-control study, the MTHFR C677T polymorphism was not significantly associated with being overweight/obesity when examining homozygous codominant, heterozygous codominant, dominant, recessive and allelic genetic models. The following meta-analysis confirmed our case-control results. Heterogeneity was minimal in the overall analysis, and sensitivity analyses and publication bias tests indicated that the meta-analytic results were reliable. Similarly, both the case-control study and meta-analysis found no significant association between the MTRR A66G polymorphism and being overweight/obesity. However, sensitivity analyses showed that the associations between the MTRR A66G polymorphism and being overweight/obesity became significant in the dominant, heterozygous codominant and allelic models after excluding our case-control study. The results from our case-control study and meta-analysis suggest that both of the two polymorphisms are not associated with being overweight/obesity. Further large-scale population-based studies, especially for the MTRR A66G polymorphism, are still needed to confirm or refute our findings. MTHFR MTRR overweight obesity polymorphism Biology (General) Chemistry Bo-Yi Yang verfasserin aut Xue-Yuan Zhi verfasserin aut Miao He verfasserin aut Da Wang verfasserin aut Yan-Xun Wang verfasserin aut Yi-Nuo Wang verfasserin aut Jian Wei verfasserin aut Quan-Mei Zheng verfasserin aut Gui-Fan Sun verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 16(2015), 6, Seite 11849-11863 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:16 year:2015 number:6 pages:11849-11863 https://doi.org/10.3390/ijms160611849 kostenfrei https://doaj.org/article/d40402f6b35e47129b15c673a4feb718 kostenfrei http://www.mdpi.com/1422-0067/16/6/11849 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2015 6 11849-11863
allfieldsSound	10.3390/ijms160611849 doi (DE-627)DOAJ039686744 (DE-599)DOAJd40402f6b35e47129b15c673a4feb718 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Shu-Jun Fan verfasserin aut Are MTHFR C677T and MTRR A66G Polymorphisms Associated with Overweight/Obesity Risk? From a Case-Control to a Meta-Analysis of 30,327 Subjects 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Several studies have examined the associations of methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase reductase (MTRR) A66G polymorphisms with being overweight/obesity. However, the results are still controversial. We therefore conducted a case-control study (517 cases and 741 controls) in a Chinese Han population and then performed a meta-analysis by combining previous studies (5431 cases and 24,896 controls). In our case-control study, the MTHFR C677T polymorphism was not significantly associated with being overweight/obesity when examining homozygous codominant, heterozygous codominant, dominant, recessive and allelic genetic models. The following meta-analysis confirmed our case-control results. Heterogeneity was minimal in the overall analysis, and sensitivity analyses and publication bias tests indicated that the meta-analytic results were reliable. Similarly, both the case-control study and meta-analysis found no significant association between the MTRR A66G polymorphism and being overweight/obesity. However, sensitivity analyses showed that the associations between the MTRR A66G polymorphism and being overweight/obesity became significant in the dominant, heterozygous codominant and allelic models after excluding our case-control study. The results from our case-control study and meta-analysis suggest that both of the two polymorphisms are not associated with being overweight/obesity. Further large-scale population-based studies, especially for the MTRR A66G polymorphism, are still needed to confirm or refute our findings. MTHFR MTRR overweight obesity polymorphism Biology (General) Chemistry Bo-Yi Yang verfasserin aut Xue-Yuan Zhi verfasserin aut Miao He verfasserin aut Da Wang verfasserin aut Yan-Xun Wang verfasserin aut Yi-Nuo Wang verfasserin aut Jian Wei verfasserin aut Quan-Mei Zheng verfasserin aut Gui-Fan Sun verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 16(2015), 6, Seite 11849-11863 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:16 year:2015 number:6 pages:11849-11863 https://doi.org/10.3390/ijms160611849 kostenfrei https://doaj.org/article/d40402f6b35e47129b15c673a4feb718 kostenfrei http://www.mdpi.com/1422-0067/16/6/11849 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2015 6 11849-11863
language	English
source	In International Journal of Molecular Sciences 16(2015), 6, Seite 11849-11863 volume:16 year:2015 number:6 pages:11849-11863
sourceStr	In International Journal of Molecular Sciences 16(2015), 6, Seite 11849-11863 volume:16 year:2015 number:6 pages:11849-11863
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	MTHFR MTRR overweight obesity polymorphism Biology (General) Chemistry
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container_title	International Journal of Molecular Sciences
authorswithroles_txt_mv	Shu-Jun Fan @@aut@@ Bo-Yi Yang @@aut@@ Xue-Yuan Zhi @@aut@@ Miao He @@aut@@ Da Wang @@aut@@ Yan-Xun Wang @@aut@@ Yi-Nuo Wang @@aut@@ Jian Wei @@aut@@ Quan-Mei Zheng @@aut@@ Gui-Fan Sun @@aut@@
publishDateDaySort_date	2015-01-01T00:00:00Z
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id	DOAJ039686744
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callnumber-first	Q - Science
author	Shu-Jun Fan
spellingShingle	Shu-Jun Fan misc QH301-705.5 misc QD1-999 misc MTHFR misc MTRR misc overweight misc obesity misc polymorphism misc Biology (General) misc Chemistry Are MTHFR C677T and MTRR A66G Polymorphisms Associated with Overweight/Obesity Risk? From a Case-Control to a Meta-Analysis of 30,327 Subjects
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topic_title	QH301-705.5 QD1-999 Are MTHFR C677T and MTRR A66G Polymorphisms Associated with Overweight/Obesity Risk? From a Case-Control to a Meta-Analysis of 30,327 Subjects MTHFR MTRR overweight obesity polymorphism
topic	misc QH301-705.5 misc QD1-999 misc MTHFR misc MTRR misc overweight misc obesity misc polymorphism misc Biology (General) misc Chemistry
topic_unstemmed	misc QH301-705.5 misc QD1-999 misc MTHFR misc MTRR misc overweight misc obesity misc polymorphism misc Biology (General) misc Chemistry
topic_browse	misc QH301-705.5 misc QD1-999 misc MTHFR misc MTRR misc overweight misc obesity misc polymorphism misc Biology (General) misc Chemistry
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title	Are MTHFR C677T and MTRR A66G Polymorphisms Associated with Overweight/Obesity Risk? From a Case-Control to a Meta-Analysis of 30,327 Subjects
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title_full	Are MTHFR C677T and MTRR A66G Polymorphisms Associated with Overweight/Obesity Risk? From a Case-Control to a Meta-Analysis of 30,327 Subjects
author_sort	Shu-Jun Fan
journal	International Journal of Molecular Sciences
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author_browse	Shu-Jun Fan Bo-Yi Yang Xue-Yuan Zhi Miao He Da Wang Yan-Xun Wang Yi-Nuo Wang Jian Wei Quan-Mei Zheng Gui-Fan Sun
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doi_str_mv	10.3390/ijms160611849
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title_sort	are mthfr c677t and mtrr a66g polymorphisms associated with overweight/obesity risk? from a case-control to a meta-analysis of 30,327 subjects
callnumber	QH301-705.5
title_auth	Are MTHFR C677T and MTRR A66G Polymorphisms Associated with Overweight/Obesity Risk? From a Case-Control to a Meta-Analysis of 30,327 Subjects
abstract	Several studies have examined the associations of methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase reductase (MTRR) A66G polymorphisms with being overweight/obesity. However, the results are still controversial. We therefore conducted a case-control study (517 cases and 741 controls) in a Chinese Han population and then performed a meta-analysis by combining previous studies (5431 cases and 24,896 controls). In our case-control study, the MTHFR C677T polymorphism was not significantly associated with being overweight/obesity when examining homozygous codominant, heterozygous codominant, dominant, recessive and allelic genetic models. The following meta-analysis confirmed our case-control results. Heterogeneity was minimal in the overall analysis, and sensitivity analyses and publication bias tests indicated that the meta-analytic results were reliable. Similarly, both the case-control study and meta-analysis found no significant association between the MTRR A66G polymorphism and being overweight/obesity. However, sensitivity analyses showed that the associations between the MTRR A66G polymorphism and being overweight/obesity became significant in the dominant, heterozygous codominant and allelic models after excluding our case-control study. The results from our case-control study and meta-analysis suggest that both of the two polymorphisms are not associated with being overweight/obesity. Further large-scale population-based studies, especially for the MTRR A66G polymorphism, are still needed to confirm or refute our findings.
abstractGer	Several studies have examined the associations of methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase reductase (MTRR) A66G polymorphisms with being overweight/obesity. However, the results are still controversial. We therefore conducted a case-control study (517 cases and 741 controls) in a Chinese Han population and then performed a meta-analysis by combining previous studies (5431 cases and 24,896 controls). In our case-control study, the MTHFR C677T polymorphism was not significantly associated with being overweight/obesity when examining homozygous codominant, heterozygous codominant, dominant, recessive and allelic genetic models. The following meta-analysis confirmed our case-control results. Heterogeneity was minimal in the overall analysis, and sensitivity analyses and publication bias tests indicated that the meta-analytic results were reliable. Similarly, both the case-control study and meta-analysis found no significant association between the MTRR A66G polymorphism and being overweight/obesity. However, sensitivity analyses showed that the associations between the MTRR A66G polymorphism and being overweight/obesity became significant in the dominant, heterozygous codominant and allelic models after excluding our case-control study. The results from our case-control study and meta-analysis suggest that both of the two polymorphisms are not associated with being overweight/obesity. Further large-scale population-based studies, especially for the MTRR A66G polymorphism, are still needed to confirm or refute our findings.
abstract_unstemmed	Several studies have examined the associations of methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase reductase (MTRR) A66G polymorphisms with being overweight/obesity. However, the results are still controversial. We therefore conducted a case-control study (517 cases and 741 controls) in a Chinese Han population and then performed a meta-analysis by combining previous studies (5431 cases and 24,896 controls). In our case-control study, the MTHFR C677T polymorphism was not significantly associated with being overweight/obesity when examining homozygous codominant, heterozygous codominant, dominant, recessive and allelic genetic models. The following meta-analysis confirmed our case-control results. Heterogeneity was minimal in the overall analysis, and sensitivity analyses and publication bias tests indicated that the meta-analytic results were reliable. Similarly, both the case-control study and meta-analysis found no significant association between the MTRR A66G polymorphism and being overweight/obesity. However, sensitivity analyses showed that the associations between the MTRR A66G polymorphism and being overweight/obesity became significant in the dominant, heterozygous codominant and allelic models after excluding our case-control study. The results from our case-control study and meta-analysis suggest that both of the two polymorphisms are not associated with being overweight/obesity. Further large-scale population-based studies, especially for the MTRR A66G polymorphism, are still needed to confirm or refute our findings.
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container_issue	6
title_short	Are MTHFR C677T and MTRR A66G Polymorphisms Associated with Overweight/Obesity Risk? From a Case-Control to a Meta-Analysis of 30,327 Subjects
url	https://doi.org/10.3390/ijms160611849 https://doaj.org/article/d40402f6b35e47129b15c673a4feb718 http://www.mdpi.com/1422-0067/16/6/11849 https://doaj.org/toc/1422-0067
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