Sodium caseinate increases the number of B lymphocytes in mouse

Introduction: Sodium caseinate, a casein salt, is a proinflammatory agent in mice, and it is able to induce granulopoiesis in vivo and to increase the production of cytokines, which is key for this biological process. Objective: To assess whether sodium caseinate is able to induce a biological effec...
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Gespeichert in:

Autor*in:	Vanihamín Domínguez [verfasserIn] Itzen Aguiñiga [verfasserIn] Leticia Moreno [verfasserIn] Beatriz Torres [verfasserIn] Edelmiro Santiago-Osorio [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch ; Spanisch

Erschienen:	2017

Schlagwörter:	linfocitos B proliferación de la célula inflamación citosina citometría de flujo ensayo de inmunoadsorción enzimática

Übergeordnetes Werk:	In: Biomédica: revista del Instituto Nacional de Salud - Instituto Nacional de Salud, 2016, 37(2017), 4, Seite 571-576
Übergeordnetes Werk:	volume:37 ; year:2017 ; number:4 ; pages:571-576

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.7705/biomedica.v37i4.3604

Katalog-ID:	DOAJ039924947

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245	1	0	\|a Sodium caseinate increases the number of B lymphocytes in mouse
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520			\|a Introduction: Sodium caseinate, a casein salt, is a proinflammatory agent in mice, and it is able to induce granulopoiesis in vivo and to increase the production of cytokines, which is key for this biological process. Objective: To assess whether sodium caseinate is able to induce a biological effect on cells from lymphoid origin and the production of cytokines involved in this lineage in vivo. Materials and methods: We used female BALB /c mice from 8 to 12 weeks old. The animals were injected intraperitoneally (IP) with 1 ml of sodium caseinate (10% PBS w/v) four times every 48 hours. The B cell populations and the incorporation of BrdU were analyzed by flow cytometry. Detection of interleukin-7 was assessed by ELISA (Enzyme-Linked ImmunoSorbent Assay). Results: We established that after intraperitoneal injection, the number of B lymphocytes 220+ from the spleen of mice treated with sodium caseinate increased compared to those that only received the vehicle (89.01±1.03 vs 75.66 ± 2.08), and the same was observed with the incorporation of BrdU in B220 + cells (38.59±4.48 vs 11.82±1.04 respectively). We also established that the concentration of interleukin-7 (IL-7) in the serum of mice treated with sodium caseinate increased compared to those that only received the vehicle (62.1 ± 17.5 vs 26.9 ± 4.4 pg/ml). Conclusion: Sodium caseinate was able to increase the number of B lymphocytes in the spleen; it also induced IL-7 production, a cytokine that is key for the B cell lymphopoiesis.
650		4	\|a linfocitos B
650		4	\|a proliferación de la célula
650		4	\|a inflamación
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650		4	\|a ensayo de inmunoadsorción enzimática
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allfields	10.7705/biomedica.v37i4.3604 doi (DE-627)DOAJ039924947 (DE-599)DOAJ3eeea1b2b9d540f5a6d76482b2a16bef DE-627 ger DE-627 rakwb eng spa RC955-962 Vanihamín Domínguez verfasserin aut Sodium caseinate increases the number of B lymphocytes in mouse 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Sodium caseinate, a casein salt, is a proinflammatory agent in mice, and it is able to induce granulopoiesis in vivo and to increase the production of cytokines, which is key for this biological process. Objective: To assess whether sodium caseinate is able to induce a biological effect on cells from lymphoid origin and the production of cytokines involved in this lineage in vivo. Materials and methods: We used female BALB /c mice from 8 to 12 weeks old. The animals were injected intraperitoneally (IP) with 1 ml of sodium caseinate (10% PBS w/v) four times every 48 hours. The B cell populations and the incorporation of BrdU were analyzed by flow cytometry. Detection of interleukin-7 was assessed by ELISA (Enzyme-Linked ImmunoSorbent Assay). Results: We established that after intraperitoneal injection, the number of B lymphocytes 220+ from the spleen of mice treated with sodium caseinate increased compared to those that only received the vehicle (89.01±1.03 vs 75.66 ± 2.08), and the same was observed with the incorporation of BrdU in B220 + cells (38.59±4.48 vs 11.82±1.04 respectively). We also established that the concentration of interleukin-7 (IL-7) in the serum of mice treated with sodium caseinate increased compared to those that only received the vehicle (62.1 ± 17.5 vs 26.9 ± 4.4 pg/ml). Conclusion: Sodium caseinate was able to increase the number of B lymphocytes in the spleen; it also induced IL-7 production, a cytokine that is key for the B cell lymphopoiesis. linfocitos B proliferación de la célula inflamación citosina citometría de flujo ensayo de inmunoadsorción enzimática Medicine R Arctic medicine. Tropical medicine Itzen Aguiñiga verfasserin aut Leticia Moreno verfasserin aut Beatriz Torres verfasserin aut Edelmiro Santiago-Osorio verfasserin aut In Biomédica: revista del Instituto Nacional de Salud Instituto Nacional de Salud, 2016 37(2017), 4, Seite 571-576 (DE-627)335934269 (DE-600)2059952-3 25907379 nnns volume:37 year:2017 number:4 pages:571-576 https://doi.org/10.7705/biomedica.v37i4.3604 kostenfrei https://doaj.org/article/3eeea1b2b9d540f5a6d76482b2a16bef kostenfrei https://www.revistabiomedica.org/index.php/biomedica/article/view/3604 kostenfrei https://doaj.org/toc/0120-4157 Journal toc kostenfrei https://doaj.org/toc/0120-4157 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 37 2017 4 571-576
spelling	10.7705/biomedica.v37i4.3604 doi (DE-627)DOAJ039924947 (DE-599)DOAJ3eeea1b2b9d540f5a6d76482b2a16bef DE-627 ger DE-627 rakwb eng spa RC955-962 Vanihamín Domínguez verfasserin aut Sodium caseinate increases the number of B lymphocytes in mouse 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Sodium caseinate, a casein salt, is a proinflammatory agent in mice, and it is able to induce granulopoiesis in vivo and to increase the production of cytokines, which is key for this biological process. Objective: To assess whether sodium caseinate is able to induce a biological effect on cells from lymphoid origin and the production of cytokines involved in this lineage in vivo. Materials and methods: We used female BALB /c mice from 8 to 12 weeks old. The animals were injected intraperitoneally (IP) with 1 ml of sodium caseinate (10% PBS w/v) four times every 48 hours. The B cell populations and the incorporation of BrdU were analyzed by flow cytometry. Detection of interleukin-7 was assessed by ELISA (Enzyme-Linked ImmunoSorbent Assay). Results: We established that after intraperitoneal injection, the number of B lymphocytes 220+ from the spleen of mice treated with sodium caseinate increased compared to those that only received the vehicle (89.01±1.03 vs 75.66 ± 2.08), and the same was observed with the incorporation of BrdU in B220 + cells (38.59±4.48 vs 11.82±1.04 respectively). We also established that the concentration of interleukin-7 (IL-7) in the serum of mice treated with sodium caseinate increased compared to those that only received the vehicle (62.1 ± 17.5 vs 26.9 ± 4.4 pg/ml). Conclusion: Sodium caseinate was able to increase the number of B lymphocytes in the spleen; it also induced IL-7 production, a cytokine that is key for the B cell lymphopoiesis. linfocitos B proliferación de la célula inflamación citosina citometría de flujo ensayo de inmunoadsorción enzimática Medicine R Arctic medicine. Tropical medicine Itzen Aguiñiga verfasserin aut Leticia Moreno verfasserin aut Beatriz Torres verfasserin aut Edelmiro Santiago-Osorio verfasserin aut In Biomédica: revista del Instituto Nacional de Salud Instituto Nacional de Salud, 2016 37(2017), 4, Seite 571-576 (DE-627)335934269 (DE-600)2059952-3 25907379 nnns volume:37 year:2017 number:4 pages:571-576 https://doi.org/10.7705/biomedica.v37i4.3604 kostenfrei https://doaj.org/article/3eeea1b2b9d540f5a6d76482b2a16bef kostenfrei https://www.revistabiomedica.org/index.php/biomedica/article/view/3604 kostenfrei https://doaj.org/toc/0120-4157 Journal toc kostenfrei https://doaj.org/toc/0120-4157 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 37 2017 4 571-576
allfields_unstemmed	10.7705/biomedica.v37i4.3604 doi (DE-627)DOAJ039924947 (DE-599)DOAJ3eeea1b2b9d540f5a6d76482b2a16bef DE-627 ger DE-627 rakwb eng spa RC955-962 Vanihamín Domínguez verfasserin aut Sodium caseinate increases the number of B lymphocytes in mouse 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Sodium caseinate, a casein salt, is a proinflammatory agent in mice, and it is able to induce granulopoiesis in vivo and to increase the production of cytokines, which is key for this biological process. Objective: To assess whether sodium caseinate is able to induce a biological effect on cells from lymphoid origin and the production of cytokines involved in this lineage in vivo. Materials and methods: We used female BALB /c mice from 8 to 12 weeks old. The animals were injected intraperitoneally (IP) with 1 ml of sodium caseinate (10% PBS w/v) four times every 48 hours. The B cell populations and the incorporation of BrdU were analyzed by flow cytometry. Detection of interleukin-7 was assessed by ELISA (Enzyme-Linked ImmunoSorbent Assay). Results: We established that after intraperitoneal injection, the number of B lymphocytes 220+ from the spleen of mice treated with sodium caseinate increased compared to those that only received the vehicle (89.01±1.03 vs 75.66 ± 2.08), and the same was observed with the incorporation of BrdU in B220 + cells (38.59±4.48 vs 11.82±1.04 respectively). We also established that the concentration of interleukin-7 (IL-7) in the serum of mice treated with sodium caseinate increased compared to those that only received the vehicle (62.1 ± 17.5 vs 26.9 ± 4.4 pg/ml). Conclusion: Sodium caseinate was able to increase the number of B lymphocytes in the spleen; it also induced IL-7 production, a cytokine that is key for the B cell lymphopoiesis. linfocitos B proliferación de la célula inflamación citosina citometría de flujo ensayo de inmunoadsorción enzimática Medicine R Arctic medicine. Tropical medicine Itzen Aguiñiga verfasserin aut Leticia Moreno verfasserin aut Beatriz Torres verfasserin aut Edelmiro Santiago-Osorio verfasserin aut In Biomédica: revista del Instituto Nacional de Salud Instituto Nacional de Salud, 2016 37(2017), 4, Seite 571-576 (DE-627)335934269 (DE-600)2059952-3 25907379 nnns volume:37 year:2017 number:4 pages:571-576 https://doi.org/10.7705/biomedica.v37i4.3604 kostenfrei https://doaj.org/article/3eeea1b2b9d540f5a6d76482b2a16bef kostenfrei https://www.revistabiomedica.org/index.php/biomedica/article/view/3604 kostenfrei https://doaj.org/toc/0120-4157 Journal toc kostenfrei https://doaj.org/toc/0120-4157 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 37 2017 4 571-576
allfieldsGer	10.7705/biomedica.v37i4.3604 doi (DE-627)DOAJ039924947 (DE-599)DOAJ3eeea1b2b9d540f5a6d76482b2a16bef DE-627 ger DE-627 rakwb eng spa RC955-962 Vanihamín Domínguez verfasserin aut Sodium caseinate increases the number of B lymphocytes in mouse 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Sodium caseinate, a casein salt, is a proinflammatory agent in mice, and it is able to induce granulopoiesis in vivo and to increase the production of cytokines, which is key for this biological process. Objective: To assess whether sodium caseinate is able to induce a biological effect on cells from lymphoid origin and the production of cytokines involved in this lineage in vivo. Materials and methods: We used female BALB /c mice from 8 to 12 weeks old. The animals were injected intraperitoneally (IP) with 1 ml of sodium caseinate (10% PBS w/v) four times every 48 hours. The B cell populations and the incorporation of BrdU were analyzed by flow cytometry. Detection of interleukin-7 was assessed by ELISA (Enzyme-Linked ImmunoSorbent Assay). Results: We established that after intraperitoneal injection, the number of B lymphocytes 220+ from the spleen of mice treated with sodium caseinate increased compared to those that only received the vehicle (89.01±1.03 vs 75.66 ± 2.08), and the same was observed with the incorporation of BrdU in B220 + cells (38.59±4.48 vs 11.82±1.04 respectively). We also established that the concentration of interleukin-7 (IL-7) in the serum of mice treated with sodium caseinate increased compared to those that only received the vehicle (62.1 ± 17.5 vs 26.9 ± 4.4 pg/ml). Conclusion: Sodium caseinate was able to increase the number of B lymphocytes in the spleen; it also induced IL-7 production, a cytokine that is key for the B cell lymphopoiesis. linfocitos B proliferación de la célula inflamación citosina citometría de flujo ensayo de inmunoadsorción enzimática Medicine R Arctic medicine. Tropical medicine Itzen Aguiñiga verfasserin aut Leticia Moreno verfasserin aut Beatriz Torres verfasserin aut Edelmiro Santiago-Osorio verfasserin aut In Biomédica: revista del Instituto Nacional de Salud Instituto Nacional de Salud, 2016 37(2017), 4, Seite 571-576 (DE-627)335934269 (DE-600)2059952-3 25907379 nnns volume:37 year:2017 number:4 pages:571-576 https://doi.org/10.7705/biomedica.v37i4.3604 kostenfrei https://doaj.org/article/3eeea1b2b9d540f5a6d76482b2a16bef kostenfrei https://www.revistabiomedica.org/index.php/biomedica/article/view/3604 kostenfrei https://doaj.org/toc/0120-4157 Journal toc kostenfrei https://doaj.org/toc/0120-4157 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 37 2017 4 571-576
allfieldsSound	10.7705/biomedica.v37i4.3604 doi (DE-627)DOAJ039924947 (DE-599)DOAJ3eeea1b2b9d540f5a6d76482b2a16bef DE-627 ger DE-627 rakwb eng spa RC955-962 Vanihamín Domínguez verfasserin aut Sodium caseinate increases the number of B lymphocytes in mouse 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Sodium caseinate, a casein salt, is a proinflammatory agent in mice, and it is able to induce granulopoiesis in vivo and to increase the production of cytokines, which is key for this biological process. Objective: To assess whether sodium caseinate is able to induce a biological effect on cells from lymphoid origin and the production of cytokines involved in this lineage in vivo. Materials and methods: We used female BALB /c mice from 8 to 12 weeks old. The animals were injected intraperitoneally (IP) with 1 ml of sodium caseinate (10% PBS w/v) four times every 48 hours. The B cell populations and the incorporation of BrdU were analyzed by flow cytometry. Detection of interleukin-7 was assessed by ELISA (Enzyme-Linked ImmunoSorbent Assay). Results: We established that after intraperitoneal injection, the number of B lymphocytes 220+ from the spleen of mice treated with sodium caseinate increased compared to those that only received the vehicle (89.01±1.03 vs 75.66 ± 2.08), and the same was observed with the incorporation of BrdU in B220 + cells (38.59±4.48 vs 11.82±1.04 respectively). We also established that the concentration of interleukin-7 (IL-7) in the serum of mice treated with sodium caseinate increased compared to those that only received the vehicle (62.1 ± 17.5 vs 26.9 ± 4.4 pg/ml). Conclusion: Sodium caseinate was able to increase the number of B lymphocytes in the spleen; it also induced IL-7 production, a cytokine that is key for the B cell lymphopoiesis. linfocitos B proliferación de la célula inflamación citosina citometría de flujo ensayo de inmunoadsorción enzimática Medicine R Arctic medicine. Tropical medicine Itzen Aguiñiga verfasserin aut Leticia Moreno verfasserin aut Beatriz Torres verfasserin aut Edelmiro Santiago-Osorio verfasserin aut In Biomédica: revista del Instituto Nacional de Salud Instituto Nacional de Salud, 2016 37(2017), 4, Seite 571-576 (DE-627)335934269 (DE-600)2059952-3 25907379 nnns volume:37 year:2017 number:4 pages:571-576 https://doi.org/10.7705/biomedica.v37i4.3604 kostenfrei https://doaj.org/article/3eeea1b2b9d540f5a6d76482b2a16bef kostenfrei https://www.revistabiomedica.org/index.php/biomedica/article/view/3604 kostenfrei https://doaj.org/toc/0120-4157 Journal toc kostenfrei https://doaj.org/toc/0120-4157 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 37 2017 4 571-576
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source	In Biomédica: revista del Instituto Nacional de Salud 37(2017), 4, Seite 571-576 volume:37 year:2017 number:4 pages:571-576
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author	Vanihamín Domínguez
spellingShingle	Vanihamín Domínguez misc RC955-962 misc linfocitos B misc proliferación de la célula misc inflamación misc citosina misc citometría de flujo misc ensayo de inmunoadsorción enzimática misc Medicine misc R misc Arctic medicine. Tropical medicine Sodium caseinate increases the number of B lymphocytes in mouse
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topic_title	RC955-962 Sodium caseinate increases the number of B lymphocytes in mouse linfocitos B proliferación de la célula inflamación citosina citometría de flujo ensayo de inmunoadsorción enzimática
topic	misc RC955-962 misc linfocitos B misc proliferación de la célula misc inflamación misc citosina misc citometría de flujo misc ensayo de inmunoadsorción enzimática misc Medicine misc R misc Arctic medicine. Tropical medicine
topic_unstemmed	misc RC955-962 misc linfocitos B misc proliferación de la célula misc inflamación misc citosina misc citometría de flujo misc ensayo de inmunoadsorción enzimática misc Medicine misc R misc Arctic medicine. Tropical medicine
topic_browse	misc RC955-962 misc linfocitos B misc proliferación de la célula misc inflamación misc citosina misc citometría de flujo misc ensayo de inmunoadsorción enzimática misc Medicine misc R misc Arctic medicine. Tropical medicine
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title	Sodium caseinate increases the number of B lymphocytes in mouse
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title_sort	sodium caseinate increases the number of b lymphocytes in mouse
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title_auth	Sodium caseinate increases the number of B lymphocytes in mouse
abstract	Introduction: Sodium caseinate, a casein salt, is a proinflammatory agent in mice, and it is able to induce granulopoiesis in vivo and to increase the production of cytokines, which is key for this biological process. Objective: To assess whether sodium caseinate is able to induce a biological effect on cells from lymphoid origin and the production of cytokines involved in this lineage in vivo. Materials and methods: We used female BALB /c mice from 8 to 12 weeks old. The animals were injected intraperitoneally (IP) with 1 ml of sodium caseinate (10% PBS w/v) four times every 48 hours. The B cell populations and the incorporation of BrdU were analyzed by flow cytometry. Detection of interleukin-7 was assessed by ELISA (Enzyme-Linked ImmunoSorbent Assay). Results: We established that after intraperitoneal injection, the number of B lymphocytes 220+ from the spleen of mice treated with sodium caseinate increased compared to those that only received the vehicle (89.01±1.03 vs 75.66 ± 2.08), and the same was observed with the incorporation of BrdU in B220 + cells (38.59±4.48 vs 11.82±1.04 respectively). We also established that the concentration of interleukin-7 (IL-7) in the serum of mice treated with sodium caseinate increased compared to those that only received the vehicle (62.1 ± 17.5 vs 26.9 ± 4.4 pg/ml). Conclusion: Sodium caseinate was able to increase the number of B lymphocytes in the spleen; it also induced IL-7 production, a cytokine that is key for the B cell lymphopoiesis.
abstractGer	Introduction: Sodium caseinate, a casein salt, is a proinflammatory agent in mice, and it is able to induce granulopoiesis in vivo and to increase the production of cytokines, which is key for this biological process. Objective: To assess whether sodium caseinate is able to induce a biological effect on cells from lymphoid origin and the production of cytokines involved in this lineage in vivo. Materials and methods: We used female BALB /c mice from 8 to 12 weeks old. The animals were injected intraperitoneally (IP) with 1 ml of sodium caseinate (10% PBS w/v) four times every 48 hours. The B cell populations and the incorporation of BrdU were analyzed by flow cytometry. Detection of interleukin-7 was assessed by ELISA (Enzyme-Linked ImmunoSorbent Assay). Results: We established that after intraperitoneal injection, the number of B lymphocytes 220+ from the spleen of mice treated with sodium caseinate increased compared to those that only received the vehicle (89.01±1.03 vs 75.66 ± 2.08), and the same was observed with the incorporation of BrdU in B220 + cells (38.59±4.48 vs 11.82±1.04 respectively). We also established that the concentration of interleukin-7 (IL-7) in the serum of mice treated with sodium caseinate increased compared to those that only received the vehicle (62.1 ± 17.5 vs 26.9 ± 4.4 pg/ml). Conclusion: Sodium caseinate was able to increase the number of B lymphocytes in the spleen; it also induced IL-7 production, a cytokine that is key for the B cell lymphopoiesis.
abstract_unstemmed	Introduction: Sodium caseinate, a casein salt, is a proinflammatory agent in mice, and it is able to induce granulopoiesis in vivo and to increase the production of cytokines, which is key for this biological process. Objective: To assess whether sodium caseinate is able to induce a biological effect on cells from lymphoid origin and the production of cytokines involved in this lineage in vivo. Materials and methods: We used female BALB /c mice from 8 to 12 weeks old. The animals were injected intraperitoneally (IP) with 1 ml of sodium caseinate (10% PBS w/v) four times every 48 hours. The B cell populations and the incorporation of BrdU were analyzed by flow cytometry. Detection of interleukin-7 was assessed by ELISA (Enzyme-Linked ImmunoSorbent Assay). Results: We established that after intraperitoneal injection, the number of B lymphocytes 220+ from the spleen of mice treated with sodium caseinate increased compared to those that only received the vehicle (89.01±1.03 vs 75.66 ± 2.08), and the same was observed with the incorporation of BrdU in B220 + cells (38.59±4.48 vs 11.82±1.04 respectively). We also established that the concentration of interleukin-7 (IL-7) in the serum of mice treated with sodium caseinate increased compared to those that only received the vehicle (62.1 ± 17.5 vs 26.9 ± 4.4 pg/ml). Conclusion: Sodium caseinate was able to increase the number of B lymphocytes in the spleen; it also induced IL-7 production, a cytokine that is key for the B cell lymphopoiesis.
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title_short	Sodium caseinate increases the number of B lymphocytes in mouse
url	https://doi.org/10.7705/biomedica.v37i4.3604 https://doaj.org/article/3eeea1b2b9d540f5a6d76482b2a16bef https://www.revistabiomedica.org/index.php/biomedica/article/view/3604 https://doaj.org/toc/0120-4157
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Objective: To assess whether sodium caseinate is able to induce a biological effect on cells from lymphoid origin and the production of cytokines involved in this lineage in vivo. Materials and methods: We used female BALB /c mice from 8 to 12 weeks old. The animals were injected intraperitoneally (IP) with 1 ml of sodium caseinate (10% PBS w/v) four times every 48 hours. The B cell populations and the incorporation of BrdU were analyzed by flow cytometry. Detection of interleukin-7 was assessed by ELISA (Enzyme-Linked ImmunoSorbent Assay). Results: We established that after intraperitoneal injection, the number of B lymphocytes 220+ from the spleen of mice treated with sodium caseinate increased compared to those that only received the vehicle (89.01±1.03 vs 75.66 ± 2.08), and the same was observed with the incorporation of BrdU in B220 + cells (38.59±4.48 vs 11.82±1.04 respectively). We also established that the concentration of interleukin-7 (IL-7) in the serum of mice treated with sodium caseinate increased compared to those that only received the vehicle (62.1 ± 17.5 vs 26.9 ± 4.4 pg/ml). 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Sodium caseinate increases the number of B lymphocytes in mouse

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