Successful Reconstruction of the Right Ventricular Outflow Tract by Implantation of Thymus Stem Cell Engineered Graft in Growing Swine

Summary: Graft cellularization holds great promise in overcoming the limitations associated with prosthetic materials currently used in corrective cardiac surgery. In this study, the authors evaluated the advantages of graft cellularization for right ventricular outflow tract reconstruction in a nov...
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Autor*in:	Ambra Albertario, PhD [verfasserIn] Megan M. Swim, PhD [verfasserIn] Eltayeb Mohamed Ahmed, MCh [verfasserIn] Dominga Iacobazzi, PhD [verfasserIn] Michael Yeong, MBBS [verfasserIn] Paolo Madeddu, MD [verfasserIn] Mohamed T. Ghorbel, PhD [verfasserIn] Massimo Caputo, MD [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Übergeordnetes Werk:	In: JACC: Basic to Translational Science - Elsevier, 2017, 4(2019), 3, Seite 364-384
Übergeordnetes Werk:	volume:4 ; year:2019 ; number:3 ; pages:364-384

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.jacbts.2019.02.001

Katalog-ID:	DOAJ039757811

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allfieldsSound	10.1016/j.jacbts.2019.02.001 doi (DE-627)DOAJ039757811 (DE-599)DOAJ9e42c604488549e4aa9bf8723d714f95 DE-627 ger DE-627 rakwb eng RC666-701 Ambra Albertario, PhD verfasserin aut Successful Reconstruction of the Right Ventricular Outflow Tract by Implantation of Thymus Stem Cell Engineered Graft in Growing Swine 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Graft cellularization holds great promise in overcoming the limitations associated with prosthetic materials currently used in corrective cardiac surgery. In this study, the authors evaluated the advantages of graft cellularization for right ventricular outflow tract reconstruction in a novel porcine model. After 4.5 months from implantation, improved myocardial strain, better endothelialization and cardiomyocyte incorporation, and reduced fibrosis were observed in the cellularized grafts compared with the acellular grafts. To the authors’ knowledge, this is the first demonstration of successful right ventricular outflow tract correction using bioengineered grafts in a large animal model. Key Words: congenital heart disease, reconstruction, right ventricular outflow swine model, tissue engineering, tract stem cells Diseases of the circulatory (Cardiovascular) system Megan M. Swim, PhD verfasserin aut Eltayeb Mohamed Ahmed, MCh verfasserin aut Dominga Iacobazzi, PhD verfasserin aut Michael Yeong, MBBS verfasserin aut Paolo Madeddu, MD verfasserin aut Mohamed T. Ghorbel, PhD verfasserin aut Massimo Caputo, MD verfasserin aut In JACC: Basic to Translational Science Elsevier, 2017 4(2019), 3, Seite 364-384 (DE-627)865612463 (DE-600)2865010-4 2452302X nnns volume:4 year:2019 number:3 pages:364-384 https://doi.org/10.1016/j.jacbts.2019.02.001 kostenfrei https://doaj.org/article/9e42c604488549e4aa9bf8723d714f95 kostenfrei http://www.sciencedirect.com/science/article/pii/S2452302X19300543 kostenfrei https://doaj.org/toc/2452-302X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2019 3 364-384
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authorswithroles_txt_mv	Ambra Albertario, PhD @@aut@@ Megan M. Swim, PhD @@aut@@ Eltayeb Mohamed Ahmed, MCh @@aut@@ Dominga Iacobazzi, PhD @@aut@@ Michael Yeong, MBBS @@aut@@ Paolo Madeddu, MD @@aut@@ Mohamed T. Ghorbel, PhD @@aut@@ Massimo Caputo, MD @@aut@@
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callnumber-first	R - Medicine
author	Ambra Albertario, PhD
spellingShingle	Ambra Albertario, PhD misc RC666-701 misc Diseases of the circulatory (Cardiovascular) system Successful Reconstruction of the Right Ventricular Outflow Tract by Implantation of Thymus Stem Cell Engineered Graft in Growing Swine
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topic_title	RC666-701 Successful Reconstruction of the Right Ventricular Outflow Tract by Implantation of Thymus Stem Cell Engineered Graft in Growing Swine
topic	misc RC666-701 misc Diseases of the circulatory (Cardiovascular) system
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title	Successful Reconstruction of the Right Ventricular Outflow Tract by Implantation of Thymus Stem Cell Engineered Graft in Growing Swine
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title_full	Successful Reconstruction of the Right Ventricular Outflow Tract by Implantation of Thymus Stem Cell Engineered Graft in Growing Swine
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author_browse	Ambra Albertario, PhD Megan M. Swim, PhD Eltayeb Mohamed Ahmed, MCh Dominga Iacobazzi, PhD Michael Yeong, MBBS Paolo Madeddu, MD Mohamed T. Ghorbel, PhD Massimo Caputo, MD
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title_sort	successful reconstruction of the right ventricular outflow tract by implantation of thymus stem cell engineered graft in growing swine
callnumber	RC666-701
title_auth	Successful Reconstruction of the Right Ventricular Outflow Tract by Implantation of Thymus Stem Cell Engineered Graft in Growing Swine
abstract	Summary: Graft cellularization holds great promise in overcoming the limitations associated with prosthetic materials currently used in corrective cardiac surgery. In this study, the authors evaluated the advantages of graft cellularization for right ventricular outflow tract reconstruction in a novel porcine model. After 4.5 months from implantation, improved myocardial strain, better endothelialization and cardiomyocyte incorporation, and reduced fibrosis were observed in the cellularized grafts compared with the acellular grafts. To the authors’ knowledge, this is the first demonstration of successful right ventricular outflow tract correction using bioengineered grafts in a large animal model. Key Words: congenital heart disease, reconstruction, right ventricular outflow swine model, tissue engineering, tract stem cells
abstractGer	Summary: Graft cellularization holds great promise in overcoming the limitations associated with prosthetic materials currently used in corrective cardiac surgery. In this study, the authors evaluated the advantages of graft cellularization for right ventricular outflow tract reconstruction in a novel porcine model. After 4.5 months from implantation, improved myocardial strain, better endothelialization and cardiomyocyte incorporation, and reduced fibrosis were observed in the cellularized grafts compared with the acellular grafts. To the authors’ knowledge, this is the first demonstration of successful right ventricular outflow tract correction using bioengineered grafts in a large animal model. Key Words: congenital heart disease, reconstruction, right ventricular outflow swine model, tissue engineering, tract stem cells
abstract_unstemmed	Summary: Graft cellularization holds great promise in overcoming the limitations associated with prosthetic materials currently used in corrective cardiac surgery. In this study, the authors evaluated the advantages of graft cellularization for right ventricular outflow tract reconstruction in a novel porcine model. After 4.5 months from implantation, improved myocardial strain, better endothelialization and cardiomyocyte incorporation, and reduced fibrosis were observed in the cellularized grafts compared with the acellular grafts. To the authors’ knowledge, this is the first demonstration of successful right ventricular outflow tract correction using bioengineered grafts in a large animal model. Key Words: congenital heart disease, reconstruction, right ventricular outflow swine model, tissue engineering, tract stem cells
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title_short	Successful Reconstruction of the Right Ventricular Outflow Tract by Implantation of Thymus Stem Cell Engineered Graft in Growing Swine
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Successful Reconstruction of the Right Ventricular Outflow Tract by Implantation of Thymus Stem Cell Engineered Graft in Growing Swine

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