Curcumin is a promising inhibitor of genotype 2 porcine reproductive and respiratory syndrome virus infection
Abstract Background Porcine reproductive and respiratory syndrome virus (PRRSV) could lead to pandemic diseases and huge financial losses to the swine industry worldwide. Curcumin, a natural compound, has been reported to serve as an entry inhibitor of hepatitis C virus, chikungunya virus and vesicu...
Ausführliche Beschreibung
Autor*in: |
Taofeng Du [verfasserIn] Yunpeng Shi [verfasserIn] Shuqi Xiao [verfasserIn] Na Li [verfasserIn] Qin Zhao [verfasserIn] Angke Zhang [verfasserIn] Yuchen Nan [verfasserIn] Yang Mu [verfasserIn] Yani Sun [verfasserIn] Chunyan Wu [verfasserIn] Hongtao Zhang [verfasserIn] En-Min Zhou [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
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2017 |
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In: BMC Veterinary Research - BMC, 2005, 13(2017), 1, Seite 9 |
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Übergeordnetes Werk: |
volume:13 ; year:2017 ; number:1 ; pages:9 |
Links: |
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DOI / URN: |
10.1186/s12917-017-1218-x |
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Katalog-ID: |
DOAJ040010708 |
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520 | |a Abstract Background Porcine reproductive and respiratory syndrome virus (PRRSV) could lead to pandemic diseases and huge financial losses to the swine industry worldwide. Curcumin, a natural compound, has been reported to serve as an entry inhibitor of hepatitis C virus, chikungunya virus and vesicular stomatitis virus. In this study, we investigated the potential effect of curcumin on early stages of PRRSV infection. Results Curcumin inhibited infection of Marc-145 cells and porcine alveolar macrophages (PAMs) by four different genotype 2 PRRSV strains, but had no effect on the levels of major PRRSV receptor proteins on Marc-145 cells and PAMs or on PRRSV binding to Marc-145 cells. However, curcumin did block two steps of the PRRSV infection process: virus internalization and virus-mediated cell fusion. Conclusions Our results suggested that an inhibition of genotype 2 PRRSV infection by curcumin is virus strain-independent, and mainly inhibited by virus internalization and cell fusion mediated by virus. Collectively, these results demonstrate that curcumin holds promise as a new anti-PRRSV drug. | ||
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10.1186/s12917-017-1218-x doi (DE-627)DOAJ040010708 (DE-599)DOAJfe7d030cb0c74153a412a70c1d06388f DE-627 ger DE-627 rakwb eng SF600-1100 Taofeng Du verfasserin aut Curcumin is a promising inhibitor of genotype 2 porcine reproductive and respiratory syndrome virus infection 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Porcine reproductive and respiratory syndrome virus (PRRSV) could lead to pandemic diseases and huge financial losses to the swine industry worldwide. Curcumin, a natural compound, has been reported to serve as an entry inhibitor of hepatitis C virus, chikungunya virus and vesicular stomatitis virus. In this study, we investigated the potential effect of curcumin on early stages of PRRSV infection. Results Curcumin inhibited infection of Marc-145 cells and porcine alveolar macrophages (PAMs) by four different genotype 2 PRRSV strains, but had no effect on the levels of major PRRSV receptor proteins on Marc-145 cells and PAMs or on PRRSV binding to Marc-145 cells. However, curcumin did block two steps of the PRRSV infection process: virus internalization and virus-mediated cell fusion. Conclusions Our results suggested that an inhibition of genotype 2 PRRSV infection by curcumin is virus strain-independent, and mainly inhibited by virus internalization and cell fusion mediated by virus. Collectively, these results demonstrate that curcumin holds promise as a new anti-PRRSV drug. PRRSV Curcumin Binding Internalization Virus-mediated cell fusion Veterinary medicine Yunpeng Shi verfasserin aut Shuqi Xiao verfasserin aut Na Li verfasserin aut Qin Zhao verfasserin aut Angke Zhang verfasserin aut Yuchen Nan verfasserin aut Yang Mu verfasserin aut Yani Sun verfasserin aut Chunyan Wu verfasserin aut Hongtao Zhang verfasserin aut En-Min Zhou verfasserin aut In BMC Veterinary Research BMC, 2005 13(2017), 1, Seite 9 (DE-627)489256538 (DE-600)2191675-5 17466148 nnns volume:13 year:2017 number:1 pages:9 https://doi.org/10.1186/s12917-017-1218-x kostenfrei https://doaj.org/article/fe7d030cb0c74153a412a70c1d06388f kostenfrei http://link.springer.com/article/10.1186/s12917-017-1218-x kostenfrei https://doaj.org/toc/1746-6148 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2017 1 9 |
spelling |
10.1186/s12917-017-1218-x doi (DE-627)DOAJ040010708 (DE-599)DOAJfe7d030cb0c74153a412a70c1d06388f DE-627 ger DE-627 rakwb eng SF600-1100 Taofeng Du verfasserin aut Curcumin is a promising inhibitor of genotype 2 porcine reproductive and respiratory syndrome virus infection 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Porcine reproductive and respiratory syndrome virus (PRRSV) could lead to pandemic diseases and huge financial losses to the swine industry worldwide. Curcumin, a natural compound, has been reported to serve as an entry inhibitor of hepatitis C virus, chikungunya virus and vesicular stomatitis virus. In this study, we investigated the potential effect of curcumin on early stages of PRRSV infection. Results Curcumin inhibited infection of Marc-145 cells and porcine alveolar macrophages (PAMs) by four different genotype 2 PRRSV strains, but had no effect on the levels of major PRRSV receptor proteins on Marc-145 cells and PAMs or on PRRSV binding to Marc-145 cells. However, curcumin did block two steps of the PRRSV infection process: virus internalization and virus-mediated cell fusion. Conclusions Our results suggested that an inhibition of genotype 2 PRRSV infection by curcumin is virus strain-independent, and mainly inhibited by virus internalization and cell fusion mediated by virus. Collectively, these results demonstrate that curcumin holds promise as a new anti-PRRSV drug. PRRSV Curcumin Binding Internalization Virus-mediated cell fusion Veterinary medicine Yunpeng Shi verfasserin aut Shuqi Xiao verfasserin aut Na Li verfasserin aut Qin Zhao verfasserin aut Angke Zhang verfasserin aut Yuchen Nan verfasserin aut Yang Mu verfasserin aut Yani Sun verfasserin aut Chunyan Wu verfasserin aut Hongtao Zhang verfasserin aut En-Min Zhou verfasserin aut In BMC Veterinary Research BMC, 2005 13(2017), 1, Seite 9 (DE-627)489256538 (DE-600)2191675-5 17466148 nnns volume:13 year:2017 number:1 pages:9 https://doi.org/10.1186/s12917-017-1218-x kostenfrei https://doaj.org/article/fe7d030cb0c74153a412a70c1d06388f kostenfrei http://link.springer.com/article/10.1186/s12917-017-1218-x kostenfrei https://doaj.org/toc/1746-6148 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2017 1 9 |
allfields_unstemmed |
10.1186/s12917-017-1218-x doi (DE-627)DOAJ040010708 (DE-599)DOAJfe7d030cb0c74153a412a70c1d06388f DE-627 ger DE-627 rakwb eng SF600-1100 Taofeng Du verfasserin aut Curcumin is a promising inhibitor of genotype 2 porcine reproductive and respiratory syndrome virus infection 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Porcine reproductive and respiratory syndrome virus (PRRSV) could lead to pandemic diseases and huge financial losses to the swine industry worldwide. Curcumin, a natural compound, has been reported to serve as an entry inhibitor of hepatitis C virus, chikungunya virus and vesicular stomatitis virus. In this study, we investigated the potential effect of curcumin on early stages of PRRSV infection. Results Curcumin inhibited infection of Marc-145 cells and porcine alveolar macrophages (PAMs) by four different genotype 2 PRRSV strains, but had no effect on the levels of major PRRSV receptor proteins on Marc-145 cells and PAMs or on PRRSV binding to Marc-145 cells. However, curcumin did block two steps of the PRRSV infection process: virus internalization and virus-mediated cell fusion. Conclusions Our results suggested that an inhibition of genotype 2 PRRSV infection by curcumin is virus strain-independent, and mainly inhibited by virus internalization and cell fusion mediated by virus. Collectively, these results demonstrate that curcumin holds promise as a new anti-PRRSV drug. PRRSV Curcumin Binding Internalization Virus-mediated cell fusion Veterinary medicine Yunpeng Shi verfasserin aut Shuqi Xiao verfasserin aut Na Li verfasserin aut Qin Zhao verfasserin aut Angke Zhang verfasserin aut Yuchen Nan verfasserin aut Yang Mu verfasserin aut Yani Sun verfasserin aut Chunyan Wu verfasserin aut Hongtao Zhang verfasserin aut En-Min Zhou verfasserin aut In BMC Veterinary Research BMC, 2005 13(2017), 1, Seite 9 (DE-627)489256538 (DE-600)2191675-5 17466148 nnns volume:13 year:2017 number:1 pages:9 https://doi.org/10.1186/s12917-017-1218-x kostenfrei https://doaj.org/article/fe7d030cb0c74153a412a70c1d06388f kostenfrei http://link.springer.com/article/10.1186/s12917-017-1218-x kostenfrei https://doaj.org/toc/1746-6148 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2017 1 9 |
allfieldsGer |
10.1186/s12917-017-1218-x doi (DE-627)DOAJ040010708 (DE-599)DOAJfe7d030cb0c74153a412a70c1d06388f DE-627 ger DE-627 rakwb eng SF600-1100 Taofeng Du verfasserin aut Curcumin is a promising inhibitor of genotype 2 porcine reproductive and respiratory syndrome virus infection 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Porcine reproductive and respiratory syndrome virus (PRRSV) could lead to pandemic diseases and huge financial losses to the swine industry worldwide. Curcumin, a natural compound, has been reported to serve as an entry inhibitor of hepatitis C virus, chikungunya virus and vesicular stomatitis virus. In this study, we investigated the potential effect of curcumin on early stages of PRRSV infection. Results Curcumin inhibited infection of Marc-145 cells and porcine alveolar macrophages (PAMs) by four different genotype 2 PRRSV strains, but had no effect on the levels of major PRRSV receptor proteins on Marc-145 cells and PAMs or on PRRSV binding to Marc-145 cells. However, curcumin did block two steps of the PRRSV infection process: virus internalization and virus-mediated cell fusion. Conclusions Our results suggested that an inhibition of genotype 2 PRRSV infection by curcumin is virus strain-independent, and mainly inhibited by virus internalization and cell fusion mediated by virus. Collectively, these results demonstrate that curcumin holds promise as a new anti-PRRSV drug. PRRSV Curcumin Binding Internalization Virus-mediated cell fusion Veterinary medicine Yunpeng Shi verfasserin aut Shuqi Xiao verfasserin aut Na Li verfasserin aut Qin Zhao verfasserin aut Angke Zhang verfasserin aut Yuchen Nan verfasserin aut Yang Mu verfasserin aut Yani Sun verfasserin aut Chunyan Wu verfasserin aut Hongtao Zhang verfasserin aut En-Min Zhou verfasserin aut In BMC Veterinary Research BMC, 2005 13(2017), 1, Seite 9 (DE-627)489256538 (DE-600)2191675-5 17466148 nnns volume:13 year:2017 number:1 pages:9 https://doi.org/10.1186/s12917-017-1218-x kostenfrei https://doaj.org/article/fe7d030cb0c74153a412a70c1d06388f kostenfrei http://link.springer.com/article/10.1186/s12917-017-1218-x kostenfrei https://doaj.org/toc/1746-6148 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2017 1 9 |
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10.1186/s12917-017-1218-x doi (DE-627)DOAJ040010708 (DE-599)DOAJfe7d030cb0c74153a412a70c1d06388f DE-627 ger DE-627 rakwb eng SF600-1100 Taofeng Du verfasserin aut Curcumin is a promising inhibitor of genotype 2 porcine reproductive and respiratory syndrome virus infection 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Porcine reproductive and respiratory syndrome virus (PRRSV) could lead to pandemic diseases and huge financial losses to the swine industry worldwide. Curcumin, a natural compound, has been reported to serve as an entry inhibitor of hepatitis C virus, chikungunya virus and vesicular stomatitis virus. In this study, we investigated the potential effect of curcumin on early stages of PRRSV infection. Results Curcumin inhibited infection of Marc-145 cells and porcine alveolar macrophages (PAMs) by four different genotype 2 PRRSV strains, but had no effect on the levels of major PRRSV receptor proteins on Marc-145 cells and PAMs or on PRRSV binding to Marc-145 cells. However, curcumin did block two steps of the PRRSV infection process: virus internalization and virus-mediated cell fusion. Conclusions Our results suggested that an inhibition of genotype 2 PRRSV infection by curcumin is virus strain-independent, and mainly inhibited by virus internalization and cell fusion mediated by virus. Collectively, these results demonstrate that curcumin holds promise as a new anti-PRRSV drug. PRRSV Curcumin Binding Internalization Virus-mediated cell fusion Veterinary medicine Yunpeng Shi verfasserin aut Shuqi Xiao verfasserin aut Na Li verfasserin aut Qin Zhao verfasserin aut Angke Zhang verfasserin aut Yuchen Nan verfasserin aut Yang Mu verfasserin aut Yani Sun verfasserin aut Chunyan Wu verfasserin aut Hongtao Zhang verfasserin aut En-Min Zhou verfasserin aut In BMC Veterinary Research BMC, 2005 13(2017), 1, Seite 9 (DE-627)489256538 (DE-600)2191675-5 17466148 nnns volume:13 year:2017 number:1 pages:9 https://doi.org/10.1186/s12917-017-1218-x kostenfrei https://doaj.org/article/fe7d030cb0c74153a412a70c1d06388f kostenfrei http://link.springer.com/article/10.1186/s12917-017-1218-x kostenfrei https://doaj.org/toc/1746-6148 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2017 1 9 |
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Curcumin is a promising inhibitor of genotype 2 porcine reproductive and respiratory syndrome virus infection |
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Curcumin is a promising inhibitor of genotype 2 porcine reproductive and respiratory syndrome virus infection |
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Taofeng Du Yunpeng Shi Shuqi Xiao Na Li Qin Zhao Angke Zhang Yuchen Nan Yang Mu Yani Sun Chunyan Wu Hongtao Zhang En-Min Zhou |
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curcumin is a promising inhibitor of genotype 2 porcine reproductive and respiratory syndrome virus infection |
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Curcumin is a promising inhibitor of genotype 2 porcine reproductive and respiratory syndrome virus infection |
abstract |
Abstract Background Porcine reproductive and respiratory syndrome virus (PRRSV) could lead to pandemic diseases and huge financial losses to the swine industry worldwide. Curcumin, a natural compound, has been reported to serve as an entry inhibitor of hepatitis C virus, chikungunya virus and vesicular stomatitis virus. In this study, we investigated the potential effect of curcumin on early stages of PRRSV infection. Results Curcumin inhibited infection of Marc-145 cells and porcine alveolar macrophages (PAMs) by four different genotype 2 PRRSV strains, but had no effect on the levels of major PRRSV receptor proteins on Marc-145 cells and PAMs or on PRRSV binding to Marc-145 cells. However, curcumin did block two steps of the PRRSV infection process: virus internalization and virus-mediated cell fusion. Conclusions Our results suggested that an inhibition of genotype 2 PRRSV infection by curcumin is virus strain-independent, and mainly inhibited by virus internalization and cell fusion mediated by virus. Collectively, these results demonstrate that curcumin holds promise as a new anti-PRRSV drug. |
abstractGer |
Abstract Background Porcine reproductive and respiratory syndrome virus (PRRSV) could lead to pandemic diseases and huge financial losses to the swine industry worldwide. Curcumin, a natural compound, has been reported to serve as an entry inhibitor of hepatitis C virus, chikungunya virus and vesicular stomatitis virus. In this study, we investigated the potential effect of curcumin on early stages of PRRSV infection. Results Curcumin inhibited infection of Marc-145 cells and porcine alveolar macrophages (PAMs) by four different genotype 2 PRRSV strains, but had no effect on the levels of major PRRSV receptor proteins on Marc-145 cells and PAMs or on PRRSV binding to Marc-145 cells. However, curcumin did block two steps of the PRRSV infection process: virus internalization and virus-mediated cell fusion. Conclusions Our results suggested that an inhibition of genotype 2 PRRSV infection by curcumin is virus strain-independent, and mainly inhibited by virus internalization and cell fusion mediated by virus. Collectively, these results demonstrate that curcumin holds promise as a new anti-PRRSV drug. |
abstract_unstemmed |
Abstract Background Porcine reproductive and respiratory syndrome virus (PRRSV) could lead to pandemic diseases and huge financial losses to the swine industry worldwide. Curcumin, a natural compound, has been reported to serve as an entry inhibitor of hepatitis C virus, chikungunya virus and vesicular stomatitis virus. In this study, we investigated the potential effect of curcumin on early stages of PRRSV infection. Results Curcumin inhibited infection of Marc-145 cells and porcine alveolar macrophages (PAMs) by four different genotype 2 PRRSV strains, but had no effect on the levels of major PRRSV receptor proteins on Marc-145 cells and PAMs or on PRRSV binding to Marc-145 cells. However, curcumin did block two steps of the PRRSV infection process: virus internalization and virus-mediated cell fusion. Conclusions Our results suggested that an inhibition of genotype 2 PRRSV infection by curcumin is virus strain-independent, and mainly inhibited by virus internalization and cell fusion mediated by virus. Collectively, these results demonstrate that curcumin holds promise as a new anti-PRRSV drug. |
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Curcumin is a promising inhibitor of genotype 2 porcine reproductive and respiratory syndrome virus infection |
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https://doi.org/10.1186/s12917-017-1218-x https://doaj.org/article/fe7d030cb0c74153a412a70c1d06388f http://link.springer.com/article/10.1186/s12917-017-1218-x https://doaj.org/toc/1746-6148 |
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