Water and ethanol extracts of Plantago major leaves show anti-inflammatory activity on oral epithelial cells
Context: The leaves of Plantago major have been used for the treatment of wounds and inflammation in folk medicine from prehistoric times. However there is no report on the use of P. major to treat inflammation in oral epithelial cell lines. Objective: The present study was undertaken to reveal poss...
Ausführliche Beschreibung
Autor*in: |
Muhammad Zubair [verfasserIn] Cecilia Widén [verfasserIn] Stefan Renvert [verfasserIn] Kimmo Rumpunen [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2019 |
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Übergeordnetes Werk: |
In: Journal of Traditional and Complementary Medicine - Elsevier, 2016, 9(2019), 3, Seite 169-171 |
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Übergeordnetes Werk: |
volume:9 ; year:2019 ; number:3 ; pages:169-171 |
Links: |
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DOI / URN: |
10.1016/j.jtcme.2017.09.002 |
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Katalog-ID: |
DOAJ039834638 |
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10.1016/j.jtcme.2017.09.002 doi (DE-627)DOAJ039834638 (DE-599)DOAJf31efb255bba4da6a196a9f60d86360f DE-627 ger DE-627 rakwb eng Muhammad Zubair verfasserin aut Water and ethanol extracts of Plantago major leaves show anti-inflammatory activity on oral epithelial cells 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Context: The leaves of Plantago major have been used for the treatment of wounds and inflammation in folk medicine from prehistoric times. However there is no report on the use of P. major to treat inflammation in oral epithelial cell lines. Objective: The present study was undertaken to reveal possible anti-inflammatory effects of Plantago major leaf extracts on oral epithelial cells in-vitro. Materials and methods: Water- and ethanol-based extracts of P. major leaves were prepared from freeze-dried plant material, and tested in-vitro using the oral epithelial cell line H400. The anti-inflammatory activity of P. major was tested against E. coli lipopolysaccharide (LPS) using the nuclear factor kappa beta (NF-kB) assay. Results: Both the water- and the ethanol-based extracts, as well as a combination of the two extracts, showed anti-inflammatory activity. A concentration of 0.1 mg/mL (on dry weight basis) yielded the best results for all extracts. Discussion and conclusion: The results show that synergistic effects of both polyphenols and water-soluble compounds (possibly polysaccharides) are responsible for anti-inflammatory activities of P. major. Keywords: Common plantain, Herbal medicine, NF-kB, Wound healing Medicine R Cecilia Widén verfasserin aut Stefan Renvert verfasserin aut Kimmo Rumpunen verfasserin aut In Journal of Traditional and Complementary Medicine Elsevier, 2016 9(2019), 3, Seite 169-171 (DE-627)740705962 (DE-600)2709698-1 22254110 nnns volume:9 year:2019 number:3 pages:169-171 https://doi.org/10.1016/j.jtcme.2017.09.002 kostenfrei https://doaj.org/article/f31efb255bba4da6a196a9f60d86360f kostenfrei http://www.sciencedirect.com/science/article/pii/S2225411017301098 kostenfrei https://doaj.org/toc/2225-4110 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2019 3 169-171 |
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10.1016/j.jtcme.2017.09.002 doi (DE-627)DOAJ039834638 (DE-599)DOAJf31efb255bba4da6a196a9f60d86360f DE-627 ger DE-627 rakwb eng Muhammad Zubair verfasserin aut Water and ethanol extracts of Plantago major leaves show anti-inflammatory activity on oral epithelial cells 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Context: The leaves of Plantago major have been used for the treatment of wounds and inflammation in folk medicine from prehistoric times. However there is no report on the use of P. major to treat inflammation in oral epithelial cell lines. Objective: The present study was undertaken to reveal possible anti-inflammatory effects of Plantago major leaf extracts on oral epithelial cells in-vitro. Materials and methods: Water- and ethanol-based extracts of P. major leaves were prepared from freeze-dried plant material, and tested in-vitro using the oral epithelial cell line H400. The anti-inflammatory activity of P. major was tested against E. coli lipopolysaccharide (LPS) using the nuclear factor kappa beta (NF-kB) assay. Results: Both the water- and the ethanol-based extracts, as well as a combination of the two extracts, showed anti-inflammatory activity. A concentration of 0.1 mg/mL (on dry weight basis) yielded the best results for all extracts. Discussion and conclusion: The results show that synergistic effects of both polyphenols and water-soluble compounds (possibly polysaccharides) are responsible for anti-inflammatory activities of P. major. Keywords: Common plantain, Herbal medicine, NF-kB, Wound healing Medicine R Cecilia Widén verfasserin aut Stefan Renvert verfasserin aut Kimmo Rumpunen verfasserin aut In Journal of Traditional and Complementary Medicine Elsevier, 2016 9(2019), 3, Seite 169-171 (DE-627)740705962 (DE-600)2709698-1 22254110 nnns volume:9 year:2019 number:3 pages:169-171 https://doi.org/10.1016/j.jtcme.2017.09.002 kostenfrei https://doaj.org/article/f31efb255bba4da6a196a9f60d86360f kostenfrei http://www.sciencedirect.com/science/article/pii/S2225411017301098 kostenfrei https://doaj.org/toc/2225-4110 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2019 3 169-171 |
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10.1016/j.jtcme.2017.09.002 doi (DE-627)DOAJ039834638 (DE-599)DOAJf31efb255bba4da6a196a9f60d86360f DE-627 ger DE-627 rakwb eng Muhammad Zubair verfasserin aut Water and ethanol extracts of Plantago major leaves show anti-inflammatory activity on oral epithelial cells 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Context: The leaves of Plantago major have been used for the treatment of wounds and inflammation in folk medicine from prehistoric times. However there is no report on the use of P. major to treat inflammation in oral epithelial cell lines. Objective: The present study was undertaken to reveal possible anti-inflammatory effects of Plantago major leaf extracts on oral epithelial cells in-vitro. Materials and methods: Water- and ethanol-based extracts of P. major leaves were prepared from freeze-dried plant material, and tested in-vitro using the oral epithelial cell line H400. The anti-inflammatory activity of P. major was tested against E. coli lipopolysaccharide (LPS) using the nuclear factor kappa beta (NF-kB) assay. Results: Both the water- and the ethanol-based extracts, as well as a combination of the two extracts, showed anti-inflammatory activity. A concentration of 0.1 mg/mL (on dry weight basis) yielded the best results for all extracts. Discussion and conclusion: The results show that synergistic effects of both polyphenols and water-soluble compounds (possibly polysaccharides) are responsible for anti-inflammatory activities of P. major. Keywords: Common plantain, Herbal medicine, NF-kB, Wound healing Medicine R Cecilia Widén verfasserin aut Stefan Renvert verfasserin aut Kimmo Rumpunen verfasserin aut In Journal of Traditional and Complementary Medicine Elsevier, 2016 9(2019), 3, Seite 169-171 (DE-627)740705962 (DE-600)2709698-1 22254110 nnns volume:9 year:2019 number:3 pages:169-171 https://doi.org/10.1016/j.jtcme.2017.09.002 kostenfrei https://doaj.org/article/f31efb255bba4da6a196a9f60d86360f kostenfrei http://www.sciencedirect.com/science/article/pii/S2225411017301098 kostenfrei https://doaj.org/toc/2225-4110 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2019 3 169-171 |
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10.1016/j.jtcme.2017.09.002 doi (DE-627)DOAJ039834638 (DE-599)DOAJf31efb255bba4da6a196a9f60d86360f DE-627 ger DE-627 rakwb eng Muhammad Zubair verfasserin aut Water and ethanol extracts of Plantago major leaves show anti-inflammatory activity on oral epithelial cells 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Context: The leaves of Plantago major have been used for the treatment of wounds and inflammation in folk medicine from prehistoric times. However there is no report on the use of P. major to treat inflammation in oral epithelial cell lines. Objective: The present study was undertaken to reveal possible anti-inflammatory effects of Plantago major leaf extracts on oral epithelial cells in-vitro. Materials and methods: Water- and ethanol-based extracts of P. major leaves were prepared from freeze-dried plant material, and tested in-vitro using the oral epithelial cell line H400. The anti-inflammatory activity of P. major was tested against E. coli lipopolysaccharide (LPS) using the nuclear factor kappa beta (NF-kB) assay. Results: Both the water- and the ethanol-based extracts, as well as a combination of the two extracts, showed anti-inflammatory activity. A concentration of 0.1 mg/mL (on dry weight basis) yielded the best results for all extracts. Discussion and conclusion: The results show that synergistic effects of both polyphenols and water-soluble compounds (possibly polysaccharides) are responsible for anti-inflammatory activities of P. major. Keywords: Common plantain, Herbal medicine, NF-kB, Wound healing Medicine R Cecilia Widén verfasserin aut Stefan Renvert verfasserin aut Kimmo Rumpunen verfasserin aut In Journal of Traditional and Complementary Medicine Elsevier, 2016 9(2019), 3, Seite 169-171 (DE-627)740705962 (DE-600)2709698-1 22254110 nnns volume:9 year:2019 number:3 pages:169-171 https://doi.org/10.1016/j.jtcme.2017.09.002 kostenfrei https://doaj.org/article/f31efb255bba4da6a196a9f60d86360f kostenfrei http://www.sciencedirect.com/science/article/pii/S2225411017301098 kostenfrei https://doaj.org/toc/2225-4110 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2019 3 169-171 |
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10.1016/j.jtcme.2017.09.002 doi (DE-627)DOAJ039834638 (DE-599)DOAJf31efb255bba4da6a196a9f60d86360f DE-627 ger DE-627 rakwb eng Muhammad Zubair verfasserin aut Water and ethanol extracts of Plantago major leaves show anti-inflammatory activity on oral epithelial cells 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Context: The leaves of Plantago major have been used for the treatment of wounds and inflammation in folk medicine from prehistoric times. However there is no report on the use of P. major to treat inflammation in oral epithelial cell lines. Objective: The present study was undertaken to reveal possible anti-inflammatory effects of Plantago major leaf extracts on oral epithelial cells in-vitro. Materials and methods: Water- and ethanol-based extracts of P. major leaves were prepared from freeze-dried plant material, and tested in-vitro using the oral epithelial cell line H400. The anti-inflammatory activity of P. major was tested against E. coli lipopolysaccharide (LPS) using the nuclear factor kappa beta (NF-kB) assay. Results: Both the water- and the ethanol-based extracts, as well as a combination of the two extracts, showed anti-inflammatory activity. A concentration of 0.1 mg/mL (on dry weight basis) yielded the best results for all extracts. Discussion and conclusion: The results show that synergistic effects of both polyphenols and water-soluble compounds (possibly polysaccharides) are responsible for anti-inflammatory activities of P. major. Keywords: Common plantain, Herbal medicine, NF-kB, Wound healing Medicine R Cecilia Widén verfasserin aut Stefan Renvert verfasserin aut Kimmo Rumpunen verfasserin aut In Journal of Traditional and Complementary Medicine Elsevier, 2016 9(2019), 3, Seite 169-171 (DE-627)740705962 (DE-600)2709698-1 22254110 nnns volume:9 year:2019 number:3 pages:169-171 https://doi.org/10.1016/j.jtcme.2017.09.002 kostenfrei https://doaj.org/article/f31efb255bba4da6a196a9f60d86360f kostenfrei http://www.sciencedirect.com/science/article/pii/S2225411017301098 kostenfrei https://doaj.org/toc/2225-4110 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2019 3 169-171 |
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However there is no report on the use of P. major to treat inflammation in oral epithelial cell lines. Objective: The present study was undertaken to reveal possible anti-inflammatory effects of Plantago major leaf extracts on oral epithelial cells in-vitro. Materials and methods: Water- and ethanol-based extracts of P. major leaves were prepared from freeze-dried plant material, and tested in-vitro using the oral epithelial cell line H400. The anti-inflammatory activity of P. major was tested against E. coli lipopolysaccharide (LPS) using the nuclear factor kappa beta (NF-kB) assay. Results: Both the water- and the ethanol-based extracts, as well as a combination of the two extracts, showed anti-inflammatory activity. A concentration of 0.1 mg/mL (on dry weight basis) yielded the best results for all extracts. Discussion and conclusion: The results show that synergistic effects of both polyphenols and water-soluble compounds (possibly polysaccharides) are responsible for anti-inflammatory activities of P. major. 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Water and ethanol extracts of Plantago major leaves show anti-inflammatory activity on oral epithelial cells |
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Context: The leaves of Plantago major have been used for the treatment of wounds and inflammation in folk medicine from prehistoric times. However there is no report on the use of P. major to treat inflammation in oral epithelial cell lines. Objective: The present study was undertaken to reveal possible anti-inflammatory effects of Plantago major leaf extracts on oral epithelial cells in-vitro. Materials and methods: Water- and ethanol-based extracts of P. major leaves were prepared from freeze-dried plant material, and tested in-vitro using the oral epithelial cell line H400. The anti-inflammatory activity of P. major was tested against E. coli lipopolysaccharide (LPS) using the nuclear factor kappa beta (NF-kB) assay. Results: Both the water- and the ethanol-based extracts, as well as a combination of the two extracts, showed anti-inflammatory activity. A concentration of 0.1 mg/mL (on dry weight basis) yielded the best results for all extracts. Discussion and conclusion: The results show that synergistic effects of both polyphenols and water-soluble compounds (possibly polysaccharides) are responsible for anti-inflammatory activities of P. major. Keywords: Common plantain, Herbal medicine, NF-kB, Wound healing |
abstractGer |
Context: The leaves of Plantago major have been used for the treatment of wounds and inflammation in folk medicine from prehistoric times. However there is no report on the use of P. major to treat inflammation in oral epithelial cell lines. Objective: The present study was undertaken to reveal possible anti-inflammatory effects of Plantago major leaf extracts on oral epithelial cells in-vitro. Materials and methods: Water- and ethanol-based extracts of P. major leaves were prepared from freeze-dried plant material, and tested in-vitro using the oral epithelial cell line H400. The anti-inflammatory activity of P. major was tested against E. coli lipopolysaccharide (LPS) using the nuclear factor kappa beta (NF-kB) assay. Results: Both the water- and the ethanol-based extracts, as well as a combination of the two extracts, showed anti-inflammatory activity. A concentration of 0.1 mg/mL (on dry weight basis) yielded the best results for all extracts. Discussion and conclusion: The results show that synergistic effects of both polyphenols and water-soluble compounds (possibly polysaccharides) are responsible for anti-inflammatory activities of P. major. Keywords: Common plantain, Herbal medicine, NF-kB, Wound healing |
abstract_unstemmed |
Context: The leaves of Plantago major have been used for the treatment of wounds and inflammation in folk medicine from prehistoric times. However there is no report on the use of P. major to treat inflammation in oral epithelial cell lines. Objective: The present study was undertaken to reveal possible anti-inflammatory effects of Plantago major leaf extracts on oral epithelial cells in-vitro. Materials and methods: Water- and ethanol-based extracts of P. major leaves were prepared from freeze-dried plant material, and tested in-vitro using the oral epithelial cell line H400. The anti-inflammatory activity of P. major was tested against E. coli lipopolysaccharide (LPS) using the nuclear factor kappa beta (NF-kB) assay. Results: Both the water- and the ethanol-based extracts, as well as a combination of the two extracts, showed anti-inflammatory activity. A concentration of 0.1 mg/mL (on dry weight basis) yielded the best results for all extracts. Discussion and conclusion: The results show that synergistic effects of both polyphenols and water-soluble compounds (possibly polysaccharides) are responsible for anti-inflammatory activities of P. major. Keywords: Common plantain, Herbal medicine, NF-kB, Wound healing |
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Water and ethanol extracts of Plantago major leaves show anti-inflammatory activity on oral epithelial cells |
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score |
7.4011583 |