Underlying Conditions and Clinical Spectrum of Chronic Pulmonary Aspergillosis (CPA): An Experience from a Tertiary Care Hospital in Karachi, Pakistan

The incidence of chronic pulmonary aspergillosis (CPA) is especially increasing in high tuberculosis (TB) burden countries. Despite a high estimated CPA burden in Pakistan, actual data on CPA are not available. The aim of the current study is to determine the underlying conditions and clinical spect...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Nousheen Iqbal [verfasserIn] Muhammad Irfan [verfasserIn] Ammar Mushtaq [verfasserIn] Kauser Jabeen [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	chronic pulmonary aspergillosis structural lung diseases developing country pakistan

Übergeordnetes Werk:	In: Journal of Fungi - MDPI AG, 2015, 6(2020), 2, p 41
Übergeordnetes Werk:	volume:6 ; year:2020 ; number:2, p 41

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jof6020041

Katalog-ID:	DOAJ039991946

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spelling	10.3390/jof6020041 doi (DE-627)DOAJ039991946 (DE-599)DOAJe36074f6081342aab101693aebbff8e3 DE-627 ger DE-627 rakwb eng QH301-705.5 Nousheen Iqbal verfasserin aut Underlying Conditions and Clinical Spectrum of Chronic Pulmonary Aspergillosis (CPA): An Experience from a Tertiary Care Hospital in Karachi, Pakistan 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The incidence of chronic pulmonary aspergillosis (CPA) is especially increasing in high tuberculosis (TB) burden countries. Despite a high estimated CPA burden in Pakistan, actual data on CPA are not available. The aim of the current study is to determine the underlying conditions and clinical spectrum of CPA at a tertiary care hospital in Karachi, Pakistan. This is a retrospective chart review study in patients admitted with CPA from January 2012 to December 2017. A total of 67 patients were identified during the study period. Mean age of CPA patients was 45.9 ± 15 years, 44 (65.7%) were male and 19 (28.4%) had diabetes. The most common type of CPA was simple aspergilloma (49.2%) followed by chronic cavitary pulmonary aspergillosis (CCPA) (44.7%). TB was the underlying cause of CPA in 58 (86.6%) patients followed by bronchiectasis caused by allergic bronchopulmonary aspergillosis (ABPA) 8 (11.9%). <i<Aspergillus flavus</i< was identified in 17 (47.2%), followed by <i<A. </i<<i<fumigatus</i< in 13 (36.1%) CPA patients. Isolation of multiple <i<Aspergillus</i< species was found in 10 (25.6%) patients. Itraconazole was given in 27 (40.3%) patients and a combination therapy of itraconazole and surgery was given in 21 (31.34%) patients. We found aspergilloma and CCPA as the most prevalent forms of CPA in our setting. Further large prospective studies using <i<Aspergillus </i<specific immunoglobulin G (IgG) antibodies testing are required for better understanding of CPA in Pakistan. chronic pulmonary aspergillosis structural lung diseases developing country pakistan Biology (General) Muhammad Irfan verfasserin aut Ammar Mushtaq verfasserin aut Kauser Jabeen verfasserin aut In Journal of Fungi MDPI AG, 2015 6(2020), 2, p 41 (DE-627)796588538 (DE-600)2784229-0 2309608X nnns volume:6 year:2020 number:2, p 41 https://doi.org/10.3390/jof6020041 kostenfrei https://doaj.org/article/e36074f6081342aab101693aebbff8e3 kostenfrei https://www.mdpi.com/2309-608X/6/2/41 kostenfrei https://doaj.org/toc/2309-608X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2020 2, p 41
allfields_unstemmed	10.3390/jof6020041 doi (DE-627)DOAJ039991946 (DE-599)DOAJe36074f6081342aab101693aebbff8e3 DE-627 ger DE-627 rakwb eng QH301-705.5 Nousheen Iqbal verfasserin aut Underlying Conditions and Clinical Spectrum of Chronic Pulmonary Aspergillosis (CPA): An Experience from a Tertiary Care Hospital in Karachi, Pakistan 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The incidence of chronic pulmonary aspergillosis (CPA) is especially increasing in high tuberculosis (TB) burden countries. Despite a high estimated CPA burden in Pakistan, actual data on CPA are not available. The aim of the current study is to determine the underlying conditions and clinical spectrum of CPA at a tertiary care hospital in Karachi, Pakistan. This is a retrospective chart review study in patients admitted with CPA from January 2012 to December 2017. A total of 67 patients were identified during the study period. Mean age of CPA patients was 45.9 ± 15 years, 44 (65.7%) were male and 19 (28.4%) had diabetes. The most common type of CPA was simple aspergilloma (49.2%) followed by chronic cavitary pulmonary aspergillosis (CCPA) (44.7%). TB was the underlying cause of CPA in 58 (86.6%) patients followed by bronchiectasis caused by allergic bronchopulmonary aspergillosis (ABPA) 8 (11.9%). <i<Aspergillus flavus</i< was identified in 17 (47.2%), followed by <i<A. </i<<i<fumigatus</i< in 13 (36.1%) CPA patients. Isolation of multiple <i<Aspergillus</i< species was found in 10 (25.6%) patients. Itraconazole was given in 27 (40.3%) patients and a combination therapy of itraconazole and surgery was given in 21 (31.34%) patients. We found aspergilloma and CCPA as the most prevalent forms of CPA in our setting. Further large prospective studies using <i<Aspergillus </i<specific immunoglobulin G (IgG) antibodies testing are required for better understanding of CPA in Pakistan. chronic pulmonary aspergillosis structural lung diseases developing country pakistan Biology (General) Muhammad Irfan verfasserin aut Ammar Mushtaq verfasserin aut Kauser Jabeen verfasserin aut In Journal of Fungi MDPI AG, 2015 6(2020), 2, p 41 (DE-627)796588538 (DE-600)2784229-0 2309608X nnns volume:6 year:2020 number:2, p 41 https://doi.org/10.3390/jof6020041 kostenfrei https://doaj.org/article/e36074f6081342aab101693aebbff8e3 kostenfrei https://www.mdpi.com/2309-608X/6/2/41 kostenfrei https://doaj.org/toc/2309-608X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2020 2, p 41
allfieldsGer	10.3390/jof6020041 doi (DE-627)DOAJ039991946 (DE-599)DOAJe36074f6081342aab101693aebbff8e3 DE-627 ger DE-627 rakwb eng QH301-705.5 Nousheen Iqbal verfasserin aut Underlying Conditions and Clinical Spectrum of Chronic Pulmonary Aspergillosis (CPA): An Experience from a Tertiary Care Hospital in Karachi, Pakistan 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The incidence of chronic pulmonary aspergillosis (CPA) is especially increasing in high tuberculosis (TB) burden countries. Despite a high estimated CPA burden in Pakistan, actual data on CPA are not available. The aim of the current study is to determine the underlying conditions and clinical spectrum of CPA at a tertiary care hospital in Karachi, Pakistan. This is a retrospective chart review study in patients admitted with CPA from January 2012 to December 2017. A total of 67 patients were identified during the study period. Mean age of CPA patients was 45.9 ± 15 years, 44 (65.7%) were male and 19 (28.4%) had diabetes. The most common type of CPA was simple aspergilloma (49.2%) followed by chronic cavitary pulmonary aspergillosis (CCPA) (44.7%). TB was the underlying cause of CPA in 58 (86.6%) patients followed by bronchiectasis caused by allergic bronchopulmonary aspergillosis (ABPA) 8 (11.9%). <i<Aspergillus flavus</i< was identified in 17 (47.2%), followed by <i<A. </i<<i<fumigatus</i< in 13 (36.1%) CPA patients. Isolation of multiple <i<Aspergillus</i< species was found in 10 (25.6%) patients. Itraconazole was given in 27 (40.3%) patients and a combination therapy of itraconazole and surgery was given in 21 (31.34%) patients. We found aspergilloma and CCPA as the most prevalent forms of CPA in our setting. Further large prospective studies using <i<Aspergillus </i<specific immunoglobulin G (IgG) antibodies testing are required for better understanding of CPA in Pakistan. chronic pulmonary aspergillosis structural lung diseases developing country pakistan Biology (General) Muhammad Irfan verfasserin aut Ammar Mushtaq verfasserin aut Kauser Jabeen verfasserin aut In Journal of Fungi MDPI AG, 2015 6(2020), 2, p 41 (DE-627)796588538 (DE-600)2784229-0 2309608X nnns volume:6 year:2020 number:2, p 41 https://doi.org/10.3390/jof6020041 kostenfrei https://doaj.org/article/e36074f6081342aab101693aebbff8e3 kostenfrei https://www.mdpi.com/2309-608X/6/2/41 kostenfrei https://doaj.org/toc/2309-608X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2020 2, p 41
allfieldsSound	10.3390/jof6020041 doi (DE-627)DOAJ039991946 (DE-599)DOAJe36074f6081342aab101693aebbff8e3 DE-627 ger DE-627 rakwb eng QH301-705.5 Nousheen Iqbal verfasserin aut Underlying Conditions and Clinical Spectrum of Chronic Pulmonary Aspergillosis (CPA): An Experience from a Tertiary Care Hospital in Karachi, Pakistan 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The incidence of chronic pulmonary aspergillosis (CPA) is especially increasing in high tuberculosis (TB) burden countries. Despite a high estimated CPA burden in Pakistan, actual data on CPA are not available. The aim of the current study is to determine the underlying conditions and clinical spectrum of CPA at a tertiary care hospital in Karachi, Pakistan. This is a retrospective chart review study in patients admitted with CPA from January 2012 to December 2017. A total of 67 patients were identified during the study period. Mean age of CPA patients was 45.9 ± 15 years, 44 (65.7%) were male and 19 (28.4%) had diabetes. The most common type of CPA was simple aspergilloma (49.2%) followed by chronic cavitary pulmonary aspergillosis (CCPA) (44.7%). TB was the underlying cause of CPA in 58 (86.6%) patients followed by bronchiectasis caused by allergic bronchopulmonary aspergillosis (ABPA) 8 (11.9%). <i<Aspergillus flavus</i< was identified in 17 (47.2%), followed by <i<A. </i<<i<fumigatus</i< in 13 (36.1%) CPA patients. Isolation of multiple <i<Aspergillus</i< species was found in 10 (25.6%) patients. Itraconazole was given in 27 (40.3%) patients and a combination therapy of itraconazole and surgery was given in 21 (31.34%) patients. We found aspergilloma and CCPA as the most prevalent forms of CPA in our setting. Further large prospective studies using <i<Aspergillus </i<specific immunoglobulin G (IgG) antibodies testing are required for better understanding of CPA in Pakistan. chronic pulmonary aspergillosis structural lung diseases developing country pakistan Biology (General) Muhammad Irfan verfasserin aut Ammar Mushtaq verfasserin aut Kauser Jabeen verfasserin aut In Journal of Fungi MDPI AG, 2015 6(2020), 2, p 41 (DE-627)796588538 (DE-600)2784229-0 2309608X nnns volume:6 year:2020 number:2, p 41 https://doi.org/10.3390/jof6020041 kostenfrei https://doaj.org/article/e36074f6081342aab101693aebbff8e3 kostenfrei https://www.mdpi.com/2309-608X/6/2/41 kostenfrei https://doaj.org/toc/2309-608X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2020 2, p 41
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author	Nousheen Iqbal
spellingShingle	Nousheen Iqbal misc QH301-705.5 misc chronic pulmonary aspergillosis misc structural lung diseases misc developing country misc pakistan misc Biology (General) Underlying Conditions and Clinical Spectrum of Chronic Pulmonary Aspergillosis (CPA): An Experience from a Tertiary Care Hospital in Karachi, Pakistan
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topic_title	QH301-705.5 Underlying Conditions and Clinical Spectrum of Chronic Pulmonary Aspergillosis (CPA): An Experience from a Tertiary Care Hospital in Karachi, Pakistan chronic pulmonary aspergillosis structural lung diseases developing country pakistan
topic	misc QH301-705.5 misc chronic pulmonary aspergillosis misc structural lung diseases misc developing country misc pakistan misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc chronic pulmonary aspergillosis misc structural lung diseases misc developing country misc pakistan misc Biology (General)
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title	Underlying Conditions and Clinical Spectrum of Chronic Pulmonary Aspergillosis (CPA): An Experience from a Tertiary Care Hospital in Karachi, Pakistan
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title_full	Underlying Conditions and Clinical Spectrum of Chronic Pulmonary Aspergillosis (CPA): An Experience from a Tertiary Care Hospital in Karachi, Pakistan
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title_sort	underlying conditions and clinical spectrum of chronic pulmonary aspergillosis (cpa): an experience from a tertiary care hospital in karachi, pakistan
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title_auth	Underlying Conditions and Clinical Spectrum of Chronic Pulmonary Aspergillosis (CPA): An Experience from a Tertiary Care Hospital in Karachi, Pakistan
abstract	The incidence of chronic pulmonary aspergillosis (CPA) is especially increasing in high tuberculosis (TB) burden countries. Despite a high estimated CPA burden in Pakistan, actual data on CPA are not available. The aim of the current study is to determine the underlying conditions and clinical spectrum of CPA at a tertiary care hospital in Karachi, Pakistan. This is a retrospective chart review study in patients admitted with CPA from January 2012 to December 2017. A total of 67 patients were identified during the study period. Mean age of CPA patients was 45.9 ± 15 years, 44 (65.7%) were male and 19 (28.4%) had diabetes. The most common type of CPA was simple aspergilloma (49.2%) followed by chronic cavitary pulmonary aspergillosis (CCPA) (44.7%). TB was the underlying cause of CPA in 58 (86.6%) patients followed by bronchiectasis caused by allergic bronchopulmonary aspergillosis (ABPA) 8 (11.9%). <i<Aspergillus flavus</i< was identified in 17 (47.2%), followed by <i<A. </i<<i<fumigatus</i< in 13 (36.1%) CPA patients. Isolation of multiple <i<Aspergillus</i< species was found in 10 (25.6%) patients. Itraconazole was given in 27 (40.3%) patients and a combination therapy of itraconazole and surgery was given in 21 (31.34%) patients. We found aspergilloma and CCPA as the most prevalent forms of CPA in our setting. Further large prospective studies using <i<Aspergillus </i<specific immunoglobulin G (IgG) antibodies testing are required for better understanding of CPA in Pakistan.
abstractGer	The incidence of chronic pulmonary aspergillosis (CPA) is especially increasing in high tuberculosis (TB) burden countries. Despite a high estimated CPA burden in Pakistan, actual data on CPA are not available. The aim of the current study is to determine the underlying conditions and clinical spectrum of CPA at a tertiary care hospital in Karachi, Pakistan. This is a retrospective chart review study in patients admitted with CPA from January 2012 to December 2017. A total of 67 patients were identified during the study period. Mean age of CPA patients was 45.9 ± 15 years, 44 (65.7%) were male and 19 (28.4%) had diabetes. The most common type of CPA was simple aspergilloma (49.2%) followed by chronic cavitary pulmonary aspergillosis (CCPA) (44.7%). TB was the underlying cause of CPA in 58 (86.6%) patients followed by bronchiectasis caused by allergic bronchopulmonary aspergillosis (ABPA) 8 (11.9%). <i<Aspergillus flavus</i< was identified in 17 (47.2%), followed by <i<A. </i<<i<fumigatus</i< in 13 (36.1%) CPA patients. Isolation of multiple <i<Aspergillus</i< species was found in 10 (25.6%) patients. Itraconazole was given in 27 (40.3%) patients and a combination therapy of itraconazole and surgery was given in 21 (31.34%) patients. We found aspergilloma and CCPA as the most prevalent forms of CPA in our setting. Further large prospective studies using <i<Aspergillus </i<specific immunoglobulin G (IgG) antibodies testing are required for better understanding of CPA in Pakistan.
abstract_unstemmed	The incidence of chronic pulmonary aspergillosis (CPA) is especially increasing in high tuberculosis (TB) burden countries. Despite a high estimated CPA burden in Pakistan, actual data on CPA are not available. The aim of the current study is to determine the underlying conditions and clinical spectrum of CPA at a tertiary care hospital in Karachi, Pakistan. This is a retrospective chart review study in patients admitted with CPA from January 2012 to December 2017. A total of 67 patients were identified during the study period. Mean age of CPA patients was 45.9 ± 15 years, 44 (65.7%) were male and 19 (28.4%) had diabetes. The most common type of CPA was simple aspergilloma (49.2%) followed by chronic cavitary pulmonary aspergillosis (CCPA) (44.7%). TB was the underlying cause of CPA in 58 (86.6%) patients followed by bronchiectasis caused by allergic bronchopulmonary aspergillosis (ABPA) 8 (11.9%). <i<Aspergillus flavus</i< was identified in 17 (47.2%), followed by <i<A. </i<<i<fumigatus</i< in 13 (36.1%) CPA patients. Isolation of multiple <i<Aspergillus</i< species was found in 10 (25.6%) patients. Itraconazole was given in 27 (40.3%) patients and a combination therapy of itraconazole and surgery was given in 21 (31.34%) patients. We found aspergilloma and CCPA as the most prevalent forms of CPA in our setting. Further large prospective studies using <i<Aspergillus </i<specific immunoglobulin G (IgG) antibodies testing are required for better understanding of CPA in Pakistan.
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title_short	Underlying Conditions and Clinical Spectrum of Chronic Pulmonary Aspergillosis (CPA): An Experience from a Tertiary Care Hospital in Karachi, Pakistan
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Underlying Conditions and Clinical Spectrum of Chronic Pulmonary Aspergillosis (CPA): An Experience from a Tertiary Care Hospital in Karachi, Pakistan

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